Having a baby and a career can feel challenging on the best of days, nearly impossible on the worst. From figuring out how to tell your boss you're pregnant to sucking in your belly bump all day long at work, to working even harder to prove your worth, there's a lot to navigate if you're newly pregnant or are even thinking about getting pregnant - and trying to juggle it all can leave you overwhelmed. It doesn t have to be this way. You can do it all, just not at the same time. And not alone. Carry Strong offers a new approach to working motherhood that wholeheartedly embraces pregnancy as an integral and concurrent part of a woman's career - and flips the script on a cultural constant to re-frame pregnancy as an opportunity to retain, instead of lose, women in the workplace. Drawing from four original studies plus hundreds of inspirational interviews, executive and career advocate Stephanie Kramer outlines essential principles for navigating your pregnancy and work simultaneously. Wi
Articulating eight decades of American style through the emotive language of clothing—from celebrated designers that established the modern legacy of sportswear to emerging creatives shaping the future of fashion in the United States “The design of the exhibition and the catalog is straightforward and compartmentalized, allowing the clothes to speak for themselves and contain their own narratives.”—Laird Borrelli-Persson, Vogue.com This new presentation of American fashion features a revised vocabulary that emphasizes its expressive qualities. Stunning new photography showcases over 100 garments from the 1940s to the present that offer a timely new perspective on the diverse and multifaceted nature of American fashion. The catalogue features works that display qualities such as belonging, comfort, desire, exuberance, fellowship, joy, nostalgia, optimism, reverence, spontaneity, strength, and sweetness by designers, from the pioneers who established the nation’s style to the up-and-coming creatives shaping its future. In America: A Lexicon of Fashion includes designs by Gilbert Adrian, Geoffrey Beene, Thom Browne, Bonnie Cashin, Willy Chavarria, Telfar Clemens, Dauphinette (Olivia Cheng), Oscar de la Renta (Fernando Garcia and Laura Kim), Denim Tears (Tremaine Emory), Perry Ellis, Tom Ford, Rudi Gernreich, Halston, Elizabeth Hawes, Carolina Herrera, Conner Ives, Charles James, Donna Karan, KidSuper (Colm Dillane), Calvin Klein, Michael Kors, Ralph Lauren, LRS (Raul Solís), Vera Maxwell, Claire McCardell, Norman Norell, Heron Preston, Pyer Moss (Kerby Jean-Raymond), Christopher John Rogers, Collina Strada (Hillary Taymour), Diane von Furstenberg, Vera Wang, and many more. Published by The Metropolitan Museum of Art/Distributed by Yale University Press Exhibition Schedule: The Metropolitan Museum of Art, New York (September 18, 2021–September 5, 2022)
In the administrative district of Munich alone, a total of 13,500 foreign civilian labourers and prisoners of war performed forced labour during the Second World War. Based partly on previously unpublished material, the authors examine the so-called 'Auslandereinsatz' (use of foreigners) in the administrative district of Munich: recruitment by force abroad, the living conditions of the forced labourers in the Munich district, and their relations to the local population. To this end, documents from the federal archive as well as from state and communal archives, interviews with contemporary witnesses and letters of former forced labourers were evaluated. This documentation of numerous individual destinies demonstrates in exemplary fashion, the forms adopted by forced labour during the Second World War."
Stefan Bräse; Franziska Gläser; Carsten Kramer; Stephanie Lindner; Anna M. Linsenmeier; Kye-Simeon Masters; Anne C. Meister; Bettina M. Ruff; Sabilla Zhong
The biological activity of mycotoxins ranges from weak and/or sometimes positive effects, such as antibacterial activity (see penicillin derivatives derived from Penicillium strains) to strong mutagenic (e. g. aflatoxins, patulin), carcinogenic (e. g. aflatoxins), teratogenic, neurotoxic (e. g. ochratoxins), nephrotoxic (e. g. fumonisins, citrinin), hepatotoxic, and immunotoxic (e. g. ochratoxins, diketopiperazines) activity. Nowadays, many laboratories around the world are specialized in the detection of mycotoxins in food products and contaminated material found in housing. In this volume, a focus on the most important classes of mycotoxins is provided and their chemistry of the last ten years is discussed. In each Section, the individual biological impact is outlined. Sections are arranged according to mycotoxin classes (e. g. aflatoxins) and/or structural classes (e. g. resorcinyl lactones, diketopiperazines). The biology of mycotoxins is also described.
Stefan Bräse; Franziska Gläser; Carsten Kramer; Stephanie Lindner; Anna M. Linsenmeier; Kye-Simeon Masters; Anne C. Meister; Bettina M. Ruff; Sabilla Zhong
The biological activity of mycotoxins ranges from weak and/or sometimes positive effects, such as antibacterial activity (see penicillin derivatives derived from Penicillium strains) to strong mutagenic (e. g. aflatoxins, patulin), carcinogenic (e. g. aflatoxins), teratogenic, neurotoxic (e. g. ochratoxins), nephrotoxic (e. g. fumonisins, citrinin), hepatotoxic, and immunotoxic (e. g. ochratoxins, diketopiperazines) activity. Nowadays, many laboratories around the world are specialized in the detection of mycotoxins in food products and contaminated material found in housing. In this volume, a focus on the most important classes of mycotoxins is provided and their chemistry of the last ten years is discussed. In each Section, the individual biological impact is outlined. Sections are arranged according to mycotoxin classes (e. g. aflatoxins) and/or structural classes (e. g. resorcinyl lactones, diketopiperazines). The biology of mycotoxins is also described.
Kirsten M Keller; Ginger Groeber; Philip Armour; Jenna W Kramer; Shirley M Ross; Diana Y Myers; Hannah Acheson-Field; Samantha E Dinicola; Shreyas Bharadwaj; Stephanie Williamson
A paperback edition of a classic text, this book gives a unique survey of the known solutions of Einstein's field equations for vacuum, Einstein-Maxwell, pure radiation and perfect fluid sources. It introduces the foundations of differential geometry and Riemannian geometry and the methods used to characterize, find or construct solutions. The solutions are then considered, ordered by their symmetry group, their algebraic structure (Petrov type) or other invariant properties such as special subspaces or tensor fields and embedding properties. Includes all the developments in the field since the first edition and contains six completely new chapters, covering topics including generation methods and their application, colliding waves, classification of metrics by invariants and treatments of homothetic motions. This book is an important resource for graduates and researchers in relativity, theoretical physics, astrophysics and mathematics. It can also be used as an introductory text on some mathematical aspects of general relativity.
In considering whether Department of Defense youth programs help bridge the civilian-military divide, the authors survey school leaders to gauge their awareness and perceptions of these programs; review curricula to understand how they support students' development of civics, leadership, and service knowledge; and conduct analyses on the influence of these programs on military applications and accessions.
Inhaltlich unver nderte Neuauflage. Der Anteil sowie die Komplexit t fremd bezogener G ter und Dienst-leis-tun-gen sind in den letzten Jahrzehnten stetig angestiegen. Dieser Trend ist eine von verschiedenen Ursachen, die zu einem starken Bedeu-tungszuwachs der Be-schaffung gef hrt haben. In den USA entstand in diesem Kontext ein Modell zur Erfassung aller zen-tra-len Kosten, die im Leben eines Kaufobjektes anfallen: Die Total Cost of Ownership (TCO) sollen helfen, bis zu zehn Prozent des Be-schaf-fungs-vo-lu-mens einzusparen. Die Autorin erl utert das Konzept der TCO und seine Anwen-dungs-m g-lich-kei-ten im Unternehmen, gibt einen Einblick in den aktuellen Stand wissen-schaft-li-cher Forschung inklusive Studien- und Literatur berblick und grenzt den Ansatz von hnlichen Verfahren, insbesondere dem Life Cycle Costing, ab. Eine Befragung von 46 Beschaffungsmanagern der gr ten deutschen Indus-trie-unternehmen zeigt abschlie end, dass das Konzept einen hohen Stellen-wert in Vergabeentscheidungen einnimmt, allerdings in verschiedenen Frage-stel-lungen noch weiterer Forschungsbedarf besteht. Das Buch richtet sich branchen bergreifend an Entscheidungstr ger in der Be-schaffung, im Management sowie an Wirtschaftswissenschaftler.
Verhandlungssituationen um Wachstumskapital mit potentiellen Kapitalgebern sind regelmäßig geprägt von standortbedingten Rahmenbedingungen, Informationsasymmetrien zwischen den Parteien und mit der Unternehmensfinanzierung verbundenen teils aufsichtsrechtlichen Reglementierungen. Vor diesem Hintergrund erfolgt durch potentielle Kapitalgeber (Beteiligungsgesellschaften und Kreditinstitute) regelmäßig eine aktive Wissenserarbeitung, die sogenannte Due Diligence bzw. Kreditwürdigkeitsprüfung, die nicht zuletzt in einer Verschiebung der Verhandlungsstärke zugunsten der potenziellen Kapitalgeber resultiert. Zur Aufrechterhaltung der Verhandlungsposition hat sich auf dem Markt für M&A-Transaktionen etablierter Unternehmen das Instrument einer aktiven Wissensvermittlung durch den Verkäufer etabliert, die sogenannte Verkäufer Due Diligence. Gegenstand und Zielsetzung dieser Arbeit ist die Untersuchung, ob dieses Instrument in Form einer Business Plan Due Diligence auf die Finanzmittelakquisition junger wachstumsstarker Unternehmen übertragen werden kann. Die Arbeit zeigt, dass sowohl Initiatoren, Anbieter als auch Adressaten einer Business Plan Due Diligence dieses Konzept als grundsätzlich anwendbar betrachten. Darüber hinaus wird in der Initiierung einer Business Plan Due Diligence das Potenzial der Verbesserung der Verhandlungsposition junger wachstumsstarker Unternehmen in Finanzierungsverhandlungen mit potenziellen Kapitalgebern gesehen. Schließlich wird eine Business Plan Due Diligence, ähnlich wie die Verkäufer Due Diligence, von potenziellen Kapitalgebern akzeptiert. Die Übertragung der Verkäufer Due Diligence auf Verhandlungssituationen um Wachstumskapital ist aufgrund des Nichtvorhandenseins detaillierten und fundierten Vergangenheitsmaterials junger wachstumsstarker Unternehmen jedoch möglicherweise nur eingeschränkt erreichbar.
Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of 'hits', which invade the databases like swarms of locusts. But far from being a plague, these innumerable compounds become a blessing if properly screened for 'drugability', i.e., for 'drug-like' properties such as good pharmacokinetic (PK) behavior. Pharmacokinetic profiling of bioactive compounds has, thus, become a sine qua non condition for cherry-picking the most promising hits. Just as important, but less visible, are the structure-property and structure-ADME relations, which emerge from PK profiling and provide useful feedback when designing new synthetic series. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming development and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, powerful biological, physicochemical, and computational approaches are being developed, whose objectives are to increase the clinical relevance of drug design and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. The profiling of ADME properties (absorption, distribution, metabolism, and excretion) is the topic of this book. Following the extraordinary success of the previous work ('Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies', Eds. B. Testa, H. van de Waterbeemd, G. Volkers, R. Guy, Verlag Helvetica Chimica Acta, Zurich, 2001, 655 pages), there was a need for an essentially new edition focusing on the latest theoretical and technological breakthroughs. In this unique work, international authorities and practicing experts from academia and industry offer state-of-the-art presentations of concepts, methods and technologies now in use or development in drug research. The biological strategies emphasized in the book include cell cultures, drug-metabolizing enzymes, transporters and plasma protein binding. The physicochemical strategies focus on artificial membrane-permeability assays, on solubility and lipophilicity and related molecular properties as factors and predictors of pharmacokinetic behavior, and on stability and solid-state properties. Computational strategies comprize the exploration of property spaces, pharmacophore searching to predict biotransformation and enzyme inhibition, and expert systems to process biopharmaceutical profiling data. In addition to its 28 chapters, the book includes a CD-ROM containing the invited lectures, oral communications, and posters (in full version) presented at the Third LogP Symposium, 'Physicochemical and Biological Profiling in Drug Research', held at the Federal Institute of Technology (ETH) of Zurich in March 2004.
Franz-Peter Weixler wurde bekannt durch seine eindringlichen Fotos, die er als Kriegsberichterstatter der deutschen Wehrmacht w hrend der Erschie ung der m nnlichen Einwohner der kretischen Gemeinde Kondomari machte. Auch die eidesstattliche Erkl rung, die er 1945 f r den Internationalen Gerichtshof in N rnberg gegen die Hauptkriegsverbrecher des Deutschen Reiches vorlegte, beschreibt auf eindrucksvolle Weise, was sich an jenem 2. Juni 1941 abspielte. Weixler fertigte vor, w hrend und nach dem Krieg fast 1000 stereoskopische Bilder an, die in der gesamten Breite im Deutschen Historischem Museum gelagert sind. Bei vielen Eins tzen als Kriegsberichterstatter hatte Weixler neben seiner normalen Kamera oftmals Bilder mit der stereoskopischen Kamera aufgenommen. Auch benutzte er zeitweise die damals noch seltenen Farbfilme. Dieses Buch soll dem interessierten Leser einen gewissen berblick ber die Arbeiten des Fotografen vermitteln. Leider war aus rechtlichen Gr nden die Wiedergabe der stereoskopischen Bilder nur in wenigen F llen m glich, da sie an anderer Stelle bereits ver ffentlicht wurden.
