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Dose-Response Analysis Using R

Dose-Response Analysis Using R

Christian Ritz; Signe Marie Jensen; Daniel Gerhard; Jens Carl Streibig

Taylor Francis Ltd
2021
nidottu
Nowadays the term dose-response is used in many different contexts and many different scientific disciplines including agriculture, biochemistry, chemistry, environmental sciences, genetics, pharmacology, plant sciences, toxicology, and zoology.In the 1940 and 1950s, dose-response analysis was intimately linked to evaluation of toxicity in terms of binary responses, such as immobility and mortality, with a limited number of doses of a toxic compound being compared to a control group (dose 0). Later, dose-response analysis has been extended to other types of data and to more complex experimental designs. Moreover, estimation of model parameters has undergone a dramatic change, from struggling with cumbersome manual operations and transformations with pen and paper to rapid calculations on any laptop. Advances in statistical software have fueled this development.Key Features: Provides a practical and comprehensive overview of dose-response analysis. Includes numerous real data examples to illustrate the methodology. R code is integrated into the text to give guidance on applying the methods. Written with minimal mathematics to be suitable for practitioners. Includes code and datasets on the book’s GitHub: https://github.com/DoseResponse. This book focuses on estimation and interpretation of entirely parametric nonlinear dose-response models using the powerful statistical environment R. Specifically, this book introduces dose-response analysis of continuous, binomial, count, multinomial, and event-time dose-response data. The statistical models used are partly special cases, partly extensions of nonlinear regression models, generalized linear and nonlinear regression models, and nonlinear mixed-effects models (for hierarchical dose-response data). Both simple and complex dose-response experiments will be analyzed.
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Yarns of a Professional Gongoozler: Tales of English Canal Life at Dixie's Marina

Yarns of a Professional Gongoozler: Tales of English Canal Life at Dixie's Marina

R. J. Adams

Independently Published
2008
nidottu
"Yarns of a Professional Gongoozler", or "Tales of English Canal Life at Dixie's Marina", is a series of nine short stories set around a fictionalised canal boat marina in the North-West of England.The British canal system stretches over two thousand miles, much of it passing through some of the most attractive and peaceful areas of countryside to be found in England and Wales. Occasional urban sections provide a wealth of historical detail relating to an industrial heritage long passed into the pages of history. Canal boating and boat ownership is a rapidly developing industry, and inland waterways marinas are continually being constructed throughout the system to accommodate the steadily increasing numbers of steel narrowboats and GRP cruisers that abound. R J Adams entered the business both as a marina manager and narrowboat dweller. During the course of some twelve or so years he met some amazing people, saw some incredible sights, and laughed uproariously at a plethora of amusing incidents. Each of the eight stories, though self-sufficient, are interlinked and best read consecutively. They are based on the author's own personal experiences over twelve years as an inland waterway's marina manager. Most of the events described in this book actually occurred, but with the exception of 'Molly", characters have been fictionalised and bear no relation to anyone, living or dead. GONGOOZLER: (Noun) An idle and inquisitive person who stands and gazes at the comings and goings of the boats on the canals. English Dictionary.
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Dose-Response Analysis Using R

Dose-Response Analysis Using R

Christian Ritz; Signe Marie Jensen; Daniel Gerhard; Jens Carl Streibig

CRC Press
2019
sidottu
Nowadays the term dose-response is used in many different contexts and many different scientific disciplines including agriculture, biochemistry, chemistry, environmental sciences, genetics, pharmacology, plant sciences, toxicology, and zoology.In the 1940 and 1950s, dose-response analysis was intimately linked to evaluation of toxicity in terms of binary responses, such as immobility and mortality, with a limited number of doses of a toxic compound being compared to a control group (dose 0). Later, dose-response analysis has been extended to other types of data and to more complex experimental designs. Moreover, estimation of model parameters has undergone a dramatic change, from struggling with cumbersome manual operations and transformations with pen and paper to rapid calculations on any laptop. Advances in statistical software have fueled this development.Key Features: Provides a practical and comprehensive overview of dose-response analysis. Includes numerous real data examples to illustrate the methodology. R code is integrated into the text to give guidance on applying the methods. Written with minimal mathematics to be suitable for practitioners. Includes code and datasets on the book’s GitHub: https://github.com/DoseResponse. This book focuses on estimation and interpretation of entirely parametric nonlinear dose-response models using the powerful statistical environment R. Specifically, this book introduces dose-response analysis of continuous, binomial, count, multinomial, and event-time dose-response data. The statistical models used are partly special cases, partly extensions of nonlinear regression models, generalized linear and nonlinear regression models, and nonlinear mixed-effects models (for hierarchical dose-response data). Both simple and complex dose-response experiments will be analyzed.
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Sins of the Mafia

Sins of the Mafia

VI Carter; E R Whyte

Carter Books
2023
pokkari
Four mafia families who rule the underworld. A power struggle that leads to war. And a forbidden love that might set it all ablaze.DamonValachi.That was the name on my mother's dying lips.That one word would spark a war.A war that I planned on winning.I would go to the Valachi famiglia, and integrate myself into their world. I would learn their weaknesses and their secrets, and I would find out who was responsible for my mother's execution.Then I met Lorenzo Valachi's daughter, Lulu. She's a queen in the making: strong, beautiful, and full of compassion. She's also an innocent... and the only thing standing in my way.Lulu lights a fire in me that threatens to burn hotter than my desire for revenge. I can't have her, though-not if I want to avenge my mother. So, I change my plans, just a little. I'll have my vengeance, and Lulu, too. LuluI'm trapped in a golden cage and men hold the key to my freedom.My father controls his world with an iron fist. When he makes Damon, a made man, his right hand, a light is lit in my darkened world.He makes me feel things I never thought would be possible.The closer we get, though, the more I crave. Until one day, he cuts me off and leaves me in the cold. Only this time I refuse to be silenced. This time I refuse to return to that dark cage. Damon hasn't just brought light into my world, but hope... and hope can be a very dangerous thing.
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Mémoires Historiques de S. A. R. Madame, Duchesse de Berry, Depuis Sa Naissance Jusqu'à CE Jour. 1

Mémoires Historiques de S. A. R. Madame, Duchesse de Berry, Depuis Sa Naissance Jusqu'à CE Jour. 1

Marie-Caroline de Bourbon Cicile-Berry

Hachette Livre - BNF
2014
pokkari
Memoires historiques de S. A. R. Madame, duchesse de Berry, depuis sa naissance jusqu'a ce jour. 1 / publ. par Alfred NettementDate de l'edition originale: 1837Sujet de l'ouvrage: Berry, Marie-Caroline de Bourbon-Sicile (1798-1870; duchesse de) -- BiographiesCe livre est la reproduction fidele d une uvre publiee avant 1920 et fait partie d une collection de livres reimprimes a la demande editee par Hachette Livre, dans le cadre d un partenariat avec la Bibliotheque nationale de France, offrant l opportunite d acceder a des ouvrages anciens et souvent rares issus des fonds patrimoniaux de la BnF.Les uvres faisant partie de cette collection ont ete numerisees par la BnF et sont presentes sur Gallica, sa bibliotheque numerique.En entreprenant de redonner vie a ces ouvrages au travers d une collection de livres reimprimes a la demande, nous leur donnons la possibilite de rencontrer un public elargi et participons a la transmission de connaissances et de savoirs parfois difficilement accessibles.Nous avons cherche a concilier la reproduction fidele d un livre ancien a partir de sa version numerisee avec le souci d un confort de lecture optimal. Nous esperons que les ouvrages de cette nouvelle collection vous apporteront entiere satisfaction.Pour plus d informations, rendez-vous sur www.hachettebnf.fr
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Mémoires Historiques de S. A. R. Madame, Duchesse de Berry, Depuis Sa Naissance Jusqu'à CE Jour. 2

Mémoires Historiques de S. A. R. Madame, Duchesse de Berry, Depuis Sa Naissance Jusqu'à CE Jour. 2

Marie-Caroline de Bourbon Cicile-Berry

Hachette Livre - BNF
2014
pokkari
Memoires historiques de S. A. R. Madame, duchesse de Berry, depuis sa naissance jusqu'a ce jour. 2 / publ. par Alfred NettementDate de l'edition originale: 1837Sujet de l'ouvrage: Berry, Marie-Caroline de Bourbon-Sicile (1798-1870; duchesse de) -- BiographiesCe livre est la reproduction fidele d une uvre publiee avant 1920 et fait partie d une collection de livres reimprimes a la demande editee par Hachette Livre, dans le cadre d un partenariat avec la Bibliotheque nationale de France, offrant l opportunite d acceder a des ouvrages anciens et souvent rares issus des fonds patrimoniaux de la BnF.Les uvres faisant partie de cette collection ont ete numerisees par la BnF et sont presentes sur Gallica, sa bibliotheque numerique.En entreprenant de redonner vie a ces ouvrages au travers d une collection de livres reimprimes a la demande, nous leur donnons la possibilite de rencontrer un public elargi et participons a la transmission de connaissances et de savoirs parfois difficilement accessibles.Nous avons cherche a concilier la reproduction fidele d un livre ancien a partir de sa version numerisee avec le souci d un confort de lecture optimal. Nous esperons que les ouvrages de cette nouvelle collection vous apporteront entiere satisfaction.Pour plus d informations, rendez-vous sur www.hachettebnf.fr
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Mémoires Historiques de S. A. R. Madame, Duchesse de Berry, Depuis Sa Naissance Jusqu'à CE Jour. 3

Mémoires Historiques de S. A. R. Madame, Duchesse de Berry, Depuis Sa Naissance Jusqu'à CE Jour. 3

Marie-Caroline de Bourbon Cicile-Berry

Hachette Livre - BNF
2014
pokkari
Memoires historiques de S. A. R. Madame, duchesse de Berry, depuis sa naissance jusqu'a ce jour. 3 / publ. par Alfred NettementDate de l'edition originale: 1837Sujet de l'ouvrage: Berry, Marie-Caroline de Bourbon-Sicile (1798-1870; duchesse de) -- BiographiesCe livre est la reproduction fidele d une uvre publiee avant 1920 et fait partie d une collection de livres reimprimes a la demande editee par Hachette Livre, dans le cadre d un partenariat avec la Bibliotheque nationale de France, offrant l opportunite d acceder a des ouvrages anciens et souvent rares issus des fonds patrimoniaux de la BnF.Les uvres faisant partie de cette collection ont ete numerisees par la BnF et sont presentes sur Gallica, sa bibliotheque numerique.En entreprenant de redonner vie a ces ouvrages au travers d une collection de livres reimprimes a la demande, nous leur donnons la possibilite de rencontrer un public elargi et participons a la transmission de connaissances et de savoirs parfois difficilement accessibles.Nous avons cherche a concilier la reproduction fidele d un livre ancien a partir de sa version numerisee avec le souci d un confort de lecture optimal. Nous esperons que les ouvrages de cette nouvelle collection vous apporteront entiere satisfaction.Pour plus d informations, rendez-vous sur www.hachettebnf.fr
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Multivariate Data Integration Using R

Multivariate Data Integration Using R

Kim-Anh Lê Cao; Zoe Marie Welham

TAYLOR FRANCIS LTD
2021
sidottu
Large biological data, which are often noisy and high-dimensional, have become increasingly prevalent in biology and medicine. There is a real need for good training in statistics, from data exploration through to analysis and interpretation. This book provides an overview of statistical and dimension reduction methods for high-throughput biological data, with a specific focus on data integration. It starts with some biological background, key concepts underlying the multivariate methods, and then covers an array of methods implemented using the mixOmics package in R. Features: Provides a broad and accessible overview of methods for multi-omics data integration Covers a wide range of multivariate methods, each designed to answer specific biological questions Includes comprehensive visualisation techniques to aid in data interpretation Includes many worked examples and case studies using real data Includes reproducible R code for each multivariate method, using the mixOmics package The book is suitable for researchers from a wide range of scientific disciplines wishing to apply these methods to obtain new and deeper insights into biological mechanisms and biomedical problems. The suite of tools introduced in this book will enable students and scientists to work at the interface between, and provide critical collaborative expertise to, biologists, bioinformaticians, statisticians and clinicians.
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Genealogy of the Powell and Montzheimer Families: the Ancestors, Descendants, and Other Relatives of William Alfred Powell (1857-1926) and Marie (Mont

Genealogy of the Powell and Montzheimer Families: the Ancestors, Descendants, and Other Relatives of William Alfred Powell (1857-1926) and Marie (Mont

Alfred R. Powell

Hassell Street Press
2021
nidottu
This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface.We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
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Genealogy of the Powell and Montzheimer Families: the Ancestors, Descendants, and Other Relatives of William Alfred Powell (1857-1926) and Marie (Mont

Genealogy of the Powell and Montzheimer Families: the Ancestors, Descendants, and Other Relatives of William Alfred Powell (1857-1926) and Marie (Mont

Alfred R. Powell

Hassell Street Press
2023
sidottu
This comprehensive genealogy traces the history of the Powell and Montzheimer families from their earliest known ancestors to the present day. Drawing on a wealth of primary sources, the author provides detailed biographical sketches of family members, along with records of births, marriages, and deaths. This book is an invaluable resource for anyone researching these two families, as well as for anyone interested in genealogy more broadly.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it.This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
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Multivariate Data Integration Using R

Multivariate Data Integration Using R

Kim-Anh Lê Cao; Zoe Marie Welham

TAYLOR FRANCIS LTD
2024
nidottu
Large biological data, which are often noisy and high-dimensional, have become increasingly prevalent in biology and medicine. There is a real need for good training in statistics, from data exploration through to analysis and interpretation. This book provides an overview of statistical and dimension reduction methods for high-throughput biological data, with a specific focus on data integration. It starts with some biological background, key concepts underlying the multivariate methods, and then covers an array of methods implemented using the mixOmics package in R. Features: Provides a broad and accessible overview of methods for multi-omics data integration Covers a wide range of multivariate methods, each designed to answer specific biological questions Includes comprehensive visualisation techniques to aid in data interpretation Includes many worked examples and case studies using real data Includes reproducible R code for each multivariate method, using the mixOmics package The book is suitable for researchers from a wide range of scientific disciplines wishing to apply these methods to obtain new and deeper insights into biological mechanisms and biomedical problems. The suite of tools introduced in this book will enable students and scientists to work at the interface between, and provide critical collaborative expertise to, biologists, bioinformaticians, statisticians and clinicians.
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