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1000 tulosta hakusanalla Georg P. Loczewski

Drug Toxicity in Embryonic Development I

Drug Toxicity in Embryonic Development I

Robert J. Kavlock; George P. Daston

Springer-Verlag Berlin and Heidelberg GmbH Co. K
2012
nidottu
Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.
Drug Toxicity in Embryonic Development II

Drug Toxicity in Embryonic Development II

Robert J. Kavlock; George P. Daston

Springer-Verlag Berlin and Heidelberg GmbH Co. K
2011
nidottu
Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.
Mountains and Plains

Mountains and Plains

Dennis H. Knight; George P. Jones; William A. Reiners; William H. Romme

Yale University Press
2015
pokkari
An up-to-date and comprehensive guide to the ecology of Wyoming and adjacent Rocky Mountain states Many changes—some discouraging, others hopeful—have occurred in the Rocky Mountain region since this widely acclaimed book was first published twenty years ago. Wildlife habitat has been fragmented at an alarming rate, the once-abundant sage grouse is now a candidate for protection by the Endangered Species Act, invasive plants and insects have become more common, and forest fires occur more frequently. Yet improved approaches to management and conservation have been adopted. For this updated and expanded Second Edition, the authors provide an easy-to-read synthesis of research pertinent to natural resource management, focusing in particular on Wyoming and adjacent parts of neighboring states. Exploring the region’s wetlands, plains, intermountain basins, foothills, and mountains, along with landscapes of special interest—Greater Yellowstone, the Black Hills, Bear Lodge Mountains, and Devils Tower, the Laramie Basin—the authors discuss an array of land management and conservation issues, always taking into account the implications of climate change. They offer answers to the questions that motivated the writing of this volume: How can ecosystems be used in ways that enable future generations to benefit from them as we have? How can we anticipate and adapt to climate changes while conserving biological diversity?
Economic Evaluation in Genomic Medicine

Economic Evaluation in Genomic Medicine

Vasilios Fragoulakis; Christina Mitropoulou; Marc Williams; George P. Patrinos

Academic Press Inc
2015
nidottu
Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists. Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process. The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine.
Civilization

Civilization

V. F. Lenzen; Stephen C. Pepper; George P. Adams; D. S. Mackay; Edward W. Strong; A. I. Melden; William R. Dennes

University of California Press
2022
pokkari
In this collection of essays first published in 1941, the authors grapple with fundamental questions about the nature and evaluation of human social patterns. Their republication invites reflection on whether the intervening decades of historical turbulence and philosophical progress have addressed these enduring issues or if the analyses remain relevant. Professor Lenzen’s exploration of the scientific revolution highlights the interplay of philosophical decisions and practical conditions, such as the rejection of Aristotelian physics in favor of mathematical methods. While he underestimated the impact of military pressures on scientific progress, his central theses about the conceptual underpinnings of breakthroughs remain intact. Similarly, Professor Melden’s critique of "sociologism" and his insights into the conditions for objective judgment in the social sciences retain their pertinence in addressing the persistent challenges of relativism and explanatory frameworks. The essays also delve into the relationship between freedom and organization, a tension explored by Professors Pepper and Mackay, whose analyses of research and communication structures are even more relevant today. At a deeper level, the works of Professors Adams, Strong, and the concluding essay tackle the philosophical core of civilization: the nature and validity of value norms. Adams’ Platonic interpretations and Strong’s naturalistic inquiries provide complementary perspectives on the grounding of values in human needs and aspirations. The concluding essay seeks to reconcile descriptive and normative perspectives on civilization while bridging natural and spiritual values. Collectively, these studies aim to stimulate rigorous reflection on civilization's intellectual and moral underpinnings, a task as vital now as when these ideas were first articulated. This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1959.
Civilization

Civilization

V. F. Lenzen; Stephen C. Pepper; George P. Adams; D. S. Mackay; Edward W. Strong; A. I. Melden; William R. Dennes

University of California Press
2022
sidottu
In this collection of essays first published in 1941, the authors grapple with fundamental questions about the nature and evaluation of human social patterns. Their republication invites reflection on whether the intervening decades of historical turbulence and philosophical progress have addressed these enduring issues or if the analyses remain relevant. Professor Lenzen’s exploration of the scientific revolution highlights the interplay of philosophical decisions and practical conditions, such as the rejection of Aristotelian physics in favor of mathematical methods. While he underestimated the impact of military pressures on scientific progress, his central theses about the conceptual underpinnings of breakthroughs remain intact. Similarly, Professor Melden’s critique of "sociologism" and his insights into the conditions for objective judgment in the social sciences retain their pertinence in addressing the persistent challenges of relativism and explanatory frameworks. The essays also delve into the relationship between freedom and organization, a tension explored by Professors Pepper and Mackay, whose analyses of research and communication structures are even more relevant today. At a deeper level, the works of Professors Adams, Strong, and the concluding essay tackle the philosophical core of civilization: the nature and validity of value norms. Adams’ Platonic interpretations and Strong’s naturalistic inquiries provide complementary perspectives on the grounding of values in human needs and aspirations. The concluding essay seeks to reconcile descriptive and normative perspectives on civilization while bridging natural and spiritual values. Collectively, these studies aim to stimulate rigorous reflection on civilization's intellectual and moral underpinnings, a task as vital now as when these ideas were first articulated. This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1959.
Pantheon of Political Philosophers: Third Edition

Pantheon of Political Philosophers: Third Edition

Chieke E. Ihejirika Ph. D.; Gari T. Chapidze Ph. D.; George P. Stasen Ph. D.

Georgian International University Press
2011
nidottu
This is a comprehensive college textbook on political theory by four internationally acclaimed academic authors, Zviad Kliment Lazarashvili Ph.D., Chieke E. Ihejirika Ph.D., Gari T. Chapidze Ph.D. and George P. Stasen, Ph.D. An excellent textbook on political theory and political economy for both undergraduate and graduate students. It contains detailed theories of 24 philosophers: Plato, Aristotle, Cicero, Philo, Marcus Aurelius, St. Augustine, Aquinas, Averroes, Machiavelli, Thomas More, Hobbes, Locke, Rousseau, Adam Smith, Marx, Kant, Mill, Henry David Thoreau, St. Ilia Chavchavadze, Confucius, Lao Tzu, MLK Jr., Hannah Arendt, John Rawls, Leo Tolstoy and Anton Makarenko. Authors present the development of political theory in a historical perspective: from Hellenist era to Theocratic philosophers, from Social Contract Theorists to Political Economists, from Rational Idealists to Humanists, from Oriental Political Thinkers to American Civil Rights Movement and European Realists. The book contains a chapter on Traditional Africanism: the case of Igbo Political Philosophy. Extensive Reference includes Magna Carta, The Declaration of Independence, The US Constitution and the Gettysburg Address - complete and unabridged versions. In 2011 the book was recognized by Gogebashvili Society in Europe (pedagogical academic society) and the authors were awarded Gogebashvili Medal and Prize for "pioneering accomplishments in pedagogy". Dr. Lazarashvili is an internationally acclaimed author. In 2011 he was recognized by the National Academy of Sciences of Ukraine and he was awarded Plato Gold Medal for his contributions to philosophy. This is the third edition which contains more detailed explanatory notes and introduction.
Mr. Ambassador

Mr. Ambassador

Edward J. Perkins; Connie Cronley; George P. Shultz

University of Oklahoma Press
2009
nidottu
""Apartheid South Africa was on fire around me.""So begins the memoir of Career Foreign Service Officer Edward J. Perkins, the first black United States ambassador to South Africa. In 1986, President Ronald Reagan gave him the unparalleled assignment: dismantle apartheid without violence.As he fulfilled that assignment, Perkins was scourged by the American press, despised by the Afrikaner government, hissed at by white South African citizens, and initially boycotted by black South African revolutionaries, including Archbishop Desmond Tutu. His advice to President-elect George H. W. Bush helped modify American policy and hasten the release of Nelson Mandela and others from prison.Perkins's up-by-your-bootstraps life took him from a cotton farm in segregated Louisiana to the white elite Foreign Service, where he became the first black officer to ascend to the top position of director general.This is the story of how one man turned the page of history.
Simeon DeWitt and Military Tract Township Names

Simeon DeWitt and Military Tract Township Names

Albert Hazen 1879-1970 Wright; DeWitt Historical Society of Tompkins; George P. (George Philip) 18 Philes

Hassell Street Press
2021
nidottu
This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface.We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Working Relationships

Working Relationships

Richard G. Luecking; Ellen S. Fabian; George P. Tilson

Brookes Publishing Co
2004
nidottu
This work covers securing satisfying jobs for people with disabilities by fostering partnerships between employment specialists and businesses. It helps readers to: understand the theoretical framework for improving career development practices through relationship building; understand what employers want and expect from employment service providers; learn about the building blocks of strong partnerships with employers; find practical guidelines for getting to know both job seekers and employers, marketing proactively to businesses, matching job seeker characteristics with employer needs; consider the possibility of non-traditional employment through customized job consultation; and explore specific ways to make employment service programmes more customer-oriented and understandable to employers.
Functional Somatic Symptoms in Children and Adolescents

Functional Somatic Symptoms in Children and Adolescents

Kasia Kozlowska; Stephen Scher; Helene Helgeland; George P. Chrousos

Springer Nature Switzerland AG
2020
nidottu
This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being.
The Gravest Danger

The Gravest Danger

Sidney D. Drell; James E. Goodby; George P. Shultz

Hoover Institution Press,U.S.
2003
nidottu
The mortal danger of nuclear weapons is unique in its terrifying potential for devastation on an unprecedented and unimaginable scale. In this book, Sidney D. Drell and James E. Goodby—each with more than twenty years' experience in national security issues both in public and private capacities—review the main policy issues surrounding nonproliferation of nuclear weapons. They address the specific actions that the community of nations—with American leadership—should take to confront and turn back the nuclear danger that imperils humanity. The nuclear genie, say the authors, cannot be put back in the bottle. Our most urgent task as a nation today is to successfully manage, contain, and reduce the grave danger of nuclear weapons—whether in the hands of adversaries or friendly states. This book hopes to stimulate active public dialogue on this important subject.