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1000 tulosta hakusanalla Gene Gordon

Gene Action

Gene Action

Werner Maas

Oxford University Press Inc
2001
sidottu
As a college student, Werner Maas took a course in genetics in 1941 and wondered why so little was said about the biochemical action of genes in controlling the specific function of an organism. Just at that time, biochemists and geneticists began to investigate jointly the basis of gene action, especially in microorganisms. Thus, Maas was able to witness firsthand the spectacular developments that led in the next twenty-five years to a clear picture of the action of genes. The history of these remarkable discoveries is the core of this book. After 1965, building on insights gained from the work with microorganisms, studies of gene action turned to animals and plants and concentrated on processes not present in microorganisms, such as embryonic development, the role of genes in diseases, and the function of the nervous system. Because of the rapidity of technical advances made in handling genes, it has been possible to learn much about these complex processes. The last part of the book deals with these developments, which are ongoing parts of the history of gene action.
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Gene Genealogies, Variation and Evolution: A primer in coalescent theory

Gene Genealogies, Variation and Evolution: A primer in coalescent theory

Hein; Schierup; Wiuf

Oxford University Press
2004
nidottu
Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia
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Gene Targeting

Gene Targeting

Oxford University Press
1999
nidottu
Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications. As with the previous edition Gene Targeting: A Practical Approach 2e concentrates on gene targeting in mouse ES cells, but the techniques described can be easily adapted to applications in tissue culture including those for human cells. The first chapter covers the design of gene targeting vectors for mammalian cells and describes how to distinguish random integrations from homologous recombination. It is followed by a chapter on extending conventional gene targeting manipulations by using site-specific recombination using the Cre-loxP and Flp-FRT systems to produce 'clean' germline mutations and conditionally (in)activating genes. Chapter 3 describes methods for introducing DNA into ES cells for homologous recombination, selection and screening procedures for identifying and recovering targeted cell clones, and a simple method for establishing new ES cell lines. Chapter 4 discusses the pros and cons or aggregation versus blastocyst injection to create chimeras, focusing on the technical aspects of generating aggregation chimeras and then describes some of the uses of chimeras. The next topic covered is gene trap strategies; the structure, components, design, and modification of GT vectors, the various types of GT screens, and the molecular analysis of GT integrations. The final chapter explains the use of classical genetics in gene targeting and phenotype interpretation to create mutations and elucidate gene functions. Gene Targeting: A Practical Approach 2e will therefore be of great value to all researchers studying gene function.
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Gene Weavers

Gene Weavers

Steve P Lee

Lulu.com
2017
pokkari
Two years have passed since Shawn was rescued from Wenlock and he has settled into a comfortable, happy life with the Lifesons. His adventures are over - or are they? Out in UIG and PER space, events are unfolding. Some are in the public eye, others very much not. Humanity's future is about to change forever. Allen Lifeson's group failed to prevent Benedict Chambers from striking an alliance with the Gene Weavers. They are about to regret that. Captain James Lifeson is sent to investigate a mystery. Little does he know what will follow.
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Gene Zema, Architect, Craftsman

Gene Zema, Architect, Craftsman

Grant Hildebrand

University of Washington Press
2011
sidottu
In the three decades following World War II, a group of architects centered in the Puget Sound region were designing buildings of extraordinary quality, whose most evident commonality was the use of wood in profusion, as exposed, meticulously detailed structure and as interior and exterior surface. Gene Zema, a 1950 graduate of the University of Washington and a student of the legendary Lionel Pries, was one of this group. In a career that spanned twenty years, Zema designed forty-six houses, seven clinics, two architectural offices, a nursery, and a golf clubhouse, and he participated in the design of two University buildings. He built several buildings with his own hands, developing a consummate sense of appropriate design in wood. The luxuriantly crafted details and uniquely dramatic spatial compositions of his work place it at the forefront of that remarkable movement.Zema was also a distinguished collector and retailer of Native American and Japanese antiquities. In 1983, relying on the sale of antiquities for income and limiting his architectural practice, he and his wife, Jane, bought a 70-acre meadow on Whidbey Island. On their property Zema built a workshop, a windmill and pump house, a chicken house, a home, a peacock house, and a kiln, all of which are as remarkable as his earlier masterpieces.Gene Zema is an iconic figure among those who know his work, but the region to which his work is intimately bound is far from the centers of architectural journalism and his story is little known. It is the story of a unique figure in an extraordinary American architectural movement and an exceptional figure in the history of the Pacific Northwest.
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Gene Future

Gene Future

Lee Thomas F.

Springer Science+Business Media
1993
nidottu
We are poised at the doorway to a future which could surpass the Industrial Revolution in its impact on the world. We are beginning to scrutinize genes in order to read the very history of evolution, and to alter plants and animals in ways undreamed of only a few years ago. As the tools of science have become more sophisticated, scientists have been able to delve deeply into the inner recesses of cells. The fruit of their labor, the new biology, promises us an unprecedented understanding of genes, offering an illuminating view into the most intimate operations of living things from microbes to humans - and with that, the potential to gain increasing control over life itself. Our gene future will soon present us with a cornucopia of products by drawing upon a variety of organisms - plants, animals, and even human cells - that will influence the lives and health of us all. As Thomas Lee, a biologist and author of the acclaimed The Human Genome Project: Cracking the Genetic Code of Life, so vividly shows, the new biology is already beginning to make its mark on our lives. Every week newspapers announce that scientists have found the gene for a disease such as cystic fibrosis or a particular form of cancer, or have seized on a gene therapy to try to combat it. The controversy over using DNA fingerprinting as admissible evidence in court has sparked public concern. The injecting of experimental genes into humans and animals has triggered recent debates. Soon genetically engineered tomatoes and other "transgenic" vegetables will be available on the shelves of our local grocers. As Lee so wisely and eloquently cautions, there may be perils along this pathway as well as miraculous discoveries. Do dangers lurk in this new technological approach to nature? May we unwittingly be doing irreparable harm to individuals, not to mention the biosphere? This perceptive author even-handedly assesses the controversies surrounding the perils that may await us as molecular science m
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Gene Conservation and Exploitation

Gene Conservation and Exploitation

Kluwer Academic/Plenum Publishers
1993
sidottu
The potato (Solanum tuberosum L. ) tuber is a major food source in many countries of the world, and subsequently potato has been the target of a good deal of effort directed at engineering disease and herbicide tolerance, and improvements in various crop characteristics. Consequently investigations into the regulation of gene expression in tubers is relevant to these endeavours, as tubers are the main target organ for modification of gene expression. We have been interested in the regulation of genes in tubers for these reasons. Morphologically tubers are modified stems, which have enlarged radially by limited cell division and substantial expansion. At the molecular level, tuber development is characterised by a massive increase in starch deposition and the synthesis of a limited number of abundant proteins. These include proteinase inhibitors and a 40kd group of proteins called patatin, which are acyl hydrolases. Together these proteins account for over 50% of tuber proteins (reviewed by Bevan, 1991). The synthesis of these proteins has parallels to the synthesis of other somatic storage proteins, especially the VSP proteins of soybean. In both potato and soybean, removal of the sink for these proteins (tubers and pods, respectively) causes deposition in other tissues (Staswick, 1990). It is hypothesised that transcriptional control of the genes encoding these proteins is regulated in part by source-sink relationships of metabolites or other factors. In the case of VSPs, both amino acid levels and jasmonic acid play a major regulatory role (Staswick et aI.
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Gene Therapy of Cancer

Gene Therapy of Cancer

Kluwer Academic/Plenum Publishers
1998
sidottu
The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.
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Gene Avatars

Gene Avatars

Pierre-Henri Gouyon; Jean-Pierre Henry; Jacques Arnould

Kluwer Academic/Plenum Publishers
2002
sidottu
`Why life?' Questions of this type were for a long time the prerogative of philosophers who left the `how' question to scientists. Nowadays, Darwin's successors no longer have any qualms about addressing the `why' as well as the `how'. Over a century ago, Darwin modestly admitted having 'thrown some light on the origin of species - this mystery of mysteries'. Two major advances in the following decades helped biologists answer many of the questions he left unsolved. The first was the discovery of the laws of heredity, the second that of DNA. Both provided Darwinian theory with the foundations that were lacking and led to the all-embracing neo-Darwinian synthesis. Since then, Theodosius Dobzhansky's aphorism `nothing in biology makes sense except in the light of evolution' has proven true more than once. This does not suit everyone, as evolutionist ideas have not lost their power to cause a scandal. Darwin toppled man from his pedestal. Evolutionary genetics - the subject of this book - sends the individual crashing. Considered until recently to be the target of selection and the focus of evolution, the individual has been usurped by the gene. The individual is nothing but the gene's avatar.
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Gene Therapy of Autoimmune Disease

Gene Therapy of Autoimmune Disease

Gerald J. Prud'homme

Kluwer Academic/Plenum Publishers
2005
sidottu
Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
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Gene Hunter

Gene Hunter

Adele Glimm

Henry (Joseph) Press
2006
nidottu
Nancy Wexler is a hunter. Her quarry is the gene responsible for a fatal, inherited sickness called Huntington's disease. Nancy's work is a breathtaking race against time not only for others but maybe for herself, as well. Nancy Wexler is the daughter of a Huntington's patient and is at risk for this disease. Finding this gene is a vital step toward preventing or curing Huntington's and thus saving lives. Nancy's work takes her all over the world, specifically to small villages in Venezuela where the mysterious gene affects more people than anywhere else on the globe. Blood samples generously donated by the villagers hold the clues to discovering the gene. Hunter, detective, scientist: Nancy is all these, plus a friend to people everywhere who are affected by Huntington's and other diseases of the brain. Gene Hunter is the powerful story of a courageous and dedicated woman whose passion for science is both personally and intellectually satisfying. Author Adele Glimm draws on firsthand accounts from Nancy and her friends, family, and colleagues to tell us how a curious, strongminded woman became an accomplished neuropsychologist. This title aligns to Common Core standards: Interest Level Grades 6 - 8; Reading Level Grade level Equivalent: 7.1: Lexile Measure: 1080L; DRA: Not Available; Guided Reading: ZTable of ContentsSample Chapter 1: The Dancing Disease
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Gene Therapy

Gene Therapy

Evelyn B. Kelly

Greenwood Press
2007
sidottu
Every day, newspapers and television news programs present stories on the latest controversies over healthcare and medical advances, but they do not have the space to provide detailed background on the issues. Websites and weblogs provide information from activists and partisans intent on presenting their side of a story. But where can students - or even ordinary citizens - go to obtain unbiased, detailed background on the medical issues affecting their daily lives? This volume in the Health and Medical Issues Today series provides readers and researchers a balanced, in-depth introduction to the medical, scientific, legal, and cultural issues surrounding gene therapy and its import in today's world of healthcare.Gene Therapy is organized to provide researchers with easy access to the information they need. Section 1 provides overview chapters on the background information needed to intelligently understand the issues and controversies surrounding gene therapy, such as the history of theories of the gene and recent developments in clinical trials. Section 2 offers capsule examinations of the contemporary issues and debates that provoke the most heated disagreements and misunderstandings, such as whether or not humans should tinker with genetic material and who pays for genetic therapies. Section 3 includes reference material on stem cells, including primary source documents from important players in the struggle over gene therapy, a timeline of important events, and an annotated bibliography of useful print and electronic resources. This volume in the Health and Medical Issues Today series provides everything a student requires to understand the issues involved in gene therapy and provides a springboard for further research into the issue.
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Gene Therapy, An Issue of Hematology/Oncology Clinics of North America

Gene Therapy, An Issue of Hematology/Oncology Clinics of North America

Daniel E. Bauer; Donald B Kohn

Elsevier - Health Sciences Division
2017
sidottu
This issue of Hematology/Oncology Clinics will focus on Gene Therapy. Topics include, but are not limited to Historical Perspective and Current Renaissance, Integrating Vectors, Nonintegrating Vectors, Gene Editing, Conditioning Therapies for Autologous HSCT, Approaches to Immunodeficiency, Approaches to Hemoglobinopathy, Approaches to Hemophilia, Hematopoietic Gene Therapies for Neurologic and Metabolic Disease, Gene Therapy Approaches to HIV and other Infectious Diseases, HSC Approaches to Cancer, and Gene Modified T Cell Therapies for Cancer.
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Gene-Based Therapies for Pediatric Blood Diseases, An Issue of Hematology/Oncology Clinics of North America

Gene-Based Therapies for Pediatric Blood Diseases, An Issue of Hematology/Oncology Clinics of North America

Elsevier - Health Sciences Division
2022
sidottu
In this issue of Hematology/Oncology Clinics, guest editors Drs. Sung-Yun Pai and Nirali N. Shah bring their considerable expertise to the topic of Gene-Based Therapies for Pediatric Blood Diseases. Top experts in the field cover key topics such as CAR T-cell therapy: current status; engineered T cells; NK-cell therapy; hemoglobinopathies: beta-thalassemia, sickle cell disease; hemophilia A/B; primary immunodeficiencies; and more. Contains 14 relevant, practice-oriented topics including the evolution of gene therapy; viral vectors in hematopoietic stem cell gene therapy; gene editing in hematopoietic stem cells; nonintegrating vectors and engineered capsids; regulatory aspects of gene therapy; and more. Provides in-depth clinical reviews on gene-based therapies for pediatric blood diseases, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
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Gene Editing, Law, and the Environment

Gene Editing, Law, and the Environment

Routledge
2019
nidottu
Technologies like CRISPR and gene drives are ushering in a new era of genetic engineering, wherein the technical means to modify DNA are cheaper, faster, more accurate, more widely accessible, and with more far-reaching effects than ever before. These cutting-edge technologies raise legal, ethical, cultural, and ecological questions that are so broad and consequential for both human and other-than-human life that they can be difficult to grasp. What is clear, however, is that the power to directly alter not just a singular form of life but also the genetics of entire species and thus the composition of ecosystems is currently both inadequately regulated and undertheorized. In Gene Editing, Law, and the Environment, distinguished scholars from law, the life sciences, philosophy, environmental studies, science and technology studies, animal health, and religious studies examine what is at stake with these new biotechnologies for life and law, both human and beyond.
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Gene Expression Data Analysis

Gene Expression Data Analysis

Pankaj Barah; Dhruba Kumar Bhattacharyya; Jugal Kumar Kalita

CRC Press
2021
sidottu
Development of high-throughput technologies in molecular biology during the last two decades has contributed to the production of tremendous amounts of data. Microarray and RNA sequencing are two such widely used high-throughput technologies for simultaneously monitoring the expression patterns of thousands of genes. Data produced from such experiments are voluminous (both in dimensionality and numbers of instances) and evolving in nature. Analysis of huge amounts of data toward the identification of interesting patterns that are relevant for a given biological question requires high-performance computational infrastructure as well as efficient machine learning algorithms. Cross-communication of ideas between biologists and computer scientists remains a big challenge.Gene Expression Data Analysis: A Statistical and Machine Learning Perspective has been written with a multidisciplinary audience in mind. The book discusses gene expression data analysis from molecular biology, machine learning, and statistical perspectives. Readers will be able to acquire both theoretical and practical knowledge of methods for identifying novel patterns of high biological significance. To measure the effectiveness of such algorithms, we discuss statistical and biological performance metrics that can be used in real life or in a simulated environment. This book discusses a large number of benchmark algorithms, tools, systems, and repositories that are commonly used in analyzing gene expression data and validating results. This book will benefit students, researchers, and practitioners in biology, medicine, and computer science by enabling them to acquire in-depth knowledge in statistical and machine-learning-based methods for analyzing gene expression data.Key Features: An introduction to the Central Dogma of molecular biology and information flow in biological systems A systematic overview of the methods for generating gene expression data Background knowledge on statistical modeling and machine learning techniques Detailed methodology of analyzing gene expression data with an example case study Clustering methods for finding co-expression patterns from microarray, bulkRNA, and scRNA data A large number of practical tools, systems, and repositories that are useful for computational biologists to create, analyze, and validate biologically relevant gene expression patterns Suitable for multidisciplinary researchers and practitioners in computer science and biological sciences
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Gene and Cell Therapies

Gene and Cell Therapies

Eve Hanna; Mondher Toumi

CRC Press
2020
nidottu
The major advances in the field of biotechnology and molecular biology in the twenty-first century have led to a better understanding of the pathophysiology of diseases. A new generation of biopharmaceuticals has emerged, including a wide and heterogeneous range of innovative cell and gene therapies. These therapies aim to prevent or treat chronic and serious life-threatening diseases, previously considered incurable. This book describes the evolution and adaptation of the regulatory environment to assess these therapies in contrast with the resistance of health technology assessment (HTA) agencies and payers to acknowledge the specificity of cell and gene therapies and the need to adapt existing decision-making frameworks. This book provides insights on the learnings from the experience of current cell and gene therapies (regulatory approval, HTA, and market access), in addition to future trends to enhance patient access to these therapies.Key Features: Describes the potential change of treatment paradigm and the specificity of cell and gene therapies, including the gradual move from repeated treatment administration to one-time single administration with the potential to be definite cure Highlights the challenges at the HTA level Discusses the affordability of future cell and gene therapies and the possible challenges for health insurance systems Provides potential solutions to address these challenges and ensure patient access to innovation while maintaining the sustainability of healthcare systems
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