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Analisi dei farmaci antimalarici nel plasma umano mediante LC-MS/MS

Analisi dei farmaci antimalarici nel plasma umano mediante LC-MS/MS

Jaivik Shah; Priyanka Shah; Shanti Swaroop Yadav

Edizioni Sapienza
2023
pokkari
Il metodo presenta una procedura di estrazione efficiente basata sull'estrazione liquido-liquido (LLE) che fornisce un recupero elevato e costante per entrambi gli analiti. L'effetto matrice stato accuratamente valutato stimando i fattori di matrice normalizzati IS anche attraverso l'infusione dell'analita dopo la colonna. Il metodo LC-MS/MS sviluppato per la quantificazione di ART, DHA, LF e DLF nel plasma umano stato completamente validato secondo le linee guida della FDA statunitense. Il metodo proposto sensibile per entrambi gli analiti rispetto a tutti gli altri metodi presentati sia come singolo analita che in combinazione in diverse matrici biologiche. Il metodo offre vantaggi significativi rispetto a quelli precedentemente riportati, in termini di minore necessit di campioni per l'analisi, semplicit della procedura di estrazione e tempo complessivo di analisi. L'assenza di interferenze della matrice efficacemente dimostrata dall'infusione postcolonna e dai valori di precisione (% CV) per le pendenze calcolate delle curve di calibrazione. Il metodo validato ha mostrato dati accettabili per tutti i parametri di validazione, con sensibilit e selettivit adeguate per la loro quantificazione simultanea in ambito clinico.
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Análise de medicamentos antimaláricos no plasma humano por LC-MS/MS

Análise de medicamentos antimaláricos no plasma humano por LC-MS/MS

Jaivik Shah; Priyanka Shah; Shanti Swaroop Yadav

Edicoes Nosso Conhecimento
2023
pokkari
O m todo apresenta um procedimento de extrac o eficiente baseado na extrac o l quido-l quido (LLE) que proporciona uma recupera o elevada e consistente tanto para os analitos como para os analitos. O efeito da matriz foi cuidadosamente avaliado atrav s da estimativa dos factores da matriz normalizada IS tamb m atrav s da infus o de analitos p s-coluna. O m todo LC-MS/MS desenvolvido para a quantifica o de ART, DHA, LF e DLF em plasma humano foi totalmente validado de acordo com as directrizes da FDA dos EUA. O m todo proposto sens vel para ambos os analitos em compara o com todos os outros m todos apresentados quer como um nico analito quer em combina o em diferentes matrizes biol gicas. O m todo oferece vantagens significativas sobre os anteriormente relatados, em termos de menor exig ncia de amostras para an lise, simplicidade do procedimento de extrac o e tempo global de an lise. A aus ncia de interfer ncia da matriz efectivamente demonstrada pela infus o p s-coluna e pelos valores de precis o (% CV) para as inclina es calculadas das curvas de calibra o. O m todo validado mostrou dados aceit veis para todos os par metros de valida o, com sensibilidade e selectividade adequadas para a sua quantifica o simult nea num cen rio cl nico.
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Design and Development of Model Predictive Primary Control of Micro Grids

Design and Development of Model Predictive Primary Control of Micro Grids

Puvvula Vidyasagar; K. Shanti Swarup

SPRINGER VERLAG, SINGAPORE
2023
sidottu
This book provides a design and development perspective MPC for micro-grid control, emphasizing step-by-step conversion of a nonlinear MPC to linear MPC preserving critical aspects of nonlinear MPC. The book discusses centralized and decentralized MPC control algorithms for a generic modern-day micro-grid consisting of vital essential constituents. It starts with the nonlinear MPC formulation for micro-grids. It also moves towards the linear time-invariant and linear time-variant approximations of the MPC for micro-grid control. The contents also discuss how the application of orthonormal special functions can improve computational complexity of MPC algorithms. It also highlights various auxiliary requirements like state estimator, disturbance compensator for robustness, selective harmonic eliminator for eliminating harmonics in the micro-grid, etc. These additional requirements are crucial for the successful online implementation of the MPC. In the end, the book shows how a well-designed MPC is superior in performance compared to the conventional micro-grid primary controllers discussed above. The key topics discussed in this book include – the detailed modeling of micro-grid components; operational modes in micro-grid and their control objectives; conventional micro-grid primary controllers; the importance of MPC as a micro-grid primary controller; understanding of MPC operation; nonlinear MPC formulation; linear approximations of MPC; application of special functions in the MPC formulation; and other online requirements for the MPC implementation. The examples in the book are available both from a calculation point of view and as MATLAB codes. This helps the students get acquainted with the subject first and then allows them to implement the subject they learn in software for further understanding and research.
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Design and Development of Model Predictive Primary Control of Micro Grids

Design and Development of Model Predictive Primary Control of Micro Grids

Puvvula Vidyasagar; K. Shanti Swarup

SPRINGER VERLAG, SINGAPORE
2024
nidottu
This book provides a design and development perspective MPC for micro-grid control, emphasizing step-by-step conversion of a nonlinear MPC to linear MPC preserving critical aspects of nonlinear MPC. The book discusses centralized and decentralized MPC control algorithms for a generic modern-day micro-grid consisting of vital essential constituents. It starts with the nonlinear MPC formulation for micro-grids. It also moves towards the linear time-invariant and linear time-variant approximations of the MPC for micro-grid control. The contents also discuss how the application of orthonormal special functions can improve computational complexity of MPC algorithms. It also highlights various auxiliary requirements like state estimator, disturbance compensator for robustness, selective harmonic eliminator for eliminating harmonics in the micro-grid, etc. These additional requirements are crucial for the successful online implementation of the MPC. In the end, the book shows how a well-designed MPC is superior in performance compared to the conventional micro-grid primary controllers discussed above. The key topics discussed in this book include – the detailed modeling of micro-grid components; operational modes in micro-grid and their control objectives; conventional micro-grid primary controllers; the importance of MPC as a micro-grid primary controller; understanding of MPC operation; nonlinear MPC formulation; linear approximations of MPC; application of special functions in the MPC formulation; and other online requirements for the MPC implementation. The examples in the book are available both from a calculation point of view and as MATLAB codes. This helps the students get acquainted with the subject first and then allows them to implement the subject they learn in software for further understanding and research.
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Cyber-Security for Smart Grid Control

Cyber-Security for Smart Grid Control

Amulya Sreejith; K. Shanti Swarup

SPRINGER VERLAG, SINGAPORE
2024
sidottu
The book focuses on a very important area of Smart Grids - cyber security. It deals in particular with the tools and techniques for cyber security analysis of the Smart Grid control systems. This includes the standards and guidelines, detailed vulnerability assessment framework, attack detection strategies, and attack mitigation methods. The book is divided into three parts. The smart grid cyber-physical system is discussed in the first part. The second part introduces the attacks in the grid system and a vulnerability assessment framework followed by a tool that can be used to analyze the grid control systems using existing cyber security standards. In the third part, different forms of attack detection methods are discussed along with Python-based implementations for the same. The book also discusses attack mitigation methods with implementation. Detailed illustrations and tables are provided in each section. The book also includes case studies based on standard test systems thushelping students to implement the discussed methods. The case studies are based on MATLAB and Python implementations thus catering to a wide range of audiences. Outputs and screenshots of the tools and programs are included so students can compare their results and improve upon the discussed methods. The book will be useful to a wide variety of audiences such as students and researchers in Smart Grids, power system operators, and device manufacturers.
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Cyber-Security for Smart Grid Control

Cyber-Security for Smart Grid Control

Amulya Sreejith; K. Shanti Swarup

SPRINGER VERLAG, SINGAPORE
2025
nidottu
The book focuses on a very important area of Smart Grids - cyber security. It deals in particular with the tools and techniques for cyber security analysis of the Smart Grid control systems. This includes the standards and guidelines, detailed vulnerability assessment framework, attack detection strategies, and attack mitigation methods. The book is divided into three parts. The smart grid cyber-physical system is discussed in the first part. The second part introduces the attacks in the grid system and a vulnerability assessment framework followed by a tool that can be used to analyze the grid control systems using existing cyber security standards. In the third part, different forms of attack detection methods are discussed along with Python-based implementations for the same. The book also discusses attack mitigation methods with implementation. Detailed illustrations and tables are provided in each section. The book also includes case studies based on standard test systems thushelping students to implement the discussed methods. The case studies are based on MATLAB and Python implementations thus catering to a wide range of audiences. Outputs and screenshots of the tools and programs are included so students can compare their results and improve upon the discussed methods. The book will be useful to a wide variety of audiences such as students and researchers in Smart Grids, power system operators, and device manufacturers.
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Design Ethnography

Design Ethnography

Sarah Pink; Vaike Fors; Debora Lanzeni; Melisa Duque; Shanti Sumartojo; Yolande Strengers

TAYLOR FRANCIS LTD
2022
nidottu
This book advances the practice and theory of design ethnography. It presents a methodologically adventurous and conceptually robust approach to interventional and ethical research design, practice and engagement.The authors, specialising in design ethnography across the fields of anthropology, sociology, human geography, pedagogy and design research, draw on their extensive international experience of collaborating with engineers, designers, creative practitioners and specialists from other fields. They call for, and demonstrate the benefits of, ethnographic and conceptual attention to design as part of our personal and public everyday lives, society, institutions and activism. Design Ethnography is essential reading for researchers, scholars and students seeking to reshape the way we research, live and design ethically and responsibly into yet unknown futures.
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Design Ethnography

Design Ethnography

Sarah Pink; Vaike Fors; Debora Lanzeni; Melisa Duque; Shanti Sumartojo; Yolande Strengers

TAYLOR FRANCIS LTD
2022
sidottu
This book advances the practice and theory of design ethnography. It presents a methodologically adventurous and conceptually robust approach to interventional and ethical research design, practice and engagement.The authors, specialising in design ethnography across the fields of anthropology, sociology, human geography, pedagogy and design research, draw on their extensive international experience of collaborating with engineers, designers, creative practitioners and specialists from other fields. They call for, and demonstrate the benefits of, ethnographic and conceptual attention to design as part of our personal and public everyday lives, society, institutions and activism. Design Ethnography is essential reading for researchers, scholars and students seeking to reshape the way we research, live and design ethically and responsibly into yet unknown futures.
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Atlas of Ophthalmic Ultrasound and Ultrasound Biomicroscopy

Atlas of Ophthalmic Ultrasound and Ultrasound Biomicroscopy

Muna Bhende; Harshali Kamat; Tandava Krishna; B Shantha; Parveen Sen; Vikas Khetan; Suchitra Pradeep

Jaypee Brothers Medical Publishers
2013
sidottu
The new edition of this atlas has been fully updated to provide practising ophthalmologists and residents with the latest advances in ophthalmic ultrasound. Divided into ten sections, the atlas begins with an introduction to imaging techniques and interpretation, followed by in depth examination of ultrasound for the diagnosis and management of ocular diseases and disorders, including vitreoretinal diseases, trauma, infections and inflammations, tumours, congenital disorders, lesions, and optic nerve disorders. A complete section is dedicated to surgical considerations. This second edition has a completely new section on ultrasound biomicroscopy, and features numerous colour fundus photographs, ultrasound illustrations and external photos, as well as CT scans and MRI scans of the orbit. A DVD ROM image bank is also included. Key points Fully updated, new edition providing latest advances in ophthalmic ultrasoundIncludes brand new section on ultrasound biomicroscopyDVD ROM image bankPrevious edition published in 2006
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Opsporing og underretning i dagtilbud

Opsporing og underretning i dagtilbud

Anne Marie Villumsen; Kirsten Elisa Petersen; Mette Blauenfeldt; Susanne Elling; Mia Glendøs; Kitt Ingemann Ivarsen; Anette Koch; Lars Ladefoged; Kamilla Shanti Melgaard; Charlotte Munch Nielsen; Louise Svendsen; Lene Mosegaard Søbjerg; Susanne Uggerly; Krishna Husted Vijayarankan

Gyldendal
2020
nidottu
Tidlig opsporing og indsats er for alvor trådt ind i daginstitutionernes hverdag som en integreret del af pædagogens arbejde. De mange opgaver med at spotte børn i mistrivsel rejser en række dilemmaer i den pædagogiske praksis. Det gælder f.eks. tillidsforholdet til forældrene og ikke mindst, hvornår en mistrivsel er så markant, at den kræver en underretning til socialforvaltningen. Denne bog sætter fokus på opsporing og underretning i dagtilbud i relation til børn, der ikke er i god trivsel. Dette arbejde involverer rammer, lovgivning og retningslinjer, men også konkret opsporingsarbejde, risikovurderinger og samarbejde med forældre og fagpersoner på vejen hen til underretningen og etableringen af det videre forløb. Bogen er med til at formidle viden om alle de mange facetter på denne vej. Opsporing og underretning i dagtilbud henvender sig til studerende på den pædagogiske professionsuddannelse med speciale inden for dagtilbud samt til alle pædagoger på dagtilbudsområdet. Forfatterne er ansat ved universiteter og professionshøjskoler eller er fagfolk, der på forskellig vis arbejder med børn og forældre i dagtilbuddet.
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