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1000 tulosta hakusanalla Shayne Lee

The Medieval Invention of Travel

The Medieval Invention of Travel

Shayne Aaron Legassie

University of Chicago Press
2017
nidottu
Over the course of the Middle Ages, the economies of Europe, Asia, and northern Africa became more closely integrated, fostering the international and intercontinental journeys of merchants, pilgrims, diplomats, missionaries, and adventurers. During a time in history when travel was often difficult, expensive, and fraught with danger, these wayfarers composed accounts of their experiences in unprecedented numbers and transformed traditional conceptions of human mobility. Exploring this phenomenon, The Medieval Invention of Travel draws on an impressive array of sources to develop original readings of canonical figures such as Marco Polo, John Mandeville, and Petrarch, as well as a host of lesser-known travel writers. As Shayne Aaron Legassie demonstrates, the Middle Ages inherited a Greco-Roman model of heroic travel, which viewed the ideal journey as a triumph over temptation and bodily travail. Medieval travel writers revolutionized this ancient paradigm by incorporating practices of reading and writing into the ascetic regime of the heroic voyager, fashioning a bold new conception of travel that would endure into modern times. Engaging methods and insights from a range of disciplines, The Medieval Invention of Travel offers a comprehensive account of how medieval travel writers and their audiences reshaped the intellectual and material culture of Europe for centuries to come.
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Safety Pharmacology in Pharmaceutical Development

Safety Pharmacology in Pharmaceutical Development

Shayne C. Gad

CRC Press
2019
nidottu
Safety pharmacology is the evaluation and study of the pharmacological effects of a potential drug that are unrelated to the desired therapeutic effect. These effects often present a hazard—particularly in individuals with compromised or limited organ system functions.Safety Pharmacology in Pharmaceutical Development: Approval and Post Marketing Surveillance, Second Edition covers safety pharmacology from the regulatory requirements down to the studies that must be done to justify them. Using the author’s more than 30 years of direct experience, the book incorporates tricks and practical insights for making studies work and understanding why they fail. The second edition includes current regulations, including USFDA and those from Europe and Japan. Presenting a clear description of what is needed and why for supporting drug development, the book focuses on updated test methods, interpretation, and science. It covers the core and supplemental batteries of test procedures and how to do them and provides an overview of available facilities and contract organizations for performing studies.
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Statistics and Experimental Design for Toxicologists and Pharmacologists

Statistics and Experimental Design for Toxicologists and Pharmacologists

Shayne C. Gad

CRC Press
2019
nidottu
Purposefully designed as a resource for practicing and student toxicologists, Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition equips you for the regular statistical analysis of experimental data. Starting with the assumption of basic mathematical skills and knowledge, the author supplies a complete and systematic yet practical introduction to the statistical methodologists available for, and used in, the discipline. For every technique presented, a worked example from toxicology is also presented. See what's new in the Fourth Edition:The first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies Coverage of Bayesian analysis and data analysis in pharmacology and toxicology Almost 200 problems with solutions Discussion of analysis of receptor binding assays, safety pharmacology assays and other standard types conducted in pharmacology A new chapter explaining the basics of Good Laboratory Practices (GLPs) For those with computer skills, this edition has been enhanced with the addition of basic SASWritten specifically for toxicologists and pharmacologists, the author draws on more than 30 years of experience to provide understanding of the philosophical underpinnings for the overall structure of analysis. The book's organization fosters the ordered development of skills and yet still facilitates ease of access to information as needed. This Fourth Edition gives you the tools necessary to perform rigorous and critical analysis of experimental data and the insight to know when to use them.
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The Selection and Use of Contract Research Organizations

The Selection and Use of Contract Research Organizations

Shayne C. Gad

CRC Press
2003
sidottu
Choosing the right contract research organization (CRO) can make the difference between getting a product to market quickly and cost-effectively, and wasting valuable time and money. The vast number of available CROs is increasing all the time, and all of them make impressive claims. The Selection and Use of Contract Research Organizations is your essential guide to choosing the best provider.A history of the CRO industry, audit checklists, and overviews of both the pharmaceutical and medical device development processes create a comprehensive overview of how to successfully select and manage a CRO for your project. The book also discusses:Guidance for selection, protocol and contract development, project management and monitoring of work Common pitfalls and problems - how to avoid them, and how to solve them if they do occur How to integrate efforts between groups to achieve the greatest cost effectiveness while maintaining quality and timely production Prototype forms and templates for increasing coordination between multiple working groups A series of appendices covering hundreds of prominent service providers worldwide, including contact information Operative regulations and lawsIn addition to providing fundamental guidance on how to select and manage a CRO in the product development process, this reference also includes a set of eight databases that contain contact information for prominent service providers in North America, Europe, and Japan, and overviews of services they offer. It is a complete resource for professionals in biotechnology, and pharmaceutical and medical device development.
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Conservation of Furniture

Conservation of Furniture

Shayne Rivers; Nick Umney

Routledge
2012
nidottu
This book is a comprehensive resource covering the principles and practice of the conservation and restoration of furniture. A review of the historical development of furniture introduces a wide range of structural types and materials that may be encountered, including wood, ivory, turtleshell, horn and metals, as well as decorative surfaces such as paint, japanning, lacquer and gilding. The nature and behaviour of these materials is explained and used as a basis from which to explore the mechanisms and consequences of deterioration caused by environment and use. Building on this foundation, the book shows how to develop and implement logical solutions to conservation problems.Combining the practical knowledge and experience of a team of conservators active in the field, with theoretical and reference material from diverse sources, Conservation of Furniture uses and integrated approach to produce a book that will prove invaluable to anyone working in or studying this subject area.
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Hard Money

Hard Money

Shayne McGuire

John Wiley Sons Inc
2010
sidottu
An in-depth guide to making gold a serious part of your portfolio Gold, the long forgotten store of value that was once the center of the global financial system, suddenly matters a great deal again. It has become a leading asset by virtue of its strong performance, and its booming demand has made it the only financial asset that remains in an uninterrupted bull market. And yet gold remains one of the least-owned financial assets in investment portfolios today. Hard Money helps investors move beyond the simple, yet widely accepted notion that gold makes sense in today's financial environment, and explores ways to magnify potential investment returns driven by precious metals. This reliable resource examines the investment vehicles (bullion, stocks, derivatives, and even rare coins) and strategies (aggressive, conservative, passive, and variations) aimed at beating the price of gold as it rises, and ways to protect a portfolio should the metal decline. Identifies five key drivers that should continue to push gold higher in the years aheadExplores the ins and outs of investing in gold and making this precious metal a part of your portfolioExamines the pros and cons of multiple ways to buy gold via coins, ETFs, mining and royalty stocks, and other investment vehiclesAuthor Shayne McGuire is a highly-regarded expert on gold Written in a straightforward and accessible style, Hard Money offers key strategies to enhancing returns with new methods for investing in gold.
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Financial Modelling in Python

Financial Modelling in Python

Shayne Fletcher; Christopher Gardner

John Wiley Sons Inc
2009
sidottu
"Fletcher and Gardner have created a comprehensive resource that will be of interest not only to those working in the field of finance, but also to those using numerical methods in other fields such as engineering, physics, and actuarial mathematics. By showing how to combine the high-level elegance, accessibility, and flexibility of Python, with the low-level computational efficiency of C++, in the context of interesting financial modeling problems, they have provided an implementation template which will be useful to others seeking to jointly optimize the use of computational and human resources. They document all the necessary technical details required in order to make external numerical libraries available from within Python, and they contribute a useful library of their own, which will significantly reduce the start-up costs involved in building financial models. This book is a must read for all those with a need to apply numerical methods in the valuation of financial claims." –David Louton, Professor of Finance, Bryant University This book is directed at both industry practitioners and students interested in designing a pricing and risk management framework for financial derivatives using the Python programming language. It is a practical book complete with working, tested code that guides the reader through the process of building a flexible, extensible pricing framework in Python. The pricing frameworks' loosely coupled fundamental components have been designed to facilitate the quick development of new models. Concrete applications to real-world pricing problems are also provided. Topics are introduced gradually, each building on the last. They include basic mathematical algorithms, common algorithms from numerical analysis, trade, market and event data model representations, lattice and simulation based pricing, and model development. The mathematics presented is kept simple and to the point. The book also provides a host of information on practical technical topics such as C++/Python hybrid development (embedding and extending) and techniques for integrating Python based programs with Microsoft Excel.
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First Tasmanians

First Tasmanians

Shayne Breen

MELBOURNE UNIVERSITY PRESS
2025
sidottu
The history of the First Tasmanians is a story of ingenuity, adaptation and resilience. In First Tasmanians historian Shayne Breen traces the 40,000 years of Aboriginal exploration, land settlement, hunting practices and controlled burning on the island. The First Tasmanians were committed to the terms of life set down by creation ancestors, their hunting and gathering skills a source of wonder to observant colonists. These skilled practitioners of land management universally respected local autonomy, and their seasonal journeys enhanced social interaction as they negotiated momentous changes in climate, vegetation and topography. Social cohesion was fostered through singing, dancing and storytelling around the evening campfire, and rituals and networks were maintained across life on earth and the afterlife. In thirty short years of the nineteenth century, this carefully nurtured collective life was destroyed by an imperial power, to be replaced by a narrative of Aboriginal resistance, struggle and protest. Multiple genocidal policies left contemporary First Tasmanians with a complex legacy of historical grief, chronic disadvantage and intergenerational trauma, a legacy that endures to this day. First Tasmanians is the first interdisciplinary account of Tasmanian Aboriginal history told in three movements: the deep hunter-gatherer past; the collective life at the time of the British invasion; and the recent past. It is a story of courage, continuity and an unwavering commitment to revitalising connections between country, culture and community.
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Courage in the Face of Apert

Courage in the Face of Apert

Shayne Stillar

Renafaye Productions
2021
pokkari
Shayne's diagnosis of Apert Syndrome (Acrocephalysyndactyly) is typically characterized by hand and feet webbing and fusing, misshapen cranial bones, progressive immobility of joints, and cervical spine, cognitive issues associated with CNS malformations, jaw malformations and dental malocclusion, and eye, ear, and nose concerns. The incidence is rare, occurring in only 1 in about 2 million births. Shayne has faced life-long issues with expected ear, nose, muscle and joint, eye, and other concerns. Clearly, one might anticipate some possible limitations and significant challenges in physical function and social, emotional, behavioral, and educational achievement. Well, don't apply the words "possible limitations" with Shayne Those words are simply not in his vocabulary. Shayne graduated from high school, college, and university with a major in radio and TV and went on to more technical training and career in wastewater management. Moreover, Shayne pursued physical challenges of road cycling and has been a consistent award winner in competitions around the country. He continues to participate in the rigorous training required and success in cycling competitions Additionally, over the years, Shayne has shared his life experiences and has challenged and inspired others with Apert Syndrome and similar conditions which are associated with physical and emotional challenges. The diagnosis of Apert simply did not define Shayne Stillar He was not an Apert patient, but rather a person with a diagnosis of a condition called Apert. And he has demonstrated so convincingly how to rise above the challenges, explore the possibilities, seek out opportunities, and with resolve and fortitude, identify purpose and take charge of his own life journey and destination. Now, Shayne has prepared this book with the aim and desire to share his experiences, challenges, and opportunities, and to challenge others to reach high and to achieve their potential. To quote Shayne: "I just want to help people "Karlind T. Moller, Ph.D Professor Emeritus University of MinnesotaSchool of Dentistry and Department of Speech-Language-Hearing SciencesFormer Director and Coordinator - Cleft Palate and Craniofacial Program
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Learning

Learning

Shayne T Pattie

Shayne Pattie
2024
pokkari
This book explores a range of ideas and perspectives on learning, offering readers different paths to better understand their own learning needs. Ideas such as the 12 Learning Styles, Sensory Impacts on learning, Psychology Frameworks, Goal Frameworks, Motivation, Music and Learning and Neurodivergence and Learning.
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Obsidian Son

Obsidian Son

Shayne Silvers

Argento Publishing, LLC
2015
pokkari
To do list: Cow-tip the Minotaur. Cure a reptile dysfunction.My name is Nate Temple, and I'm secretly a wizard. I ride a foul-mouthed unicorn, I drink with Achilles, and I'm pals with the Four Horsemen. I've even cow-tipped the Minotaur. I understand the theory of following the rules...I'm just not very good at the application.Because rules were meant to be broken.Especially when I find out a monster just murdered my parents. Now all I can hear is the sweet, soothing song of vengeance in my ears, playing on repeat.But when shifter dragons come to town, I'm forced to step away from hunting down the scumbag murderer. Because I know the cure for a reptile dysfunction, and the dragons aren't going to like it.This fight soon opens up Pandora's Box, and suddenly every flavor of supernatural thug is after me. The only way out of it-to save my city-is to murder my best friend.I didn't want, ask for, or start any of this. But I will finish it. It's time I show St. Louis that magic is very, very real. And that an angry wizard is truly something to see-at least once in your life.You know, right before he puts you and everyone you've ever met in the grave...If you like Jim Butcher, Kevin Hearne, Steve McHugh, Michael Anderle, Ilona Andrews, Patricia Briggs, Shannon Mayer, or K.F. Breene, you won't be able to put down the highly addictive Nate Temple Series."Shayne Silvers, Jim Butcher, and Kevin Hearne are easily my favorite Urban Fantasy Authors. In that order." - Michael Anderle, Amazon Top 25 Bestselling AuthorMore than 1m copies downloaded and thousands of five-star reviews. Available in digital, print, and audiobook formats.What Amazon readers are saying: ★★★★★ 'His foul-mouthed unicorn murders rainbows '★★★★★ 'Move over Dresden '★★★★★ 'The Temple Verse HAS to be picked up by Netflix soon.'★★★★★ 'Silvers could write a grocery list on a dirty napkin and make it an international bestseller.'★★★★★ 'I went from crying my eyes out to laughing uncontrollably, repeatedly.'★★★★★ 'It's like the characters walked off the page, joined me at the bar, and bought me a drink.'★★★★★ 'I am astounded as to how the author keeps the story fresh and exciting.'★★★★★ 'I usually see plot twists a mile away. Shayne has proven me wrong. Every time.'★★★★★ 'Best books I've read in thirty years.'★★★★★ 'His intense actions scenes let you see the fangs and claws, hear the gunshots, feel the magic, and smell the fear.'★★★★★ 'Everything you thought you knew about vampires, shifters, dragons, wizards, fairies and gods is flat wrong.'★★★★★ 'Publishers who didn't snap up this series are missing out on a gold mine.'Silvers has pleasured over one million readers with the Temple Universe. Now it's your turn for a little pleasuring...
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Blood Debts

Blood Debts

Shayne Silvers

Argento Publishing, LLC
2015
pokkari
A Wizard, an Angel, and a Horseman of the Apocalypse walk into a bar...The ancient pact between mankind, Heaven, and Hell has been broken. And this upstart wizard's quest for vengeance may have just kicked off Armageddon. So, time for a drink... or maybe two.Already plagued with sinister night terrors that could qualify him as a card-carrying psychopathic insomniac, Nate can barely even manage to put his pants on in the morning, let alone pick teams for the Apocalypse.But when he's framed as a demon sympathizer, condemned by the Armies of Heaven, and hunted down by both his allies and the Four Horsemen, this wizard doesn't think it can get any worse...Then they take away his magic. And a wizard without magic stands no chance against the forces of Heaven and Hell...If you like Jim Butcher, Kevin Hearne, or Patrick Rothfuss, you will LOVE the second installment of The Nate Temple Supernatural Thriller series.Click or tap BUY NOW to jump into the deathly hilarious adventure TODAY INTERVIEW WITH THE AUTHOR: Q: So, what makes the Nate Temple series special?A: I wanted to write a series of stories that mirrored the books I liked to read in my childhood. My top picks were usually urban fantasy, paranormal best sellers, and of course, books featuring your classic gritty, pulp-fiction heroes. Basically, anything with a lot of creepy crawly supernatural characters: mythical creatures, ancient heroes, super villains, and gods. You will find that my stories focus on the ancient myths, characters, and stories we all know, fear, and love. Then twist them up and toss them back like an empty beer can.Q: What order should I read the books in?A: I've written the series with the intent that they should be read in order to get the full effect of the bigger picture; however the stories can be read in any order if you are looking for a quick, fast-paced romp through Adrenaline-ville. I suggest the following sequence: Obsidian SonBlood DebtsFairy Tale - Prequel (FREE to email subscribers)GrimmSilver TongueQ: So, why should readers give these books a try?A: Because the Nate Temple series is a present day thrill-ride that takes no prisoners. Dragons, Angels, Demons, Greek Legends, Wizards, werewolves, and a whole slew of other supernatural 'Freaks' abound in my stories. Blood Debts has hit the top ten bestsellers list on Kindle for Urban Fantasy and Paranormal. The plot twists and turns until the last page, and my twisted sense of humor will have you cackling out loud at things you really shouldn't be laughing at.Nate Temple Supernatural Thriller Book categories: Superhero FictionSupernatural CrimeDark FantasyUrban Fantasy ThrillerSupernatural ThrillersAngels & DemonsScience Fiction & FantasyParanormal and UrbanMagical RealismScroll up and tap or click BUY NOW to jump face-first into the deathly hilarious adventure TODAY
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An Introduction to Finite Tight Frames

An Introduction to Finite Tight Frames

Shayne F. D. Waldron

Birkhauser Boston Inc
2018
sidottu
This textbook is an introduction to the theory and applications of finite tight frames, an area that has developed rapidly in the last decade. Stimulating much of this growth are the applications of finite frames to diverse fields such as signal processing, quantum information theory, multivariate orthogonal polynomials, and remote sensing. The first book entirely devoted to finite frames, it features extensive exercises and MATLAB examples for classroom use, important examples, and numerous illustrations. The book provides an overview of the field of finite tight frames and discusses future research directions in the field. The book is well suited as a textbook for a graduate course or seminar involving finite frames. The self-contained, user-friendly presentation also makes the work useful as a self-study resource or reference for graduate students, instructors, researchers, and practitioners in pure and applied mathematics, engineering, mathematical physics, and signal processing.
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Family Matters in Indian Buddhist Monasticisms

Family Matters in Indian Buddhist Monasticisms

Shayne Clarke

University of Hawai'i Press
2013
sidottu
Scholarly and popular consensus has painted a picture of Indian Buddhist monasticism in which monks and nuns severed all ties with their families when they left home for the religious life. In this view, monks and nuns remained celibate, and those who faltered in their “vows” of monastic celibacy were immediately and irrevocably expelled from the Buddhist Order. This romanticized image is based largely on the ascetic rhetoric of texts such as the Rhinoceros Horn Sutra.Through a study of Indian Buddhist law codes (vinaya), Shayne Clarke dehorns the rhinoceros, revealing that in their own legal narratives, far from renouncing familial ties, Indian Buddhist writers take for granted the fact that monks and nuns would remain in contact with their families. Surveying the still largely uncharted terrain of Indian Buddhist monastic law codes preserved in Sanskrit, Tibetan, and Chinese, Clarke provides a comprehensive, pan-Indian picture of Buddhist monastic attitudes toward family. Whereas scholars have often assumed that monastic Buddhism must be anti-familial, he demonstrates that these assumptions were clearly not shared by the authors/redactors of Indian Buddhist monastic law codes.Shayne Clarke provides a basis to rethink later forms of Buddhist monasticism such as those found in Central Asia, Ka?m?r, Nepal, and Tibet not in terms of corruption and decline but of continuity and development of a monastic or renunciant ideal that we have yet to understand fully.
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Ending Human Trafficking – A Handbook of Strategies for the Church Today

Ending Human Trafficking – A Handbook of Strategies for the Church Today

Shayne Moore; Sandra Morgan; Kimberly McOwen Yim; John Cotton Richmond

IVP Academic
2022
nidottu
Author Sandra Morgan awarded Wilberforce Award Human trafficking is one of the most pressing social justice issues of our time, and in recent years there has been renewed interest among Christians, as many have been stirred up to take their part in the ongoing battle. This is a wonderful thing—and yet misinformed and misguided efforts can do more harm than good. Ending Human Trafficking is a handbook designed to educate churches and parachurch organizations for truly effective work. In collaboration with The Global Center for Women and Justice at Vanguard University, Ending Human Trafficking is an accessible and compelling resource for Christian leaders, written by seasoned leaders in the struggle against modern slavery. Grounded in a theological response to the issue and filled with stories, up-to-date data, and practical tools and tips, it promises to be an invaluable resource for years to come.
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Refuse to Do Nothing

Refuse to Do Nothing

Shayne Moore; Kimberly McOwen Yim; Elisa Morgan

INTERVARSITY PRESS
2012
nidottu
2014 Outreach Magazine Resource of the Year Slavery didn't end in 1833, when William Wilberforce's decades-long campaign finally resulted in the Slavery Abolition Act. It didn't end in 1863, when Abraham Lincoln signed the Emancipation Proclamation. It didn't end in 1949, when the United Nations declared trafficking "incompatible with the dignity and worth of the human person." The sad truth is, slavery never ended. It just went underground, where it continues to exploit powerless men, women and children in horrific ways throughout the world. Now for the good news: you have power. In Refuse to Do Nothing, "Abolitionist Mamas" Shayne Moore and Kimberly Yim share their stories of coming to terms with the power available to them in their normal, everyday lives to illuminate the shadows where those who traffic in people hidecompel corporations to fight slavery in how their products are mademotivate politicians to fight for human dignitymobilize friends and strangers alike to fight slavery at home and throughout the world Slavery doesn't end without a fight. But get to know Shayne and Kimberly and their abolitionist friends, and you'll find the power God grants to all who fight for the powerless, and the joy awaiting those who refuse to do nothing.
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Statistics and Experimental Design for Toxicologists and Pharmacologists

Statistics and Experimental Design for Toxicologists and Pharmacologists

Shayne C. Gad

CRC Press Inc
2005
sidottu
Purposefully designed as a resource for practicing and student toxicologists, Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition equips you for the regular statistical analysis of experimental data. Starting with the assumption of basic mathematical skills and knowledge, the author supplies a complete and systematic yet practical introduction to the statistical methodologists available for, and used in, the discipline. For every technique presented, a worked example from toxicology is also presented. See what's new in the Fourth Edition:The first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies Coverage of Bayesian analysis and data analysis in pharmacology and toxicology Almost 200 problems with solutions Discussion of analysis of receptor binding assays, safety pharmacology assays and other standard types conducted in pharmacology A new chapter explaining the basics of Good Laboratory Practices (GLPs) For those with computer skills, this edition has been enhanced with the addition of basic SASWritten specifically for toxicologists and pharmacologists, the author draws on more than 30 years of experience to provide understanding of the philosophical underpinnings for the overall structure of analysis. The book's organization fosters the ordered development of skills and yet still facilitates ease of access to information as needed. This Fourth Edition gives you the tools necessary to perform rigorous and critical analysis of experimental data and the insight to know when to use them.
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