Since the seventeenth century, ethnicity has been the central issue in the American search for a national identity. The articulation of this issue can clearly be seen in the representation of non-white others in the literature of the nineteenth century, specifically in the works of James Fenimore Cooper and Herman Melville. This book examines how both Cooper and Melville manipulated literary images of Native Americans, African Americans, and other non-Europeans, thus revealing how America created the image of the savage – by which it was alternately attracted and repulsed – as a way of defining its own identity.
This book focuses on broadly defined areas of chemical information science— with special emphasis on chemical informatics— and computer-aided molecular design. The computational and cheminformatics methods discussed, and their application to drug discovery, are essential for sustaining a viable drug development pipeline. It is increasingly challenging to identify new chemical entities and the amount of money and time invested in research to develop a new drug has greatly increased over the past 50 years. The average time to take a drug from clinical testing to approval is currently 7.2 years. Therefore, the need to develop predictive computational techniques to drive research more efficiently to identify compounds and molecules, which have the greatest likelihood of being developed into successful drugs for a target, is of great significance. New methods such as high throughput screening (HTS) and techniques for the computational analysis of hits have contributed to improvements in drug discovery efficiency. The SARMs developed by Jürgen and colleagues have enabled display of SAR data in a more transparent scaffold/functional SAR table. There are many tools and databases available for use in applied drug discovery techniques based on polypharmacology. The cheminformatics approaches and methodologies presented in this volume and at the Skolnik Award Symposium will pave the way for improved efficiency in drug discovery. The lectures and the chapters also reflect the various aspects of scientific enquiry and research interests of the 2015 Herman Skolnik award recipient.
Defying odds longer than that of Arcangues winning the 1993 Breeder's Cup Classic horse race, the Scorpions rose to rock and roll royalty from relative obscurity in Hannover, West Germany during the late 1970's and early 1980's. Herman Rarebell, aka Herman "Ze German", was part of it all. More than just a drummer, Herman's additional input through his imaginative and inspired songwriting was conceivably the key ingredient and missing component that led to their rise to prominence while most of those in the so-called "know" said they were only kidding themselves. Dieter Dierks, the long time producer of the Scorpions says: Herman was an integral part in the development of that which eventually became known as the classic Scorpions sound. Music all starts with the drummer. Not many people realize this. However, if you look at the "success" of the group, or, perhaps more appropriately, the lack thereof, prior to the arrival of Herman "Ze German" as well as that which has eluded them since his departure, I think you can see exactly how pivotal his role was within the band.However, there is much more here than just the ordinary, self-glorifying chronicle of a man's life. This book is anything but that. Shrewdly concealed within this autobiography is not only what can be considered the quintessential, definitive history of arguably the greatest band of their era, but also a masterful weaving of some of the most entertaining wit, whimsy and sage wisdom ever shared within the covers of a simple book. Sure to be considered a masterpiece by those who have a love of tongue in cheek irony and satire not to mention great storytelling, it raises the bar for such offerings to a decidedly new level. With his endless anecdotes and tales, Herman draws the lines that led to the group's ascension to the Mount Olympus of rock music, while his co-writer, Michael Krikorian, clearly lends his assistance to color them in providing more hues and tones than Crayola ever put in a box of crayons. Together they set a table and serve up a banquet of sarcasm and memories truly fit for a king (The King of Monaco to be precise.) There are no sacred cherubs spared from the harpoon of a master yarn-spinner as the puns, innuendo and endless wordplay are meant to entertain and lampoon much of the history not only of an incredible band but also of a generation. Though having none of the calories but plenty of the guilt, the frankness and honesty expressed upon each sinfully delicious page will never spoil your appetite but only leave you yearning for more.
Brother Lawrence was born Nicolas Herman in H rim nil, near Lun ville in the region of Lorraine, located in modern day eastern France. Having felt he had received a revelation of the providence and power of God at the age of 18, within six years he joined the Discalced Carmelite Priory in Paris. In this intervening period he fought in the Thirty Years' War and later served as a valet. Nicolas entered the priory in Paris as a lay brother, not having the education necessary to become a cleric, and took the religious name, "Lawrence of the Resurrection". He spent almost all of the rest of his life within the walls of the priory, working in the kitchen for most of his life and as a repairer of sandals in his later years. Despite his lowly position in life and the priory, his character attracted many to him. He had a reputation for experiencing profound peace and visitors came to seek spiritual guidance from him. The wisdom he passed on to them, in conversations and in letters, would later become the basis for the book, The Practice of the Presence of God. Father Joseph de Beaufort, later vicar general to the Archbishop of Paris, compiled this work after Brother Lawrence died. It became popular among Catholics and Protestants alike, with John Wesley and A. W. Tozer recommending it to others. As a young man, Herman's poverty forced him into joining the army, which guaranteed him meals and a small stipend. During this period, Herman claimed an experience that set him on a unique spiritual journey. He considered it a supernatural clarity into a common sight, more so than as a supernatural vision. During the winter, Herman looked at a barren tree, stripped of leaves and fruit, and realized it awaited the sure hope of a springtime revival and summer abundance. Gazing at the tree, Herman grasped deeply the extravagance of God's grace and the unfailing sovereignty of divine providence. Like the tree, he felt seemingly dead, but held hope that God had life waiting for him, and the turn of seasons would bring fullness. At that moment, he said, that leafless tree "first flashed in upon my soul the fact of God," and a love for God that never ceased. Shortly after, an injury forced his retirement from the army, and after a stint as a footman, he sought a place where he could suffer for his failures. He thus entered the Discalced Carmelite monastery in Paris as Brother Lawrence. This is an out-of-print manuscript. All pages are intact and it has been carefully reviewed.
Moby-Dick; or, The Whale is a novel by American writer Herman Melville, published in 1851 during the period of the American Renaissance. Sailor Ishmael tells the story of the obsessive quest of Ahab, captain of the whaler the Pequod, for revenge on Moby Dick, the white whale that on the previous whaling voyage bit off Ahab's leg at the knee. The novel was a commercial failure and out of print at the time of the author's death in 1891, but during the 20th century, its reputation as a Great American Novel was established. William Faulkner confessed he wished he had written it himself, and D. H. Lawrence called it "one of the strangest and most wonderful books in the world", and "the greatest book of the sea ever written". "Call me Ishmael" is among world literature's most famous opening sentences.The product of a year and a half of writing, the book draws on Melville's experience at sea, on his reading in whaling literature, and on literary inspirations such as Shakespeare and the Bible. The white whale is modeled on the notoriously hard to catch actual albino whale Mocha Dick, and the ending is based on the sinking of the whaler Essex by a whale. The detailed and realistic descriptions of whale hunting and of extracting whale oil, as well as life aboard ship among a culturally diverse crew, are mixed with exploration of class and social status, good and evil, and the existence of God. In addition to narrative prose, Melville uses styles and literary devices ranging from songs, poetry, and catalogs to Shakespearean stage directions, soliloquies, and asides. Dedicated to Nathaniel Hawthorne, "in token of my admiration for his genius", the work was first published as The Whale in London in October 1851, and under its definitive title in New York in November. Hundreds of differences, mostly slight and some important, are seen between the two editions. The London publisher censored or changed sensitive passages and Melville made revisions, as well, including the last-minute change in the title for the New York edition. The whale, however, appears in both editions as "Moby Dick", with no hyphen. Because the British edition lacked the Epilogue, which accounts for Ishmael's survival, it seemed that the story was told by someone who was supposed to have perished. Many reviewers in British magazines recognized a violation of the rules of fiction and criticized the author for a serious flaw. Other reviewers, however, found the book too fascinating to dismiss it for these reasons. Some of the scornful British reviews were either reprinted or quoted in American periodicals, wrongfooting the American readers though the Epilogue was present in Moby-Dick. About 3,200 copies were sold during the author's life..... Nathaniel Hathorne; July 4, 1804 - May 19, 1864) was an American novelist, Dark Romantic, and short story writer.He was born in 1804 in Salem, Massachusetts, to Nathaniel Hathorne and the former Elizabeth Clarke Manning. His ancestors include John Hathorne, the only judge involved in the Salem witch trials who never repented of his actions. Nathaniel later added a "w" to make his name "Hawthorne" in order to hide this relation. ... Herman Melville (August 1, 1819 - September 28, 1891) was an American novelist, short story writer, and poet of the American Renaissance period. His best known works include Typee (1846), a romantic account of his experiences in Polynesian life, and his whaling novel Moby-Dick (1851). His work was almost forgotten during his last thirty years.....
Moby-Dick; or, The Whale is a novel by American writer Herman Melville, published in 1851 during the period of the American Renaissance. Sailor Ishmael tells the story of the obsessive quest of Ahab, captain of the whaler the Pequod, for revenge on Moby Dick, the white whale that on the previous whaling voyage bit off Ahab's leg at the knee. The novel was a commercial failure and out of print at the time of the author's death in 1891, but during the 20th century, its reputation as a Great American Novel was established. William Faulkner confessed he wished he had written it himself, and D. H. Lawrence called it "one of the strangest and most wonderful books in the world", and "the greatest book of the sea ever written". "Call me Ishmael" is among world literature's most famous opening sentences.The product of a year and a half of writing, the book draws on Melville's experience at sea, on his reading in whaling literature, and on literary inspirations such as Shakespeare and the Bible. The white whale is modeled on the notoriously hard to catch actual albino whale Mocha Dick, and the ending is based on the sinking of the whaler Essex by a whale. The detailed and realistic descriptions of whale hunting and of extracting whale oil, as well as life aboard ship among a culturally diverse crew, are mixed with exploration of class and social status, good and evil, and the existence of God. In addition to narrative prose, Melville uses styles and literary devices ranging from songs, poetry, and catalogs to Shakespearean stage directions, soliloquies, and asides. Dedicated to Nathaniel Hawthorne, "in token of my admiration for his genius", the work was first published as The Whale in London in October 1851, and under its definitive title in New York in November. Hundreds of differences, mostly slight and some important, are seen between the two editions. The London publisher censored or changed sensitive passages and Melville made revisions, as well, including the last-minute change in the title for the New York edition. The whale, however, appears in both editions as "Moby Dick", with no hyphen. Because the British edition lacked the Epilogue, which accounts for Ishmael's survival, it seemed that the story was told by someone who was supposed to have perished. Many reviewers in British magazines recognized a violation of the rules of fiction and criticized the author for a serious flaw. Other reviewers, however, found the book too fascinating to dismiss it for these reasons. Some of the scornful British reviews were either reprinted or quoted in American periodicals, wrongfooting the American readers though the Epilogue was present in Moby-Dick. About 3,200 copies were sold during the author's life..... Nathaniel Hathorne; July 4, 1804 - May 19, 1864) was an American novelist, Dark Romantic, and short story writer.He was born in 1804 in Salem, Massachusetts, to Nathaniel Hathorne and the former Elizabeth Clarke Manning. His ancestors include John Hathorne, the only judge involved in the Salem witch trials who never repented of his actions. Nathaniel later added a "w" to make his name "Hawthorne" in order to hide this relation. ... Herman Melville (August 1, 1819 - September 28, 1891) was an American novelist, short story writer, and poet of the American Renaissance period. His best known works include Typee (1846), a romantic account of his experiences in Polynesian life, and his whaling novel Moby-Dick (1851). His work was almost forgotten during his last thirty years.....
![The two first cantos of Richardetto, freely translated from the original of N. Fortiguerra [by John Herman Merivale], etc.](/covers/9781241023003.jpg)
