Kirjahaku

Research physicians face intractable dilemmas when they consider introducing new medical procedures. Innovations carry the promise of preventing or curing life-threatening diseases, but they can also lead to injury or even death. How have clinical scientists made high-stakes decisions about undertaking human tests of new medical treatments? In Lesser Harms, Sydney Halpern explores this issue as she examines vaccine trials in America during the early and mid-twentieth century.Today's scientists follow federal guidelines for research on human subjects developed during the 1960s and 1970s. But long before these government regulations, medical investigators observed informal rules when conducting human research. They insisted that the dangers of natural disease should outweigh the risks of a medical intervention, and they struggled to accurately assess the relative hazards. Halpern explores this logic of risk in immunization controversies extending as far back as the eighteenth century. Then, focusing on the period between 1930 and 1960, she shows how research physicians and their sponsors debated the moral quandaries involved in moving vaccine use from the laboratory to the clinic.This probing work vividly describes the efforts of clinical investigators to balance the benefits and dangers of untested vaccines, to respond to popular sentiment about medical hazards, and to strategically present risk laden research to sponsors and the public. “Concise and extremely well-written. . . . A fascinating synthesis of sociology, history, and institutional theory.”—Samuel C. Blackman, Journal of the American Medical Association

Research physicians face intractable dilemmas when they consider introducing new medical procedures. Innovations carry the promise of preventing or curing life-threatening diseases, but they can also lead to injury or even death. How have clinical scientists made high-stakes decisions about undertaking human tests of new medical treatments? In Lesser Harms, Sydney Halpern explores this issue as she examines vaccine trials in America during the early and mid-twentieth century.Today's scientists follow federal guidelines for research on human subjects developed during the 1960s and 1970s. But long before these government regulations, medical investigators observed informal rules when conducting human research. They insisted that the dangers of natural disease should outweigh the risks of a medical intervention, and they struggled to accurately assess the relative hazards. Halpern explores this logic of risk in immunization controversies extending as far back as the eighteenth century. Then, focusing on the period between 1930 and 1960, she shows how research physicians and their sponsors debated the moral quandaries involved in moving vaccine use from the laboratory to the clinic.This probing work vividly describes the efforts of clinical investigators to balance the benefits and dangers of untested vaccines, to respond to popular sentiment about medical hazards, and to strategically present risk laden research to sponsors and the public. “Concise and extremely well-written. . . . A fascinating synthesis of sociology, history, and institutional theory.”—Samuel C. Blackman, Journal of the American Medical Association

The untold history of America’s mid-twentieth-century program of hepatitis infection research, its scientists’ aspirations, and the damage the project caused human subjects “Sydney Halpern has written a compelling, if unsettling, history of hepatitis research during World War II and the Cold War. It will become a must-read for anyone interested in bioethics and medical history.”—Susan E. Lederer, author of Subjected to Science and Flesh and Blood From 1942 through 1972, American biomedical researchers deliberately infected people with hepatitis. Government-sponsored researchers were attempting to discover the basic features of the disease and the viruses causing it, and to develop interventions that would quell recurring outbreaks. Drawing from extensive archival research and in-person interviews, Sydney Halpern traces the hepatitis program from its origins in World War II through its expansion during the initial Cold War years, to its demise in the early 1970s amid an outcry over research abuse. The subjects in hepatitis studies were members of stigmatized groups—conscientious objectors, prison inmates, the mentally ill, and developmentally disabled adults and children. The book reveals how researchers invoked military and scientific imperatives and the rhetoric of a common good to win support for the experiments and access to recruits. Halpern examines the participants’ long-term health consequences and raises troubling questions about hazardous human experiments aimed at controlling today’s epidemic diseases.

Today's parents routinely consult pediatricians for care of sick youngsters, information on child development, and advice on problems of child management. Yet only a hundred years ago, special medical services for children barely existed. During the intervening century, physicians defined a new field and built occupational structures that established pediatrics as a permanent division of medical practice. Professor Halpern traces the development of American pediatrics over the last century and identifies social processes underlying its evolution. How did the pediatric specialty arise? Through what processes did it emerge? What forces shaped its changing scope and organization? In addressing these questions, the author draws on a rich combination of primary and secondary historical sources, unpublished documents, and interview data. She shows how successive generations of specialists redefined pediatrics and created a series of occupational institutions, including professional societies, academic divisions, training programs, and certifying boards. American Pediatrics offers an original approach to the study of medical specialties and professions and contributes a new perspective on professionalism. Showing specialties to be both products and agents of societal change, the book highlights multiple and interrelated forces contributing to the rise of new professions and documents the influence of surrounding occupations on the shape specialties assume. Halpern enriches our understanding of American medicine and clarifies the origins of expert services for children and families. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1988.

Today's parents routinely consult pediatricians for care of sick youngsters, information on child development, and advice on problems of child management. Yet only a hundred years ago, special medical services for children barely existed. During the intervening century, physicians defined a new field and built occupational structures that established pediatrics as a permanent division of medical practice. Professor Halpern traces the development of American pediatrics over the last century and identifies social processes underlying its evolution. How did the pediatric specialty arise? Through what processes did it emerge? What forces shaped its changing scope and organization? In addressing these questions, the author draws on a rich combination of primary and secondary historical sources, unpublished documents, and interview data. She shows how successive generations of specialists redefined pediatrics and created a series of occupational institutions, including professional societies, academic divisions, training programs, and certifying boards. American Pediatrics offers an original approach to the study of medical specialties and professions and contributes a new perspective on professionalism. Showing specialties to be both products and agents of societal change, the book highlights multiple and interrelated forces contributing to the rise of new professions and documents the influence of surrounding occupations on the shape specialties assume. Halpern enriches our understanding of American medicine and clarifies the origins of expert services for children and families. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1988.