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296 tulosta hakusanalla Midhat Ajanovic
Zytokine wirken sich auf krebsassoziierte zelluläre Mechanismen aus
Dalia Medhat
Verlag Unser Wissen
2025
pokkari
Impacto de las citoquinas en los mecanismos celulares asociados al cáncer
Dalia Medhat
Ediciones Nuestro Conocimiento
2025
nidottu
Impact des cytokines sur les mécanismes cellulaires associés au cancer
Dalia Medhat
Editions Notre Savoir
2025
pokkari
L'impatto delle citochine sui meccanismi cellulari associati al cancro
Dalia Medhat
Edizioni Sapienza
2025
pokkari
Wplyw cytokin na mechanizmy komórkowe zwiazane z rakiem
Dalia Medhat
Wydawnictwo Nasza Wiedza
2025
pokkari
Impacto das citocinas nos mecanismos celulares associados ao cancro
Dalia Medhat
Edicoes Nosso Conhecimento
2025
pokkari
Ludzki mikrobiom jest istotnym i elastycznym metagenomem, kt ry r żni się w zależności od miejsca ciala, środowiska i stanu zdrowia. Zakl cenia - znane jako dysbiozy - zmieniają spoleczności drobnoustroj w ze zdrowych w chore. Mikroby wydzielają bioaktywne cząsteczki, kt re wplywają na lokalne tkanki i odlegle narządy poprzez modulowanie metabolizmu, odporności i r wnowagi fizjologicznej. Zar wno nadmierna r żnorodnośc w typowych miejscach o niskiej r żnorodności, jak i zmniejszona r żnorodnośc w bogatych środowiskach może zwiększac ryzyko chor b. Ukierunkowana modulacja mikrobiomu poprzez dietę, antybiotyki lub probiotyki stanowi zatem obiecującą strategię zapobiegania i leczenia chor b. Niniejsza książka oferuje zaktualizowaną syntezę aktualnej wiedzy na temat interakcji mikrobioty jelitowej, ich fizjologicznych i patologicznych r l oraz najnowszych postęp w w badaniach.
Autophagy is an intracellular degradation system that delivers cytoplasmic components to the lysosome. Despite its apparent simplicity, recent research has revealed that it plays a wide range of physiological and pathophysiological roles, many of which are highly complex. The process of autophagy occurs through several sequential steps-sequestration, transport to lysosomes, degradation, and utilization of degradation products-with each step potentially fulfilling distinct functions. In cancer progression, metastasis represents an especially complex process. Autophagy exerts stage-specific effects: in the early stages, it functions as a tumor suppressor by preventing necrosis and limiting inflammation, whereas in advanced stages, it can promote metastasis by enabling malignant cells to disseminate into the bloodstream. This book explores the mechanisms of autophagy and its role in driving cancer metastasis, with particular attention to how it enhances tumor aggressiveness in a process-dependent manner.
Via PI3K/AKT: Un centro molecolare nella salute e nella malattia
Dalia Medhat
Edizioni Sapienza
2025
nidottu
Ścieżka PI3K/AKT: Molekularne centrum zdrowia i choroby
Dalia Medhat
Wydawnictwo Nasza Wiedza
2025
nidottu
The prevalence of Crohn's disease (CD), a chronic and life-threatening inflammatory bowel disease (IBD), is steadily increasing worldwide. A shift to personalized medicine is required because CD is a very heterogeneous disease that poses ongoing challenges in prognosis and treatment selection. The crucial and quickly developing field of disease prognosis receives a significant amount of attention. In addition to examining markers for predicting disease course and the growing potential of proteomics for forecasting disease activity and treatment response, the book goes beyond conventional evaluations to emphasize the clinical significance of biomarkers in CD. Finally, the book offers an exhaustive review of potential factors associated with the progression of CD and the current medical treatments guiding toward effective, personalized patient management.
O microbioma humano um metagenoma vital e adapt vel que varia consoante os locais do corpo, os ambientes e as condi es de sa de. As perturba es - conhecidas como disbioses - mudam as comunidades microbianas de estados saud veis para estados de doen a. Os micr bios segregam mol culas bioactivas que influenciam os tecidos locais e os rg os distantes, modulando o metabolismo, a imunidade e o equil brio fisiol gico. Tanto a diversidade excessiva em locais tipicamente de baixa diversidade como a diversidade reduzida em ambientes ricos podem aumentar o risco de doen a. A modula o direcionada do microbioma atrav s da dieta, antibi ticos ou probi ticos representa, assim, uma estrat gia promissora para a preven o e gest o de doen as. Este livro oferece uma s ntese actualizada dos conhecimentos actuais sobre as intera es do microbiota intestinal, os seus pap is fisiol gicos e patol gicos e os recentes avan os da investiga o.
Das menschliche Mikrobiom ist ein vitales und anpassungsf higes Metagenom, das je nach K rperstelle, Umgebung und Gesundheitszustand variiert. St rungen - bekannt als Dysbiosen - verschieben mikrobielle Gemeinschaften von gesunden zu kranken Zust nden. Mikroben scheiden bioaktive Molek le aus, die lokale Gewebe und entfernte Organe beeinflussen, indem sie den Stoffwechsel, die Immunit t und das physiologische Gleichgewicht modulieren. Sowohl eine berm ige Diversit t an typischerweise artenarmen Standorten als auch eine reduzierte Diversit t in reichhaltigen Umgebungen k nnen das Krankheitsrisiko erh hen. Die gezielte Modulation des Mikrobioms durch Ern hrung, Antibiotika oder Probiotika stellt daher eine vielversprechende Strategie zur Pr vention und Behandlung von Krankheiten dar. Dieses Buch bietet eine aktualisierte Synthese des aktuellen Wissens ber die Interaktionen der Darmmikrobiota, ihre physiologische und pathologische Rolle und die j ngsten Forschungsfortschritte.
The human microbiome is a vital and adaptable metagenome that varies across body sites, environments, and health conditions. Disruptions-known as dysbioses-shift microbial communities from healthy to diseased states. Microbes secrete bioactive molecules that influence local tissues and distant organs by modulating metabolism, immunity, and physiological balance. Both excessive diversity in typically low-diversity sites and reduced diversity in rich environments can increase disease risk. Targeted microbiome modulation through diet, antibiotics, or probiotics thus represents a promising strategy for disease prevention and management. This book offers an updated synthesis of current knowledge on gut microbiota interactions, their physiological and pathological roles, and recent research advances.
Le microbiome humain est un m tag nome vital et adaptable qui varie selon les sites corporels, les environnements et les tats de sant . Les perturbations, connues sous le nom de dysbioses, font passer les communaut s microbiennes d'un tat sain un tat pathologique. Les microbes s cr tent des mol cules bioactives qui influencent les tissus locaux et les organes distants en modulant le m tabolisme, l'immunit et l' quilibre physiologique. Une diversit excessive dans des sites typiquement peu diversifi s et une diversit r duite dans des environnements riches peuvent augmenter le risque de maladie. La modulation cibl e du microbiome par l'alimentation, les antibiotiques ou les probiotiques repr sente donc une strat gie prometteuse pour la pr vention et la gestion des maladies. Cet ouvrage propose une synth se actualis e des connaissances actuelles sur les interactions entre les microbiotes intestinaux, leurs r les physiologiques et pathologiques, et les avanc es r centes de la recherche.