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Modulating CYP450 Isozymes to Prevent DB[a, l]P-Induced Mammary Cancer

Modulating CYP450 Isozymes to Prevent DB[a, l]P-Induced Mammary Cancer

Mohammad Kalim Ahmad Khan; Salman Akhtar; Mohd Umar Azeem

Lap Lambert Academic Publishing
2024
pokkari
Carcinogens transform into electrophilic metabolites, bind to DNA, and cause cancer via metabolic activation, detoxification, angiogenesis, and metastasis. CYP isozymes are therapeutic targets in DBP-induced mammary cancer. LBVS, molecular docking, MD simulations, and in vitro studies have focused on CYP1A1, 1A2, and 1B1. LBVS identified hits, refined using Lipinski's RO5 and ADMET filters, and docked them using AutoDock4. CHEMBL1, CHEMBL2, and CHEMBL3 showed superior binding affinities to ANF. The stability was confirmed via MD simulations. ADMET filtering yielded nontoxic hits, with ANA8430692 and ANA7923580 exhibiting optimal stability. Molecular dynamics and enzyme inhibition assays validated their potential as CYP inhibitors. Designed analogs ANA6917483, ANA8430692, and ANA6451816 displayed strong binding and interaction patterns, suggesting anticancer potential. This study enhances our understanding of the DBP-induced prevention of mammary cancer.
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Modulierung von CYP450-Isozymen zur Verhinderung von DB[a, l]P-induziertem Mammakarzinom

Modulierung von CYP450-Isozymen zur Verhinderung von DB[a, l]P-induziertem Mammakarzinom

Mohammad Kalim Ahmad Khan; Salman Akhtar; Mohd Umar Azeem

Verlag Unser Wissen
2025
pokkari
Karzinogene wandeln sich in elektrophile Metaboliten um, binden an die DNA und verursachen Krebs durch Stoffwechselaktivierung, Entgiftung, Angiogenese und Metastasierung. CYP-Isoenzyme sind therapeutische Ziele bei DBP-induziertem Brustkrebs. LBVS, molekulares Docking, MD-Simulationen und In-vitro-Studien konzentrierten sich auf CYP1A1, 1A2 und 1B1. LBVS identifizierte Treffer, verfeinerte sie mit Lipinskis RO5 und ADMET-Filtern und dockte sie mit AutoDock4 an. CHEMBL1, CHEMBL2 und CHEMBL3 zeigten eine hohe Bindungsaffinit t zu ANF. Die Stabilit t wurde durch MD-Simulationen best tigt. Die ADMET-Filterung ergab ungiftige Treffer, wobei ANA8430692 und ANA7923580 eine optimale Stabilit t aufwiesen. Molekulardynamik- und Enzyminhibitionstests best tigten ihr Potenzial als CYP-Inhibitoren. Die Analoga ANA6917483, ANA8430692 und ANA6451816 zeigten starke Bindungs- und Interaktionsmuster, die auf ein Potenzial zur Krebsbek mpfung schlie en lassen. Diese Studie verbessert unser Verst ndnis der DBP-induzierten Pr vention von Brustkrebs.
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Drawn Together, Studio DB

Drawn Together, Studio DB

Briit Zunino

RIZZOLI INTERNATIONAL PUBLICATIONS
2025
sidottu
Studio DB, a Manhattan-based interiors firm headed by husband-and-wife duo Damian and Britt Zunino, is inspired by the European ideal of an appreciation for the beauty in everyday life the resulting work embraces the juxtaposition and tension between polished and playful, between modern and traditional. In each project, there is a creative mix of materials, unusual forms, and whimsical patterns and colors, all anchored by a contemporary desire for livability and ease. Thoughtful design details also distinguish their work, with tactile and natural materials interpreted in fresh and interesting ways. Examples include exquisite hand-painted de Gournay wallpaper in a dining room, paired with suspended lamps in a variety of geometric forms; the terrazzo floor of a city foyer, incorporating massive chunks of stone slabs and smaller rocks from the client s travel adventures; and a subtly patterned wallpaper applied to the ceiling of an entrance hall to add a note of gentle distinction. The studio organically launched in 2007 after Britt and Damian had worked together on several residential projects. Britt's unconventional background includes work in fashion, editorial styling, interior design, and the action sports industry. Damian s love of planning, construction, and design was fostered during his time at the Yale School of Architecture. The pair s unique experiences and expertise complement each other, bringing a collaborative and comprehensive approach to each scheme. As the duo states in the book s introduction, 'In the end, it s the dialog, the push and pull between different viewpoints from different eras, that makes the end result more engaging.'
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Designing and Implementing Cloud-native Applications Using Microsoft Azure Cosmos DB

Designing and Implementing Cloud-native Applications Using Microsoft Azure Cosmos DB

Steve Flowers

APRESS
2023
nidottu
This book will help prepare you for the Microsoft DP-420 exam. Whether you are new to Azure Cosmos DB or have experience working with the platform, Designing and Implementing Cloud-Native Applications Using Microsoft Azure Cosmos DB is organized to address the specific skills measured in the DP-420 exam. The topics covered include NoSQL models, code, and real-world scenarios aimed at helping you to understand and solve the case studies included in the exam. Beyond the exam, this book will assist you in your journey to adopt Microsoft Azure Cosmos DB for your own projects. You’ll learn what makes Azure Cosmos DB such a robust NoSQL service, as well as how NoSQL approaches help enable modern applications. You’ll also get practical guidance for your own implementations. The topics covered in this book are essential to knowing how to leverage the Cosmos DB service and provide best practices that will guide you to success both on the exam and in your career. What You Will Learn Understand and hone the skills needed to pass the DP-420 examGain insight into the test-taking experience, whether at a testing center or virtuallyEvaluate and understand features of Azure Cosmos DB using real-world use cases and code samplesLearn from case studies in the book that will help you to correctly address case studies in the examBuild a foundation that goes beyond the exam and gives you the confidence to implement Azure Cosmos DB in your own projectsDetermine the trade-offs between different configurations, whether your implementation is small and local or large and requires global scale Who This Book Is For Anyone planning to take the DP-420 exam, as well as developers, engineers, and architects seeking a better understanding of Azure Cosmos DB and how it is used in developing modern applicationsusing a NoSQL approach.
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Modulazione degli isozimi CYP450 per prevenire il cancro mammario indotto da DB[a, l]P

Modulazione degli isozimi CYP450 per prevenire il cancro mammario indotto da DB[a, l]P

Mohammad Kalim Ahmad Khan; Salman Akhtar; Mohd Umar Azeem

Edizioni Sapienza
2025
pokkari
Le sostanze cancerogene si trasformano in metaboliti elettrofili, si legano al DNA e causano il cancro attraverso l'attivazione metabolica, la disintossicazione, l'angiogenesi e le metastasi. Gli isozimi CYP sono bersagli terapeutici nel cancro mammario indotto da DBP. L'LBVS, il docking molecolare, le simulazioni MD e gli studi in vitro si sono concentrati sui CYP1A1, 1A2 e 1B1. L'LBVS ha identificato gli hit, li ha raffinati usando i filtri RO5 e ADMET di Lipinski e li ha agganciati usando AutoDock4. CHEMBL1, CHEMBL2 e CHEMBL3 hanno mostrato un'affinit di legame superiore con ANF. La stabilit stata confermata tramite simulazioni MD. Il filtraggio ADMET ha prodotto risultati non tossici, con ANA8430692 e ANA7923580 che hanno mostrato una stabilit ottimale. La dinamica molecolare e i saggi di inibizione enzimatica hanno convalidato il loro potenziale come inibitori del CYP. Gli analoghi progettati ANA6917483, ANA8430692 e ANA6451816 hanno mostrato forti modelli di legame e interazione, suggerendo un potenziale antitumorale. Questo studio migliora la nostra comprensione della prevenzione del cancro mammario indotta dal DBP.
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Modulowanie izoenzymów CYP450 w celu zapobiegania rakowi sutka wywolanemu przez DB[a, l]P

Modulowanie izoenzymów CYP450 w celu zapobiegania rakowi sutka wywolanemu przez DB[a, l]P

Mohammad Kalim Ahmad Khan; Salman Akhtar; Mohd Umar Azeem

Wydawnictwo Nasza Wiedza
2025
pokkari
Substancje rakotw rcze przeksztalcają się w elektrofilowe metabolity, wiążą się z DNA i powodują raka poprzez aktywację metaboliczną, detoksykację, angiogenezę i przerzuty. Izozymy CYP są celami terapeutycznymi w raku sutka wywolanym przez DBP. LBVS, dokowanie molekularne, symulacje MD i badania in vitro skupily się na CYP1A1, 1A2 i 1B1. LBVS zidentyfikowal trafienia, udoskonalil je za pomocą filtr w RO5 i ADMET Lipinskiego i zadokowal je za pomocą AutoDock4. CHEMBL1, CHEMBL2 i CHEMBL3 wykazaly lepsze powinowactwo wiązania do ANF. Stabilnośc zostala potwierdzona za pomocą symulacji MD. Filtrowanie ADMET dalo nietoksyczne trafienia, z ANA8430692 i ANA7923580 wykazującymi optymalną stabilnośc. Dynamika molekularna i testy inhibicji enzym w potwierdzily ich potencjal jako inhibitor w CYP. Zaprojektowane analogi ANA6917483, ANA8430692 i ANA6451816 wykazywaly silne wzorce wiązania i interakcji, sugerując potencjal przeciwnowotworowy. Badanie to poglębia naszą wiedzę na temat zapobiegania rakowi sutka wywolanemu przez DBP.
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Modulação dos isozimas CYP450 para prevenir o cancro da mama induzido por DB[a, l]P

Modulação dos isozimas CYP450 para prevenir o cancro da mama induzido por DB[a, l]P

Mohammad Kalim Ahmad Khan; Salman Akhtar; Mohd Umar Azeem

Edicoes Nosso Conhecimento
2025
pokkari
Os carcinog neos transformam-se em metabolitos electrof licos, ligam-se ao ADN e causam cancro atrav s da ativa o metab lica, desintoxica o, angiog nese e met stases. As isozimas CYP s o alvos terap uticos no cancro da mama induzido por DBP. LBVS, docking molecular, simula es MD e estudos in vitro centraram-se em CYP1A1, 1A2 e 1B1. LBVS identificou hits, refinou-os utilizando os filtros RO5 e ADMET de Lipinski e acoplou-os utilizando AutoDock4. CHEMBL1, CHEMBL2 e CHEMBL3 mostraram afinidades de liga o superiores a ANF. A estabilidade foi confirmada atrav s de simula es MD. A filtragem ADMET produziu resultados n o t xicos, com ANA8430692 e ANA7923580 a exibirem uma estabilidade ptima. A din mica molecular e os ensaios de inibi o enzim tica validaram o seu potencial como inibidores do CYP. Os an logos concebidos ANA6917483, ANA8430692 e ANA6451816 apresentaram fortes padr es de liga o e intera o, sugerindo potencial anticancer geno. Este estudo melhora a nossa compreens o da preven o do cancro da mama induzida pelo DBP.
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Modulation des isoenzymes CYP450 pour prévenir le cancer mammaire induit par le DB[a, l]P

Modulation des isoenzymes CYP450 pour prévenir le cancer mammaire induit par le DB[a, l]P

Mohammad Kalim Ahmad Khan; Salman Akhtar; Mohd Umar Azeem

Editions Notre Savoir
2025
pokkari
Les substances canc rig nes se transforment en m tabolites lectrophiles, se lient l'ADN et provoquent le cancer par le biais de l'activation m tabolique, de la d toxification, de l'angiogen se et des m tastases. Les isozymes CYP sont des cibles th rapeutiques dans le cancer mammaire induit par le DBP. LBVS, l'amarrage mol culaire, les simulations MD et les tudes in vitro se sont concentr s sur CYP1A1, 1A2 et 1B1. LBVS a identifi des hits, les a affin s en utilisant les filtres RO5 et ADMET de Lipinski et les a amarr s l'aide d'AutoDock4. CHEMBL1, CHEMBL2 et CHEMBL3 ont montr des affinit s de liaison sup rieures au FNA. La stabilit a t confirm e par des simulations MD. Le filtrage ADMET a donn des r sultats non toxiques, ANA8430692 et ANA7923580 pr sentant une stabilit optimale. Des essais de dynamique mol culaire et d'inhibition enzymatique ont valid leur potentiel en tant qu'inhibiteurs du CYP. Les analogues con us ANA6917483, ANA8430692 et ANA6451816 ont pr sent des mod les de liaison et d'interaction forts, sugg rant un potentiel anticanc reux. Cette tude nous permet de mieux comprendre la pr vention du cancer mammaire induite par le DBP.
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Aldicarb, Ametryn, 2,4-DB, Dicamba, Dimethipin, Disulfoton, Diuron, et al. - Tolerance Actions (US Environmental Protection Agency Regulation) (EPA) (

Aldicarb, Ametryn, 2,4-DB, Dicamba, Dimethipin, Disulfoton, Diuron, et al. - Tolerance Actions (US Environmental Protection Agency Regulation) (EPA) (

The Law Library

Createspace Independent Publishing Platform
2018
nidottu
Aldicarb, Ametryn, 2,4-DB, Dicamba, Dimethipin, Disulfoton, Diuron, et al. - Tolerance Actions (US Environmental Protection Agency Regulation) (EPA) (2018 Edition) The Law Library presents the complete text of the Aldicarb, Ametryn, 2,4-DB, Dicamba, Dimethipin, Disulfoton, Diuron, et al. - Tolerance Actions (US Environmental Protection Agency Regulation) (EPA) (2018 Edition). Updated as of May 29, 2018 EPA is revoking certain tolerances for the insecticides/nematicides aldicarb, ethoprop, and oxamyl; the insecticides disulfoton, malathion, and methyl parathion; the miticide/acaricide propargite; the fungicides o-phenylphenol and its sodium salt, triadimefon, triadimenol, and ziram; the herbicides ametryn, dicamba, diuron, oxyfluorfen, and paraquat; the growth regulator/herbicide dimethipin; and the antimicrobial/insecticidal fumigant propylene oxide. Also, EPA is modifying certain tolerances for the insecticide/nematicide oxamyl; the insecticide fenitrothion; the miticide/acaricide propargite; the molluscicide metaldehyde; the fungicides triadimefon and tridemorph; the herbicides ametryn, 2,4-DB, dicamba, and diuron; and the antimicrobial/insecticidal fumigant propylene oxide. In addition, EPA is establishing tolerances for the insecticide/nematicide oxamyl; the molluscicide metaldehyde; the fungicides etridiazole and streptomycin; the herbicides 2,4-DB, dicamba, and diuron; and the antimicrobial/insecticidal fumigant propylene oxide and propylene chlorohydrin (a reaction product formed during the propylene oxide sterilization process). Finally, because tolerances expired in 2005, EPA is removing 40 CFR 180.167 for nicotine-containing compounds. The regulatory actions finalized in this document are in follow-up to the Agency's reregistration program under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), and tolerance reassessment program under the Federal Food, Drug, and Cosmetic Act (FFDCA), section 408(q). This book contains: - The complete text of the Aldicarb, Ametryn, 2,4-DB, Dicamba, Dimethipin, Disulfoton, Diuron, et al. - Tolerance Actions (US Environmental Protection Agency Regulation) (EPA) (2018 Edition) - A table of contents with the page number of each section
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