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1000 tulosta hakusanalla Alain Goetzmann

Alzhei... who?

Alzhei... who?

Alain L Fymat

Tellwell Talent
2019
sidottu
It is clear that our approach to identifying the root cause of Alzheimer's disease and curing it has not been successful so far despite decades of research, billions of dollars spent worldwide, 244 experimental drugs developed, and many clinical trials that have failed. What is happening? Have we got the cause of Alzheimer's all wrong? I believe so Instead of remaining focused on the primary endpoint of a cure, the emphasis had shifted to surrogate endpoints that had not been clinically demonstrated to correlate well with the disease. In this book, I identify the root cause of the disease and attempt to reorient our approach along a path that I am convinced will be more successful in leading us to a cure. I will provide the outlines of this new approach and even suggest the methodology to be followed. At the same time, I am also hoping to be able to co-opt the support I need from the general public, particularly those already afflicted by the disease or fearing they might succumb to it, as well as their families, friends, and caregivers. For them, I will also try to demystify the disease and describe ways they can do something about it in addition to seeking medical treatment.
Vertaile hintoja
Parkin...ss..oo..nn

Parkin...ss..oo..nn

Alain L Fymat

Tellwell Talent
2020
sidottu
Despite decades of research, billions of dollars spent worldwide, the development of many drugs, many failed clinical trials, and the extensive publication of research and other articles on the subject, it is clear that our approach to solving Parkinson's disease is not really working. Indeed, presently, no drug can cure or stop this disease from progressing What is happening? Like in the case of Alzheimer's and other neurodegenerative diseases, Dr. Fymat believes we got the cause all wrong and, instead, of remaining focused on the primary end-point of a cure, the emphasis had shifted to surrogate often uncorrelated, end-points. In this book, he elucidates the disease and attempts to reorient our approach along a path he is convinced will be more successful in leading us to a cure. He breaks down barriers to make research accessible and focuses on the important aspects of the underlying research. He distills this information and conveys to Parkinson's patients and their caregivers the results of research, including his own, on this devastating disease. He also reports on his breakthrough as to the underlying root cause of the disease, provides the outlines of his new approach, and even suggests the methodology to be followed.
Vertaile hintoja
Parkin...ss..oo..nn

Parkin...ss..oo..nn

Alain L Fymat

Tellwell Talent
2020
pokkari
Despite decades of research, billions of dollars spent worldwide, the development of many drugs, many failed clinical trials, and the extensive publication of research and other articles on the subject, it is clear that our approach to solving Parkinson's disease is not really working. Indeed, presently, no drug can cure or stop this disease from progressing What is happening? Like in the case of Alzheimer's and other neurodegenerative diseases, Dr. Fymat believes we got the cause all wrong and, instead, of remaining focused on the primary end-point of a cure, the emphasis had shifted to surrogate often uncorrelated, end-points. In this book, he elucidates the disease and attempts to reorient our approach along a path he is convinced will be more successful in leading us to a cure. He breaks down barriers to make research accessible and focuses on the important aspects of the underlying research. He distills this information and conveys to Parkinson's patients and their caregivers the results of research, including his own, on this devastating disease. He also reports on his breakthrough as to the underlying root cause of the disease, provides the outlines of his new approach, and even suggests the methodology to be followed.
Vertaile hintoja
Lyme Disease

Lyme Disease

Alain L Fymat

Tellwell Talent
2020
sidottu
Lyme disease is a tick-borne bacterial infection affecting humans and animals. It can be very serious as it can involve the joints, the heart, and the nervous system. Known in Europe since the early-mid 20th century, it was identified in the U.S. only in 1975 after a mysterious outbreak of what appeared to be juvenile rheumatoid arthritis in children who lived in Lyme and Old Lyme, Connecticut, for which it was originally (mis)named. Although early recognition and treatment lead to resolution of the illness, there are many persons who live with debilitating symptoms and persistent infection. Yet, after these several past decades, Lyme and other tick-borne diseases remain poorly understood and often undiagnosed, misdiagnosed or over-treated. There still are controversies and challenges as to diagnosis and treatment This book elucidates these diseases and addresses the associated controversial and challenging issues. While the scientific evidence continues to evolve, it must be recognized that many in the greater medical community may not be sufficiently versed in it, giving rise to misconceptions about the disease. Beyond strongly encouraging patients to be actively involved in decisions affecting their medical care, I also describe ways they can do something about it in addition to seeking medical treatment.
Vertaile hintoja
Lyme Disease

Lyme Disease

Alain L Fymat

Tellwell Talent
2020
pokkari
Lyme disease is a tick-borne bacterial infection affecting humans and animals. It can be very serious as it can involve the joints, the heart, and the nervous system. Known in Europe since the early-mid 20th century, it was identified in the U.S. only in 1975 after a mysterious outbreak of what appeared to be juvenile rheumatoid arthritis in children who lived in Lyme and Old Lyme, Connecticut, for which it was originally (mis)named. Although early recognition and treatment lead to resolution of the illness, there are many persons who live with debilitating symptoms and persistent infection. Yet, after these several past decades, Lyme and other tick-borne diseases remain poorly understood and often undiagnosed, misdiagnosed or over-treated. There still are controversies and challenges as to diagnosis and treatment This book elucidates these diseases and addresses the associated controversial and challenging issues. While the scientific evidence continues to evolve, it must be recognized that many in the greater medical community may not be sufficiently versed in it, giving rise to misconceptions about the disease. Beyond strongly encouraging patients to be actively involved in decisions affecting their medical care, I also describe ways they can do something about it in addition to seeking medical treatment.
Vertaile hintoja
Dementia

Dementia

Alain L Fymat

Tellwell Talent
2020
pokkari
Dementia is an umbrella term for several brain diseases affecting memory, other cognitive abilities, and behavior. It causes a long-term gradual decrease in the ability to think and remember, interfering significantly with daily living activities. Other common symptoms include emotional problems, language difficulties, and decreased motivation. Although age is its strongest known risk factor, dementia is not a normal part of aging. With increasing lifespan in the developed world, dementia has emerged as an increasing public health concern. It was uncommon in pre-industrial times and relatively rare before the 20th century. Billions of dollars are spent each year in rising related healthcare costs, in addition to the financial and emotional burdens on families, friends, and care partners/givers. However, dementia is not an emerging disease It has been referred to in medical texts since Antiquity. It remains to this day one of the most misunderstood diseases in medicine. The causal etiology of many types of dementia, including the most prevalent Alzheimer's, still remains unclear so that many theories (rather hypotheses) have therefore been advanced. Whereas much is known about the disease and the underlying and contributing factors, and much has been published on the subject, we still do not understand the deep biology of the disease. We have so far failed to find a cure and continue to be limited to symptomatic treatments that have limited or no effect. What is going on? Have we got the cause of dementia all wrong? I believe so. Rather than remaining focused on the primary endpoint of a cure, we have meandered around and shifted the emphasis to surrogate endpoints even though the latter had not been clinically demonstrated to correlate well with the disease. More recently, I have posited that the root cause (not a risk factor) of Alzheimer's and other neurodegenerative diseases is but an autoimmune disease having gone rogue. In writing this book, following that discovery, I am attempting to reorient our approach along a path that I am convinced will be more successful in leading us to a cure. At the same time, I will also try to fend off this menacing disease and describe ways those already afflicted by the disease, or those fearing they might succumb to it, as well as their families, friends, and care partners/givers, can do something about it in addition to seeking medical treatment.
Vertaile hintoja
Dementia

Dementia

Alain L Fymat

Tellwell Talent
2020
sidottu
Dementia is an umbrella term for several brain diseases affecting memory, other cognitive abilities, and behavior. It causes a long-term gradual decrease in the ability to think and remember, interfering significantly with daily living activities. Other common symptoms include emotional problems, language difficulties, and decreased motivation. Although age is its strongest known risk factor, dementia is not a normal part of aging. With increasing lifespan in the developed world, dementia has emerged as an increasing public health concern. It was uncommon in pre-industrial times and relatively rare before the 20th century. Billions of dollars are spent each year in rising related healthcare costs, in addition to the financial and emotional burdens on families, friends, and care partners/givers. However, dementia is not an emerging disease It has been referred to in medical texts since Antiquity. It remains to this day one of the most misunderstood diseases in medicine. The causal etiology of many types of dementia, including the most prevalent Alzheimer's, still remains unclear so that many theories (rather hypotheses) have therefore been advanced. Whereas much is known about the disease and the underlying and contributing factors, and much has been published on the subject, we still do not understand the deep biology of the disease. We have so far failed to find a cure and continue to be limited to symptomatic treatments that have limited or no effect. What is going on? Have we got the cause of dementia all wrong? I believe so. Rather than remaining focused on the primary endpoint of a cure, we have meandered around and shifted the emphasis to surrogate endpoints even though the latter had not been clinically demonstrated to correlate well with the disease. More recently, I have posited that the root cause (not a risk factor) of Alzheimer's and other neurodegenerative diseases is but an autoimmune disease having gone rogue. In writing this book, following that discovery, I am attempting to reorient our approach along a path that I am convinced will be more successful in leading us to a cure. At the same time, I will also try to fend off this menacing disease and describe ways those already afflicted by the disease, or those fearing they might succumb to it, as well as their families, friends, and care partners/givers, can do something about it in addition to seeking medical treatment.
Vertaile hintoja
The Human Brain - Wonders and Disorders

The Human Brain - Wonders and Disorders

Alain L Fymat

Tellwell Talent
2021
pokkari
Our earliest recorded history of brain diseases dates back to the neolithic period (12,000 BCE) when trephination (or trepanation) was practiced by diverse societies. Although begun in prehistory, trephination did not disappear as human society progressed. Trephined skulls were found in ancient regions of the Middle East, Europe, and China. Even today, a different form of the world's oldest surgery (craniotomy) is sometimes performed by modern brain surgeons; for instance, to remove a brain tumor or treat an aneurysm. However, unlike trephination, which results in a permanent hole in the skull, the modern process requires the replacement of the removed bone fragment after the brain surgery is completed. As an entity, the brain was already known in Ancient Egypt as evidenced by an Egyptian hieroglyph dating back to 1700 BCE. A papyrus (acquired by Edwin Smith in Luxor in 1862), prepared a century later, is the world's oldest surviving surgical document. While it describes in exquisite details anatomical observations, examinations, diagnoses, treatments, and prognoses of 48 types of medical and brain problems, it did not reveal any Ancient Egyptian attempt at brain surgery. Skipping over the intervening centuries, I aim in this book to share with the reader not only the disorders of the human brain but also its wonders as fathomed during these modern times. I hope the journey will be an informative and enjoyable one.
Vertaile hintoja
The Human Brain - Wonders and Disorders

The Human Brain - Wonders and Disorders

Alain L Fymat

Tellwell Talent
2021
sidottu
Our earliest recorded history of brain diseases dates back to the neolithic period (12,000 BCE) when trephination (or trepanation) was practiced by diverse societies. Although begun in prehistory, trephination did not disappear as human society progressed. Trephined skulls were found in ancient regions of the Middle East, Europe, and China. Even today, a different form of the world's oldest surgery (craniotomy) is sometimes performed by modern brain surgeons; for instance, to remove a brain tumor or treat an aneurysm. However, unlike trephination, which results in a permanent hole in the skull, the modern process requires the replacement of the removed bone fragment after the brain surgery is completed. As an entity, the brain was already known in Ancient Egypt as evidenced by an Egyptian hieroglyph dating back to 1700 BCE. A papyrus (acquired by Edwin Smith in Luxor in 1862), prepared a century later, is the world's oldest surviving surgical document. While it describes in exquisite details anatomical observations, examinations, diagnoses, treatments, and prognoses of 48 types of medical and brain problems, it did not reveal any Ancient Egyptian attempt at brain surgery. Skipping over the intervening centuries, I aim in this book to share with the reader not only the disorders of the human brain but also its wonders as fathomed during these modern times. I hope the journey will be an informative and enjoyable one.
Vertaile hintoja
Cancer

Cancer

Alain L Fymat

Tellwell Talent
2021
pokkari
Cancer is one of the oldest diseases seen in human specimens, quite possibly the oldest, the quest for its cure having begun some 4,000 years ago. However, it was fleetingly rare, hidden by other illnesses such as cholera, dropsy, leprosy, plague, pneumonia, smallpox, and tuberculosis. As these diseases were vanquished, and as the human lifespan lengthens, cancer has emerged. Many diseases are lumped together under the denomination "cancer," because they share a fundamental biological feature, namely abnormal cell growth. However, cancer is not a single disease. It is a multiplicity of diseases caused by the uncontrolled growth of a single cell unleashed by mutations. Cancer cells can grow faster, flourish more profusely, adapt better, recover more rapidly, and repair faster than normal cells. They are in effect more perfect versions of normal cells, and can even become immortal We naively thought that cancer could be defeated by either preventing mutations from occurring in normal cells or else finding the means to eliminate the mutated cells without compromising normal growth. Unfortunately, this view did not take into account the pernicious genetic intertwining of normal and cancerous growths. Woven into our genome, the mutated genes are but distorted versions of the normal ones; they are braided together, and unbraiding them continues to be the most formidable undertaking. Fortunately, the vast majority of cancer cases are due to environmental risk factors, many of which being controllable lifestyle choices, and thus preventable. In developing cancer, individuals differ in both their inherited tendency and exposure to the environment. This book presents the nine major recent developments in cancer treatment, which provide great hope for the future. These include innate immunotherapy with neutrophil-mediated drug delivery for the suppression of postoperative malignant glioma recurrence; synthetic immunotherapy using either chimeric antigen receptor T-cells or programmed-death inhibitors; DNA origami/Trojan technique to foil drug resistance in solid tumors; enzyme mnk-2 conversion to overcome drug resistance in breast, lung and colon cancers; antiangiogenesis to cut off the blood vessels alimenting the cancer cells; self-eradication of cancer during meiosis; combating inflammation to limit tumor invasion, progression, and metastasis; electropermeabilizing the cancer cell membrane to deliver drugs to the cell's interior; and employing nanochemotherapy to deliver nanoparticles encapsulating cytotoxic drugs to tumors.
Vertaile hintoja
Cancer

Cancer

Alain L Fymat

Tellwell Talent
2021
sidottu
Cancer is one of the oldest diseases seen in human specimens, quite possibly the oldest, the quest for its cure having begun some 4,000 years ago. However, it was fleetingly rare, hidden by other illnesses such as cholera, dropsy, leprosy, plague, pneumonia, smallpox, and tuberculosis. As these diseases were vanquished, and as the human lifespan lengthens, cancer has emerged. Many diseases are lumped together under the denomination "cancer," because they share a fundamental biological feature, namely abnormal cell growth. However, cancer is not a single disease. It is a multiplicity of diseases caused by the uncontrolled growth of a single cell unleashed by mutations. Cancer cells can grow faster, flourish more profusely, adapt better, recover more rapidly, and repair faster than normal cells. They are in effect more perfect versions of normal cells, and can even become immortal We naively thought that cancer could be defeated by either preventing mutations from occurring in normal cells or else finding the means to eliminate the mutated cells without compromising normal growth. Unfortunately, this view did not take into account the pernicious genetic intertwining of normal and cancerous growths. Woven into our genome, the mutated genes are but distorted versions of the normal ones; they are braided together, and unbraiding them continues to be the most formidable undertaking. Fortunately, the vast majority of cancer cases are due to environmental risk factors, many of which being controllable lifestyle choices, and thus preventable. In developing cancer, individuals differ in both their inherited tendency and exposure to the environment. This book presents the nine major recent developments in cancer treatment, which provide great hope for the future. These include innate immunotherapy with neutrophil-mediated drug delivery for the suppression of postoperative malignant glioma recurrence; synthetic immunotherapy using either chimeric antigen receptor T-cells or programmed-death inhibitors; DNA origami/Trojan technique to foil drug resistance in solid tumors; enzyme mnk-2 conversion to overcome drug resistance in breast, lung and colon cancers; antiangiogenesis to cut off the blood vessels alimenting the cancer cells; self-eradication of cancer during meiosis; combating inflammation to limit tumor invasion, progression, and metastasis; electropermeabilizing the cancer cell membrane to deliver drugs to the cell's interior; and employing nanochemotherapy to deliver nanoparticles encapsulating cytotoxic drugs to tumors.
Vertaile hintoja
Covid-19

Covid-19

Alain L Fymat; Norma Norm; Joachim Kapalanga

Tellwell Talent
2022
pokkari
Human history has been befallen by a long chain of famines, epidemics, and pandemics. During this current COVID-19 pandemic, our world remains under-prepared to predict, detect, respond, prevent infectious disease outbreaks, and a fortiori pandemics-whether naturally occurring, accidental, or deliberately released. These threats endanger lives, disrupt families and societies, and wreak havoc on economies. They represent the ultimate equal opportunity condition They do not respect national boundaries, do not discriminate between different ethnicities, religions, social or economic status or even age, and can spread rapidly, jeopardizing the health, security, and prosperity of all world countries. Indeed, physical distance alone no longer provides protection as pathogens can move from one point on Earth to almost any other place in the world within less than 36 hours Yet, the cost of failing to control outbreaks, ruining and losing lives, destabilizing the social fabric, and decimating economies is considerably greater than the cost of prevention. It is therefore in each country's security interest to strengthen global health security and manage the risk of infectious disease outbreaks that might further develop into full-blown pandemics. Having hosted several variants of the original causal coronavirus, this global warning applies particularly to the African continent where health security needs particular highlighting, multidisciplinary engagement and multisector coordination need strengthening, and financial preparedness is direly needed. Against this background, COVID-19 was naturally selected as the main theme for the 2020-2021 SASA International Conference that was jointly co-hosted by the Society for the Advancement of Science in Africa, the Uganda Ministry of Health, and other partners (World Health Organization). This volume encapsulates a range of perspectives and associated recommendations. The health as well as socio-economic challenges glaringly manifested by the pandemic are discussed for preparation and control to render African societies more resilient, including response and treatment to meet the African contexts; education and transformation to address poverty concerns; envisaging and shaping new futures to cater for a more holistic and inclusive wellbeing; and adoption of scientific innovation to meet future demands for disease control.
Vertaile hintoja
Covid-19

Covid-19

Alain L Fymat; Norma Norm; Joachim Kapalanga

Tellwell Talent
2022
sidottu
Human history has been befallen by a long chain of famines, epidemics, and pandemics. During this current COVID-19 pandemic, our world remains under-prepared to predict, detect, respond, prevent infectious disease outbreaks, and a fortiori pandemics-whether naturally occurring, accidental, or deliberately released. These threats endanger lives, disrupt families and societies, and wreak havoc on economies. They represent the ultimate equal opportunity condition They do not respect national boundaries, do not discriminate between different ethnicities, religions, social or economic status or even age, and can spread rapidly, jeopardizing the health, security, and prosperity of all world countries. Indeed, physical distance alone no longer provides protection as pathogens can move from one point on Earth to almost any other place in the world within less than 36 hours Yet, the cost of failing to control outbreaks, ruining and losing lives, destabilizing the social fabric, and decimating economies is considerably greater than the cost of prevention. It is therefore in each country's security interest to strengthen global health security and manage the risk of infectious disease outbreaks that might further develop into full-blown pandemics. Having hosted several variants of the original causal coronavirus, this global warning applies particularly to the African continent where health security needs particular highlighting, multidisciplinary engagement and multisector coordination need strengthening, and financial preparedness is direly needed. Against this background, COVID-19 was naturally selected as the main theme for the 2020-2021 SASA International Conference that was jointly co-hosted by the Society for the Advancement of Science in Africa, the Uganda Ministry of Health, and other partners (World Health Organization). This volume encapsulates a range of perspectives and associated recommendations. The health as well as socio-economic challenges glaringly manifested by the pandemic are discussed for preparation and control to render African societies more resilient, including response and treatment to meet the African contexts; education and transformation to address poverty concerns; envisaging and shaping new futures to cater for a more holistic and inclusive wellbeing; and adoption of scientific innovation to meet future demands for disease control.
Vertaile hintoja
Epilepsy

Epilepsy

Alain L Fymat

Tellwell Talent
2022
pokkari
Epilepsy is an ancient disease that has fascinated and frightened scientists and laymen alike. Before we acquired a working knowledge of the central nervous system, seizures were shrouded in mystery. In antiquity, the disease was accredited to gods and demonic possession, causing those with epilepsy to be feared and isolated. Epilepsy patients continued to face discrimination through the mid-20th century. This discrimination ranged from lack of access to health insurance, jobs, marriage inequality, and even forced sterilizations. Despite the strides that have been made, there are still many misconceptions globally regarding epilepsy. While there has been substantial progress, more work needs to be done to educate people across the globe about the pathology of the disease, its causes, and mechanisms. Studies show that patients with epilepsy living in communities that understand the pathology and cause of seizures are generally more successful in social and educational environments. In this book, beyond current treatments that may include anti-epileptic drugs (also called anti-seizure medications), neurosurgery, neurostimulation, lifestyle modifications, and dietary changes, I will discuss the recent modalities of gene therapy, immunotherapy, and neutrophil therapy, and will outline more advanced research options, some of which remain to be pursued. I will also posit that the root cause of epilepsy is an autoimmune disease that had gone rogue, damaging the brain's normal functions and leading to neurodegenerative diseases, including epilepsy. Under this theory, the seizures are but the symptoms of that disease. Brain function being highly non-linear, it is not too surprising that anti-seizure/anti-epileptic drugs that assume a linear brain function have been only partly successful. In all these endeavors, the well-being of the patient is foremost, and that is why I will also include suggestions, recommendations, and available supporting resources for patients and their caregivers, how they can live and cope with their epilepsy, and what they can do about it.
Vertaile hintoja
Epilepsy

Epilepsy

Alain L Fymat

Tellwell Talent
2022
sidottu
Epilepsy is an ancient disease that has fascinated and frightened scientists and laymen alike. Before we acquired a working knowledge of the central nervous system, seizures were shrouded in mystery. In antiquity, the disease was accredited to gods and demonic possession, causing those with epilepsy to be feared and isolated. Epilepsy patients continued to face discrimination through the mid-20th century. This discrimination ranged from lack of access to health insurance, jobs, marriage inequality, and even forced sterilizations. Despite the strides that have been made, there are still many misconceptions globally regarding epilepsy. While there has been substantial progress, more work needs to be done to educate people across the globe about the pathology of the disease, its causes, and mechanisms. Studies show that patients with epilepsy living in communities that understand the pathology and cause of seizures are generally more successful in social and educational environments. In this book, beyond current treatments that may include anti-epileptic drugs (also called anti-seizure medications), neurosurgery, neurostimulation, lifestyle modifications, and dietary changes, I will discuss the recent modalities of gene therapy, immunotherapy, and neutrophil therapy, and will outline more advanced research options, some of which remain to be pursued. I will also posit that the root cause of epilepsy is an autoimmune disease that had gone rogue, damaging the brain's normal functions and leading to neurodegenerative diseases, including epilepsy. Under this theory, the seizures are but the symptoms of that disease. Brain function being highly non-linear, it is not too surprising that anti-seizure/anti-epileptic drugs that assume a linear brain function have been only partly successful. In all these endeavors, the well-being of the patient is foremost, and that is why I will also include suggestions, recommendations, and available supporting resources for patients and their caregivers, how they can live and cope with their epilepsy, and what they can do about it.
Vertaile hintoja
Multiple Sclerosis

Multiple Sclerosis

Alain L Fymat

Tellwell Talent
2023
pokkari
Multiple sclerosis (MS) is a chronic debilitating demyelinating disease of the central nervous system. It is caused by an autoimmune attack resulting in the progressive loss of the myelin sheath on neuronal axons. The resultant decrease in the speed of signal transduction leads to a loss of functionality that includes both cognitive and motor impairment depending on the location of the lesion. The progression of MS occurs due to episodes of increasing inflammation, which is proposed to be due to the release of antigens such as myelin oligodendrocyte glycoprotein, myelin basic protein, and proteolipid protein, causing an autoimmune response. This sets off a cascade of signaling molecules that result in T-cells, B-cells, and macrophages to cross the blood-brain barrier and attack myelin on neuronal axons leading to inflammation. Further release of antigens drives subsequent degeneration, causing increased inflammation. MS presents itself as a spectrum based on the degree of inflammation. A majority of patients experience early relapsing and remitting episodes of neuronal deterioration following a period of recovery. Some of these individuals may transition to a more linear progression of the disease, while about 15% of others begin with a progressive course on the onset of MS. The inflammatory response contributes to the loss of the grey matter and, as a result, current literature devotes itself to combatting the auto-inflammatory aspect of the disease. While there are several proposed causal links between the Epstein-Barr virus (EBV) and the HLA-DRB1*15:01 allele to the onset of MS - they may contribute to the degree of autoimmune attack and the resultant inflammation - they do not determine the onset of MS.
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