The phenomenal internationalization of taxation occurring in recent years has called for a second edition of this classic handbook. Even though a quarter of a century has passed, the farsighted first edition has remained in constant use worldwide and has even grown in importance. Now it has been thoroughly updated by the author, who has brought his piercing insight to bear on the current world of international tax law while retaining the book's practical format, structure of primary materials, and detailed commentary. Emphasizing the need for an international consciousness in relation to issues of taxation, Professor Qureshi focuses extensively on the problems associated with fiscal jurisdiction, international constraints in domestic taxation, double taxation, and tax evasion and avoidance. In particular the following are covered: treaty law with specific reference to taxation; fiscal aspects of international monetary, investment, and trade law; enforcement of international tax claims; exchange of information; assistance in recovery of tax claims; mechanisms for the resolution of international tax disputes; base erosion and profit shifting in the framework of public international law; and contribution of international institutions to fiscal capacity development. Assimilating in one source the basic materials in public international law germane to taxation - including cases, texts of international agreements, discourse in secondary sources, and incisive commentary, all updated to the present - this new edition of the most authoritative and important book in its field will be of immeasurable value to tax practitioners worldwide, national taxation authorities, international institutions, and the international tax community more generally.
The cost of drug development is increasing, and investment returns are decreasing. The number of drugs approved by FDA is in decline in terms of the number of new molecular entities (NMEs). Amongst the reasons noted for this are the adverse side effects and reduced efficiency of many of the potential compounds. This is a problem both for the pharmaceutical industry and for those suffering from diseases for which there are no or few available treatments. Advances in computational chemistry, computer science, structural biology and molecular biology have all contributed to improved drug design strategies and reduced the time taken for drug discovery. By interfacing cheminformatics and bioinformatics with systems biology we can create a powerful tool for understanding the mechanisms of patho-physiological systems and identifying lead molecules for various diseases. This integration of drug design approaches can also play a crucial role in the prediction and rationalization of drug effects and side effects, improving safety and efficacy and leading to better approval rates. Addressing the lack of knowledge on the fundamental aspects of the various computational tools for drug discovery, this book is a compilation of recent bioinformatics and cheminformatics approaches, and their integration with systems biology. Written primarily for researchers and academics in chem- and bioinformatics, it may also be a useful resource for advanced-level students.
This book is a compelling and comprehensive guide to the dynamic world of antennas tailored for healthcare. With its practical case studies, forward-looking perspectives, and a keen focus on the potential of 6G wireless communications, this book serves as an indispensable resource, driving the advancement of wireless technologies in the realm of biomedical applications, ultimately transforming the future of healthcare. The authors bridge the gap between complex scientific concepts and practical applications, making this book accessible to healthcare professionals, researchers, students, and anyone interested in understanding how antennas play a pivotal role in transforming the landscape of healthcare technologies. The book delves into the principles of different types of antennas, such as microstrip patch antennas, dipole antennas, helical antennas, and planar inverted-F antennas, explaining how each one serves a specific purpose in healthcare. Offers a comprehensive exploration of antennas designed explicitly for healthcare applicationsCovers various types of antennas, including principles, design, optimization, and practical case studiesWritten in non-specialists' terms, making content easily accessible to a broad audience
Minimally invasive surgery (MIS) is an approach to surgery that minimises cutting through the skin and tissues. Surgeons use MIS techniques and technology to cause as little trauma as possible during a procedure. Smaller cuts reduce the potential for pain, complications and recovery time. Laparoscopic, endoscopic and robotic procedures are all types of minimally invasive surgery. Comprising more than 1500 pages, this two-volume set is a complete guide to laparoscopic, endoscopic and robotic surgical procedures. Divided into six sections, the book begins with an introduction to the types, basic principles and equipment for minimally invasive surgery. Each of the remaining sections covers operative procedures for different sections of the gastrointestinal system – oesophagus, stomach and small intestine; colon, rectum and anal canal; liver, biliary tract, pancreas, and spleen; bariatrics and metabolic surgery; and abdominal wall hernia. Each chapter provides step by step detail on a different procedure, assisted by illustrative figures and useful tables. Access to demonstrative videos illustrating surgical procedures is included with the book.
