Kirjahaku

Alcohol Interactions with Drugs and Chemicals is a concise volume that identifies, documents, and assesses the capacity of alcohol to alter the toxicity of chemical pollutants and drugs in animal models and humans. The book systematically assesses interactions according to general chemical classes of inorganic and organic agents. It also presents an integrative discussion of the significance of these findings to public health.Alcohol Interactions with Drugs and Chemicals will be a valuable reference tool for environmental scientists, toxicologists, epidemiologists, and alcohol researchers studying the interactions of alcohol with drugs and chemical pollutants.

Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

This new book covers drinking water regulations such as disinfectant by-products, synthetic organics, inorganic chemicals, microbiological contaminants, volatile organic chemicals, radionuclides, fluoride, toxicological approaches to setting new national drinking water regulations, and trihalomethanes. In addition, organic and inorganic compounds scheduled to be regulated in 1989 and new candidates for the 1990s regulations are detailed.

Alcohol Interactions with Drugs and Chemicals is a concise volume that identifies, documents, and assesses the capacity of alcohol to alter the toxicity of chemical pollutants and drugs in animal models and humans. The book systematically assesses interactions according to general chemical classes of inorganic and organic agents. It also presents an integrative discussion of the significance of these findings to public health.Alcohol Interactions with Drugs and Chemicals will be a valuable reference tool for environmental scientists, toxicologists, epidemiologists, and alcohol researchers studying the interactions of alcohol with drugs and chemical pollutants.

Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

This new book covers drinking water regulations such as disinfectant by-products, synthetic organics, inorganic chemicals, microbiological contaminants, volatile organic chemicals, radionuclides, fluoride, toxicological approaches to setting new national drinking water regulations, and trihalomethanes. In addition, organic and inorganic compounds scheduled to be regulated in 1989 and new candidates for the 1990s regulations are detailed.

Biological Effects of Low-Level Exposures, more commonly referred to as BELLE, began as a conference in May 1990. Its members are committed to the enhanced understanding of low-dose responses of all types to human exposures to chemical and physical agents, whether of an expected or paradoxical nature. The focus of BELLE encompasses dose-response relationships to toxic agents, pharmaceuticals, and natural products over wide dosage ranges in both in vitro systems and in vivo systems, including human populations. While BELLE promotes the scientific understanding of low-level effects, its primary goal is the scientific evaluation of existing literature and ways to improve research and assessment methods.