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B Cell Receptor Signaling

B Cell Receptor Signaling

Springer International Publishing AG
2016
sidottu
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, whilealso paving the way for eventually combating these diseases.
B Cell Receptor Signaling

B Cell Receptor Signaling

Springer International Publishing AG
2018
nidottu
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, whilealso paving the way for eventually combating these diseases.
B Corp Entrepreneurs

B Corp Entrepreneurs

Florentine Mariele Sophie Roth; Ingo Winkler

Birkhauser Verlag AG
2018
sidottu
Highlighting the motivations of B Corp entrepreneurs in Chile, this book explores the phenomenon behind for-profit organisations that are committed to social and ecological sustainability as well as human welfare. By examining the personal and social drivers of businesses which are not solely focused on profit-making, the authors reveal a dual orientation that is an important factor in the creation of hybrid organisations. Offering an in-depth study of B Corp entrepreneurs in Chile, the largest B Corp community outside of North America, this pioneering book challenges dominant assumptions that there is only one ideal type of entrepreneur and argues that the values of the purely profit-driven and purely social-driven do in fact intersect. An enlightening read for researchers of social business and sustainability, this book analyses perceptions towards success, and the desire to solve environmental problems, underlining a fundamental aspect of the entrepreneur’s personal valuestructure.
B-Model Gromov-Witten Theory

B-Model Gromov-Witten Theory

Birkhauser Verlag AG
2019
sidottu
This book collects various perspectives, contributed by both mathematicians and physicists, on the B-model and its role in mirror symmetry. Mirror symmetry is an active topic of research in both the mathematics and physics communities, but among mathematicians, the “A-model” half of the story remains much better-understood than the B-model. This book aims to address that imbalance. It begins with an overview of several methods by which mirrors have been constructed, and from there, gives a thorough account of the “BCOV” B-model theory from a physical perspective; this includes the appearance of such phenomena as the holomorphic anomaly equation and connections to number theory via modularity. Following a mathematical exposition of the subject of quantization, the remainder of the book is devoted to the B-model from a mathematician’s point-of-view, including such topics as polyvector fields and primitive forms, Givental’s ancestor potential, and integrablesystems.
B'tong: ein Umweltroman

B'tong: ein Umweltroman

Roland Platte

tredition GmbH
2020
nidottu
Carsten Krause macht eine bahnbrechende Erfindung in Sachen Beton. Sie erm glicht es, Bebautes auf einfachste Weise wieder in Natur zur ck zu verwandeln. Alle Welt ist nun hinter Carsten her, um an die Erfindung heranzukommen. Leider interessieren sich aber auch dubiose Gesch ftsleute, korrupte Politiker, gef hrliche Gangster sowie virulente Chaoten und Aktivisten f r diese Erfindung. Selbst seine Familie und gute Freunde geraten zunehmend unter Druck. So verwandelt sich die einzigartige Erfindung in einen Albtraum, der seinen H hepunkt in der skurrilen Entf hrung von Carstens Frau Sybille findet. In diesem Roman mit spannenden kriminalistischen Aspekten geht es darum, wie sogenannte gutgemeinte, geniale Erfindungen das Verh ltnis des Menschen zur Natur beeintr chtigen und letztlich mehr zerst ren, als aufbauen.
B'tong: ein Umweltroman

B'tong: ein Umweltroman

Roland Platte

tredition GmbH
2020
sidottu
Carsten Krause macht eine bahnbrechende Erfindung in Sachen Beton. Sie erm glicht es, Bebautes auf einfachste Weise wieder in Natur zur ck zu verwandeln. Alle Welt ist nun hinter Carsten her, um an die Erfindung heranzukommen. Leider interessieren sich aber auch dubiose Gesch ftsleute, korrupte Politiker, gef hrliche Gangster sowie virulente Chaoten und Aktivisten f r diese Erfindung. Selbst seine Familie und gute Freunde geraten zunehmend unter Druck. So verwandelt sich die einzigartige Erfindung in einen Albtraum, der seinen H hepunkt in der skurrilen Entf hrung von Carstens Frau Sybille findet. In diesem Roman mit spannenden kriminalistischen Aspekten geht es darum, wie sogenannte gutgemeinte, geniale Erfindungen das Verh ltnis des Menschen zur Natur beeintr chtigen und letztlich mehr zerst ren, als aufbauen.