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953 tulosta hakusanalla "Genomics"

Genomics of Disease

Genomics of Disease

Springer-Verlag New York Inc.
2010
nidottu
The title will develop from the 24th Stadler symposium. It will explore the general theme "GENOME EXPLOITATION: Data Mining the Genomes". The idea behind the theme is to discuss and illustrate how scientists are going to characterize and make use of the massive amount of information being accumulated about plant and animal genomes. The book will present a state-of-the-art picture on mining the Genome databases. This will be one of the few times that researchers in both plants and animals will be working together to create a seminal data resource.
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Genomics of the Saccharinae

Genomics of the Saccharinae

Springer-Verlag New York Inc.
2012
sidottu
The Saccharinae clade of the Poaceae (grass) family of flowering plants includes several important crops with a rich history of contributions to humanity and the promise of still-greater contributions, as a result of some of the highest biomass productivity levels known, resilience to drought and other environmental challenges that are likely to increase, amenability to production systems that may mitigate or even reverse losses of ecological capital such as topsoil erosion, and the recent blossoming of sorghum as a botanical and genomic model for the clade. In Genomics of the Saccharinae, advances of the past decade and earlier are summarized and synthesized to elucidate the current state of knowledge of the structure, function, and evolution of the Sorghum, Saccharum, and Miscanthus genera, and progress in the application of this knowledge to crop improvement. As a backdrop, it is important to understand the naturally occurring diversity in each genus, its organization and distribution, and its evolutionary history. Genomic tools and methods for Saccharinae biology and improvement have improved dramatically in the past few years – a detailed summary of these tools and their applications is a central element of this book. Application of genomic tools to priorities in crop improvement, including understanding and manipulating plant growth and development, composition, and defense, as well as increasing the quality and productivity of seed/grain, sugar, biomass, and other value-added products under a range of conditions and inputs, are addressed. In particular, as the first native African crop to emerge as a genomic model, sorghum offers an excellent case study of challenges and opportunities in linking new advances in biosciences to solving some of Africa’s major agricultural problems. Several members of the clade, exemplified by Sorghum halepense (Johnsongrass) offer insights into weediness and invasion biology. The firstsequence for a member of the clade, sorghum, as well as progress and challenges toward sequencing of additional members and the new opportunities that this will create, are also explored. Indeed, the very complexities that have hindered study of some clade members also offer intriguing opportunities to gain insight into fundamental questions such as roles of polyploidy in agricultural productivity and post-polyploidy evolution.
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Genomics, Proteomics, and the Nervous System

Genomics, Proteomics, and the Nervous System

Springer-Verlag New York Inc.
2010
sidottu
This newest volume of Advances in Neurobiology discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.
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Genomics of Foodborne Bacterial Pathogens

Genomics of Foodborne Bacterial Pathogens

Springer-Verlag New York Inc.
2011
sidottu
Foodborne illnesses caused by various bacterial, viral, and fungal pathogens lead to a high number of morbidity and mortality in the U.S. and throughout the world. Recent advances in microbial genomics have significantly improved our understanding of the physiology, evolution, ecology, epidemiology, and pathogenesis of different foodborne pathogens. This book focuses on the genomics of foodborne bacterial pathogens. It begins with a brief overview of the recent advances in microbial genomics and the impact of genomics on food safety research. Then, eight chapters follow that elaborate some in-depth reviews on the genomics of several common foodborne bacterial pathogens including Bacillus, Campylobacter, Clostridium, Escherichia coli, Listeria, Salmonella, Staphylococcus, and Vibrio. Finally, the last four chapters focus on some current genomic, transcriptomic, and proteomic technologies and their applications in studying the epidemiology, evolution, and pathogenesis of foodborne bacterial pathogens. Genomics of Foodborne Bacterial Pathogens can be used as a reference by scientists and professionals in academia, government, and industry who are interested in understanding microbial genomics and using genomics tools to study foodborne bacterial pathogens. This book can also be used as a textbook for instructors and professors who teach food microbiology or microbial genomics-related courses at the post-graduate level.
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Genomics of Tree Crops

Genomics of Tree Crops

Springer-Verlag New York Inc.
2012
sidottu
Trees that are indispensably supportive to human life pose a formidable challenge to breed them to suit to human needs. From soft drinks to breweries to beverages to oil to tires, the value added products from trees give a spectrum of products to human kind. While attempts to tap these resources through conventional breeding are underway, the quick and elegant way of manipulating the genetic systems at the genome level is an essential chapter of modern science. Books featuring genomics of tree crops are few, and genomics is such a science that changes rapidly. Genomics of Tree Crops is an earnest attempt towards compiling genomics of tree crops.Plant genomics has made monumental strides in the last decade providing insights into intra-genomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology and is a common topic of modern genetic research. A genome is the sum total of all of an individual organism's genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA (genotype), mRNA (transcriptome), or protein (proteome) levels. The complete sequencing of the three billion base pair human genome with 25,000 genes identified and the invention of DNA microarrays ushered in a new era in the science of genomics leading to explosive advancements in oncology diagnostics. This impetus into the genomics era lead the way toward advances in plant genomics which started with Arabidopsis thaliana and went through an array of crops such as rice, maize, papaya, various cereals and legumes, with pigeon pea added to the list towards the end of 2011. Trees, on the other hand, are the least attended taxa with regard to genomic research. Some of the areas that attained attention of the scientists are: DNA sequencing, bioinformatics,genomics of flowering, gene flow, spatial structure, local adaptation and assisted migration in trees, transformation of fruit trees, genomics of tropical and temperate fruit trees, genomics of Hevea rubber, genomics of papaya and genomics of palms. Genomics of Tree Crops compiles this information with chapters authored by experts on these crops.
Vertaile hintoja
Genomics Applications for the Developing World

Genomics Applications for the Developing World

Springer-Verlag New York Inc.
2012
sidottu
This book evolved from the editors strong belief that the information and new developments that were evolving from the rapidly growing field of genomics and that are happening primarily in the developed world have not happened at a parallel rate in the developing world. One would have hoped that by now the technologies and approaches would have been adapted on a far greater scale. In addition to this, the associated information is not always easily accessible, and is not disseminated in a format that can become a useful reference for scientists, students and others who reside in developing countries.
Vertaile hintoja
Genomics, Proteomics, and the Nervous System

Genomics, Proteomics, and the Nervous System

Springer-Verlag New York Inc.
2013
nidottu
This newest volume of Advances in Neurobiology discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.
Vertaile hintoja
Genomics of Foodborne Bacterial Pathogens

Genomics of Foodborne Bacterial Pathogens

Springer-Verlag New York Inc.
2013
nidottu
Foodborne illnesses caused by various bacterial, viral, and fungal pathogens lead to a high number of morbidity and mortality in the U.S. and throughout the world. Recent advances in microbial genomics have significantly improved our understanding of the physiology, evolution, ecology, epidemiology, and pathogenesis of different foodborne pathogens. This book focuses on the genomics of foodborne bacterial pathogens. It begins with a brief overview of the recent advances in microbial genomics and the impact of genomics on food safety research. Then, eight chapters follow that elaborate some in-depth reviews on the genomics of several common foodborne bacterial pathogens including Bacillus, Campylobacter, Clostridium, Escherichia coli, Listeria, Salmonella, Staphylococcus, and Vibrio. Finally, the last four chapters focus on some current genomic, transcriptomic, and proteomic technologies and their applications in studying the epidemiology, evolution, and pathogenesis of foodborne bacterial pathogens. Genomics of Foodborne Bacterial Pathogens can be used as a reference by scientists and professionals in academia, government, and industry who are interested in understanding microbial genomics and using genomics tools to study foodborne bacterial pathogens. This book can also be used as a textbook for instructors and professors who teach food microbiology or microbial genomics-related courses at the post-graduate level.
Vertaile hintoja
Genomics and the Reimagining of Personalized Medicine

Genomics and the Reimagining of Personalized Medicine

Richard Tutton

Routledge
2014
sidottu
Drawing on insights from work in medical history and sociology, this book analyzes changing meanings of personalized medicine over time, from the rise of biomedicine in the twentieth century, to the emergence of pharmacogenomics and personal genomics in the 1990s and 2000s. In the past when doctors championed personalization they did so to emphasize that patients had unique biographies and social experiences in the name of caring for their patients as individuals. However, since the middle of the twentieth century, geneticists have successfully promoted the belief that genes are implicated in why some people develop diseases and why some have adverse reactions to drugs when others do not. In doing so, they claim to offer a new way of personalizing the prediction, prevention and treatment of disease. As this book shows, the genomic reimagining of personalized medicine centres on new forms of capitalization and consumption of genetic information. While genomics promises the ultimate individualization of medicine, the author argues that personalized medicine exists in the imaginative gap between the problems and limits of current scientific practices and future prospects to individualize medical interventions. A rigorous, critical examination of the promises of genomics to transform the economics and delivery of medicine, Genomics and the Reimagining of Personalized Medicine examines the consequences of the shift towards personalization for the way we think about and act on health and disease in society. As such, it will be of interest to scholars and students of the sociology of medicine and health, science and technology studies, and health policy.
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Genomics and Proteomics

Genomics and Proteomics

Springer-Verlag New York Inc.
2013
nidottu
Genome research will certainly be one of the most important and exciting sci- tific disciplines of the 21st century. Deciphering the structure of the human genome, as well as that of several model organisms, is the key to our understanding how genes fu- tion in health and disease. With the combined development of innovativetools, resources, scientific know-how, and an overall functional genomic strategy, the origins of human and other organisms’geneticdiseases can be traced. Scientificresearch groups and dev- opmental departments of several major pharmaceutical and biotechnological companies are using new, innovative strategies to unravel how genes function, elucidating the gene protein product, understanding how genes interact with others-both in health and in the disease state. Presently, the impact of the applications of genome research on our society in medicine, agriculture and nutrition will be comparable only to that of communication technologies. In fact, computational methods, including networking, have been playing a substantial role even in genomics and proteomics from the beginning. We can observe, however, a fundamental change of the paradigm in life sciences these days: research focused until now mostly on the study of single processes related to a few genes or gene products, but due to technical developments of the last years we can now potentially identify and analyze all genes and gene products of an organism and clarify their role in the network of lifeprocesses.
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Genomics with Care

Genomics with Care

Mike Fortun

DUKE UNIVERSITY PRESS
2023
sidottu
In Genomics with Care Mike Fortun presents an experimental ethnography of contemporary genomics, analyzing science as a complex amalgam of cognition and affect, formal logics and tacit knowledge, statistics, and ethics. Fortun examines genomics in terms of care-a dense composite of affective and cognitive forces that drive scientists and the relations they form with their objects of research, data, knowledge, and community. Reading genomics with care shows how each resists definition yet is so entangled as to become indistinguishable. Fortun analyzes four patterns of genomic care-curation, scrupulousness, solicitude, and friendship-seen in the conceptual, technological, social, and methodological changes that transpired as the genetics of the 1980s became the genomics of the 1990s, and then the “post-genomics” of the 2000s. By tracing the dense patterns made where care binds to science, Fortun shows how these patterns mark where scientists are driven to encounter structural double binds that are impossible to resolve, and yet are where scientific change and creativity occur.
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Genomics with Care

Genomics with Care

Mike Fortun

DUKE UNIVERSITY PRESS
2023
pokkari
In Genomics with Care Mike Fortun presents an experimental ethnography of contemporary genomics, analyzing science as a complex amalgam of cognition and affect, formal logics and tacit knowledge, statistics, and ethics. Fortun examines genomics in terms of care-a dense composite of affective and cognitive forces that drive scientists and the relations they form with their objects of research, data, knowledge, and community. Reading genomics with care shows how each resists definition yet is so entangled as to become indistinguishable. Fortun analyzes four patterns of genomic care-curation, scrupulousness, solicitude, and friendship-seen in the conceptual, technological, social, and methodological changes that transpired as the genetics of the 1980s became the genomics of the 1990s, and then the “post-genomics” of the 2000s. By tracing the dense patterns made where care binds to science, Fortun shows how these patterns mark where scientists are driven to encounter structural double binds that are impossible to resolve, and yet are where scientific change and creativity occur.
Vertaile hintoja
Genomics of the Saccharinae

Genomics of the Saccharinae

Springer-Verlag New York Inc.
2014
nidottu
The Saccharinae clade of the Poaceae (grass) family of flowering plants includes several important crops with a rich history of contributions to humanity and the promise of still-greater contributions, as a result of some of the highest biomass productivity levels known, resilience to drought and other environmental challenges that are likely to increase, amenability to production systems that may mitigate or even reverse losses of ecological capital such as topsoil erosion, and the recent blossoming of sorghum as a botanical and genomic model for the clade. In Genomics of the Saccharinae, advances of the past decade and earlier are summarized and synthesized to elucidate the current state of knowledge of the structure, function, and evolution of the Sorghum, Saccharum, and Miscanthus genera, and progress in the application of this knowledge to crop improvement. As a backdrop, it is important to understand the naturally occurring diversity in each genus, its organization and distribution, and its evolutionary history. Genomic tools and methods for Saccharinae biology and improvement have improved dramatically in the past few years – a detailed summary of these tools and their applications is a central element of this book. Application of genomic tools to priorities in crop improvement, including understanding and manipulating plant growth and development, composition, and defense, as well as increasing the quality and productivity of seed/grain, sugar, biomass, and other value-added products under a range of conditions and inputs, are addressed. In particular, as the first native African crop to emerge as a genomic model, sorghum offers an excellent case study of challenges and opportunities in linking new advances in biosciences to solving some of Africa’s major agricultural problems. Several members of the clade, exemplified by Sorghum halepense (Johnsongrass) offer insights into weediness and invasion biology. The firstsequence for a member of the clade, sorghum, as well as progress and challenges toward sequencing of additional members and the new opportunities that this will create, are also explored. Indeed, the very complexities that have hindered study of some clade members also offer intriguing opportunities to gain insight into fundamental questions such as roles of polyploidy in agricultural productivity and post-polyploidy evolution.
Vertaile hintoja
Genomics of Tree Crops

Genomics of Tree Crops

Springer-Verlag New York Inc.
2014
nidottu
Trees that are indispensably supportive to human life pose a formidable challenge to breed them to suit to human needs. From soft drinks to breweries to beverages to oil to tires, the value added products from trees give a spectrum of products to human kind. While attempts to tap these resources through conventional breeding are underway, the quick and elegant way of manipulating the genetic systems at the genome level is an essential chapter of modern science. Books featuring genomics of tree crops are few, and genomics is such a science that changes rapidly. Genomics of Tree Crops is an earnest attempt towards compiling genomics of tree crops.Plant genomics has made monumental strides in the last decade providing insights into intra-genomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology and is a common topic of modern genetic research. A genome is the sum total of all of an individual organism's genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA (genotype), mRNA (transcriptome), or protein (proteome) levels. The complete sequencing of the three billion base pair human genome with 25,000 genes identified and the invention of DNA microarrays ushered in a new era in the science of genomics leading to explosive advancements in oncology diagnostics. This impetus into the genomics era lead the way toward advances in plant genomics which started with Arabidopsis thaliana and went through an array of crops such as rice, maize, papaya, various cereals and legumes, with pigeon pea added to the list towards the end of 2011. Trees, on the other hand, are the least attended taxa with regard to genomic research. Some of the areas that attained attention of the scientists are: DNA sequencing, bioinformatics,genomics of flowering, gene flow, spatial structure, local adaptation and assisted migration in trees, transformation of fruit trees, genomics of tropical and temperate fruit trees, genomics of Hevea rubber, genomics of papaya and genomics of palms. Genomics of Tree Crops compiles this information with chapters authored by experts on these crops.
Vertaile hintoja
Genomics in the Cloud

Genomics in the Cloud

Geraldine van der Auwera; Brian D. O'connor

O'Reilly Media
2020
nidottu
Data in the genomics field is booming. In just a few years, organizations such as the National Institutes of Health (NIH) will host 50+ petabytes-or over 50 million gigabytes-of genomic data, and they're turning to cloud infrastructure to make that data available to the research community. How do you adapt analysis tools and protocols to access and analyze that volume of data in the cloud? With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra. With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra. Geraldine Van der Auwera, longtime custodian of the GATK user community, and Brian O'Connor of the UC Santa Cruz Genomics Institute, guide you through the process. You'll learn by working with real data and genomics algorithms from the field. This book covers: Essential genomics and computing technology background Basic cloud computing operations Getting started with GATK, plus three major GATK Best Practices pipelines Automating analysis with scripted workflows using WDL and Cromwell Scaling up workflow execution in the cloud, including parallelization and cost optimization Interactive analysis in the cloud using Jupyter notebooks Secure collaboration and computational reproducibility using Terra
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Genomics Applications for the Developing World

Genomics Applications for the Developing World

Springer-Verlag New York Inc.
2014
nidottu
This book evolved from the editors strong belief that the information and new developments that were evolving from the rapidly growing field of genomics and that are happening primarily in the developed world have not happened at a parallel rate in the developing world. One would have hoped that by now the technologies and approaches would have been adapted on a far greater scale. In addition to this, the associated information is not always easily accessible, and is not disseminated in a format that can become a useful reference for scientists, students and others who reside in developing countries.
Vertaile hintoja
Genomics: A Revolution in Health and Disease Discovery

Genomics: A Revolution in Health and Disease Discovery

Hans C. Andersson; Whitney Stewart

Twenty-First Century Books (Tm)
2020
sidottu
Over the past 50 years, scientists have made incredible progress in the application of genetic research to human health care and disease treatment. Innovative tools and techniques, including gene therapy and CRISPR-Cas9 editing, can treat inherited disorders that were previously untreatable, or prevent them from happening in the first place. You can take a DNA test to learn where your ancestors are from. Police officers can use genetic evidence to identify criminals--or innocents. And some doctors are using new medical techniques for unprecedented procedures.Genomics: A Revolution in Health and Disease Discovery delves into the history, science, and ethics behind recent breakthroughs in genetic research. Authors Whitney Stewart and Hans Andersson, MD, present fascinating case studies that show how real people have benefitted from genetic research. Though the genome remains full of mysteries, researchers and doctors are working hard to uncover its secrets and find the best ways to treat patients and cure diseases. The discoveries to come will inform how we target disease treatment, how we understand our health, and how we define our very identities.
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Genomics, Proteomics, and Clinical Bacteriology

Genomics, Proteomics, and Clinical Bacteriology

Humana Press Inc.
2004
sidottu
Gazing into crystal balls is beyond the expertise of most scientists. Yet, as we look further into the 21st century, one does not have to be Nostradamus to predict that the current genomics and proteomics "revolution" will have an immense impact on medical bacteriology. This impact is already being re- ized in many academic departments, and although encroachment on routine diagnostic bacteriology, particularly in the hospital setting, is likely to occur at a slower pace, it remains nonetheless inevitable. Therefore, it is important that no one working in bacteriology should find themselves distanced from these fundamental developments. The involvement of all clinical bacteriologists is essential if the significant achievements of genome sequencing and analysis are to be turned into tangible advances, with resulting benefits for patient care and m- agement. It is our hope that Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews will play a part in bringing such a development to fruition. The advances in genomics and proteomics have already given us frequent opportunities to reassess our knowledge and understanding of established b- terial adversaries, and have provided us with the means to identify new foes. The new knowledge gained is enabling us to reconsider, for example, our c- cepts of bacterial pathogenicity, phylogeny and novel targets for antibacterial chemotherapy. These topics, and others, are considered in Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews.
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