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Molecular Basis for Therapy of AIDS-Defining Cancers

Molecular Basis for Therapy of AIDS-Defining Cancers

Springer-Verlag New York Inc.
2014
nidottu
Cancer incidences increase in people living with HIV/AIDS. Over 2 million people currently live with HIV/AIDS in the US. This number will increase as HAART prolongs the average lifespan and as (at least in some states) the number of new HIV infections increase again. As this population ages their incidence rates for cancer will increase, as well. Recently, new rational targets for cancer therapy have emerged. But their application to the care of HIV+ patients is slow, because of concerns about the weakened immune status of the patients, because of possible drug interactions with HAART and because some of the AIDS defining cancer are rare.
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Metabolic Basis of Obesity

Metabolic Basis of Obesity

Springer-Verlag New York Inc.
2014
nidottu
The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.
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Genetic Basis for Respiratory Control Disorders

Genetic Basis for Respiratory Control Disorders

Springer-Verlag New York Inc.
2014
nidottu
Bringing together top-level contributions on all aspects of the subject, this book provides an overview of the recent advances in the genetics of respiratory control in health and disease. It also shows how combined studies in humans and mouse models have helped to improve our understanding of the mechanisms that underlie genetically determined respiratory control disorders with the goal of developing new therapeutic interventions.
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The Bards will Sing

The Bards will Sing

J. W. Kent

Createspace Independent Publishing Platform
2013
nidottu
Returning from the Northern Wastes, Fergus was dismayed to find that the Bards were indeed "singing his name", as he made a joyous reunion with his comrades of the TKT. His time on the plains of Valdenheim was short lived however, and given his first command, he was sent on a treacherous journey, south through the infamous Illesian swamps to the exotic Southern lands. There, amid the burning sands, an ancient horror awaited them... one that not only thirsted for their lives, but for their very souls.
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Behind Bars

Behind Bars

Mike Gerrard

GLOBE PEQUOT PRESS
2024
pokkari
Behind Bars is filled with stories both ancient and urgent of what happens when alcohol meets crime, from illicit stills in the Scottish Highlands to moonshine in the USA, rum smuggled by Caribbean pirates, the roaring times of Prohibition, to current-day gangs selling millions of dollars’ worth of fake Bordeaux and the often-unsolved cases of people walking into a liquor store, stealing whiskey bottles worth tens of thousands of dollars, and walking out, never to be seen again.Award-winning travel and drinks writer Mike Gerrard takes readers on a centuries-long journey highlighting the most bizarre – and expensive – alcohol-related crimes all while revealing the inside world of booze: how it has been distilled, legislated, imbibed, and infused into culture and society for hundreds of years. Discover the evolution of the world-leading whiskey industry in Scotland; how the war in Ukraine has impacted illicit vodka rings; how Southern smugglers laid the foundation for NASCAR; and the machinations behind the Whiskey Ring Scandal, a White-House Prohibition conspiracy involving high-ranking American officials under President Grant.These crimes have not died with Prohibition. In 2018 at the Scottish Universities Environmental Research Centre scientists used radiocarbon-dating techniques to examine fifty-five bottles of rare and expensive Scotch whiskies. Twenty-one of them were found to be fake. Gerrard interviews today’s leading experts that employ cutting-edge testing techniques to investigate suspect bottles of rare and high-priced alcohol. Fake booze goes back even further than that. Archaeologists excavating around Pompeii in Campania, Italy, a region whose wine was much sought-after and expensive, have uncovered evidence that local wine merchants were filling amphorae with wine from other parts of Italy and passing it off as the real thing. Behind Bars smartly and swiftly shows that the link between alcohol and crime is a never-ending story.
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Molecular Basis of Pulmonary Disease

Molecular Basis of Pulmonary Disease

Humana Press Inc.
2016
nidottu
Dr. SharonRounds, theeditorforthisserieswhoinvitedustowriteabookonrare lungdiseases, developedtheideaafterattendingthe2004Lymphangioleiomyomatosis (LAM)Foundationannualresearchmeeting. Shewasakeynotespeakeratthatevent (duringhertenureasthepresidentoftheAmericanThoracicSociety)andwasw- nesstothepowerofpatientadvocacyandthemission-basedscienti ceffortthathad broughtthisrarediseaseofwomenfromobscuritytoclinicaltrialswithtargetedmol- ulartherapiesinunderadecade. Theprogressinpulmonaryalveolarproteinosis(PAP), pulmonaryalveolarmicrolithiasis(PAM), inheriteddisordersofsurfactantmetabolism, and pulmonary arterial hypertension, to name a few, has been no less astounding. Advanceshavecomefromthemostsurprisingdirections;fruit iesforLAM, gen- ically engineered mice made for other purposes for PAP, and groundbreaking hi- densitySNP(single-nucleotidepolymorphism)analysesdoneonahandfuloffamilies forPAM. Inmanycases, insightsintobiologygainedfromrarediseaseshaveinformed researchapproachesandtreatmentstrategiesformorecommondiseases;forexample, knowledgegainedfromthestudyofPAPabouttheroleofGM-CSFinthelunghas sparkedinterestintheuseofantiGM-CSFapproachestocontrolbothpulmonaryand extrapulmonaryin ammationinavarietyofdiseases. The ndingthatinterstitiallung diseasedevelopsinfamilieswithcytotoxicmutationsinsurfactantproteinC(SP-C), agenewhichisexpressedonlyinalveolartypecells, hasunderscoredtheimportance oftheintegrityofthealveolarepitheliuminthepathogenesisofparenchymal brosis. Opportunitiestoapproachlungdiseasepathogenesisfromthevantagepointofap- marymoleculardefectaregiftsfromnaturethatareuniquelyabundantamongtherare lungdisorders. WesalutetheNIHandtheNationalCenterforResearchResourcesfortheirvisionin facilitatingthetranslationofbasicresearchadvancesinrarelungdiseasesintoclinical realitythroughtheRareLungDiseaseConsortium, anetworkof13USandinter- tionalsitesthatiscurrentlyconductingclinicaltrialsandstudiesinLAM, alphaone antitrypsin de ciency, pediatric interstitial lung disease, and PAP. It has been a rare privilegetoworkonsuchfascinatingdiseaseswithsuchcapableinvestigatorsfromall overtheworldoverthepast6years. v vi Preface Theformatforthisvolumeisunique. Mostchaptershavebeenauthoredbyacli- cianandabasicscientistwhoareexpertinthediseasetopicandunderlyingmolecular defect, respectively. Theirchargewastofocusonthegeneticbasisandmolecularpat- genesisofdisease, animalmodels, clinicalfeatures, diagnosticapproach, conventional managementandtreatment, andfuturetherapeutictargetsanddirections. Theintentwas nottoprovideabroadoverview, butrathertoshedlightonthemolecularmechanisms thatevoketheclinicalpresentationandengendertreatmentstrategiesforeachdisease. Wehopethatthisapproachwillproveusefulforpulmonarycliniciansandscientists alike. Wethankourwives, Holly, Jean, andVicky, fortheirsupportandindulgencewith latenightemailsandwork- lledweekends, Dr. Roundsfortheinvitationtowritethe book, andalloftheauthorswhocontributed. FrancisMcCormack, MD RalphPanos, MD BruceTrapnell, MD Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 AClinicalApproachtoRareLungDiseases. . . . . . . . . . . . . . . . 1 RalphJ. Panos 2 ClinicalTrialsforRareLungDiseases. . . . . . . . . . . . . . . . . . . 31 JeffreyKrischer 3 IdiopathicandFamilialPulmonaryArterialHypertension . . . . . . . . 39 JeanM. Elwing, GailH. Deutsch, WilliamC. Nichols, andTimothyD. LeCras 4 Lymphangioleiomyomatosis. . . . . . . . . . . . . .
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Technical Basis and Implementation Guidelines for A Technique for Human Event Analysis

Technical Basis and Implementation Guidelines for A Technique for Human Event Analysis

U. S. Nuclear Regulatory Commission

Createspace Independent Publishing Platform
2014
nidottu
This report describes the most recent version of a second-generation human reliability analysis method called "A Technique for Human Event Analysis", NUREG-1625, Rev..1. ATHENA is a result of development efforts sponsored by the Probabilistic Risk Analysis Branch in the U.S. Nuclear Regulatory Commissions's Office of Nuclear Regulatory Research.
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