This is a concise how-to of successfully treating previously deemed "untreatable" retinal and optic nerve conditions with stem cell therapies. Based on the results of 11 years of experience treating approximately 600 patients, this text will serve as a template for others to develop similar stem cell based treatments in their specialty. Author, Jeffrey N. Weiss, MD is specifically poised to offer dependable insight on stem cell surgery for both the retina and the optic nerve, having performed the first retinal stem cell surgery in 2010, with Institutional Review Board (IRB) approved studies that are registered with the National Institute of Health (NIH), and listed on ClinicalTrials.gov. Featuring all original work from Dr. Jeffrey Weiss's specialization in stem cell ophthalmology, this book is primarily written for ophthalmologists, but structured so that specialists across disciplines can take the model presented and create their own studies and clinical trials using stem cell therapies.
This is a concise how-to of successfully treating previously poorly or untreatable neurologic conditions with stem cell therapies. The text examines the IRB approved protocols of NEST (Neurologic Bone Marrow Derived Stem Cell Treatment Study), SCiExVr (Stem Cell Spinal Cord Injury Exoskeleton and Virtual Reality Treatment Study), and ACIST (Alzheimer’s and Cognitive Impairment Stem Cell Treatment Study). The discussion focuses on the protocols and informed consents and may be used as a template for specialists to develop clinical trials utilizing stem cell based therapy. Other potential noninvasive treatments for brain injury are also discussed. Neurologic Stem Cell Surgery, the sister text to the recently published Retinal and Optic Nerve Stem Cell Surgery, is an invaluable reference for all physicians with an interest in the development of stem cell based treatments.
This book is a concise guide that provides an easy to follow template for other physicians to develop similar stem cell based treatments within their specialty. It identifies and summarizes the current world-wide orthopedic stem cell trials. Organized into three sections, Orthopedic Stem Cell Surgery presents clinical studies that examine the procedures for setting up and implementing stem cell surgery within the specialty of orthopedics. Chapters maintain an accessible narrative while also addressing complex studies related to orthopedic stem cell surgery. A sister text to the recently published, Retinal and Optic Nerve Stem Cell Surgery, and Neurologic Stem Cell Surgery this expertly written book examines critical Institutional Review Board (IRB) approved studies.
This book is a concise guide that provides an easy to follow template for other physicians to develop similar stem cell based treatments within their specialty. It identifies and summarizes the current world-wide orthopedic stem cell trials. Organized into three sections, Orthopedic Stem Cell Surgery presents clinical studies that examine the procedures for setting up and implementing stem cell surgery within the specialty of orthopedics. Chapters maintain an accessible narrative while also addressing complex studies related to orthopedic stem cell surgery. A sister text to the recently published, Retinal and Optic Nerve Stem Cell Surgery, and Neurologic Stem Cell Surgery this expertly written book examines critical Institutional Review Board (IRB) approved studies.
This book examines the application of stem cell surgery for diabetes and heart failure. Organized into two sections, the first identifies and summarizes the current worldwide stem cell trials for heart failure. Subsequent chapters in part two analyze the current worldwide stem cell trials in patients with Diabetes Mellitus. Both sections utilize studies that include non-expanded stem cells; each study is grouped by stem cell type and geographic location. Stem Cell Surgery Trials in Diabetes and Heart Failure is a comprehensive, convenient reference for cardiologists, endocrinologists, internists, and family physicians.
For the millions of people with untreatable blindness the thought of a visual prosthesis that would allow them to live a normal life has always been a distant hope. There have been intermittent bright spots that periodically fan that hope such as when Dr. Dobelle’s visual prosthesis patient drove a car in an empty parking lot. This book will serve as an update of the work in developing a visual prosthesis. Chapters discuss the physiologic and engineering issues, alternative strategies, and patents, as well as recent research studies. Visual Prosthesis - A Concise Guide is a must-have resource for ophthalmologists, neurologists, engineers and physicists.
For the millions of people with untreatable blindness the thought of a visual prosthesis that would allow them to live a normal life has always been a distant hope. There have been intermittent bright spots that periodically fan that hope such as when Dr. Dobelle’s visual prosthesis patient drove a car in an empty parking lot. This book will serve as an update of the work in developing a visual prosthesis. Chapters discuss the physiologic and engineering issues, alternative strategies, and patents, as well as recent research studies. Visual Prosthesis - A Concise Guide is a must-have resource for ophthalmologists, neurologists, engineers and physicists.
Blindness or serious vision impairment is one of the most feared disabilities known to humankind. A 2016 report compiled by the National Eye Institute (NEI) of the National Institutes of Health (NIH) and Prevent Blindness America states that although half of all blindness can be prevented, the number of people who suffer vision loss continues to increase. The technique of dynamic light scattering (DLS) was developed by physicists in the late 1960s to early 1970s. DLS is now emerging as a potential ophthalmic tool, making possible studies of virtually every tissue and fluid comprising the eye, thus pushing the envelope for broader applications in ophthalmology. This book presents a comprehensive review of the application of light scattering in clinical use. It is the first of its kind, offering insight to how DLS can be applied to the human eye as well as animals. Chapters discuss DLS in neurological diseases, including protocols, informed consent, andpatents. Dynamic Light Scattering Spectroscopy of the Human Eye is a must-have resource for physicians, engineers, and physicists interested in the clinical application of DLS to diagnose and potentially treat medical conditions in a non-invasive, quantitative and novel way.
Blindness or serious vision impairment is one of the most feared disabilities known to humankind. A 2016 report compiled by the National Eye Institute (NEI) of the National Institutes of Health (NIH) and Prevent Blindness America states that although half of all blindness can be prevented, the number of people who suffer vision loss continues to increase. The technique of dynamic light scattering (DLS) was developed by physicists in the late 1960s to early 1970s. DLS is now emerging as a potential ophthalmic tool, making possible studies of virtually every tissue and fluid comprising the eye, thus pushing the envelope for broader applications in ophthalmology. This book presents a comprehensive review of the application of light scattering in clinical use. It is the first of its kind, offering insight to how DLS can be applied to the human eye as well as animals. Chapters discuss DLS in neurological diseases, including protocols, informed consent, andpatents. Dynamic Light Scattering Spectroscopy of the Human Eye is a must-have resource for physicians, engineers, and physicists interested in the clinical application of DLS to diagnose and potentially treat medical conditions in a non-invasive, quantitative and novel way.
This book is the first volume to individually dissect and explore the reasons physicians are leaving medicine. It lays out potential solutions to many of the problems, which will result in a happier practicing physician. Chapters begin with the nature of the problem, and go through a physician's life cycle on the job, from medical school through post-grad and onwards. Chapters will also cover issues as a practicing physician and how to help alleviate these problems. The book ends with potential solutions to the issue of physician burnout. Physician Burnout: Why Doctors Are Leaving Medicine and How to Fix It is a must-have resource for practicing physicians, healthcare providers, and healthcare management. It is also a great resource for medical school students and those looking to get into the healthcare field.
This book is a compendium of the worldwide ocular stem cell studies registered with clinicaltrials.gov. The study title is provided, along with the country of origin and the clinical trial number in order to make it easier for the reader to locate the study and obtain further information. An analysis of the type of stem cell utilized and study support is also provided. The final section deals with issues encountered by the stem cell researchers. Ocular Stem Cell Studies: A Comprehensive Overview of Global Clinical Trials is a valuable resource for ophthalmologists, optometrists, other physicians, and researchers.
This book is a compendium of the worldwide ocular stem cell, gene therapy, optogenetic, and other miscellaneous studies treating Retinitis Pigmentosa registered with Clinicaltrials.gov. Clinicaltrials.gov is the largest website listing of registered clinical research studies in the world. The study title and the Clinical Trial Number is provided in order to make it easier for the reader to obtain further information. The book contains chapters that act as an introduction to Retinitis Pigmentosa, as well as discussion and analysis of the studies. References are also included for the readers’ use. Clinical Trials in Retinitis Pigmentosa Treatment is a valuable resource for ophthalmologists, optometrists, other physicians, and researchers.
This book is a compendium of the worldwide ocular stem cell, gene therapy, pharmaceutical, and other miscellaneous studies treating Age-Related Macular Degeneration registered with Clinicaltrials.gov. Clinicaltrials.gov is the largest website listing of registered clinical research studies in the world. The study and the clinical trial numbers are provided in order to make it easier for the reader to obtain further information. The book also includes an introduction on Age-Related Macular Degeneration as well as analysis of the clinical studies. Clinical Trials in Age-Related Macular Degeneration Treatment is a valuable resource for ophthalmologists, optometrists, other physicians, and researchers.
This book is a compendium of the worldwide ocular stem cell, gene therapy, pharmaceutical, and other miscellaneous studies treating Stargardt Disease registered with Clinicaltrials.gov. Clinicaltrials.gov is the largest website listing of registered clinical research studies in the world. The study numbers and the clinical trial numbers are provided in order to make it easier for the reader to obtain further information. The book also contains an introduction to Stargardt Disease as well as analysis of the clinical trials. Clinical Trials in Stargardt Disease Treatment is a valuable resource for ophthalmologists, optometrists, other physicians, and researchers.
This book is a compendium of the worldwide studies of Alzheimer’s disease utilizing the eye as a biomarker, or as a treatment method, that are registered with the United States National Institutes of Health website, clinicaltrials.gov. Clinicaltrials.gov is the largest listing of research studies in the world. The study titles are provided, as is the country of origin and the Clinical Trial Number in order to make it easier for the reader to locate the study and obtain further information. New drug development is costly and time consuming. If through the use of biomarkers, study durations and research costs decrease, there is a greater possibility of a new and effective drug to treat this devastating disease. The eye offers the possibility of early diagnosis and of treatment. Alzheimer’s Disease and the Eye is a valuable resource for ophthalmologists, optometrists, other physicians, and researchers.
This book is a compendium of the worldwide ocular stem cell, gene therapy, and other studies treating Optic Nerve Disease that are registered with Clinicaltrials.gov. The study and the Clinical Trial number is provided in order to make it easier for the reader to obtain further information. The book contains an introduction to Optic Nerve Disease as well as a summary of common optic nerve conditions. Clinical Trials in Optic Nerve Disease Treatment is a valuable resource for ophthalmologists, optometrists, other physicians, and researchers.
This book is a compendium of the worldwide studies of gene therapy in neurologic conditions, that are registered with the United States National Institutes of Health website, clinicaltrials.gov. Clinicaltrials.gov is the largest listing of research studies in the world. The study titles are provided, as is the country of origin and the Clinical Trial Number in order to make it easier for the reader to locate the study and obtain further information. The book covers topics such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, Muscular Dystrophy, Frontotemporal Dementia, Epilepsy, and many more. Chapters will examine currently recruiting studies as well as soon-to-be recruiting studies. Neurologic Gene Therapy: A Comprehensive Review of Global Clinical Trials will be a valuable resource for neurologists, neurosurgeons, related and allied physicians, PhDs, and researchers.
This book offers a comprehensive review of the global exosome trials in neurology and ophthalmology, that are registered with the United States National Institutes of Health website, clinicaltrials.gov. Clinicaltrials.gov is the largest listing of research studies in the world. The study titles are provided, as is the country of origin and the Clinical Trial Number in order to make it easier for the reader to locate the study and obtain further information. The book begins with an introduction to exosomes and exosome therapy, which involves the injection or infusion of exosomes, making it less invasive than traditional gene therapy, which involves the introduction, removal, or alteration of genetic material. Subsequent chapters discuss neurologic exosome therapy trials and ophthalmic exosome therapy trials. The book covers topics such as Alzheimer's Disease, back pain, cancer, dementia, neuralgia, dry eyes, diabetic retinopathy, and macular hole. Chapters will examine currently recruiting studies as well as soon-to-be recruiting studies. Global Exosome Trials in Neurology and Ophthalmology will be a valuable resource for neurologists, neurosurgeons, ophthalmologists, related and allied physicians, PhDs, and researchers.
