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Development of Analytical Methods By Using Various Hydrotropy Methods

Development of Analytical Methods By Using Various Hydrotropy Methods

Deepak Shrivastava

LAP Lambert Academic Publishing
2020
pokkari
In the various methods of some poorly water soluble drugs and their formulation for quantitative analysis the use of organic solvents can be replaced by using hydrotropy, mixed hydrotropy and mixed solvency giving ecofriendly analytical techniqueThe main drawbacks of organic solvents include high cost, toxicity and pollution. Organic solvents possess different adverse effects caused by single exposure like dermatitis, The hydrotropic solubilization, mixed hydrotropic solubilization and mixed solvency concept provide ecofriendly spectrophotometric estimations of poorly water-soluble drugs from their bulk drug samples and various dosage forms precluding the use of organic solvents providing simple, economic, eco-friendly, safe (free from toxicity) and accurate analytical methods. We can also use better hydrotropic agents for better results.Commonly used organic solvents for spectrophotometric analysis of water insoluble drugs include methanol, ethanol, chloroform, benzene, dichloromethane, dimethyl formamide, acetonitrile, ethyl acetate, toluene, carbon tetrachloride, acetone, hexane etc.
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Molecular Modeling Study of Antibacterial Agents

Molecular Modeling Study of Antibacterial Agents

Deepak Kumawat; Raksha Goswami

LAP Lambert Academic Publishing
2020
pokkari
β-ketoacyl-acyl carrier protein synthase III (FabH) is an emerging target for the development of novel antibacterial agent.Ligand-based design of a series of benzoylaminobenzoic acid derivatives led to the discovery of potent inhibitors of β-ketoacyl-acyl carrier protein synthase III (FabH). These FabH inhibitors demonstrated potent antibacterial activity (MIC) and as such have the potential to be novel and potent antibacterial agents. Given the unforeseen structural differences within the active site of some pathogenic FabH enzymes the key to discovering inhibitors with broad-spectrum antibacterial activity. The discovery of FabH inhibitors is now of special interest in the treatment of bacterial infection. In the present study a benzoylaminobenzoic acid derivative were designed based on the Pharmacophore modling to identify the pharmacophoric feature required for inhibitory activity CoMFA analysis to identify the essential structural requirements in 3D chemical space for the modulation of FabH inhibitory activity of benzoylaminobenzoic acid derivatives.
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Synthesize Benzimidazole Derivatives Using QSAR Technique

Synthesize Benzimidazole Derivatives Using QSAR Technique

Deepak Shrivastava

LAP Lambert Academic Publishing
2020
pokkari
The present work was aimed to design and Synthesize benzimidazole derivatives having antibacterial activity using QSAR technique of indirect designing. The indirect drug design approach has been decided to be used because defined three dimensional coordinates for the receptor site of antibacterial benzimidazole was not available. QSAR is capable of determining appropriate distribution of chemical groups around the nucleus, which are necessary to provide desired biological activity.The aim of present study is to design and synthesis of some potent antibacterial benzimidazole derivatives. Their structure confirmation and evaluation of biological activities. Based on the QSAR studies a few new benzimidazole derivatives were synthesized and virtual screening of this synthesized compound was performed.
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General And Dental Pharmacology

General And Dental Pharmacology

Deepak Prashar

LAP Lambert Academic Publishing
2020
pokkari
This book is meant for BDS-II year students. After going through this book they will be able to answer the queries related to Pharmacology. This book is a concised approaches to the use of drugs in dentistry. Notes provided through this book has proven to be useful for all categories of dental students. The students will find this book as a fruitful tool in over coming their problems related to the subject.
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Parameters in 2-stage Flow Shop Scheduling Models

Parameters in 2-stage Flow Shop Scheduling Models

Deepak Gupta; Bharat Goyal

LAP Lambert Academic Publishing
2020
pokkari
The book throws light on the basics of scheduling theory and its one particular area of Flow Shop Scheduling Models under various parameters. The concept of Job Block or grouping of two jobs along with separated set up times of machines has been well thought of. The objective of the scheduling models here considered is to obtain a schedule that minimizes the total of the times spent in waiting by the jobs.
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Metabolic sizes of cows v/s Bacterial milk quality

Metabolic sizes of cows v/s Bacterial milk quality

Deepak Kr Verma; Ram Pal Singh

LAP Lambert Academic Publishing
2020
pokkari
The present study was undertaken to determine standard plate count (SPC) for total bacteria, lactic acid bacterial count (LABC), lipolytic bacterial count (LBC), Proteolytic bacterial count (PBC) and coliforms for determining bacterial quality of raw milk as influenced by metabolic size of healthy crossbred cows by dry full hand method of milking at SHUATS dairy farm Prayagraj. The analysis of variance showed significant effect of metabolic size on SPC, LBC, and coliforms but showed no significant differences in LABC and PBC in raw milk. The result indicated that the overall rating of bacterial quality was found better for raw milk produced by 262 to 296, and 297 to 333 followed by cows of 190 to 225 and 226 to 261 metabolic size. If the quality is judged on the basis of coliform than the quality of milk of was better from cows of metabolic size 226 to 261 and 297 to 333 followed by cows of 262 to 296 and 190 to 225 metabolic size.
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Endodontic Mishaps

Endodontic Mishaps

Deepak Kurup; Hridya Menon; Shashit Shetty B

LAP Lambert Academic Publishing
2020
pokkari
Root canal treatment or endodontic treatment is a procedure for the infected pulp of a tooth which is intended to result in the elimination of infection and protection of the decontaminated tooth from future microbial invasion and preserve the tooth as long as possible in the oral cavity. For this, step by step procedures like cleaning, shaping, disinfection and obturation has to preform. Mistakes in any of these sequences can lead to a number of accidents which are collectively called "Endodontic Mishaps". Sometimes, lack of knowledge about the procedures, poor application, compromises in the usage of materials or skipping or breaking the steps leads to these mishaps. This book gives an exact picture of these endodontic mishaps and how to fix these problems.
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Entrepreneurship & Project Management

Entrepreneurship & Project Management

Deepak Sharma; Yogita Patil

LAP Lambert Academic Publishing
2020
pokkari
An entrepreneur is someone who takes on an entrepreneurial venture to create something new that solves a problem; small business ownership and franchising are also entrepreneurial options. The venture could be for profit or not for profit, depending on the problem it intends to solve. Entrepreneurs can remain in a full-time job while pursuing their ideas on the side, to mitigate risk. On the opposite end of the spectrum, entrepreneurs can take on lifestyle ventures and become serial entrepreneurs. Many factors are driving the growth of entrepreneurship, including employment instability, motivation to create something new, financial factors and free time associated with retirement, and the greater acceptance of entrepreneurship as a career choice. The cultures of nations around the world affect the ability for entrepreneurs to start a venture, making a leader in entrepreneurial innovation. Entrepreneurs often find inspiration in social, environmental, and economic issues. This book shows the overall concept of an entrepreneur and process of registration how to became an entrepreneur.
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Unternehmertum & Projektmanagement

Unternehmertum & Projektmanagement

Deepak Sharma; Yogita Patil

Verlag Unser Wissen
2020
pokkari
Ein Unternehmer ist jemand, der ein unternehmerisches Wagnis eingeht, um etwas Neues zu schaffen, das ein Problem l st; Kleinunternehmensbesitz und Franchising sind ebenfalls unternehmerische Optionen. Die Unternehmung kann gewinnorientiert oder nicht gewinnorientiert sein, je nachdem, welches Problem sie zu l sen beabsichtigt. Unternehmer k nnen in einem Vollzeitjob bleiben, w hrend sie nebenbei ihre Ideen verfolgen, um das Risiko zu mindern. Am anderen Ende des Spektrums k nnen Unternehmer Lifestyle-Ventures eingehen und Serienunternehmer werden. Viele Faktoren treiben das Wachstum des Unternehmertums an, darunter Besch ftigungsinstabilit t, die Motivation, etwas Neues zu schaffen, finanzielle Faktoren und Freizeit im Zusammenhang mit dem Ruhestand sowie die gr ere Akzeptanz des Unternehmertums als Berufswahl. Die Kulturen der Nationen auf der ganzen Welt wirken sich auf die F higkeit von Unternehmern aus, ein Unternehmen zu gr nden und eine f hrende Rolle in der unternehmerischen Innovation zu bernehmen. Unternehmer finden oft Inspiration in sozialen, kologischen und wirtschaftlichen Fragen. Dieses Buch zeigt das Gesamtkonzept eines Unternehmers und den Prozess der Registrierung, wie man Unternehmer wird.
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