This book covers a broad range of questions related to the importance of cell geometry in many areas, including nuclear positioning, chromosome dynamics, cytoskeletal remodeling, tissue patterning, cell-matrix and multicellular contacts. It also addresses medical implications, from its implication in the development of tumors to its role in fibrosis. Together, the chapters in this book will highlight current knowledge and modern approaches to investigating the biophysical design principles underlying key biological functions, with the overall goal of elucidating the connections between cell geometry and nuclear mechanics.