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165 tulosta hakusanalla Hesketh Pearson
The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy.
Despite the medical advances of the last century, the science behind cancer and its treatment remains a mystery to many people. In Betrayed by Nature, Robin Hesketh provides a concise and comprehensive history of both the science and the medical advances. It is also an illuminating look at the future of one of the world's oldest killers.
THE NATIONAL BESTSELLER A lifelong beekeeper, Albert Honig is deeply acquainted with the ways and workings of the hives. He knows that bees dislike wool clothing and foul language; that the sweetest honey is made from the blooms of eucalyptus; and that bees are at their gentlest in a swarm. But Albert is less versed in the ways of people, especially his beautiful, courageous, and secretive friend Claire. A friend and neighbor since childhood, Claire was a hovering presence--and then a glaring absence--in Albert's life, a change that has never been reconciled. When she is killed in a seemingly senseless accident during a burglary gone wrong, Albert is haunted by the loss. In the aftermath of this tragedy, he is left to piece together the events of their lives to attempt to make sense of their shared past and the silence that persisted between them for a decade before her death. What Albert comes to learn is that Claire's secrets were far darker than anything he could have imagined...
It's the first week of the second grade and Lily has a problem: She doesn't know what to do about her backpack full of mean words Find out what happens in this story about bullying, resilience, and one heavy backpack.
Tell me, sir, is it on your grandmother's or your grandfather's side that you are descended from an ape? In June of 1860, some of Britain's most influential scientific and religious authorities gathered in Oxford to hear a heated debate on the merits of Charles Darwin's recently published Origin of Species. The Bishop of Oxford, "Soapy" Samuel Wilberforce, clashed swords with Darwin's most outspoken supporter, Thomas Henry Huxley. The latter's triumph, amid quips about apes and ancestry, has become a mythologized event, symbolizing the supposed war between science and Christianity. But did the debate really happen in this way? Of Apes and Ancestors argues that this one-dimensional interpretation was constructed and disseminated by Darwin's supporters, becoming an imagined victory in the struggle to overcome Anglican dogmatism. By reconstructing the Oxford debate and carefully considering the individual perspectives of the main participants, Ian Hesketh argues that personal jealousies and professional agendas played a formative role in shaping the response to Darwin's hypothesis, with religious anxieties overlapping with a whole host of other cultural and scientific considerations. An absorbing study, Of Apes and Ancestors sheds light on the origins of a debate that continues, unresolved, to this day.
Based on original fieldwork in Chiapas and Oaxaca, Mexico, this book offers a bridge between geography and historical sociology. Chris Hesketh examines the production of space within the global political economy. Drawing on multiple disciplines, Hesketh’s discussion of state formation in Mexico takes us beyond the national level to explore the interplay between global, regional, national, and sub-national articulations of power. These are linked through the novel deployment of Antonio Gramsci’s concept of passive revolution, understood as the state-led institution or expansion of capitalism that prevents the meaningful participation of the subaltern classes.Furthermore, the author brings attention to the conflicts involved in the production of space, placing particular emphasis on indigenous communities and movements and their creation of counterspaces of resistance. Hesketh argues that indigenous movements are now the leading social force of popular mobilization in Latin America. The author reveals how the wider global context of uneven and combined development frames these specific indigenous struggles, and he explores the scales at which they must now seek to articulate themselves.
Based on original fieldwork in Chiapas and Oaxaca, Mexico, this book offers a bridge between geography and historical sociology. Chris Hesketh examines the production of space within the global political economy. Drawing on multiple disciplines, Hesketh’s discussion of state formation in Mexico takes us beyond the national level to explore the interplay between global, regional, national, and sub-national articulations of power. These are linked through the novel deployment of Antonio Gramsci’s concept of passive revolution, understood as the state-led institution or expansion of capitalism that prevents the meaningful participation of the subaltern classes.Furthermore, the author brings attention to the conflicts involved in the production of space, placing particular emphasis on indigenous communities and movements and their creation of counterspaces of resistance. Hesketh argues that indigenous movements are now the leading social force of popular mobilization in Latin America. The author reveals how the wider global context of uneven and combined development frames these specific indigenous struggles, and he explores the scales at which they must now seek to articulate themselves.
New attitudes towards history in nineteenth-century Britain saw a rejection of romantic, literary techniques in favour of a professionalized, scientific methodology. The development of history as a scientific discipline was undertaken by several key historians of the Victorian period, influenced by German scientific history and British natural philosophy. This study examines parallels between the professionalization of both history and science at the time, which have previously been overlooked. Hesketh challenges accepted notions of a single scientific approach to history. Instead, he draws on a variety of sources - monographs, lectures, correspondence - from eminent Victorian historians to uncover numerous competing discourses.
Wouldn't it be great if you could always get people to see things your way? Now you can. You won't go far in business if you can't bring people round to your way of thinking. Some people find it easy; the rest of us just need a little help. How to Persuade and Influence People reveals some of the most powerful influencing and persuasion techniques known to man. This enhanced second edition contains new tools, new research, new case studies and plenty of practical exercises to help you: Find the perfect way to win people overBecome an amazing negotiatorOvercome objectionsAppreciate and understand the other person's standpointUnderstand why people buy what they buyEnsure people remember you and what you wantBuild long-term trust and credibility Philip Hesketh is a full-time international business speaker on the psychology of persuasion. Thousands of people have benefited from his advice. In this book, he maps out countless simple and memorable persuasion techniques that can be applied to a whole range of life's challenges. It's up to you to use them. How to Persuade and Influence People is a completely revised and updated edition of Life's a Game So Fix The Odds.
Learn how to influence others and get your own way more often Wouldn't it be great if you could get the pay rise you've asked for, win the business you've pitched for or get that job you so desperately want? Well, with this book you can learn how to get inside the head of the person making the decision and find out exactly what is it that's going to get them to say yes! Persuade explains the seven psychological drivers that motivate us all. By understanding these drivers and the impact they have on our own lives, we can gain valuable insights into how we can motivate ourselves, improve our relationships, negotiate more effectively, get people to like us and ultimately get our own way more often. Persuade: Is written in Philip's trademark humorous, yet well-researched styleDraws from scientific and psychological sourcesIs delivered in short, accessible, bite-sized chapters
Highly Commended by The Forward Prize 2010At once erudite, humourous and stylishly contemporary, Sarah Hesketh's debut collection invokes a world of frozen lakes, 'snow-spun streets' and people who have stayed too long.With formal control and precise, crafted language, these poems examine the 'small relics of lives': china horses in an old people's home, a caged bird, the thighbone of a Saxon saint. Drawing from myth, history and a close reading of the present, Napoleon's Travelling Bookshelf is an impressive and engaging journey into love, identity and what it is to be alone – 'lost from sight / behind the ice-mapped waves'."What Sarah Hesketh's poems do so remarkably is to string a row of images together in such a way that each keeps its distinct hardness while at the same time contributing to a crystalline whole. They are original and utterly convincing."Bernard O'Donoghue"Sarah Hesketh writes superbly crafted poems with a very firm hand. Her poems are overflowing with intelligence and scorn for the easy and the clichéd, but her ear is as keen as her passion for the right word, the properly perceived state of affairs. When she writes lines like: 'I am content to form / the small oh of glory, / to add a little polish / to your morning epaulettes' (in 'Faking') you know that the irony you are dealing with is as intricate as lace but as sharp as daggers. Her terrain is not, to extend our analogies, exactly Jane Austen's 'two inches of ivory' because Hesketh's imagination ranges far and wide into some fairly exotic real and literary spaces, but the sense of ivory is there, as is the fierce, delicate carving. It is a melancholy but rigorously beautiful world her poems describe. We also know that every tiny part of every line has been fiercely fought for and that that is the source of the authority."George Szirtes"Hesketh's first collection is a striking debut, abounding in verve and rigour. In stark, lucid language, pared to the bone, summoning images that are sometimes cryptic yet always singing, Hesketh whirls us through a breathless breadth of forms, subjects and perspectives, from an old woman "forever remembering the waltz" in 'The Ballroom at West Riding Asylum' to 'The Boy Who read Homer to His Cat', juggling a giddying array of themes and allusions, often in the same poem, such as in 'Chaconne for Ice', where Roald Amundsen and Neil Diamond meet cheek by jowl for the first and probably only time. There is a real musicality to Hesketh's writing, imbuing her whittled words with a rhythmic vitality that is utterly compelling. A fine first collection from an exciting new poet."Poetry Book Society BulletinSarah Hesketh was born in 1983 and grew up in Pendle, East Lancashire. She attended Merton College, Oxford and holds an MA in Creative Writing from UEA. In 2007 her collaboration with composer Alastair Caplin was performed at the Leeds Lieder Festival. She currently works as Assistant Director at the writers' charity English PEN.
Big History is a seemingly novel approach that seeks to situate human history within a grand cosmic story of life. It claims to do so by uniting the historical sciences in order to construct a linear and accurate timeline of 'threshold moments' beginning with the Big Bang and ending with the present and future development of humanity itself. As well as examining the theory and practice of Big History, this Element considers Big History alongside previous largescale attempts to unite human and natural history, and includes comparative discussions of the practices of chronology, universal history, and the evolutionary epic.
One in two of us will develop cancer at some point in our lives and yet many of us don't understand how cancers arise. How many different kinds of cancer are there? What treatments are available? What does the future hold in terms of developing new therapies? This book demystifies cancer by explaining the underlying cell and molecular biology in a clear and accessible style. It answers the questions commonly asked about cancer such as what causes cancer and how cancer develops. It explains how DNA makes proteins and how mutations can corrupt those proteins. It also gives an overview of current therapies and how treatments may advance over the next decades, as well as explaining what actions we can take to help prevent cancer developing. Understanding Cancer is an accessible and engaging introduction to cancer biology for any interested reader.
From basic principles to insights into pioneering research, this introductory textbook provides the fundamentals of cancer biology that will enable students of biology and medicine to enter the field with confidence. It opens with a discussion of global cancer patterns, how cancers arise, and the risk factors involved. A description of the normal signalling pathways within cells then explains how DNA mutations affect proteins and what this means for the development and behaviour of tumours. Later chapters discuss methods for tumour detection, biomarker identification and the impact of genome sequencing, before reviewing the development of anti-cancer drugs and exciting current advances in treatment. With 50% new material, including two new chapters on genetic analysis of cancer and cancer chemotherapy, improved pedagogy, examples of revolutionising technologies in drug design and delivery, and useful online resources, this textbook offers an accessible and engaging account of cancer biology for undergraduate and graduate students.
This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface.We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface.We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Through the Heart of Patagonia
H (Hesketh) Hesketh-Prichard; John Guille Millais
Anson Street Press
2025
pokkari
Through the Heart of Patagonia
H (Hesketh) Hesketh-Prichard; John Guille Millais
Anson Street Press
2025
sidottu