April 11th, 1997: An eastbound train heading for Washington D.C. mysteriously derails in a horrific accident, leaving dozens dead or injured. But when one of the bodies is suspected to have been murdered on the train, the only hopes of solving the case rests on the shoulders of a detective, a key witness with amnesia, and another passenger to work together as they seek the truth behind that fateful event, track down the killer, discover what the train was carrying, and if there is a larger and more sinister hand at play.