Since the seventeenth century, ethnicity has been the central issue in the American search for a national identity. The articulation of this issue can clearly be seen in the representation of non-white others in the literature of the nineteenth century, specifically in the works of James Fenimore Cooper and Herman Melville. This book examines how both Cooper and Melville manipulated literary images of Native Americans, African Americans, and other non-Europeans, thus revealing how America created the image of the savage – by which it was alternately attracted and repulsed – as a way of defining its own identity.
This book focuses on broadly defined areas of chemical information science— with special emphasis on chemical informatics— and computer-aided molecular design. The computational and cheminformatics methods discussed, and their application to drug discovery, are essential for sustaining a viable drug development pipeline. It is increasingly challenging to identify new chemical entities and the amount of money and time invested in research to develop a new drug has greatly increased over the past 50 years. The average time to take a drug from clinical testing to approval is currently 7.2 years. Therefore, the need to develop predictive computational techniques to drive research more efficiently to identify compounds and molecules, which have the greatest likelihood of being developed into successful drugs for a target, is of great significance. New methods such as high throughput screening (HTS) and techniques for the computational analysis of hits have contributed to improvements in drug discovery efficiency. The SARMs developed by Jürgen and colleagues have enabled display of SAR data in a more transparent scaffold/functional SAR table. There are many tools and databases available for use in applied drug discovery techniques based on polypharmacology. The cheminformatics approaches and methodologies presented in this volume and at the Skolnik Award Symposium will pave the way for improved efficiency in drug discovery. The lectures and the chapters also reflect the various aspects of scientific enquiry and research interests of the 2015 Herman Skolnik award recipient.
The 18th century was a wealth of knowledge, exploration and rapidly growing technology and expanding record-keeping made possible by advances in the printing press. In its determination to preserve the century of revolution, Gale initiated a revolution of its own: digitization of epic proportions to preserve these invaluable works in the largest archive of its kind. Now for the first time these high-quality digital copies of original 18th century manuscripts are available in print, making them highly accessible to libraries, undergraduate students, and independent scholars.Medical theory and practice of the 1700s developed rapidly, as is evidenced by the extensive collection, which includes descriptions of diseases, their conditions, and treatments. Books on science and technology, agriculture, military technology, natural philosophy, even cookbooks, are all contained here.++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++British LibraryT130387Half-title: 'An account of the life of Dr H. Boerhaave.'. Text continuous despite pagination.London: printed for Henry Lintot, 1746. 4],2, vii, 3],184, 1],188-226p., plate: port.; 8
Defying odds longer than that of Arcangues winning the 1993 Breeder's Cup Classic horse race, the Scorpions rose to rock and roll royalty from relative obscurity in Hannover, West Germany during the late 1970's and early 1980's. Herman Rarebell, aka Herman "Ze German", was part of it all. More than just a drummer, Herman's additional input through his imaginative and inspired songwriting was conceivably the key ingredient and missing component that led to their rise to prominence while most of those in the so-called "know" said they were only kidding themselves. Dieter Dierks, the long time producer of the Scorpions says: Herman was an integral part in the development of that which eventually became known as the classic Scorpions sound. Music all starts with the drummer. Not many people realize this. However, if you look at the "success" of the group, or, perhaps more appropriately, the lack thereof, prior to the arrival of Herman "Ze German" as well as that which has eluded them since his departure, I think you can see exactly how pivotal his role was within the band.However, there is much more here than just the ordinary, self-glorifying chronicle of a man's life. This book is anything but that. Shrewdly concealed within this autobiography is not only what can be considered the quintessential, definitive history of arguably the greatest band of their era, but also a masterful weaving of some of the most entertaining wit, whimsy and sage wisdom ever shared within the covers of a simple book. Sure to be considered a masterpiece by those who have a love of tongue in cheek irony and satire not to mention great storytelling, it raises the bar for such offerings to a decidedly new level. With his endless anecdotes and tales, Herman draws the lines that led to the group's ascension to the Mount Olympus of rock music, while his co-writer, Michael Krikorian, clearly lends his assistance to color them in providing more hues and tones than Crayola ever put in a box of crayons. Together they set a table and serve up a banquet of sarcasm and memories truly fit for a king (The King of Monaco to be precise.) There are no sacred cherubs spared from the harpoon of a master yarn-spinner as the puns, innuendo and endless wordplay are meant to entertain and lampoon much of the history not only of an incredible band but also of a generation. Though having none of the calories but plenty of the guilt, the frankness and honesty expressed upon each sinfully delicious page will never spoil your appetite but only leave you yearning for more.
Brother Lawrence was born Nicolas Herman in H rim nil, near Lun ville in the region of Lorraine, located in modern day eastern France. Having felt he had received a revelation of the providence and power of God at the age of 18, within six years he joined the Discalced Carmelite Priory in Paris. In this intervening period he fought in the Thirty Years' War and later served as a valet. Nicolas entered the priory in Paris as a lay brother, not having the education necessary to become a cleric, and took the religious name, "Lawrence of the Resurrection". He spent almost all of the rest of his life within the walls of the priory, working in the kitchen for most of his life and as a repairer of sandals in his later years. Despite his lowly position in life and the priory, his character attracted many to him. He had a reputation for experiencing profound peace and visitors came to seek spiritual guidance from him. The wisdom he passed on to them, in conversations and in letters, would later become the basis for the book, The Practice of the Presence of God. Father Joseph de Beaufort, later vicar general to the Archbishop of Paris, compiled this work after Brother Lawrence died. It became popular among Catholics and Protestants alike, with John Wesley and A. W. Tozer recommending it to others. As a young man, Herman's poverty forced him into joining the army, which guaranteed him meals and a small stipend. During this period, Herman claimed an experience that set him on a unique spiritual journey. He considered it a supernatural clarity into a common sight, more so than as a supernatural vision. During the winter, Herman looked at a barren tree, stripped of leaves and fruit, and realized it awaited the sure hope of a springtime revival and summer abundance. Gazing at the tree, Herman grasped deeply the extravagance of God's grace and the unfailing sovereignty of divine providence. Like the tree, he felt seemingly dead, but held hope that God had life waiting for him, and the turn of seasons would bring fullness. At that moment, he said, that leafless tree "first flashed in upon my soul the fact of God," and a love for God that never ceased. Shortly after, an injury forced his retirement from the army, and after a stint as a footman, he sought a place where he could suffer for his failures. He thus entered the Discalced Carmelite monastery in Paris as Brother Lawrence. This is an out-of-print manuscript. All pages are intact and it has been carefully reviewed.
![The two first cantos of Richardetto, freely translated from the original of N. Fortiguerra [by John Herman Merivale], etc.](/covers/9781241023003.jpg)
