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1000 tulosta hakusanalla Mark Chang

Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials

Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials

Mark Chang; John Balser; Jim Roach; Robin Bliss

Taylor Francis Ltd
2021
nidottu
"This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development…. Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously." Jay Herson, Johns Hopkins UniversityThe pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However, these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost, time, or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization, including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs, precision medicine, survival-endpoints, dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons, this book incorporates both statistical and "clinical/medical" perspectives.
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Expressly Human

Expressly Human

Mark Changizi; Tim Barber

Benbella Books
2022
pokkari
Good communication, conventional wisdom suggests, is calm, logical, rational. Emotions, we’re told, just get in the way. But what if this is backwards? What if those emotional overtones are the main messages we’re sending to one another, and all that logical language is just window dressing?Over billions of years of evolution, animals have become increasingly sophisticated and increasingly sentient. In the process, they evolved emotions, which helped improve their odds of survival in complex situations. These emotions were, at first, purely internal. But at some point, social animals began expressing their emotions, in increasingly dramatic ways. These emotional expressions could accurately reflect internal emotions (smiling to express happiness)—or they could be quite different (smiling to cover up that you’re actually furious, but can’t tell your boss that). Why did once-stone-faced animals evolve to be so emotionally expressive—to be us? The answer, as evolutionary neurobiologist Mark Changizi and mathematician Tim Barber reveal, is that emotional expressions are our first and most important language—one that allows us, as social animals, to engage in highly sophisticated communications and negotiations. Expressly Human introduces an original theory that explains, from first principles, how the broad range of emotional expressions evolved, and provides a Rosetta Stone for human communication. It will revolutionize the way you see every social interaction, from deciding who gets the last slice of pizza to multimillion-dollar business negotiations, and change your definition of what makes us human.
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The Vision Revolution

The Vision Revolution

Mark Changizi

BenBella Books
2010
pokkari
In The Vision Revolution, Mark Changizi, prominent neuroscientist and vision expert, addresses four areas of human vision and provides explanations for why we have those particular abilities, complete with a number of full-color illustrations to demonstrate his conclusions and to engage the reader. Written for both the casual reader and the science buff hungry for new information, The Vision Revolution is a resource that dispels commonly believed perceptions about sight and offers answers drawn from the field's most recent research. Changizi focuses on four "why" questions: 1. Why do we see in color? 2. Why do our eyes face forward? 3. Why do we see illusions? 4. Why does reading come so naturally to us? The Vision Revolution explores phenomena such as cyclopses, peeking and many more you hadn't even thought to wonder about. Changizi shows how deeply involved these evolutionary aspects of our vision are in why we see the way we do--and what the future holds for us. The Vision Revolution is a book that finally gives attention to what before has been largely neglected by other works on human vision--a book that looks at the "why."
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Harnessed

Harnessed

Mark Changizi

BenBella Books
2011
nidottu
The scientific consensus is that our ability to understand human speech has evolved over hundreds of thousands of years. After all, there are whole portions of the brain devoted to human speech. We learn to understand speech before we can even walk, and can seamlessly absorb enormous amounts of information simply by hearing it. Surely we evolved this capability over thousands of generations. Or did we? Portions of the human brain are also devoted to reading. Children learn to read at a very young age and can seamlessly absorb information even more quickly through reading than through hearing. We know that we didn't evolve to read because reading is only a few thousand years old. In Harnessed, cognitive scientist Mark Changizi demonstrates that human speech has been very specifically "designed" to harness the sounds of nature, sounds we've evolved over millions of years to readily understand. Long before humans evolved, mammals have learned to interpret the sounds of nature to understand both threats and opportunities. Our speech--regardless of language--is very clearly based on the sounds of nature. Even more fascinating, Changizi shows that music itself is based on natural sounds. Music--seemingly one of the most human of inventions--is literally built on sounds and patterns of sound that have existed since the beginning of time. From Library Journal: "Many scientists believe that the human brain's capacity for language is innate, that the brain is actually "hard-wired" for this higher-level functionality. But theoretical neurobiologist Changizi (director of human cognition, 2AI Labs; The Vision Revolution) brilliantly challenges this view, claiming that language (and music) are neither innate nor instinctual to the brain but evolved culturally to take advantage of what the most ancient aspect of our brain does best: process the sounds of nature ...it will certainly intrigue evolutionary biologists, linguists, and cultural anthropologists and is strongly recommended for libraries that have Changizi's previous book." From Forbes: "In his latest book, Harnessed, neuroscientist Mark Changizi manages to accomplish the extraordinary: he says something compellingly new about evolution...Instead of tackling evolution from the usual position and become mired in the usual arguments, he focuses on one aspect of the larger story so central to who we are, it may very well overshadow all others except the origin of life itself: communication. "
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Motorcycle Mind

Motorcycle Mind

Mark Changizi

Ukiyoto Publishing
2025
nidottu
"Motorcycle Mind takes you beyond the handlebars and into the fascinating cognitive and perceptual world of motorcycling-a ride that's more than just transportation; it's a transformative way of being. Unlike car drivers, motorcyclists become one with their machine, immersed in the road, the wind, and the rhythm of the ride. This unique connection turns every journey into an art form, deeply engaging the mind and body.In this groundbreaking book, evolutionary neuroscientist and acclaimed author Mark Changizi reveals the science behind why motorcycling feels so exhilarating. From the dynamics of human perception and emotion to the physical symbiosis between rider and machine, Motorcycle Mind uncovers how the ride transforms us into something primal-instinctive, expressive, and alive.With a narrative style that bridges cutting-edge science and the thrill of the open road, Changizi brings his expertise to bear, drawing on years of research and collaborations with Yamaha Motors. This is the first book of its kind to explore the neuroscience and psychology of motorcycling, offering insights that will captivate riders and enthusiasts alike.Whether you're a seasoned rider or simply curious about the allure of two wheels, Motorcycle Mind will leave you with a deeper appreciation for the science, emotion, and artistry that make the motorcycle experience unparalleled."
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Motorcycle Mind

Motorcycle Mind

Mark Changizi

Ukiyoto Publishing
2025
sidottu
"Motorcycle Mind takes you beyond the handlebars and into the fascinating cognitive and perceptual world of motorcycling-a ride that's more than just transportation; it's a transformative way of being. Unlike car drivers, motorcyclists become one with their machine, immersed in the road, the wind, and the rhythm of the ride. This unique connection turns every journey into an art form, deeply engaging the mind and body.In this groundbreaking book, evolutionary neuroscientist and acclaimed author Mark Changizi reveals the science behind why motorcycling feels so exhilarating. From the dynamics of human perception and emotion to the physical symbiosis between rider and machine, Motorcycle Mind uncovers how the ride transforms us into something primal-instinctive, expressive, and alive.With a narrative style that bridges cutting-edge science and the thrill of the open road, Changizi brings his expertise to bear, drawing on years of research and collaborations with Yamaha Motors. This is the first book of its kind to explore the neuroscience and psychology of motorcycling, offering insights that will captivate riders and enthusiasts alike.Whether you're a seasoned rider or simply curious about the allure of two wheels, Motorcycle Mind will leave you with a deeper appreciation for the science, emotion, and artistry that make the motorcycle experience unparalleled."
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Adaptive Design Methods in Clinical Trials

Adaptive Design Methods in Clinical Trials

Shein-Chung Chow; Mark Chang

TAYLOR FRANCIS LTD
2023
nidottu
With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA’s recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials. It unifies the vast and continuously growing literature and research activities on regulatory requirements, scientific and practical issues, and statistical methodology.New to the Second EditionAlong with revisions throughout the text, this edition significantly updates the chapters on protocol amendment and clinical trial simulation to incorporate the latest changes. It also includes five entirely new chapters on two-stage adaptive design, biomarker adaptive trials, target clinical trials, sample size and power estimation, and regulatory perspectives.Following in the tradition of its acclaimed predecessor, this second edition continues to offer an up-to-date resource for clinical scientists and researchers in academia, regulatory agencies, and the pharmaceutical industry. Written in an intuitive style at a basic mathematical and statistical level, the book maintains its practical approach with an emphasis on concepts via numerous examples and illustrations.
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Adaptive Design Methods in Clinical Trials

Adaptive Design Methods in Clinical Trials

Shein-Chung Chow; Mark Chang

Taylor Francis Inc
2011
sidottu
With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA’s recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials. It unifies the vast and continuously growing literature and research activities on regulatory requirements, scientific and practical issues, and statistical methodology.New to the Second EditionAlong with revisions throughout the text, this edition significantly updates the chapters on protocol amendment and clinical trial simulation to incorporate the latest changes. It also includes five entirely new chapters on two-stage adaptive design, biomarker adaptive trials, target clinical trials, sample size and power estimation, and regulatory perspectives.Following in the tradition of its acclaimed predecessor, this second edition continues to offer an up-to-date resource for clinical scientists and researchers in academia, regulatory agencies, and the pharmaceutical industry. Written in an intuitive style at a basic mathematical and statistical level, the book maintains its practical approach with an emphasis on concepts via numerous examples and illustrations.
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Mark: Life-Changing Power Through Jesus

Mark: Life-Changing Power Through Jesus

Angelo Juliani; Barbara Miller Juliani

New Growth Press
2026
nidottu
What would you like to change about yourself and the world we live in? How would you go about making the change--and making it stick? In the Gospel of Mark, we learn that all real change comes from meeting Jesus. When he came near, everything changed. The sick were healed, wrongs were righted, sinners were saved, storms were stopped, and death is ended. These stories from long ago still bring us the same hope today--forgiveness and new life forever. Mark: All Things Are Possible with Jesus makes Jesus's words and actions come alive, bringing with them amazement, conviction, comfort, and the power to change us and our messed-up world. Jesus is still doing his work in the world today, bringing the kingdom of God near and giving life to all who love him. Featuring twelve lessons from the Gospel of Mark, this easy-to-use small group resource includes leader's notes, discussion questions, a short article, and a practical application section that can be used for one-to-one discipleship, small group, or large group settings. Part of The Gospel-Centered Life in the Bible series, Mark: All Things Are Possible with Jesus examines how the gospel story is revealed through both the Old and New Testaments and is published in partnership with Serge.
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The Half-Century; Or, a History of Changes That Have Taken Place, and Events That Have Transpired, Chiefly in the United States, Between 1800 and 1850. with an Introduction by Mark Hopkins.

The Half-Century; Or, a History of Changes That Have Taken Place, and Events That Have Transpired, Chiefly in the United States, Between 1800 and 1850. with an Introduction by Mark Hopkins.

Emerson Davis; Mark Hopkins

British Library, Historical Print Editions
2011
pokkari
Title: The Half-Century; or, a History of changes that have taken place, and events that have transpired, chiefly in the United States, between 1800 and 1850. With an introduction by Mark Hopkins.Publisher: British Library, Historical Print EditionsThe British Library is the national library of the United Kingdom. It is one of the world's largest research libraries holding over 150 million items in all known languages and formats: books, journals, newspapers, sound recordings, patents, maps, stamps, prints and much more. Its collections include around 14 million books, along with substantial additional collections of manuscripts and historical items dating back as far as 300 BC.The GENERAL HISTORICAL collection includes books from the British Library digitised by Microsoft. This varied collection includes material that gives readers a 19th century view of the world. Topics include health, education, economics, agriculture, environment, technology, culture, politics, labour and industry, mining, penal policy, and social order. ++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++ British Library Davis, Emerson; Hopkins, Mark; 1851. xxiii, 444 p.; 12 . 9603.c.24.
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Speaking Story: Using the Magic of Storytelling to Make Your Mark, Pitch Your Ideas, and Ignite Meaningful Change

Speaking Story: Using the Magic of Storytelling to Make Your Mark, Pitch Your Ideas, and Ignite Meaningful Change

Sally Z

Wise Ink
2024
sidottu
In this empowering public speaking book, learn how to move audiences to action--whether it's in a boardroom, keynote presentation, or the TEDx stage.It takes courage to stand up and speak your story. But true leadership--and the potential to create meaningful change --requires it from us.Sally Z is an award-winning professional speaker with 25+ years of presentation experience and a master's degree in persuasion. She coaches high-potential dreamers from their first gig to their high-paying and world-changing keynote. Her clients range from small business owners and creative entrepreneurs to leaders at Fortune 500 corporations like Viacom, Paramount, and more.With her signature enthusiasm--and you guessed it, entertaining storytelling--Sally Z shares the tools and mindset shifts that make speaking feel not just approachable, but achievable.Speaking Story includes exercises and tools in every chapter, learn how speaking can catapult your career to the next level with: powerful insights for increased prospects, income, and impact, conference room confidence in presentation skills and pitching, expert skills for social media marketing in reels and videos, andtactical steps on how to become a thought leader and trusted authority in your industry-stepping onto bigger stages to make a more meaningful impact.Speaking Story is not a call to tell your story perfectly. It's permission to tell your story anyway--despite your fears, reservations, or feelings of self-doubt. Because everyone has a story that belongs on stage.Move from the sidelines to the spotlight . . . and move the world with your story."I can't imagine where I'd be without Sally Z's program. It has changed my life." --Jenn Whitmer, international TedX and keynote speaker and leadership consultant
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Mark-Up-Preisbestimmung, Einkommensverteilung Und Wirtschaftswachstum

Mark-Up-Preisbestimmung, Einkommensverteilung Und Wirtschaftswachstum

Min-Chang Ko

Peter Lang AG
2004
nidottu
Die Arbeit untersucht die Entwicklung der kurzfristigen Theorie der effektiven Nachfrage hin zur langfristigen postkeynesianischen Verteilungs- und Wachstumstheorie. Durch eine theoriegeschichtliche Betrachtung wird versucht, die Grundlagen fur die Bildung einer einheitlichen postkeynesianischen langfristigen Theorie der effektiven Nachfrage zu diskutieren. Die Untersuchung zeigt, dass eine langfristige Theorie der effektiven Nachfrage entgegen der neoklassischen Vorstellung moeglich ist.
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Climate Change

Climate Change

Mark Maslin

Oxford University Press
2021
nidottu
Very Short Introductions: Brilliant, Sharp, Inspiring In the last few years global awareness of climate change has grown very rapidly - through the school strikes led by Greta Thunberg, groups like Extinction Rebellion, the IPCC's recent high impact reports, tv documentaries, and declarations from governments around the world that we are in a climate emergency. This awareness is continuing to grow, as the science shows us that our planet and our species are facing a massive crisis, which we ourselves have caused. Climate change is one of the few scientific theories that make us examine the whole basis of modern society. It is a challenge that has politicians arguing, sets nations against each other, queries individual lifestyle choices, and ultimately asks questions about humanity's relationship with the rest of the planet. This Very Short Introduction draws on the very latest science from the 2021 IPCC Report, examining the evidence that climate change is already happening, and discussing its potential catastrophic impacts in the future. Mark Maslin also explores the geopolitics of climate change and the win-win solutions we can employ to avoid the very worst effects of climate change. Throughout, he demonstrates how we must develop new modes of thinking for the 21st century at individual, corporate, and government levels to collectively tackle the challenge of climate change. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
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My Changes

My Changes

Mark Oestreicher; Scott Rubin

ZonderKidz
2008
nidottu
In My Changes, you’ll discover the reasons behind a lot of your changes, and get tips on how to survive all of them. You’ll find valuable insights on changes happening in your body, your brain and thoughts, your identity, your emotions, your gender, and more. After reading the books in the Middle School Survival Series, you’ll be ready to take on the rest of middle school with the confidence and knowledge you need to survive (and thrive) as a young teen.
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Sex Changes

Sex Changes

Mark Blechner

Routledge
2009
nidottu
The last half-century has seen enormous changes in society’s attitude toward sexuality. In the 1950s, homosexuals in the United States were routinely arrested; today, homosexual activity between consenting adults is legal in every state, with same-sex marriage legal in Massachusetts and Connecticut. In the 1950s, ambitious women were often seen as psychopathological and were told by psychoanalysts that they had penis envy that needed treatment; today, a woman has campaigned for President of the United States.Mark Blechner has lived and worked through these startling changes in society, and Sex Changes collects papers he has written over the last 45 years on sex, gender, and sexuality. Interspersed with these papers are reflections on the changes that have occurred during that time period, both within the scope of society at large as well as in his personal experiences inside and outside of the therapeutic setting. He shows how changes in society, changes in his life, and changes in his writing on sexuality - as well as changes within psychoanalysis itself - have affected one another. One hundred years ago, psychoanalysis was at the cutting edge of new ideas about sex and gender, but in the latter half of the 20th Century, psychoanalysts were often seen as reactionary upholders of society’s prejudices. Sex Changes seeks to restore the place of psychoanalysis as the "once and future queer science," and aims for a radical shift in psychoanalytic thinking about sexuality, gender, normalcy, prejudice, and the relationship of therapeutic aims and values.
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Electoral Change

Electoral Change

Mark Franklin; Thomas Mackie; Henry Valen

ECPR Press
2009
nidottu
Until the last quarter of the 20th Century, Western party systems appeared to be frozen and stability was generally taken to be the central characteristic of individual-level party choice. But during the 1970s and 1980s, in a spasm of change that appeared to occur in all countries, this ceased to be true. Voters in Western countries suddenly demonstrated an unexpected and increasing unpredictability in their choices between parties, often to the extent of voting for parties that are quite new to the political scene. Understanding these fundamental changes became a pressing concern for political scientists and commentators alike, and a matter of extensive controversy and debate. In the middle 1980s, an international team of leading scholars set out to explore the reasons for these shifts in voting patterns in sixteen western countries: all those of the (then) European Community (except for Luxembourg and Portugal), together with Australia, Canada, New Zealand, Norway, Sweden and the United States. In this book they report their findings regarding the connections between social divisions and party choice, and the manner in which these links had changed since the mid-1960s. The authors based their country studies on a common research design. By doing so, they were able to focus on the characteristics that the sixteen countries had in common so as to evaluate the extent to which the changes had a common source. The passage of time has not dated this book, and in this edition the original text is augmented by a new Preface that describes the ways in which the book's findings retain their relevance for contemporary scholarship, and by an Epilogue in which the main analyses reported in the book are brought up to date.
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