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1000 tulosta hakusanalla Anil Kumar

Economic History of India: 1857-1947

Economic History of India: 1857-1947

Anilkumar K

New Century Publications
2020
sidottu
The British came to India as merchants in the middle of the 17th century. After gaining foothold on the coastline, they spread to every corner of the Indian peninsula. They gained political supremacy around the middle of the 18th century. After winning the Battle of Plassey in 1757 and the Battle of Buxer in 1764, they established themselves firmly as the rulers of India and ruled it till 1947 to sub-serve their economic interests. The British rule in India can be divided into two periods: (a) the rule of the East India Company from 1757 to 1858 and (b) the rule of the British Government from 1858 to 1947. The British interests in India were governed by the requirements of the Industrial Revolution which started in Britain in the middle of the 18th century and then spread to other regions of Europe. These were two-fold: (a) to secure raw materials from India for factories in Britain and (b) to ensure permanent market in India for the British manufactures. To fulfil these objectives, they adopted measures which proved disastrous for the Indian economy. This book gives a comprehensive and vivid account of various aspects of the Indian economy during the period 1857 to 1947. It is spread over 30 chapters which have been organized into 5 theme parts.
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Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement

Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement

Anilkumar Shinde; Ravindra Jarag; Harinath More

Lap Lambert Academic Publishing
2024
pokkari
The objective of present work was to prepare nanocrystals of Nitrendipin (NTD) to enhance its solubility and dissolution rate with aim of dose reduction and minimising the side effects associated with it's oral administration. The optimised nanocrystals formulation had particle size 335nm, PDI 0.262, practical yield 85%, and ZP in the range of of -20 to -45mv. X-Ray diffraction studies (XRPD) and Differential scanning calorimetry (DSC) studies suggested nanocrystal formation and absence of crystalline peaks, indicating loss of crystallinity, additionally confirmed by scanning electron microscopy (SEM). Nanocrystals showed 30.45 fold enhancements in aqueous solubility, and 38.5 fold in phosphate buffer pH 1.2, as compared to pure NTD. In vitro release studies have demonstrated 96.186% cumulative drug release within 60 min from nanocrystals compared to 22.17% from pure NTD. Stable NTD nanocrystals formulated by anti-solvent precipitation method shows improved solubility and dissolution. It has been concluded that NTD nanocrystals were obtained with significant improvement in saturation solubility and drug losing it's crystalline nature, when compared with plain drug.
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Formulação, Desenvolvimento de Comprimidos de Mesalamina para o tratamento do cólon

Formulação, Desenvolvimento de Comprimidos de Mesalamina para o tratamento do cólon

Anilkumar Shinde; Firoj Tamboli; Harinath More

Edicoes Nosso Conhecimento
2025
nidottu
O objetivo do presente trabalho foi preparar sistemas de administra o espec ficos do c lon para o cido 5-aminossalic lico (5-ASA) utilizando goma de feno-grego e quitosano como transportador para o c lon. M todos: Foram preparados comprimidos com n cleo contendo 5-ASA por granula o h mida, utilizando polivinilpirrolidona (PVP) como aglutinante e glicolato de amido e s dio como superdesintegrante. Os gr nulos preparados foram avaliados quanto ao ngulo de repouso, ao ndice de compressibilidade e ao r cio de Hausner. Os comprimidos preparados foram avaliados quanto dureza, friabilidade, varia o de peso e estudos de desintegra o. Os comprimidos do n cleo foram revestidos com a concentra o de 2%, 5% e 7% na propor o de 50:50, 40:60, 60:40, 70:30 e 30:70 de goma de feno-grego e quitosano. Os comprimidos com revestimento ent rico foram caracterizados quanto desintegra o e dissolu o in vitro. Os estudos de compatibilidade f rmaco-pol mero foram determinados utilizando o estudo FT-IR e n o se verificou qualquer intera o entre o f rmaco e os pol meros. Resultados: A forma o de complexos entre a goma de feno-grego e o quitosano impede a liberta o do f rmaco no est mago. Os comprimidos revestidos com solu es de concentra o de 7% no r cio 70:30 (goma de feno-grego: quitosano) apresentam uma melhor propriedade de dilata o.
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