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1000 tulosta hakusanalla David E. Garland
Advances in Melanoma, An Issue of Hematology/Oncology Clinics
David E. Fisher
W B Saunders Co Ltd
2009
sidottu
The field of melanoma biology has experienced a remarkable surge in recent years, owing to progress which has ranged from the most basic laboratory/preclinical discoveries to clinical developments that have begun to transform the management and prognosis for at least certain melanoma patients. Among the key areas that have contributed to this progress are studies relating to signaling and transcriptional pathways that regulate control over differentiation and survival of the melanocyte lineage. The identification of recurring activating mutations in specific signaling factors (B-RAF, N-Ras, c-KIT), amplification of other melanoma oncogenes (MITF, NEDD9), and the crucial recognition that certain of these genomic events occur within melanomas arising with specific clinical features (eg mucosal or acral origin) have led to clear recognition that melanoma is indeed "many different diseases.? While the various subclasses of melanoma may share common features, such as profound invasive and metastatic propensity, it is also likely that sharply focused therapeutic strategies may exploit the functionally critical molecular engines, which distinguish these subclasses. Certain strategies focus upon the immunogenicity and striking clinical opportunities afforded by immune modulation, while others focus more directly on tumor-specific targeting. This issue brings together some of the leaders who have contributed significant insights from basic melanoma biology to progress in the clinic.
Situates Borges at the limit of philosophy and literature.Kant's Dog provides fresh insight into Borges's preoccupation with the contradiction of the time that passes and the identity that endures. By developing the implicit logic of the Borgesian archive, which is most often figured as the universal demand for and necessary impossibility of translation, Kant's Dog is able to spell out Borges's responses to the philosophical problems that most concerned him, those of the constitution of time, eternity, and identity; the determination of original and copy; the legitimacy of authority; experience; the nature of language and the possibility of a decision; and the name of God. Kant's Dog offers original interpretations of several of Borges's best known and most important stories and of the works of key figures in the history of philosophy, including Aristotle, Saint Paul, Maimonides, Hume, Locke, Kant, Heidegger, and Derrida. This study outlines Borges's curious relationship to literature and philosophy and, through a reconsideration of the relation between necessity and accident, opens the question of the constitution of philosophy and literature. The afterword develops the logic of translation toward the secret at the heart of every culture in order to posit a Borgesian challenge to anthropology and cultural studies.
Explores the evolution of Heidegger's thinking about nature and its relevance for environmental ethics.In Naturalizing Heidegger, David E. Storey proposes a new interpretation of Heidegger's importance for environmental philosophy, finding in the development of his thought from the early 1920s to his later work in the 1940s the groundwork for a naturalistic ontology of life. Primarily drawing on Heidegger's engagement with Nietzsche, but also on his readings of Aristotle and the biologist Jakob von Uexküll, Storey focuses on his critique of the nihilism at the heart of modernity, and his conception of the intentionality of organisms and their relation to their environments. From these ideas, a vision of nature emerges that recognizes the intrinsic value of all living things and their kinship with one another, and which anticipates later approaches in the philosophy of nature, such as Hans Jonas's phenomenology of life and Evan Thompson's contemporary attempt to naturalize phenomenology.
Rise of the Dark Queen: The Frontmire Histories - Book II
David E. Daigle
Booksurge Publishing
2009
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Kravorctiva: Mistress of Chaos - The Frontmire Histories- Book III
David E. Daigle
Booksurge Publishing
2009
nidottu
Practical Aspects of Interview and Interrogation, Third Edition
David E. Zulawski; Douglas E. Wicklander; David R. Thompson
CRC Press Inc
2025
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Techniques for interview and interrogation have become even more sophisticated and complex in recent years. With all chapters revised and expanded, the third edition of this bestselling book provides the latest information on establishing credibility as well as interpreting verbal and physical behavior, among other important topics. The text includes two new chapters that address juvenile interrogations and profiling. In addition, all of the existing chapters have been updated to reflect the current state of interrogation and interviewing techniques. This popular title remains essential for criminal justice professionals.
Implementing and Developing Cloud Computing Applications
David E. Y. Sarna
Taylor Francis Inc
2010
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From small start-ups to major corporations, companies of all sizes have embraced cloud computing for the scalability, reliability, and cost benefits it can provide. It has even been said that cloud computing may have a greater effect on our lives than the PC and dot-com revolutions combined.Filled with comparative charts and decision trees, Implementing and Developing Cloud Computing Applications explains exactly what it takes to build robust and highly scalable cloud computing applications in any organization. Covering the major commercial offerings available, it provides authoritative guidance through the implementation process. It puts cloud computing into historical context and considers how cloud computing affects project management, budgeting, and lifecycle management in your organization. It also explains how to: Choose the best combination of platforms, tools, and servicesDevelop new cloud applications from scratch Migrate legacy software Prevent lock-in to a single vendorEstimate costs and benefitsAddress reliability, availability, and security concernsUse interclouding, Cloud Brokers, and other techniques for safe deployment in public, private, and hybrid cloudsTake advantage of the latest developments, including OpenStack From software and testing tools to best practices and service providers, this book considers the entire cloud application environment. It details the platforms available, tools that facilitate development, as well as the costs involved. Designed for software developers and their managers, this complete resource includes case studies that illustrate the latest cloud computing technologies, implementation issues, and solutions. It also provides access to a blog to keep you current on the latest developments.
Chemistry and Pharmacology of Anticancer Drugs
David E. Thurston; Ilona Pysz
CRC Press Inc
2021
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While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies.The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure–function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines.Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"
Whether you are a supervisor, a business owner, or an HR professional, it is essential that you understand the laws and rules governing how one treats employees and interacts with unions. In a comprehensive and accessible format, Labor Law: A Basic Guide to the National Labor Relations Act provides a practice-oriented foundation on labor law. The book sheds light on one of America's most important laws and one which is also, perhaps, the most misunderstood. This book presents an overview of labor and employment laws such that managers may understand their rights as employers as well and their employees' rights. It covers an introduction to the topic of labor and employment law as well as a brief history within the United States. Other chapters deal with unions and union relations, collective bargaining agreements, grievances, labor arbitration, unfair labor practice proceedings, and strikes and lockouts. The author does not focus on complex regulations and convoluted case law, but distills them to reveal the essence of the NLRA and how it works. As important as it is, at times labor law can seem counter-intuitive. Written by a highly experienced labor lawyer, this book contains concise explanations in an easy-to-use format. Clearly delineating a process that can be fraught with traps for the unwary, it supplies a quick reference that can be used in a crisis situation to understand the parameters of what you can and cannot do.
This compact yet comprehensive guide provides a wealth of information that is timely, easy to understand, and relevant to the academic and civic lives of students, teachers, researchers, and the general public.Economics surround us, impacting the decisions people make as consumers, producers, workers, savers, investors, taxpayers, and voters. This guide offers a thorough and understandable overview of basic economic concepts and principles, providing building blocks for understanding the systems of economics in today's complex world. It then explores contemporary, economics-related topics, issues, and challenges that exist within local communities, the U.S. economy, and the global economy. Using language that is clear, precise, and accessible to high school and community college students as well as to general readers, the book covers microeconomic topics, macroeconomic topics, and international economics. It connects theory and practice as it examines how economic decisions are made and looks at the roles of the private and public sectors in achieving growth, stability, and employment. In addition, the author explores overarching trends in the global economy and the prospects for economic development in emerging nations and offers specific ways to locate other quality print and online resources on economics.
This outstanding resource guide for students and young adults provides an introduction to the history of prescription drug abuse that explains how this problem has arisen and examines the social, political, economic, and health issues associated with prescription drug abuse in modern society.Evidence suggests that both adults and youth are abusing a wider range of prescription drugs and abusing them more frequently than has been the case in the past. Prescription drugs are the second most common class of drugs abused by Americans, more than twice as commonly abused as cocaine, and five times as commonly abused as heroin. This book provides readers with information about the specific health effects that can result from using certain types of medical chemicals, particularly opioid analgesics, stimulants, depressants, and hallucinogenics; explains the most important factors that have led to the growth of prescription drug problems; and reviews the current status of the issue in the United States and other nations.Readers will learn about the dangers associated with the use of prescription drugs for nonmedical purposes, the methods that have been put in place and are being developed to prevent the abuse of prescription drugs, and the trends in prescription drug misuse, with possible explanations for these trends. The book also reviews some of the steps being taken by governments and other organizations and agencies to combat the problem of prescription drug abuse.
How is water scarcity becoming a serious problem worldwide—including in the United States? This book provides a broad overview of water, sanitation, and hygiene problems faced by both developing and developed nations around the globe and suggests how these problems can be solved by imaginative and innovative thinking.Human society depends on sufficient clean water. In many parts of the world, however, this most basic commodity is in very short supply. Even in developed, first-world nations, climate change and other factors have begun to create alarming water supply issues. The Global Water Crisis: A Reference Handbook provides a detailed overview of this important topic, enabling readers to understand the nature of the world's water, sanitation, and hygiene (WASH) problems and to know what resources are best for conducting their own research on the topic.The first chapter of the book provides the historical background information pertaining to the world's water and sanitation problems; the second chapter documents the problems, explores the issues, and presents potential solutions for understanding the nature of WASH issues. The other sections provide the needed resources for readers to study the issue of the global water crisis further: perspective essays, primary documents, biographical profiles, data and documents, an extended annotated bibliography, a chronology, and a glossary.
This text provides readers with an in-depth understanding of the essential aspects of youth substance abuse—an important contemporary personal, social, and public health issue.Humans have been using natural and synthetic chemicals for at least two millennia—primarily for the purpose of treating medical problems, but also for recreational purposes. The 2014 Monitoring the Future survey of eighth, tenth, and twelfth grade students indicates a general decline in the use of illicit drugs over the last two decades. On the other hand, perceptions among youth that certain types of drug use—like marijuana and e-cigarettes—are harmless are growing. Youth Substance Abuse: A Reference Handbook provides an overview of the history and development of youth substance abuse along with a discussion of the medical, social, psychological, legal, and economic issues associated with youth substance abuse both in the United States and other parts of the world.The book begins with a comprehensive introduction to the subject of youth substance abuse that explains how modern societies have reached the point where abuse of both legal and illegal substances is a major health issue in many nations. Readers will learn about the effects of substances such as cocaine, marijuana, and heroin as well as substances that are typically legal but have deleterious health, social, or psychological effects, such as tobacco, alcohol, prescription drugs, and electronic cigarettes. Subsequent chapters address how and why youth substance abuse has become a problem in the United States and other countries, the demographics of this widespread problem, the direct and indirect effects of youth substance abuse and addiction, and the range of services and methods that are available for treating substance abuse.