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Lentiviral Vector Systems for Gene Transfer

Lentiviral Vector Systems for Gene Transfer

Kluwer Academic/Plenum Publishers
2003
sidottu
The human immunodeficiency viruses (HIVs), in particular HIV-1, are the causative agent responsible for the current worldwide epidemic of acquired immunodeficiency syndrome (AIDS). A major effort has thus been underway over the past two decades to understand and control this pathogen. During this time, an enormous knowledge base has accumulated regarding the role of viral factors in the HIV-1 life cycle, and the interaction of HIV-1 with the host cell is becoming increasingly understood. Certain features of HIV, for example its ability to infect non-dividing cells, are being exploited in the development of novel gene therapy vehicles. This volume provides an overview of the current information regarding the HIV replication cycle and will serve as an introduction to subsequent chapters that address specific aspects of lentiviral-based gene therapy.
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Chaos Vector

Chaos Vector

Megan E. O'Keefe

ORBIT
2020
nidottu
Dazzling space battles, intergalactic politics, and rogue AI collide in the second book in this epic space opera by award-winning author Megan O'Keefe.Sanda and Tomas are fleeing for their lives after letting the most dangerous smartship in the universe run free. Now, unsure of who to trust, Sanda knows only one thing for certain -- to be able to save herself from becoming a pawn of greater powers, she needs to discover the secret of the coordinates hidden in her skull. But getting to those coordinates is a problem she can't solve alone. They exist beyond a dead gate -- a Casimir gate that opened up into a dead-end system without resources worth colonizing, and was sealed off. To get through the dead gate, she needs the help of the enemy Nazca. But some Nazca are only interested in the chip in her head -- and they'll crack her open to get to it.
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Chaos Vector

Chaos Vector

Megan E. O'Keefe

Orbit
2020
pokkari
'METICULOUSLY PLOTTED, EDGE-OF-YOUR-SEAT SPACE OPERA WITH A SOUL' Kirkus on Velocity WeaponThe fate of the galaxy is on the line in the second book of this gripping, visionary space opera by award-winning author Megan E. O'Keefe.Sanda and Tomas are fleeing for their lives after letting the most dangerous smartship in the universe run free. Now, unsure of who to trust, Sanda knows only one thing for certain - to be able to save herself from becoming a pawn of greater powers, she needs to discover the secret of the coordinates hidden in her skull.But getting to those coordinates is a problem she can't solve alone. They exist beyond a deadgate - a sealed-off Casimir gate that opens up into a dead-end system. And there's a dangerous new player who wants the coordinates for their own ends - a player who will happily crack her open to get them.Dazzling space battles, intergalactic politics and rogue AI collide in the follow-up to the Philip K. Dick award-shortlisted Velocity Weapon.Praise for the series:'A brilliantly plotted yarn of survival and far-future political intrigue' Guardian'Full of twists, feints, and deception, O'Keefe's latest presents a visionary world rife with political intrigue and space adventure' Booklist (starred review)'Skillfully interweaves intrigue, action, and strong characterization' Publishers Weekly'A must-read for fans of James S. A. Corey and Alastair Reynolds' Bookbag'O'Keefe keeps the pace pumping, timing the big twists perfectly' SFX
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Nonsmooth Vector Functions and Continuous Optimization

Nonsmooth Vector Functions and Continuous Optimization

V. Jeyakumar; Dinh The Luc

Springer-Verlag New York Inc.
2007
sidottu
A recent significant innovation in mathematical sciences has been the progressive use of nonsmooth calculus, an extension of the differential calculus, as a key tool of modern analysis in many areas of mathematics, operations research, and engineering. Focusing on the study of nonsmooth vector functions, this book presents a comprehensive account of the calculus of generalized Jacobian matrices and their applications to continuous nonsmooth optimization problems and variational inequalities in finite dimensions. The treatment is motivated by a desire to expose an elementary approach to nonsmooth calculus by using a set of matrices to replace the nonexistent Jacobian matrix of a continuous vector function. Such a set of matrices forms a new generalized Jacobian, called pseudo-Jacobian. A direct extension of the classical derivative that follows simple rules of calculus, the pseudo-Jacobian provides an axiomatic approach to nonsmooth calculus, a flexible tool for handling nonsmooth continuous optimization problems. Illustrated by numerous examples of known generalized derivatives, the work may serve as a valuable reference for graduate students, researchers, and applied mathematicians who wish to use nonsmooth techniques and continuous optimization to model and solve problems in mathematical programming, operations research, and engineering. Readers require only a modest background in undergraduate mathematical analysis to follow the material with minimal effort.
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Support Vector Machines

Support Vector Machines

Ingo Steinwart; Andreas Christmann

Springer-Verlag New York Inc.
2008
sidottu
Every mathematical discipline goes through three periods of development: the naive, the formal, and the critical. David Hilbert The goal of this book is to explain the principles that made support vector machines (SVMs) a successful modeling and prediction tool for a variety of applications. We try to achieve this by presenting the basic ideas of SVMs together with the latest developments and current research questions in a uni?ed style. In a nutshell, we identify at least three reasons for the success of SVMs: their ability to learn well with only a very small number of free parameters, their robustness against several types of model violations and outliers, and last but not least their computational e?ciency compared with several other methods. Although there are several roots and precursors of SVMs, these methods gained particular momentum during the last 15 years since Vapnik (1995, 1998) published his well-known textbooks on statistical learning theory with aspecialemphasisonsupportvectormachines. Sincethen,the?eldofmachine learninghaswitnessedintenseactivityinthestudyofSVMs,whichhasspread moreandmoretootherdisciplinessuchasstatisticsandmathematics. Thusit seems fair to say that several communities are currently working on support vector machines and on related kernel-based methods. Although there are many interactions between these communities, we think that there is still roomforadditionalfruitfulinteractionandwouldbegladifthistextbookwere found helpful in stimulating further research. Many of the results presented in this book have previously been scattered in the journal literature or are still under review. As a consequence, these results have been accessible only to a relativelysmallnumberofspecialists,sometimesprobablyonlytopeoplefrom one community but not the others.
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Topological Vector Spaces

Topological Vector Spaces

H.H. Schaefer

Springer-Verlag New York Inc.
1999
sidottu
The present book is intended to be a systematic text on topological vector spaces and presupposes familiarity with the elements of general topology and linear algebra. The author has found it unnecessary to rederive these results, since they are equally basic for many other areas of mathematics, and every beginning graduate student is likely to have made their acquaintance. Simi­ larly, the elementary facts on Hilbert and Banach spaces are widely known and are not discussed in detail in this book, which is :plainly addressed to those readers who have attained and wish to get beyond the introductory level. The book has its origin in courses given by the author at Washington State University, the University of Michigan, and the University of Ttibingen in the years 1958-1963. At that time there existed no reasonably ccmplete text on topological vector spaces in English, and there seemed to be a genuine need for a book on this subject. This situation changed in 1963 with the appearance of the book by Kelley, Namioka et al. [1] which, through its many elegant proofs, has had some influence on the final draft of this manuscript. Yet the two books appear to be sufficiently different in spirit and subject matter to justify the publication of this manuscript; in particular, the present book includes a discussion of topological tensor products, nuclear spaces, ordered topological vector spaces, and an appendix on positive operators.
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Threat Vector

Threat Vector

Tom Clancy; Mark Greaney

BERKLEY BOOKS
2013
pokkari
For President Jack Ryan, his son Jack Ryan, Jr., and the covert organization known as The Campus, the fight against America's enemies is never over. But the danger has just hit home in a way they never expected in this #1 New York Times bestselling Tom Clancy thriller.... The Campus has been discovered. And whoever knows they exist knows they can be destroyed. Meanwhile, President Jack Ryan has been swept back into the Oval Office--and his wisdom and courage are needed more desperately than ever. Internal political and economic strife has pushed the leadership of China to the edge of disaster. And those who wish to consolidate their power are using the opportunity to strike at long-desired Taiwan, as well as the Americans who have protected the tiny nation. Now, as two of the world's superpowers move ever closer to a final confrontation, President Ryan must use the only wild card he has left--The Campus. But with their existence about to be revealed, they might not even have a chance to enter the battle before the world is consumed by war.
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Integrated Vector Management

Integrated Vector Management

G. A. Matthews

John Wiley Sons Inc
2011
sidottu
Diseases transmitted by insects continue to have a major impact on human populations. Malaria, dengue, onchocerciasis, sleeping sickness and leishmaniasis all adversely affect man. Malaria is one of the most important causes of child mortality and reduces economic development in many countries, with agricultural productivity often greatly reduced, as many vectors are active in the wet season favourable for crop production. Vector control is crucial to reduce the extent to which drugs are needed to treat the diseases, as the parasite can become resistant, or the drugs are often too expensive for those living in rural areas and urban slums most affected by these diseases. Chemical control of vectors is often the only method that can reduce vector populations in a disease epidemic, but with vectors developing resistance to insecticides, there is increasing awareness that a single control method is often insufficient and also that chemical control must be integrated where possible with other control measures. In Integrated Vector Management, Graham Matthews covers the main chemical methods of vector control, including the use of indoor residual spraying, space treatments, the use of treated bed nets and larviciding, but also stresses the importance of drainage schemes and improvement of houses to prevent access of indoor vectors, techniques that have largely been responsible for reducing the risk of vector borne diseases in Europe and the USA. This book combines practical information from successful vector control programmes, including early use of DDT, and recent research into a vital resource for all those now involved in combating insect vector borne diseases. Integrated Vector Management is an essential tool, not only for medical entomologists and those directly involved in government health departments, but also for all those who provide the skills and management needed to operate successful area-wide vector management programmes. Libraries in all universities and research establishments world-wide, where biological sciences, medicine and agriculture are studied and taught should have multiple copies of this important book.
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Matrix Vector Analysis

Matrix Vector Analysis

Richard L Eisenman

Dover Publications Inc.
2005
pokkari
This text and reference applies matrix ideas to vector methods, using physical ideas to illustrate and motivate mathematical concepts but employing a mathematical continuity of development rather than a physical approach. Features approximately 50 problems at each chapter's end as well as 25 exercises. Answers are given to selected questions. 1963 edition. Includes 121 figures.
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Topological Vector Spaces and Distributions

Topological Vector Spaces and Distributions

John Horvarth

Dover Publications Inc.
2012
nidottu
"The most readable introduction to the theory of vector spaces available in English and possibly any other language."--J. L. B. Cooper, MathSciNet ReviewMathematically rigorous but user-friendly, this classic treatise discusses major modern contributions to the field of topological vector spaces. The self-contained treatment includes complete proofs for all necessary results from algebra and topology. Suitable for undergraduate mathematics majors with a background in advanced calculus, this volume will also assist professional mathematicians, physicists, and engineers.The precise exposition of the first three chapters--covering Banach spaces, locally convex spaces, and duality--provides an excellent summary of the modern theory of locally convex spaces. The fourth and final chapter develops the theory of distributions in relation to convolutions, tensor products, and Fourier transforms. Augmented with many examples and exercises, the text includes an extensive bibliography.
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Microbe-vector Interactions in Vector-borne Diseases

Microbe-vector Interactions in Vector-borne Diseases

Cambridge University Press
2004
sidottu
Several billion people are at daily risk of life threatening vector-borne diseases such as malaria, trypanosomiasis and dengue. This volume describes the way in which the causal pathogens of such diseases interact with the vectors that transmit them. It details the elegant biological adaptations that have enabled pathogens to live with their vectors and, in some circumstances, to control them. This knowledge has led to novel preventative strategies in the form of antibiotics and new vaccines which are targeted not at the pathogen itself but at its specific vector.
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Aphid Vector Dynamics and Temporal and Spatial Characterization of Watermelon Virus Epidemics

Aphid Vector Dynamics and Temporal and Spatial Characterization of Watermelon Virus Epidemics

Gustavo Mora-Aguilera

Dissertation Discovery Company
2019
pokkari
Dissertation Discovery Company and University of Florida are dedicated to making scholarly works more discoverable and accessible throughout the world. This dissertation, "Aphid Vector Dynamics and Temporal and Spatial Characterization of Watermelon Virus Epidemics" by Gustavo Mora-Aguilera, was obtained from University of Florida and is being sold with permission from the author. A digital copy of this work may also be found in the university's institutional repository, IR@UF. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation.
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Aphid Vector Dynamics and Temporal and Spatial Characterization of Watermelon Virus Epidemics

Aphid Vector Dynamics and Temporal and Spatial Characterization of Watermelon Virus Epidemics

Gustavo Mora-Aguilera

Dissertation Discovery Company
2019
sidottu
Dissertation Discovery Company and University of Florida are dedicated to making scholarly works more discoverable and accessible throughout the world. This dissertation, "Aphid Vector Dynamics and Temporal and Spatial Characterization of Watermelon Virus Epidemics" by Gustavo Mora-Aguilera, was obtained from University of Florida and is being sold with permission from the author. A digital copy of this work may also be found in the university's institutional repository, IR@UF. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation.
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Threat Vector

Threat Vector

Tom Clancy; Mark Greaney

Penguin Books Ltd
2013
pokkari
INSPIRATION FOR THE THRILLING AMAZON PRIME SERIES, JACK RYAN, FROM THE NO. 1 BESTSELLING AUTHOR'A brilliant, enthralling read, I couldn't put this book down' 5***** Reader Review'Action from the start right through to the final pages' 5***** Reader Review______The spies are being spied on . . .When Jack Ryan Jr, on a highly secret, off-the-books Campus mission in Turkey, discovers that his team's every move is monitored, he knows that US intelligence has been fatally compromised.Back in the States, President Ryan watches in horror as China's weakened leader bends to a war-mongering general intent on turning the East into a bloodbath. At the same time, America comes under cyber-attack from China, crippling government and military infrastructure.President Ryan needs to act: a covert team must go in and neutralise these threats, and the Campus is the perfect fit.Except a sinister figure known only as the Center is watching the Campus and Jack Ryan Jr's every move.Any wrong step might just be their last . . .______'Exhilarating. No other novelist is giving so full a picture of modern conflict' Sunday TimesPraise for Tom Clancy:'Clancy creates not only compelling characters but frighteningly topical situations and heart-stopping action' Washington Post'He constantly taps the current world situation for its imminent dangers and spins them into an engrossing tale' New York Times Book Review
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General Vector and Dyadic Analysis

General Vector and Dyadic Analysis

Chen-To Tai

IEEE Publications,U.S.
1997
sidottu
Unmatched in its coverage of the topic, the first edition of GENERALIZED VECTOR AND DYADIC ANALYSIS helped revolutionize the treatment of boundary-value problems, establishing itself as a classic in the field. This expanded, revised edition is the most comprehensive book available on vector analysis founded upon the new method symbolic vector. GENERALIZED VECTOR AND DYADIC ANALYSIS presents a copious list of vector and dyadic identities, along with various forms of Green's theorems with derivations. In addition, this edition presents an historical study of the past mis-understandings and contradictions that have occurred in vector analysis presentations, furthering the reader's understanding of the subject. Sponsored by: IEEE Antennas and Propagation Society.
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