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1000 tulosta hakusanalla Sumit Sarin

Secondary Metabolites Pathway Genes from Coleus forskohlii

Secondary Metabolites Pathway Genes from Coleus forskohlii

Praveen Awasthi; Sumit G Gandhi

LAP Lambert Academic Publishing
2018
pokkari
Coleus forskohlii, an important medicinal plant in the Indian system of medicine, accumulates a wide array of pharmaceutically important secondary metabolites, including forskolin (a reversible and potent activator of adenylate cyclase), which imparts anti-hypertensive property to the herb. Cytochrome P450 monooxygenases (CYP450s) constitute one of the largest gene families in plants. CYP450s play vital roles in the biosynthesis of secondary metabolites, phytohormones as well as in detoxification of harmful chemicals. This work attempts to understand the role of CYP450s in different metabolic pathways of Coleus forskohlii. Apart from CYP450s, we also carried out the cloning and expression analysis of two important key enzymes of flavonoid biosynthesis in C.forskohlii: CfCHS and Cf4CL.
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Structure Based Drug Design for Malaria

Structure Based Drug Design for Malaria

Sujit Kumar; Sumit Pal

LAP Lambert Academic Publishing
2019
pokkari
Bioinformatics now entails the creation and advancement of database, algorithms, computational and statistical techniques and theory to solve formal and practical problems arising from the management and analysis of biological data. Malaria is a mosquito-borne infectious disease caused by a eukaryotic protist of the genus Plasmodium. It is prevalent in tropical and subtropical regions, including parts of the America (USA), Asia and Africa. Each year, there are approximately 300-450 million cases of malaria, killing between one and four million people, the majority of whom are young children in Sub-Saharan Africa. Drug Chloroquine (- 476.114k.cal/mol) performing more docking than Quinine (- 488.416k.cal/mol).
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Study of ECMM parameter using S1 Tool steel

Study of ECMM parameter using S1 Tool steel

Love Kishore Sharma; Sumit Sharma

LAP Lambert Academic Publishing
2019
pokkari
The concept Electrochemical machining (ECM) is broadly implemented in manufacturing area for the past two decades because of several advantages e.g. almost negligible tool wear, resistance of W.P. to thermal and mechanical stress and strain and the ease to form complicated shapes in tough material. Several optimization techniques had been implemented for studying the process factors of different non-conventional machining processes. Analysis of surface texture by implementation of RSM had been discussed by authors but they have not included the ROC& MRR. A precise investigation of ROC and MRR is studied in detail. Our aim for the present work is to optimize the independent parameter of ECMM using S1 tool steel also called as shock resistant tool steel, for maximizing the amount of material removal and for minimizing the radial over cut using RSM. The multi-parameter examinations of the MRR and ROC obtained from RSM have been in depth analysed by contour and surface plots. Voltage is maximum effect on machining rate whereas the E.C. largely affects ROC in comparison to other parameters. The optimum performance parameters for ECMM setup are determined for future investigation.
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Properties Optimization of Al 6082 using Response Surface Methodology

Properties Optimization of Al 6082 using Response Surface Methodology

Devendra K Vishwakarma; Sumit Sharma

LAP Lambert Academic Publishing
2019
pokkari
Al 6082 is one of the most important alloy present in 6xxx series as a new alloy. This is because of its high strength to weight ratio, good formability, and machinability. In present work, heat treatment on Al 6082 alloy in order to study its effect on thermal and mechanical properties and also optimize it for thermal and mechanical properties using Response Surface Methodology. The process parameters are solutionizing time, aging temperature, and aging time. Solutionization is followed by artificial aging of samples for a period of 90 minutes to 450 minutes. The heating process takes place in Muffle Furnace. The mathematical model for the thermal conductivity, coefficient of thermal expansion and Vickers hardness has been developed. All the mathematical models obtained hold good at 95% confidence level. The optimum parameters will be obtained for thermal & mechanical properties.
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Application of Finite Element Method on Sheet Metal Product

Application of Finite Element Method on Sheet Metal Product

Mukesh Kumar; Sumit Sharma

LAP Lambert Academic Publishing
2019
pokkari
Sheet metal forming is a common process to produce various sheet metal based products like cylindrical cups, square cups etc. It has various types of defects which can reduce product quality, but wrinkling is the most critical defect in sheet metal products. Flange wrinkling is very common problem in sheet metal form based products and this is due to undesirable deformation of sheet, thickness and compressive stresses. When drawing process starts and increase draw depth, after certain height the flange region plastically buckles into a number of waves and the process fails down. It was found that small scale industries working in this field have less technical knowledge for forming defects.
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Application of finite element method on sheet metal product

Application of finite element method on sheet metal product

Mukesh Kumar; Sumit Sharma

LAP Lambert Academic Publishing
2019
pokkari
Sheet metal forming is a common process to produce various sheet metal based products like cylindrical cups, square cups etc. It has various types of defects which can reduce product quality, but wrinkling is the most critical defect in sheet metal products. Flange wrinkling is very common problem in sheet metal form based products and this is due to undesirable deformation of sheet, thickness and compressive stresses. When drawing process starts and increase draw depth, after certain height the flange region plastically buckles into a number of waves and the process fails down. It was found that small scale industries working in this field have less technical knowledge for forming defects.
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Abutment in implant dentistry

Abutment in implant dentistry

Mohammad Kashif Noorani; Sumit Verma; Kumar Adarsh

LAP Lambert Academic Publishing
2020
pokkari
Many treatment options were proposed in the past for the rehabilitation of the missing teeth. with the advancement in dentistry and the introduction of the implant in the dental fraternity, we are now able to provide better prosthesis. The function and esthetics of these prostheses are predicted by the abutments. So wise selection of these abutments is crucial. This book will emphasize on proper selection of these abutments for better predictability.
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