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1000 tulosta hakusanalla Deepak Gupta

Synthesis, evaluation of some benzoxazoles derivatives

Synthesis, evaluation of some benzoxazoles derivatives

Deepak Shrivastava

LAP Lambert Academic Publishing
2020
pokkari
5methyl substituted phenol benzoxazoles derivatives were synthesized by the reaction of 5 methyl 2 amino phenol with various aldehydes in the presence of Ethyl alcohol and lead tetra acetate.all the compounds were characterized by their analytical and spectral data (IR,1HNMR and Mass). synthesized compounds have been evaluated for their antimicrobial and antifungal activities by gram + and gram - and C. Albicans benzoxazoles derivatives shown significant activity as compared to Griseofulvin standard drugs.
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Synthesized & evaluate of hetero cyclic compounds different activity

Synthesized & evaluate of hetero cyclic compounds different activity

Deepak Shrivastava

LAP Lambert Academic Publishing
2020
pokkari
Advancement of medicinal chemistry in this century has been possible due to the integration of various disciplines like organic chemistry, pharmacology, molecular biology, biochemistry and other allied subjects that work hand in hand as a team.A successful medical agent has its birth in stages viz. chemical synthesis, screening for activity/activities, toxicological studies, metabolic studies, clinical trials of a tolerance tests, teratogenic tests, QSAR studies and so on. The biological action of a drug occurs due to the interaction of molecule with other specific molecules or receptors or enzymes. Ariens later elaborated the concept of receptor theory.The isosteric replacement of -O-, -S- and -N- gives rise to the compounds, benzoxazole, benzothiazole and benzimidazole respectively
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Optimization Technique For Recent Dosage Form Development

Optimization Technique For Recent Dosage Form Development

Deepak Shrivastava

LAP Lambert Academic Publishing
2020
pokkari
Conventional tablets available in market are not suitable where quick onset of action is required. Besides, the conventional tablets also show poor patient compliance particularly by the geriatric and pediatric patients who experience difficulty in swallowing, and by those who are bed ridden or who are traveling and do not have an easy access of water. To provide the patients with the most conventional mode of administration, there was a need to develop rapidly disintegrating dosageIn this study, tablets of Fexofenadine HCl were prepared by direct compression, where SSG, CCS, KCL, Xanthan Gum and Ludiflash were used as disintegrants.
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Carriers For Drug Delivery System

Carriers For Drug Delivery System

Deepak Shrivastava

LAP Lambert Academic Publishing
2020
pokkari
Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and channel the active entity to the site of action. At present, no available drug delivery system behaves ideally achieving all the lofty goals, but sincere attempts have been made to achieve them through novel approaches in drug delivery. A number of novel drug delivery systems have emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery. Encapsulation of the drug in vesicular structures is one such system, which can be predicted to prolong the existence of the drug in systemic circulation, and reduce the toxicity, if selective uptake can be achieved. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes, transfersomes, and pharmacosomes were developed. Advances have since been made in the area of vesicular drug delivery, leading to the development of systems that allow drug targeting, and the sustained or controlled release of conventional medicines.
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Synthesize Isoniazid Derivatives And Evaluate Different Activity

Synthesize Isoniazid Derivatives And Evaluate Different Activity

Deepak Shrivastava

LAP Lambert Academic Publishing
2020
pokkari
The current approach is to develop new and effective antituberculotic agents by sunthesizing new isoniazid derivatives.Isoniazid is used as anti-tuberculotic drug alon and with the combination with other antibiotics. The review of literature survey reveals that maximum of antimicrobial agents contains heterocyclic rings in their structure. The antimicrobial activity of many antibiotics is increased by attaching heterocyclic rings like azetidine, thiozole, oxazole, indole, imidazole etc with the antibiotics.number of potent medicinal agents consists of azetidine, thiazolidine, oxazolidine and imidazolidine ring in their structure having good antimicrobial potency. From the consideration of the above factors research work was aimed to synthesize isoniazid derivatives and evaluate for antimicrobial, antifungal and anti-tuberculotic activity as compared to standard drugs.
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Development of Analytical Methods By Using Various Hydrotropy Methods

Development of Analytical Methods By Using Various Hydrotropy Methods

Deepak Shrivastava

LAP Lambert Academic Publishing
2020
pokkari
In the various methods of some poorly water soluble drugs and their formulation for quantitative analysis the use of organic solvents can be replaced by using hydrotropy, mixed hydrotropy and mixed solvency giving ecofriendly analytical techniqueThe main drawbacks of organic solvents include high cost, toxicity and pollution. Organic solvents possess different adverse effects caused by single exposure like dermatitis, The hydrotropic solubilization, mixed hydrotropic solubilization and mixed solvency concept provide ecofriendly spectrophotometric estimations of poorly water-soluble drugs from their bulk drug samples and various dosage forms precluding the use of organic solvents providing simple, economic, eco-friendly, safe (free from toxicity) and accurate analytical methods. We can also use better hydrotropic agents for better results.Commonly used organic solvents for spectrophotometric analysis of water insoluble drugs include methanol, ethanol, chloroform, benzene, dichloromethane, dimethyl formamide, acetonitrile, ethyl acetate, toluene, carbon tetrachloride, acetone, hexane etc.
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Molecular Modeling Study of Antibacterial Agents

Molecular Modeling Study of Antibacterial Agents

Deepak Kumawat; Raksha Goswami

LAP Lambert Academic Publishing
2020
pokkari
β-ketoacyl-acyl carrier protein synthase III (FabH) is an emerging target for the development of novel antibacterial agent.Ligand-based design of a series of benzoylaminobenzoic acid derivatives led to the discovery of potent inhibitors of β-ketoacyl-acyl carrier protein synthase III (FabH). These FabH inhibitors demonstrated potent antibacterial activity (MIC) and as such have the potential to be novel and potent antibacterial agents. Given the unforeseen structural differences within the active site of some pathogenic FabH enzymes the key to discovering inhibitors with broad-spectrum antibacterial activity. The discovery of FabH inhibitors is now of special interest in the treatment of bacterial infection. In the present study a benzoylaminobenzoic acid derivative were designed based on the Pharmacophore modling to identify the pharmacophoric feature required for inhibitory activity CoMFA analysis to identify the essential structural requirements in 3D chemical space for the modulation of FabH inhibitory activity of benzoylaminobenzoic acid derivatives.
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Synthesize Benzimidazole Derivatives Using QSAR Technique

Synthesize Benzimidazole Derivatives Using QSAR Technique

Deepak Shrivastava

LAP Lambert Academic Publishing
2020
pokkari
The present work was aimed to design and Synthesize benzimidazole derivatives having antibacterial activity using QSAR technique of indirect designing. The indirect drug design approach has been decided to be used because defined three dimensional coordinates for the receptor site of antibacterial benzimidazole was not available. QSAR is capable of determining appropriate distribution of chemical groups around the nucleus, which are necessary to provide desired biological activity.The aim of present study is to design and synthesis of some potent antibacterial benzimidazole derivatives. Their structure confirmation and evaluation of biological activities. Based on the QSAR studies a few new benzimidazole derivatives were synthesized and virtual screening of this synthesized compound was performed.
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General And Dental Pharmacology

General And Dental Pharmacology

Deepak Prashar

LAP Lambert Academic Publishing
2020
pokkari
This book is meant for BDS-II year students. After going through this book they will be able to answer the queries related to Pharmacology. This book is a concised approaches to the use of drugs in dentistry. Notes provided through this book has proven to be useful for all categories of dental students. The students will find this book as a fruitful tool in over coming their problems related to the subject.
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Metabolic sizes of cows v/s Bacterial milk quality

Metabolic sizes of cows v/s Bacterial milk quality

Deepak Kr Verma; Ram Pal Singh

LAP Lambert Academic Publishing
2020
pokkari
The present study was undertaken to determine standard plate count (SPC) for total bacteria, lactic acid bacterial count (LABC), lipolytic bacterial count (LBC), Proteolytic bacterial count (PBC) and coliforms for determining bacterial quality of raw milk as influenced by metabolic size of healthy crossbred cows by dry full hand method of milking at SHUATS dairy farm Prayagraj. The analysis of variance showed significant effect of metabolic size on SPC, LBC, and coliforms but showed no significant differences in LABC and PBC in raw milk. The result indicated that the overall rating of bacterial quality was found better for raw milk produced by 262 to 296, and 297 to 333 followed by cows of 190 to 225 and 226 to 261 metabolic size. If the quality is judged on the basis of coliform than the quality of milk of was better from cows of metabolic size 226 to 261 and 297 to 333 followed by cows of 262 to 296 and 190 to 225 metabolic size.
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Endodontic Mishaps

Endodontic Mishaps

Deepak Kurup; Hridya Menon; Shashit Shetty B

LAP Lambert Academic Publishing
2020
pokkari
Root canal treatment or endodontic treatment is a procedure for the infected pulp of a tooth which is intended to result in the elimination of infection and protection of the decontaminated tooth from future microbial invasion and preserve the tooth as long as possible in the oral cavity. For this, step by step procedures like cleaning, shaping, disinfection and obturation has to preform. Mistakes in any of these sequences can lead to a number of accidents which are collectively called "Endodontic Mishaps". Sometimes, lack of knowledge about the procedures, poor application, compromises in the usage of materials or skipping or breaking the steps leads to these mishaps. This book gives an exact picture of these endodontic mishaps and how to fix these problems.
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