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422 tulosta hakusanalla "Tissue Engineering"

Fundamental Biomechanics in Bone Tissue Engineering

Fundamental Biomechanics in Bone Tissue Engineering

Xiaodu Wang; Jeffrey Nyman; Xuanliang Dong; Huijie Leng; Michael Reyes

Springer International Publishing AG
2010
nidottu
This eight-chapter monograph intends to present basic principles and applications of biomechanics in bone tissue engineering in order to assist tissue engineers in design and use of tissue-engineered products for repair and replacement of damaged/deformed bone tissues. Briefly, Chapter 1 gives an overall review of biomechanics in the field of bone tissue engineering. Chapter 2 provides detailed information regarding the composition and architecture of bone. Chapter 3 discusses the current methodologies for mechanical testing of bone properties (i.e., elastic, plastic, damage/fracture, viscoelastic/viscoplastic properties). Chapter 4 presents the current understanding of the mechanical behavior of bone and the associated underlying mechanisms. Chapter 5 discusses the structure and properties of scaffolds currently used for bone tissue engineering applications. Chapter 6 gives a brief discussion of current mechanical and structural tests of repair/tissue engineered bone tissues. Chapter 7 summarizes the properties of repair/tissue engineered bone tissues currently attained. Finally, Chapter 8 discusses the current issues regarding biomechanics in the area of bone tissue engineering. Table of Contents: Introduction / Bone Composition and Structure / Current Mechanical Test Methodologies / Mechanical Behavior of Bone / Structure and Properties of Scaffolds for Bone Tissue Regeneration / Mechanical and Structural Evaluation of Repair/Tissue Engineered Bone / Mechanical and Structural Properties of Tissues Engineered/Repair Bone / Current Issues of Biomechanics in Bone Tissue Engineering
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Central Nervous System Tissue Engineering

Central Nervous System Tissue Engineering

Ashley E. Wilkinson; Aleesha M. McCormick; Nic D. Leipzig

Springer International Publishing AG
2010
nidottu
Combating neural degeneration from injury or disease is extremely difficult in the brain and spinal cord, i.e. central nervous system (CNS). Unlike the peripheral nerves, CNS neurons are bombarded by physical and chemical restrictions that prevent proper healing and restoration of function. The CNS is vital to bodily function, and loss of any part of it can severely and permanently alter a person's quality of life. Tissue engineering could offer much needed solutions to regenerate or replace damaged CNS tissue. This review will discuss current CNS tissue engineering approaches integrating scaffolds, cells and stimulation techniques. Hydrogels are commonly used CNS tissue engineering scaffolds to stimulate and enhance regeneration, but fiber meshes and other porous structures show specific utility depending on application. CNS relevant cell sources have focused on implantation of exogenous cells or stimulation of endogenous populations. Somatic cells of the CNS are rarely utilized for tissue engineering; however, glial cells of the peripheral nervous system (PNS) may be used to myelinate and protect spinal cord damage. Pluripotent and multipotent stem cells offer alternative cell sources due to continuing advancements in identification and differentiation of these cells. Finally, physical, chemical, and electrical guidance cues are extremely important to neural cells, serving important roles in development and adulthood. These guidance cues are being integrated into tissue engineering approaches. Of particular interest is the inclusion of cues to guide stem cells to differentiate into CNS cell types, as well to guide neuron targeting. This review should provide the reader with a broad understanding of CNS tissue engineering challenges and tactics, with the goal of fostering the future development of biologically inspired designs. Table of Contents: Introduction / Anatomy of the CNS and Progression of Neurological Damage / Biomaterials for Scaffold Preparation / Cell Sources for CNS TE / Stimulation and Guidance / Concluding Remarks
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Biologic Foundations for Skeletal Tissue Engineering

Biologic Foundations for Skeletal Tissue Engineering

Ericka Bueno; Julie Glowacki

Springer International Publishing AG
2011
nidottu
Tissue engineering research for bone and joint applications entails multidisciplinary teams bringing together the needed expertise in anatomy, biology, biochemistry, pathophysiology, materials science, biomechanics, fluidics, and clinical and veterinary orthopedics. It is the goal of this volume to provide students and investigators who are entering this exciting area with an understanding of the biologic foundations necessary to appreciate the problems in bone and cartilage that may benefit from innovative tissue engineering approaches. This volume includes state-of-the-art information about bone and cartilage physiology at the levels of cell and molecular biology, tissue structure, developmental processes, their metabolic and structural functions, responses to injury, mechanisms of post-natal healing and graft incorporation, the many congenital and acquired disorders, effects of aging, and current clinical standards of care. It reviews the strengths and limitations of various experimental animal models, sources of cells, composition and design of scaffolds, activities of growth factors and genes to enhance histogenesis, and the need for new materials in the context of cell-based and cell-free tissue engineering. These building blocks constitute the dynamic environments in which innovative approaches are needed for addressing debilitating disorders of the skeleton. It is likely that a single tactic will not be sufficient for different applications because of variations in the systemic and local environments. The realizations that tissue regeneration is complex and dynamic underscore the continuing need for innovative multidisciplinary investigations, with an eye to simple and safe therapies for disabled patients. Table of Contents: Introduction / Structure and Function of Bone and Cartilage Tissue / Development / Responses to Injury and Grafting / Clinical Applications for Skeletal Tissue Engineering / Animal Models / Tissue Engineering Principles for Bone and Cartilage / Perspectives
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Biomaterials and Tissue Engineering

Biomaterials and Tissue Engineering

Springer International Publishing AG
2023
sidottu
This contributed volume covers all fundamental principles for researchers and professionals interested in the field of Biomaterials and Tissue Engineering, an interdisciplinary field of research with contributions from biomedical scientists, engineers, and physicians. With a strong focus on biomaterials and scaffolds, the book also covers testing and evaluation pathways for in vitro and in vivo studies. This book also presents a broad range of topics including fundamentals of 3D printing and bioprinting, followed by contemporary technology used in tissue engineering applications as well as currently available biomaterials suitable for tissue repair and regeneration. This volume provides information on: (i) why humans need biomaterials, especially in medical applications, (ii) different types of tissue engineering strategies, and (iii) modeling, characterization, and evaluation of outputs of those strategies. This book is a reference material in the field of tissueengineering, and it is very useful for bachelor, M.Sc., and Ph.D. students, researchers, academics, medical, industry, and healthcare professionals from diverse backgrounds.
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Collagen-Based Biotextiles for Tissue Engineering

Collagen-Based Biotextiles for Tissue Engineering

Fan Zhang; Daxian Zha; Yihan Huang; Monica Vijay Deshpande; Ting He; Jiyang Chen; Tushar Bambharoliya; Martin W. King

Springer International Publishing AG
2024
sidottu
Based on the author's extensive research experience in collagen textiles and tissue engineering, this book presents a comprehensive introduction and guidelines for engineering artificial tissue using collagen-based fibrous material as a therapeutic candidate for regenerative medicine. The book covers different aspects of fibrous collagen material, including its chemistry, sourcing, fabrication, and applications in tissue engineering and regenerative medicine. Collagen-Based Biotextiles for Tissue Engineering provides a state-of-the-art overview of fibrous collagen-based materials and their application in tissue engineering and regenerative medicine for academic researchers, material scientists, and bioengineers.
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Hydrogels and Bioinks in Tissue Engineering

Hydrogels and Bioinks in Tissue Engineering

Springer International Publishing AG
2025
sidottu
This book offers an in-depth exploration of both natural and synthetic polymeric hydrogels and bioinks, with a focus on their groundbreaking use in medical applications, particularly in the production of 3D tissue constructs and organ models. It covers the science and applications of hydrogels, beginning with a foundational understanding of tissue engineering and scaffold types. It describes the versatile 3D printing techniques that bring bioinks to life, followed by in-depth analyses of natural and synthetic hydrogels. Special emphasis is placed on hydrogels that mimic the extracellular matrix, providing crucial insights for researchers working to create realistic tissue environments. From smart hydrogels with adaptive properties to injectable solutions and conductive formulations, this book highlights innovations that are transforming therapeutic strategies. The text also covers a range of biomedical applications, including hydrogels in controlled delivery systems, nerve, cartilage, bone, skin, and cornea therapies, and their use in producing contact and intraocular lenses. Meticulously curated by leading experts in the field, this volume bridges the gap between cutting-edge research and practical applications, making it an essential guide for advancing tissue engineering and regenerative medicine.
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Bioimaging in Tissue Engineering and Regeneration

Bioimaging in Tissue Engineering and Regeneration

Springer International Publishing AG
2025
sidottu
This updatable reference work gives a comprehensive overview about how to fully exploit the potential of bioimaging to characterize tissue regeneration holistically and to gain complementary, multi-scale information about relevant structure, function, dynamics and molecular composition. To keep pace with the highly dynamic nature of the field and fast-developing imaging technology, it is essential to allow the book to be updated and dynamic. It guides the reader through real-case biomedical applications organized by chapter and gives a tissue-specific overview on how to best assess parameters of interest. Additionally, all imaging techniques, including emerging modalities, are explained in greater detail in the Appendix, which serves as a reference chapter and enables the reader to understand the physical principles behind each modality. The book provides a unique overview of available biological and (pre)clinical imaging techniques in the field and enables the reader to understandtheir benefits and limitations for real-case applications. The reader will be equipped with a comprehensive tool to properly chose the most promising technique for her/his biomedical research question - and respond to novel trends due to the dynamic nature of the book. The book is of high interest to all researchers, physicians, physicists and life scientists working in the field to deepen their theoretical and practical knowledge about bioimaging and about the wide range of tissue-specific biomedical applications. The continuously updated e-book will be a valuable reference in the field for bioimaging.
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Polymer-Based Biomaterials and Tissue Engineering

Polymer-Based Biomaterials and Tissue Engineering

MDPI AG
2023
sidottu
Polymers in the form of films, fibers, nano- and microspheres, composites, and porous supports are promising biomaterials for a wide range of advanced biomedical applications. This Special Issue presents novel studies and new approaches in the field of biomaterials for tissue engineering and drug delivery. It includes seven original research articles and two reviews on biomaterials based on polymeric matrices with various structures, including porous composites, nanofibrous scaffolds, meshes, and hydrogels, which can include micro- or nanoparticles (graphene nanosheets, bioactive glass, and hydroxyapatite and halloysite nanotubes).
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Cell-ECM Interactions for Tissue Engineering and Tissue Regeneration

Cell-ECM Interactions for Tissue Engineering and Tissue Regeneration

MDPI AG
2024
sidottu
The extracellular matrix (ECM) is a dynamic scaffold structure that surrounds all cells in the body and provides structural integrity as well as dynamic signaling cues. These ECM cues influence many aspects of cellular function and phenotype, including cell death, proliferation, cell fate specification, and tissue morphogenesis. Therefore, it is critically important to understand the impact of ECM interactions on disease pathology, tissue engineering, and tissue regeneration. These original research and review articles illustrate the importance of ECM interactions on fundamental cell behavior. Using bioengineering and biomaterial strategies, the effects of the ECM on cell behavior and function can be systematically studied. Cell-ECM interactions are further explored in a variety of tissue and disease models, including cardiovascular, musculoskeletal, lymphatic, and skin applications. These articles were published from 2022 to 2023 in Bioengineering.
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Hydrogels in Tissue Engineering

Hydrogels in Tissue Engineering

Mdpi AG
2018
pokkari
Hydrogels are the foundation of regenerative medicine as a supportive matrix for cell immobilization and growth factor delivery. The fate of implanted cells is mediated by cell-matrix interaction at multiple scales and timed-release of growth factors to guide the differentiation and maturation of cells. Recently, there has been great interest in hydrogels with a hierarchical structure that mimics the complex interaction of cells with a microenvironment that can locally release growth factors to specific cells. Related topics in this Special Issue include hydrogels with a hierarchical structure; hybrid, degradable, and load-bearing hydrogels; hydrogels for cell encapsulation, micro-patterning, microfluidic devices, biofabrication, and high-throughput screening; and hydrogels that modulate the body's immune response.
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Novel Biomaterials for Tissue Engineering 2018

Novel Biomaterials for Tissue Engineering 2018

Mdpi AG
2019
pokkari
The concept of regenerating tissues, with properties and functions that mimic natural tissues, has attracted significant attention in recent years. It provides potential solutions for treating many diseases and other healthcare issues. To fully realize the potential of the approach, it is crucial to have a rational biomaterial design to create novel scaffolds, and other materials systems suitable for tissue engineering, repair and regeneration. Research advances on the topic include the design of new biomaterials and their composites, the scaffold fabrication via subtractive and additive manufacturing approaches, the development of implantable scaffolds for disease monitoring, diagnostics, and treatment, as well as the understanding of cells-biomaterial scaffolds interaction. This Special Issue, "Novel Biomaterials for Tissue Engineering," covers a selection of timely research activities in the field of biomaterials for tissue engineering and regeneration purposes. Promising findings on different approaches to design and develop new biomaterials, biomaterial systems and methods for tissue engineering, are presented and discussed. Recent advances in biofabrication techniques for tissue engineering are additionally demonstrated. The issue comprises a series of state-of-the-art experimental works, up-to-date review articles and commentaries.]
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3D Printing for Tissue Engineering and Regenerative Medicine

3D Printing for Tissue Engineering and Regenerative Medicine

Mdpi AG
2020
sidottu
Three-dimensional (3D) printing enables the fabrication of tissue-engineered constructs and devices from a patient's own medical data, leading to the creation of anatomically matched and patient-specific constructs. There is a growing interest in applying 3D printing technologies in the fields of tissue engineering and regenerative medicine. The main printing methods include extrusion-based, vat photopolymerization, droplet-based, and powder-based printing. A variety of materials have been used for printing, from metal alloys and ceramics to polymers and elastomers as well as from hydrogels to extracellular matrix proteins. More recently, bioprinting, a subcategory of 3D printing, has enabled the precise assembly of cell-laden biomaterials (i.e., bioinks) for the construction of complex 3D functional living tissues or artificial organs. In this Special Issue, we aim to capture state-of-the-art research papers and the most current review papers focusing on 3D printing for tissue engineering and regenerative medicine. In particular, we seek novel studies on the development of 3D printing and bioprinting approaches, developing printable materials (inks and bioinks), and utilizing 3D-printed scaffolds for tissue engineering and regenerative medicine applications. These applications are not limited to but include scaffolds for in vivo tissue regeneration and tissue analogues for in vitro disease modeling and/or drug screening.
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Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine

Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine

Naznin Sultana; Mohd Izzat Hassan; Mim Mim Lim

Springer International Publishing AG
2014
nidottu
This book addresses important biomaterials which are commonly used to fabricate scaffolds and it describes two major protocols employed in scaffold fabrication. Tissue engineering or regenerative medicine aims at restoring ex-novo tissues and organs whose functionality has been compromised as a consequence of diseases or traumatic events. The innovative concept underlying tissue engineering is the use of autologous cells, obtained from a biopsy of the patient. Cells are seeded on a porous scaffold which has the role of supporting and guiding cells towards the development of tissue-like structures as well as providing a platform for the delivery under controlled condition of growth factor release, etc. The successful manufacture of scaffolds for tissue engineering applications is crucial. In this book, these biomaterials are discussed. The book also covers illustrated examples, structure and properties of scaffolds, cellular interactions and drug delivery.
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Vascularization for Tissue Engineering and Regenerative Medicine

Vascularization for Tissue Engineering and Regenerative Medicine

Springer International Publishing AG
2021
sidottu
This reference work presents the basic principles of angiogenesis induction, including the roles of signaling factors such as hypoxia-inducible factors, biophysical stimulation and angiogenic cells. The book also covers lymphogenesis induction. Both the established fundamentals in the field as well as new trends in the vascularization of engineered tissues are discussed. These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks. The authors expand on these concepts with current studies of dual-level approaches to engineer vascularized tissue composites. The book concludes with a discussion of current clinical approaches and the use of vascular grafts in the context of providing clinical practice with new tissue engineering strategies.
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Extracellular Matrix for Tissue Engineering and Biomaterials

Extracellular Matrix for Tissue Engineering and Biomaterials

Birkhauser Verlag AG
2018
sidottu
This volume provides a state-of-art-report on the new methodologies in tissue engineering and developments in the biomaterials field based on the extracellular matrix-relevant discovery. Extracellular Matrix for Tissue Engineering and Biomaterials opens with an overview of the latest extracellular matrix research and in Part I, focuses on its biology and its role on cell behavior and cell fate relevant for the design of biomimetic surfaces. Part II details issues regarding the strategies currently applied in the research of biologically inspired materials and material systems for the replacement, repair and regeneration of tissues and organs. Part III presents the latest development methods applying knowledge from biology towards nanotechnology, to promote the restoration of the functionality of a living tissue. The book ranges from fundamental biology associated with tissue regeneration for the development of biomimetic approaches to controlling tissue formation, cell function,differentiation and angiogenesis using factors involved in normal tissue development and function. With the breadth and depth of the coverage of this topic, this book will serve as a valuable reference for anyone working in tissue engineering or biomaterials – from scientists, chemists and biologists through physicists, bioengineers and clinicians.
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Mending Tiny Hearts: Tissue Engineering Solutions for Neonatal Congenital Heart Disease

Mending Tiny Hearts: Tissue Engineering Solutions for Neonatal Congenital Heart Disease

Mittal

tredition GmbH
2024
nidottu
"Mending Tiny Hearts: Tissue Engineering Solutions for Neonatal Congenital Heart Disease" uses a more empathetic approach compared to the previous title. It describes the use of tissue engineering, a cutting-edge medical field, to treat heart defects in newborns. This book offers a beacon of hope for parents facing this difficult situation. Tissue engineering creates replacement tissues specifically designed for a child's growing body, potentially eliminating the need for multiple surgeries and offering improved long-term health. The book explores the current research and potential of this approach in repairing heart valves, patching defects, and even building new blood vessels.
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Stimuli-Responsive Materials for Tissue Engineering

Stimuli-Responsive Materials for Tissue Engineering

Wiley-VCH Verlag GmbH
2025
sidottu
Enables advanced tissue regeneration approaches via expertise from the fields of materials science and biology Stimuli-Responsive Materials for Tissue Engineering comprehensively reviews the use of stimuli-responsive materials in the context of advanced tissue engineering approaches, highlighting applications, challenges, and solutions and reporting on the current state of the art of smart and multifunctional materials being used for tissue engineering, focusing on material types and their properties. The progress that has already been achieved in the field is put into perspective by covering the remaining challenges in the research field of tissue engineering, and solutions are outlined to overcome those. By addressing challenges and ways to overcome them, Stimuli-Responsive Materials for Tissue Engineering is a highly practical resource on advanced tissue regeneration. Stimuli-Responsive Materials for Tissue Engineering contains information on: Smart and multifunctional materials for tissue engineering, covering electroactive and magnetoactive materialsShape memory, photo-responsive, and controlled degradation of stimuli-responsive materialsTissue regeneration strategies based on smart and active biomaterials, covering bone, heart, and neural tissue regenerationMain applications where these biomaterials can be applied, such as in bone, muscle, and skin regenerationOther potential areas where the covered biomaterials are expected to make a major impact in the next decade With comprehensive coverage of the subject, Stimuli-Responsive Materials for Tissue Engineering is an essential resource for materials scientists, bioengineers, engineering scientists, and biotechnologists seeking to understand advanced tissue regeneration approaches, current challenges, and potential solutions to advance progress in the field.
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