Kirjahaku

Deprescribing practice in hospice medicine has expanded exponentially in recent years. This book systematically addresses the groups of extremely useful medications to manage chronic disease conditions and prevent complications. It highlights the positive intervention of reducing polypharmacy, improving a terminally ill patient's quality of life, providing individual patient context and helping clinicians in deprescribing. It discusses good ethics, patient wishes and side effect protocols to discontinue no longer relevant medications, thus improving decision-making with the goal of enhancing the patient's quality of life during the time when it is needed the most.Key Features:Empowers the patient, their families, and the providers to have an open discussion about well-informed decision-making.Equips the hospice and palliative care clinicians to comfortably explain the rationale and the discontinuation process of the unessential medications.Highlights the most important facts in bullets along with a unique feature of providing ready-to-go conversational phrases.

Deprescribing practice in hospice medicine has expanded exponentially in recent years. This book systematically addresses the groups of extremely useful medications to manage chronic disease conditions and prevent complications. It highlights the positive intervention of reducing polypharmacy, improving a terminally ill patient's quality of life, providing individual patient context and helping clinicians in deprescribing. It discusses good ethics, patient wishes and side effect protocols to discontinue no longer relevant medications, thus improving decision-making with the goal of enhancing the patient's quality of life during the time when it is needed the most.Key Features:Empowers the patient, their families, and the providers to have an open discussion about well-informed decision-making.Equips the hospice and palliative care clinicians to comfortably explain the rationale and the discontinuation process of the unessential medications.Highlights the most important facts in bullets along with a unique feature of providing ready-to-go conversational phrases.

5methyl substituted phenol benzoxazoles derivatives were synthesized by the reaction of 5 methyl 2 amino phenol with various aldehydes in the presence of Ethyl alcohol and lead tetra acetate.all the compounds were characterized by their analytical and spectral data (IR,1HNMR and Mass). synthesized compounds have been evaluated for their antimicrobial and antifungal activities by gram + and gram - and C. Albicans benzoxazoles derivatives shown significant activity as compared to Griseofulvin standard drugs.

Advancement of medicinal chemistry in this century has been possible due to the integration of various disciplines like organic chemistry, pharmacology, molecular biology, biochemistry and other allied subjects that work hand in hand as a team.A successful medical agent has its birth in stages viz. chemical synthesis, screening for activity/activities, toxicological studies, metabolic studies, clinical trials of a tolerance tests, teratogenic tests, QSAR studies and so on. The biological action of a drug occurs due to the interaction of molecule with other specific molecules or receptors or enzymes. Ariens later elaborated the concept of receptor theory.The isosteric replacement of -O-, -S- and -N- gives rise to the compounds, benzoxazole, benzothiazole and benzimidazole respectively

Conventional tablets available in market are not suitable where quick onset of action is required. Besides, the conventional tablets also show poor patient compliance particularly by the geriatric and pediatric patients who experience difficulty in swallowing, and by those who are bed ridden or who are traveling and do not have an easy access of water. To provide the patients with the most conventional mode of administration, there was a need to develop rapidly disintegrating dosageIn this study, tablets of Fexofenadine HCl were prepared by direct compression, where SSG, CCS, KCL, Xanthan Gum and Ludiflash were used as disintegrants.

Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and channel the active entity to the site of action. At present, no available drug delivery system behaves ideally achieving all the lofty goals, but sincere attempts have been made to achieve them through novel approaches in drug delivery. A number of novel drug delivery systems have emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery. Encapsulation of the drug in vesicular structures is one such system, which can be predicted to prolong the existence of the drug in systemic circulation, and reduce the toxicity, if selective uptake can be achieved. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes, transfersomes, and pharmacosomes were developed. Advances have since been made in the area of vesicular drug delivery, leading to the development of systems that allow drug targeting, and the sustained or controlled release of conventional medicines.

The current approach is to develop new and effective antituberculotic agents by sunthesizing new isoniazid derivatives.Isoniazid is used as anti-tuberculotic drug alon and with the combination with other antibiotics. The review of literature survey reveals that maximum of antimicrobial agents contains heterocyclic rings in their structure. The antimicrobial activity of many antibiotics is increased by attaching heterocyclic rings like azetidine, thiozole, oxazole, indole, imidazole etc with the antibiotics.number of potent medicinal agents consists of azetidine, thiazolidine, oxazolidine and imidazolidine ring in their structure having good antimicrobial potency. From the consideration of the above factors research work was aimed to synthesize isoniazid derivatives and evaluate for antimicrobial, antifungal and anti-tuberculotic activity as compared to standard drugs.

In the various methods of some poorly water soluble drugs and their formulation for quantitative analysis the use of organic solvents can be replaced by using hydrotropy, mixed hydrotropy and mixed solvency giving ecofriendly analytical techniqueThe main drawbacks of organic solvents include high cost, toxicity and pollution. Organic solvents possess different adverse effects caused by single exposure like dermatitis, The hydrotropic solubilization, mixed hydrotropic solubilization and mixed solvency concept provide ecofriendly spectrophotometric estimations of poorly water-soluble drugs from their bulk drug samples and various dosage forms precluding the use of organic solvents providing simple, economic, eco-friendly, safe (free from toxicity) and accurate analytical methods. We can also use better hydrotropic agents for better results.Commonly used organic solvents for spectrophotometric analysis of water insoluble drugs include methanol, ethanol, chloroform, benzene, dichloromethane, dimethyl formamide, acetonitrile, ethyl acetate, toluene, carbon tetrachloride, acetone, hexane etc.

The present work was aimed to design and Synthesize benzimidazole derivatives having antibacterial activity using QSAR technique of indirect designing. The indirect drug design approach has been decided to be used because defined three dimensional coordinates for the receptor site of antibacterial benzimidazole was not available. QSAR is capable of determining appropriate distribution of chemical groups around the nucleus, which are necessary to provide desired biological activity.The aim of present study is to design and synthesis of some potent antibacterial benzimidazole derivatives. Their structure confirmation and evaluation of biological activities. Based on the QSAR studies a few new benzimidazole derivatives were synthesized and virtual screening of this synthesized compound was performed.