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189 tulosta hakusanalla Monocle

Honolulu

Honolulu

Monocle

gestalten
2016
sidottu
Honolulu --where surfers and hula dancers mingle on pristine beaches beneath a volcano. The capital of paradise, Honolulu is more than just the gateway to surf, sand, and sun. Beyond the beaches and behind the palmlined streets there's a bustling city of culture and the arts, of fine dining and clubs. It's a city by the sea where cultures melt and mingle and the beautiful surroundings are a backdrop for even more incredible goings on. The Monocle team has set sail to bring back more than just picture postcard sunsets, reporting on the vibrant nightlife in Chinatown, the starred chefs and farmers markets, the pan-Pacific arts scene, and more. This guide also provides unique possibilities for getting away from it all: make Honolulu your base for hikes up volcanic mountains and relaxing beach excursions --or finally learn how to surf. The city is truly a world apart. And now you've got the key.
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Liberte Vol. Iv: A Reader of French Culture & Society in the 19th Century

Liberte Vol. Iv: A Reader of French Culture & Society in the 19th Century

monOcle-Lash Anti-Press

Lulu.com
2013
nidottu
This reader has been prepared specially for use in the multidisciplinary course Liberte: France's Impact on the Nineteenth Century led by Brian Counihan at Community High School in Roanoke, Virginia, though it is intended to be useful to independent readers as well. The course is intended to present an introduction to the dramatic and hotly-contested progress of French society as it entered, and helped to create, the modern age. I have brought together artifacts and texts from the domains of politics, literature, history, philosophy, and art that attempt to indicate not only the dominant trends in French society, but also those underground counter-currents which have always existed within and against it. This is the final volume of four; it covers the period from the Franco-Prussian War to century's end.
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Rêvenance Omnibus, Vol. I

Rêvenance Omnibus, Vol. I

Monocle-Lash Anti-Press

Monocle-Lash Anti-Press
2019
pokkari
R venance is dedicated to the forgotten or untold histories of 19th Century avant-garde and dissenting countercultures. It promotes history practiced as game, activism, trans-generational collaboration, communal memory, which refuses to describe history as finished: a committed historiography, which does not stand apart from its object: intellectual and precise, yet ludic and multi-form, one moment manifest as an essay, the next as a poem. A historiography created within the utopian fringe, and for the same community, responsive to our changing conditions, needs, and desires. A historiography that we take personally, merging imperceptibly into experiments in daily life, social praxis, and thought. Vol. I. Issues 1-5 of of R venance reproduced exactly in a single perfect-bound volume, preceded by a new preface by the editor and a complete table of contents, and followed by a full index of all five issues. Future volumes will be released every five issues, with continually updated index.
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Monoclonal Antibodies

Monoclonal Antibodies

Steven Shire

Woodhead Publishing Ltd
2015
sidottu
Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies.
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Monoclonal Antibodies

Monoclonal Antibodies

Academic Press Inc
2021
nidottu
Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS). This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization.
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Monoclonal Antibodies

Monoclonal Antibodies

Kresina

CRC Press
2019
nidottu
Presents a sampling of new and novel approaches to the amelioration of musculoskeletal disease pathology, emphasizing prevention and therapy. Where applicable, these new technologies are focused on their application to human autoimmune diseases, but the volume mainly discusses and details the use of
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Monoclonal Antibodies

Monoclonal Antibodies

Heddy Zola

CRC Press
2019
nidottu
This book describes, in detail, tested techniques for the produc-tion and use of monoclonal antibodies. It covers those aspects of interest to all scientists working with monoclonal antibodies and presents methods in a step-by-step format for easy refer-ence. The text serves as a laboratory manual; and discusses rationale behind each method, and the choices between methods. It also provides a rational basis where several alternative methods are available.
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Monoclonal Antibodies to Receptors

Monoclonal Antibodies to Receptors

Chapman and Hall
1984
sidottu
Receptor specific antibodies are excellent probes for a wide range of biological investigations on receptor structure and function. The hybridoma technology (Kohler and Milstein, 1975) has inevitably had a major impact on this field with most of the better known receptors now identified with monoclonal antibodies. This volume of the Receptors and Recognition series provides reviews of recent developments in this field and emphasizes in particular the new opportunities afforded by the judicious application of monoclonal reagents. It is assumed that most readers will be familiar with the now fairly routine methods of cell fusion, hybridoma cloning and selection for producing monoclonal antibodies and so few details of the basic technical procedures are described. Several good reviews on this topic are however available (see Galfre and Milstein, 1981; Goding, 1980; Yelton and Scharf, 1981; McMichael and Fabre, 1982). By no means all vertebrate receptor species are discussed here; omissions include antibodies to low density lipoprotein receptors (Beisiegel et al. , 1981; Kita et al. , 1981), prolactin and growth hormone receptors (Friesen etal. , 1982; Simpson et al. , 1983) and the hepatocyte asialoglycoprotein receptor (Schwartz et al. , 1981; Harford et al. , 1982). Nevertheless the coverage is comprehensive and critical and the individual chapters provided illustrate vividly the rapid progress being made.
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Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer

Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer

John Wiley Sons Inc
2010
sidottu
Oncology Book of 2011, British Medical Association's Medical Book Awards Awarded first prize in the Oncology category at the 2011 BMA Medical Book Awards, Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer helps readers understand this hot pharmaceutical field with up-to-date developments. Expert discussion covers a range of diverse topics associated with this field, including the optimization of design of biomolecules and radiochemistry, cell and animal models for preclinical evaluation, discoveries from key clinical trials, radiation biology and dosimetry, and considerations in regulatory approval. With chapters authored by internationally renowned experts, this book delivers a wealth of information to push future discovery.
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Monoclonal Antibodies in Biotechnology

Monoclonal Antibodies in Biotechnology

Kenneth C. McCullough; Raymond E. Spier

Cambridge University Press
2009
pokkari
Monoclonal antibodies are one of the most exciting developments in biotechnology in recent years; this book provides a comprehensive description of principles, methodologies and applications of this powerful technology to modern science and industry. The immune system of the body, in particular the role of antibodies, is described; and details provided on the isolation of antibody-producing cells, how hybridomas are formed and maintained in culture such that the required antibody can be produced to a very high degree of purity. The material is presented in such a way that students, researchers and managers in research and development will be able to make choices as to which are the most suitable techniques for their particular requirements. The text is comprehensively referenced and, in short, the book is a necessary resource for all those who have the need to be involved in the production of monoclonal antibodies from hybridoma cells in culture.
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Monoclonal Antibodies in Biotechnology

Monoclonal Antibodies in Biotechnology

Kenneth C. McCullough; Raymond E. Spier

Cambridge University Press
1990
sidottu
Monoclonal antibodies are one of the most exciting developments in biotechnology in recent years; this book provides a comprehensive description of principles, methodologies and applications of this powerful technology to modern science and industry. The immune system of the body, in particular the role of antibodies, is described; and details provided on the isolation of antibody-producing cells, how hybridomas are formed and maintained in culture such that the required antibody can be produced to a very high degree of purity. The material is presented in such a way that students, researchers and managers in research and development will be able to make choices as to which are the most suitable techniques for their particular requirements. The text is comprehensively referenced and, in short, the book is a necessary resource for all those who have the need to be involved in the production of monoclonal antibodies from hybridoma cells in culture.
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Monoclonal Antibodies

Monoclonal Antibodies

Cambridge University Press
1995
pokkari
Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject. Monoclonal antibodies provide highly specific reagents with which to identify, analyse, quantitate and manipulate molecules - both in solution and in solid phase, such as at a cell surface. The aim of this book is therefore to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications of these antibodies in many areas of clinical medicine, including histopathology, oncology, transplantation, infectious diseases, rheumatology, haematology and dermatology.
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Monoclonal Antibodies

Monoclonal Antibodies

Cambridge University Press
1995
sidottu
Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject. Monoclonal antibodies provide highly specific reagents with which to identify, analyse, quantitate and manipulate molecules - both in solution and in solid phase, such as at a cell surface. The aim of this book is therefore to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications of these antibodies in many areas of clinical medicine, including histopathology, oncology, transplantation, infectious diseases, rheumatology, haematology and dermatology.
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Monoclonal Antibodies

Monoclonal Antibodies

Kresina

CRC Press Inc
1991
sidottu
Presents a sampling of new and novel approaches to the amelioration of musculoskeletal disease pathology, emphasizing prevention and therapy. Where applicable, these new technologies are focused on their application to human autoimmune diseases, but the volume mainly discusses and details the use of
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