Kirjojen hintavertailu. Mukana 11 717 486 kirjaa ja 12 kauppaa.

Kirjahaku

Etsi kirjoja tekijän nimen, kirjan nimen tai ISBN:n perusteella.

1000 tulosta hakusanalla M. Ouida

Zukünftige selektive CDKs-Inhibitoren als Krebsmedikamente

Zukünftige selektive CDKs-Inhibitoren als Krebsmedikamente

Khulood H Oudah; Khaled A M Abouzid

Verlag Unser Wissen
2024
pokkari
CDKs geh ren zur Familie der Serin/Threonin-Kinasen und sind Schl sselenzyme bei der Zellzyklusprogression und Transkription sowie bei anderen wichtigen biologischen Prozessen wie der neuronalen Differenzierung und dem Stoffwechsel. Eine konstitutive oder deregulierte Hyperaktivit t dieser Kinasen aufgrund von Amplifikation, berexpression oder Mutation von Cyclinen oder CDK tr gt zur Proliferation von Krebszellen bei, und eine unregelm ige Aktivit t dieser Kinasen wurde bei einer Vielzahl von menschlichen Krebsarten festgestellt. Daher gelten CDKs als attraktive pharmakologische Ziele f r die Entwicklung von Krebstherapeutika. Dieses Buch gibt zun chst einen berblick ber die verschiedenen Funktionen der CDKs und ihre biologische Struktur, den Zellzyklus und ihre Rolle bei der Regulierung des Zellzyklus. Dann werden CDKs-Inhibitoren als Krebsmedikamente und die verschiedenen Strategien zu ihrer Entwicklung, CDK2-Inhibitoren, die sich in der klinischen Erprobung befinden, und CDK4/6-Inhibitoren, die kurz vor der Zulassung stehen, er rtert. Die Zukunftsperspektive von CDKs-Inhibitoren als Krebsmedikamente wird in der Entwicklung neuer CDK1-, CDK5-, CDK7-, CDK8-, CDK9- und CDK12-Inhibitoren definiert.
Inhibiteurs sélectifs de CDKs à venir en tant que médicaments anticancéreux

Inhibiteurs sélectifs de CDKs à venir en tant que médicaments anticancéreux

Khulood H Oudah; Khaled A M Abouzid

Editions Notre Savoir
2024
pokkari
Les CDK sont des membres de la famille des s rine/thr onine kinases et des enzymes cl s dans la progression du cycle cellulaire, la transcription et d'autres processus biologiques majeurs, notamment la diff renciation neuronale et le m tabolisme. L'hyperactivit constitutive ou d r gul e de ces kinases, due l'amplification, la surexpression ou la mutation des cyclines ou des CDK, contribue la prolif ration des cellules canc reuses, et une activit irr guli re de ces kinases a t signal e dans une grande vari t de cancers humains. Par cons quent, les CDK sont consid r es comme des cibles pharmacologiques attrayantes pour le d veloppement de traitements anticanc reux. Ce livre r sume d'abord les diff rentes fonctions des CDK et la structure biologique des CDK, le cycle cellulaire et leur r le dans la r gulation du cycle cellulaire. Il se concentre ensuite sur les inhibiteurs de CDK en tant qu'anticanc reux et les diff rentes strat gies de d veloppement, les inhibiteurs de CDK2 en cours d'essais cliniques et les inhibiteurs de CDK4/6 en voie d'homologation ont t discut s. Les perspectives d'avenir des inhibiteurs de CDK en tant qu'anticanc reux seront d finies dans le d veloppement de nouvelles cibles, savoir les inhibiteurs de CDK1, CDK5, CDK7, CDK8, CDK9 et CDK12.
Inibitori selettivi delle CDK di prossima uscita come farmaci antitumorali

Inibitori selettivi delle CDK di prossima uscita come farmaci antitumorali

Khulood H Oudah; Khaled A M Abouzid

Edizioni Sapienza
2024
pokkari
Le CDK sono membri della famiglia delle serina/treonina chinasi ed enzimi chiave nella progressione del ciclo cellulare e nella trascrizione e in altri importanti processi biologici, tra cui la differenziazione neurale e il metabolismo. L'iperattivit costitutiva o deregolata di queste chinasi, dovuta all'amplificazione, alla sovraespressione o alla mutazione delle cicline o delle CDK, contribuisce alla proliferazione delle cellule tumorali e l'attivit irregolare di queste chinasi stata segnalata in un'ampia variet di tumori umani. Pertanto, le CDK sono considerate bersagli farmacologici interessanti per lo sviluppo di terapie antitumorali. Questo libro riassume innanzitutto le diverse funzioni delle CDK e la loro struttura biologica, il ciclo cellulare e il loro ruolo nella regolazione del ciclo cellulare. Poi si concentra sugli inibitori delle CDK come antitumorali e sulle diverse strategie di sviluppo, sugli inibitori delle CDK2 in fase di sperimentazione clinica e sugli inibitori delle CDK4/6 in via di approvazione. La prospettiva futura degli inibitori delle CDK come antitumorali sar definita nello sviluppo di nuovi target CDK1, CDK5, CDK7, CDK8, CDK9 e CDK12.
Futuros inibidores selectivos das CDKs como fármacos anticancerígenos

Futuros inibidores selectivos das CDKs como fármacos anticancerígenos

Khulood H Oudah; Khaled A M Abouzid

Edicoes Nosso Conhecimento
2024
pokkari
As CDKs s o membros da fam lia das serina/treonina quinase e enzimas-chave na progress o e transcri o do ciclo celular e noutros processos biol gicos importantes, incluindo a diferencia o neural e o metabolismo. A hiperatividade constitutiva ou desregulada destas cinases, devido amplifica o, sobreexpress o ou muta o das ciclinas ou CDK, contribui para a prolifera o de c lulas cancerosas, tendo sido registada uma atividade irregular destas cinases numa grande variedade de cancros humanos. Por conseguinte, as CDK s o consideradas alvos farmacol gicos atractivos para o desenvolvimento de terap uticas anticancer genas. Este livro come a por resumir as diferentes fun es das CDKs e a estrutura biol gica das CDKs, o ciclo celular e o seu papel na regula o do ciclo celular. Em seguida, centra-se nos inibidores das CDKs como agentes anticancer genos e nas diferentes estrat gias para o seu desenvolvimento, tendo sido discutidos os inibidores da CDK2 que se encontram em ensaios cl nicos e os inibidores da CDK4/6 que est o em vias de aprova o. A perspetiva futura dos inibidores de CDKs como anticancer genos ser definida no desenvolvimento de novos inibidores de CDK1, CDK5, CDK7, CDK8, CDK9 e CDK12.
Next Generation Sequencing Technologies and Challenges in Sequence Assembly

Next Generation Sequencing Technologies and Challenges in Sequence Assembly

Sara El-Metwally; Osama M. Ouda; Mohamed Helmy

Springer-Verlag New York Inc.
2014
nidottu
The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field.This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.
M

M

Antonio Scurati

Fourth Estate Ltd
2021
sidottu
THE PHENOMENAL INTERNATIONAL BESTSELLER M. is a startling look into the fascist mindset, a portrait of unrelenting determination, and an impeccable work of historical fiction. Italy is exhausted. Tired of the political class. Tired of the inept moderates and the agonizing machinations of a democracy that no longer seems to be working. While the leaders of the country have sat idly in the safety of parliament, achieving nothing, one man on the outside has risen to the top. He is a misfit par excellence, a protector of the demobilized, a lost drifter searching for the way. He speaks for the outcasts, the renegades and the ideologically pure. He is a former socialist leader ousted by his party, the director of a small opposition newspaper, a tireless political agitator. Like an animal, he can smell that change is coming. He is Benito Mussolini. M tells the story of the rise of fascism from within the mind of its founder. Rich in historical detail, and interspersed with real documents and sources, this is a masterful work of historical fiction with urgent resonance for our times
M

M

Antonio Scurati

HARPERCOLLINS PUBLISHERS
2021
nidottu
THE PHENOMENAL INTERNATIONAL BESTSELLERM. is a startling look into the fascist mindset, a portrait of unrelenting determination, and an impeccable work of historical fiction.
M

M

Antonio Scurati

HARPERCOLLINS PUBLISHERS
2022
nidottu
THE PHENOMENAL INTERNATIONAL BESTSELLER ‘An anti-fascist history lesson disguised as a novel’ New York Times ‘Extraordinary’ TLS ‘A masterpiece’ Roberto Saviano A startling look into the fascist mindset, a portrait of unrelenting determination, and an impeccable work of historical fiction. M tells the story of the rise of fascism from within the mind of its founder. A gripping and masterful exposé, it explores Benito Mussolini’s rise to power and a movement that, amidst a failing democracy, came to shape the world. ‘Panoptic and polyphonic, Scurati’s book gives us the experiences of the fearful and the feared, the rhetoric of both the revolutionaries and the reactionaries … an immense mosaic’ Lucy Hughes-Hallett, New Statesman ‘An indisputable literary achievement … Italo Calvino would have loved it’ El Paìs
M

M

Joyful Creations

Blurb
2025
pokkari
This beautifully designed monogram initial letter notebook is great for writing down your thoughts, to-do lists, ideas, poems, plans, and goals. Lined notebooks can be used for various purposes such as a journal, planner, diary, and organizer. A compact 6"x 9" notebook which is spacious enough for your writing needs yet portable. Features: White paper Glossy monogram initial letter cover Joyful Creations offer a wide range of journals and notebooks that are suitable for back to school, home or office. Our journals make excellent gifts for birthdays, celebrations, Mother's Day, Father's Day, Valentine's Day, anniversaries, weddings, Secret Santa, bridal showers, Christmas and much more.
Making of M+

Making of M+

M+

ThamesHudson Ltd
2021
pokkari
This visually driven compendium combines brief narrative descriptions and widely sourced images to tell the fascinating story of the creation of Hong Kong's new global museum of modern and contemporary visual culture.
M

M

Andrew Cook

The History Press Ltd
2006
nidottu
William Melville was one of the most influential counter - espionage figures of the twentieth century. This work presents the true story of the real M, William Melville, MI5s founding father and the inspiration for Ian Flemings character in "James Bond".
M

M

Wesleyan University Press
1973
nidottu
Although literary historians generally connect the rise of the novel to the needs of the middle classes of England, Maiorino demonstrates that its deepest roots are in the culture of indigence that developed at the peripheries of ...
M

M

Hannah Brooks-Motl

Song Cave
2016
nidottu
Poetry. Swinging between examination and revelation, Hannah Brooks-Motl's second collection of poems, M, holds a unique place in contemporary poetry, written almost as a document to chart the act of a writer reading. By transposing lines directly from the essays of Michel de Montaigne with her own, she creates a shimmering mirage that enables two distinct voices to blend with confidence and to question the steps we take to make sense of the world. That degree of ambition requires great care and thoroughness, the ability to see the past clearly in order to invent a skillfully considered and electric present. Blowing hot and cold with the same mouth The weapon of memory shattered the sun Lift your eyes to it In the venerable tradition of mining, Hannah Brooks-Motl engages the poetics of excavation, taking Montaigne's Essays as substrate. The 'M' of the title may be far removed, but his (and her) spirit holds sway via 'the burning light of the past' in 'the little way of adjacency.' Montaigne's 'very limits of the possible' lead onto a quiet exuberance in a poem, for example, where 'Invention got big / in the world / and bigger /... I made it // Wild with making' (this, on imagination). If Brooks-Motl's subtleties sometimes defy a quick 'get, ' they also persist in their nested reference, '...like an infant wall of belief / Climbing with ivy at night.' This is the 'great fond wager' of a rich and mysterious work.--Jean Day M may be for Montaigne, the sixteenth century essayist whose humanist imagination gives Brooks-Motl permission to look elsewhere, into the past for her poetic material, but M is also for 'mind, ' a place these poems love to dwell. As readers, we get to dwell there, too, trusting Brooks-Motl to sculpt with care and patience in order to offer a world that 'blooms and moves' more generously. These ambitious and gorgeous poems are continuously surprising, pushing language into a secret landscape, or a secret history of the intellect. Every turn of phrase, every figure and gesture flickers open, making manifest the intimate and precipitous experience of reading into and with the past, alongside its fragments and tendencies.--Juliana Leslie
M

M

Rwg

Rwg Publishing
2019
pokkari
College rule (also known as medium ruled paper) is the most common lined paper in use in the United States. It is generally used in middle school through to college and is also popular with adults. This is a good choice for teen or adult notebooks and composition books (known as exercise books outside the US).
The Path to Happiness, Explored and Illustrated. By M*** *****. Second Edition
The 18th century was a wealth of knowledge, exploration and rapidly growing technology and expanding record-keeping made possible by advances in the printing press. In its determination to preserve the century of revolution, Gale initiated a revolution of its own: digitization of epic proportions to preserve these invaluable works in the largest archive of its kind. Now for the first time these high-quality digital copies of original 18th century manuscripts are available in print, making them highly accessible to libraries, undergraduate students, and independent scholars.The Age of Enlightenment profoundly enriched religious and philosophical understanding and continues to influence present-day thinking. Works collected here include masterpieces by David Hume, Immanuel Kant, and Jean-Jacques Rousseau, as well as religious sermons and moral debates on the issues of the day, such as the slave trade. The Age of Reason saw conflict between Protestantism and Catholicism transformed into one between faith and logic -- a debate that continues in the twenty-first century.++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++British LibraryT076662London: printed by Jaques and Thomas, for T. Egerton; J. Woodhouse. Sold also at No.2, Chapel Street, Grosvenor Place, 1797. 4],103, 1]p.; 12