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1000 tulosta hakusanalla Daniel M. Davis

Résistance potentielle des cellules cancéreuses aux multi-médicaments

Résistance potentielle des cellules cancéreuses aux multi-médicaments

Esther Priyadharshini Daniel; Tameem Tabbasum M D

Editions Notre Savoir
2023
pokkari
Le cancer est une maladie redoutable dans laquelle les cellules anormales prolif rent de mani re incontr l e et envahissent d'autres parties du corps, donnant lieu une tumeur. Les causes du cancer comprennent le tabagisme, l'exc s de poids, les mutations g n tiques h r ditaires, les hormones, l' tat immunitaire, etc. Selon les conclusions de l'Organisation mondiale de la sant (OMS), le nombre annuel de cas de cancer devrait passer de 14 millions en 2012 22 au cours des deux prochaines d cennies. Il s'agit d'une v ritable alarme pour la soci t , qui nous donne l'occasion de briser cette menace. Malgr les traitements contre le cancer, le taux de r ussite est moindre. La raison en est que les cellules canc reuses d veloppent une r sistance au traitement et r g n rent leurs propri t s. C'est pourquoi ce livre fournit des informations sur leur r sistance au traitement ainsi que des donn es sur quelques types de cancers et leurs strat gies pour surmonter le traitement. Diff rents types de transporteurs qui sont responsables de la r sistance des cellules canc reuses au traitement sont mentionn s. Il s'agit notamment des transporteurs ABC, P-gp, Pten, etc. De nombreux m dicaments capables de surmonter la r sistance sont num r s et inclus. Les cellules canc reuses s'adaptent instantan ment chaque condition et les strat gies des cellules canc reuses sont discut es.
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Potenziale resistenza delle cellule tumorali ai farmaci multipli

Potenziale resistenza delle cellule tumorali ai farmaci multipli

Esther Priyadharshini Daniel; Tameem Tabbasum M D

Edizioni Sapienza
2023
pokkari
Il cancro una terribile malattia in cui le cellule anomale proliferano senza controllo e invadono altre parti del corpo dando origine a un tumore. Tra le cause del cancro vi sono il consumo di tabacco, l'eccesso di peso corporeo, le mutazioni genetiche ereditate, gli ormoni, le condizioni immunitarie, ecc. Secondo le conclusioni dell'Organizzazione Mondiale della Sanit (OMS), si prevede che i casi di cancro annui passeranno dai 14 milioni del 2012 a 22 entro i prossimi due decenni. Si tratta di un vero e proprio allarme per la societ e ci offre un'opportunit stimolante per sventare la minaccia. Nonostante i trattamenti per il cancro, il tasso di successo inferiore. Il motivo che le cellule tumorali sviluppano una resistenza al trattamento e rigenerano le loro propriet . Questo libro fornisce quindi informazioni sulla loro resistenza al trattamento, oltre a dati su alcuni tipi di cancro e sulle loro strategie per superare il trattamento. Vengono citati diversi tipi di trasportatori che sono responsabili della resistenza delle cellule tumorali durante il trattamento. Alcuni di essi sono i trasportatori ABC, P-gp, Pten ecc. Vengono elencati e inclusi molti farmaci in grado di superare la resistenza. Le cellule tumorali si adattano istantaneamente a ogni condizione e le strategie delle cellule tumorali sono discusse.
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Resistência potencial por células cancerígenas para multi-drogas

Resistência potencial por células cancerígenas para multi-drogas

Esther Priyadharshini Daniel; Tameem Tabbasum M D

Edicoes Nosso Conhecimento
2023
pokkari
O cancro uma doen a terr vel em que as c lulas anormais proliferam sem controlo e invadem outras partes do corpo, resultando em tumores. As causas do cancro incluem o consumo de tabaco, excesso de peso corporal, muta es gen ticas herdadas, hormonas, condi o imunit ria, etc. De acordo com a descoberta da Organiza o Mundial de Sa de (OMS), espera-se que os casos anuais de cancro aumentem de 14 milh es em 2012 para 22 dentro das pr ximas duas d cadas. Isto um verdadeiro alarme para a sociedade e d -nos uma oportunidade desafiante de quebrar a amea a. Apesar de ter tratamento para o cancro, a taxa de sucesso menor. A raz o que as c lulas cancer genas desenvolvem resist ncia para o tratamento e regeneram as suas propriedades. Portanto, este livro fornece informa es sobre a sua resist ncia ao tratamento juntamente com dados sobre poucos tipos de cancros e as suas estrat gias para ultrapassar o tratamento. S o mencionados diferentes tipos de transportadores que s o respons veis pela resist ncia das c lulas cancerosas durante o tratamento. Poucos s o os transportadores ABC, P-gp, Pten, etc. Muitos medicamentos com capacidade para superar a resist ncia s o listados e inclu dos. As c lulas cancer genas adaptam-se instantaneamente a cada condi o e as estrat gias das c lulas cancer genas s o discutidas.
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Om du var et menneske

Om du var et menneske

Sunniva M. Roligheten; Daniel A. Wilondja

Cappelen Damm
2024
sidottu
Om du var et menneske er en alvorlig, humoristisk, original og smertefull fortelling om et vennskap.Han arbeider i en gruve i Kongo, der det utvinnes mineraler til bruk i mobiltelefonene våre. Noen ganger raser gruvene sammen. En gang tjente han nok penger til å både kjøpe en skoleuniform til lillebroren og gi moren sin penger. Det var den beste dagen i hans liv.Hun jobber med en rapport om gruvedrift, og slik møtes de i Norge.De to blir venner, selv om de ikke deler språk og må kommunisere via Google translate. Hun får en vill idé: Hvis de skriver en bok sammen, kan han få penger til utdannelse, og de vil kunne studere sammen i Norge.Hva vet du om landet du skal til?det er et land med mye snø,det er styrt av en konge, og ikke en president,det ligger i Europa
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Middle-earth: From Script to Screen

Middle-earth: From Script to Screen

Daniel Falconer; Weta; K.M. Rice

Harper Collins UK
2017
sidottu
For the first time ever, the epic, in-depth story of the creation of one of the most famous fantasy worlds ever imagined, a richly illustrated compendium that reveals the breathtaking craftsmanship, artistry, and technology behind the magical Middle-earth of The Lord of the Rings and The Hobbit Motion Picture Trilogies, directed by Peter Jackson.
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Middle-Earth from Script to Screen: Building the World of the Lord of the Rings and the Hobbit

Middle-Earth from Script to Screen: Building the World of the Lord of the Rings and the Hobbit

Daniel Falconer; K. M. Rice

William Morrow Company
2026
sidottu
The epic, in-depth story of the creation of one of the most famous fantasy worlds ever imagined, a richly illustrated compendium that reveals the breathtaking craftsmanship, artistry, and technology behind the magical Middle-earth of The Lord of the Rings and The Hobbit Motion Picture Trilogies, directed by Peter Jackson. Middle-earth: From Script to Screen tells the complete story of how J.R.R. Tolkien's magic world was brought to vivid life on the big screen in the record-breaking film trilogies of The Lord of the Rings and The Hobbit. Drawing on resources, stories, and content from the archives of the companies and individuals behind the films, much of which have never appeared in print before, as well as interviews with director Peter Jackson and key members of the Art Department, Shooting Crews, Park Road Post, and Weta Digital teams who share their personal insights on the creative process, this astonishing resource reveals: How the worlds were built, brick by brick and pixel by pixel; How environments were extended digitally or imagined entirely as computer generated spaces; How the multiple shooting units functioned; How cast members and characters interacted with their environments. Daniel Falconer takes fans from storyboard concepts to deep into the post-production process where the films were edited, graded, and scored, explaining in depth how each enhanced the films. He also discusses how the processes involved in establishing Middle-earth for the screen have evolved over the fifteen years between the start and finish of the trilogies. Going region by region and culture by culture in this fantasy realm, Middle-earth: From Script to Screen describes how each area created for the films was defined, what made it unique, and what role it played in the stories. Illustrated with final film imagery, behind-the-scenes pictures and conceptual artwork, including places not seen in the final films, this monumental compilation offers unique and far-reaching insights into the creation of the world we know and love as Middle-earth.
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The Employee Assistance Treatment Planner

The Employee Assistance Treatment Planner

James M. Oher; Daniel J. Conti; Timothy J. Bruce

WILEY
2026
nidottu
Streamline EAP treatment planning with DSM 5-TR aligned documentation tools The Employee Assistance Treatment Planner, now in its Second Edition, equips mental health professionals with ready-to-use elements for creating formal treatment plans addressing problems that impair work performance. Authored by EAP specialists including the Director of a global, hybrid EAP that served a Fortune 15 company, this resource enables clinicians to quickly develop individualized plans from well-crafted, measurable descriptions. This updated edition incorporates DSM 5-TR content throughout, including revised behavioral definitions and diagnostic suggestions. New objectives, many consistent with empirically supported treatments, address therapeutic relationship building, plus the assessment of insight, motivation, comorbidity, cultural factors, and suicidality. Updated interventions reflect current evidence-based practice. Two new appendices compile bibliotherapy references and professional resources cited throughout the chapters. Key features include: Treatment plan construction recommendations guiding therapists in meeting third-party payer and JCAHO accreditation requirements for documentation Measurable objective statements and intervention options organized by presenting problems for efficient plan development Updated DSM 5-TR aligned behavioral definitions and diagnostic terminology reflecting current diagnostic standards and practices New therapeutic relationship objectives reflecting empirical support for the role of alliance building in optimizing treatment outcomes Comprehensive appendices providing bibliotherapy references and professional resources for continued clinical development The Employee Assistance Treatment Planner serves social workers, counselors, clinical psychologists, psychotherapists, and other mental health professionals working in employee assistance programs. This practical resource streamlines documentation while ensuring treatment plans meet accreditation standards and reflect current evidence-based therapeutic practices.
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Frequently Asked Questions about Alcohol Abuse and Binge Drinking

Frequently Asked Questions about Alcohol Abuse and Binge Drinking

Daniel E. Harmon; Henrietta M. Lily

Rosen Young Adult
2011
sidottu
Alcohol is the most commonly used and abused drug among teens in the U.S. Young people who binge drink are more likely to experience academic and social problems, physical illnesses, risky sexual activity, car crashes, and accidental injuries. Alcohol poisoning, which can cause unconsciousness or even death, brings many underage drinkers to the emergency room each year. This book explains the health problem clearly and arms teens to make smart choices about alcohol.
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Under the Oracle

Under the Oracle

Ben M. Ford; Daniel Poore; Ruth Shaffrey; David R. P. Wilkinson

Oxford University School of Archaeology
2013
sidottu
Excavations carried out by Oxford Archaeology in advance of the building of the Oracle shopping centre revealed a long sequence of development of the Kennet floodplain at Reading. This volume reports on the substantial evidence recovered for medieval and post-medieval water management, milling at the Minster Mill and St Giles Mill, the tanning, leather working and dyeing industries, and an unusual building interpreted as the 12th- to 13th-century cookhouse of Reading Abbey. The stories of two well-known Reading sites, the Oracle Workhouse and the Yield Hall, are followed from the medieval period up to the 19th century. Substantial specialist reports include pottery, glass, leatherworking, dendrochronology and clay pipes.
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Highway Engineering

Highway Engineering

Daniel J. Findley; Bastian Schroeder; Christopher M. Cunningham; Thomas H. Brown Jr

Butterworth-Heinemann Inc
2015
nidottu
This book helps readers maximize effectiveness in all facets of highway engineering including planning, design, operations, safety, and geotechnical engineering. Highway Engineering: Planning, Design, and Operations features a seven part treatment, beginning with a clear and rigorous exposition of highway engineering concepts. These include project development, and the relationship between planning, operations, safety, and highway types (functional classification). Planning concepts and a four-step process overview are covered, along with trip generation, equations versus rates, trip distribution, and shortest path models equations versus rates. This is followed by parts concerning applications for horizontal and vertical alignment, highway geometric design, traffic operations, traffic safety, and civil engineering topics.
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Model Checking

Model Checking

Edmund M. Clarke Jr.; Orna Grumberg; Daniel Kroening; Doron Peled; Helmut Veith

MIT Press
2018
sidottu
An expanded and updated edition of a comprehensive presentation of the theory and practice of model checking, a technology that automates the analysis of complex systems.Model checking is a verification technology that provides an algorithmic means of determining whether an abstract model-representing, for example, a hardware or software design-satisfies a formal specification expressed as a temporal logic formula. If the specification is not satisfied, the method identifies a counterexample execution that shows the source of the problem. Today, many major hardware and software companies use model checking in practice, for verification of VLSI circuits, communication protocols, software device drivers, real-time embedded systems, and security algorithms. This book offers a comprehensive presentation of the theory and practice of model checking, covering the foundations of the key algorithms in depth. The field of model checking has grown dramatically since the publication of the first edition in 1999, and this second edition reflects the advances in the field. Reorganized, expanded, and updated, the new edition retains the focus on the foundations of temporal logic model while offering new chapters that cover topics that did not exist in 1999: propositional satisfiability, SAT-based model checking, counterexample-guided abstraction refinement, and software model checking. The book serves as an introduction to the field suitable for classroom use and as an essential guide for researchers.
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Civil Society in Central Asia

Civil Society in Central Asia

M. Holt Ruffin; Daniel Waugh; S. Frederick Starr

University of Washington Press
1999
pokkari
Central Asia, known as the home of Tamerlane and the Silk Road, is a crossroads of great cultures and civilizations. In 1991 five nations at the heart of the region—Kazakstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan— suddenly became independent. Today they sit strategically between Russia, China, and Iran and hold some of the world's largest deposits of oil and natural gas. Long-suppressed ethnic identities are finding new expression in language, religion, and occasional civil conflicts.Civil Society in Central Asia is a pathbreaking collection of essays by scholars and activists that illuminates the social and institutional forces shaping this important region's future. An appendix provides a guide to projects being carried out by local and international groups.
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Civil Society in Central Asia

Civil Society in Central Asia

M. Holt Ruffin; Daniel Waugh; S. Frederick Starr

University of Washington Press
2015
sidottu
Central Asia, known as the home of Tamerlane and the Silk Road, is a crossroads of great cultures and civilizations. In 1991 five nations at the heart of the region—Kazakstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan— suddenly became independent. Today they sit strategically between Russia, China, and Iran and hold some of the world's largest deposits of oil and natural gas. Long-suppressed ethnic identities are finding new expression in language, religion, and occasional civil conflicts.Civil Society in Central Asia is a pathbreaking collection of essays by scholars and activists that illuminates the social and institutional forces shaping this important region's future. An appendix provides a guide to projects being carried out by local and international groups.
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Intr Hist Cameroon 19&20th Cent

Intr Hist Cameroon 19&20th Cent

Daniel Abwa; Emmanuel Chiabi; Derrick Jonathan; Lovett Zephaniph Elango; Verkijika Godfrey Fanso; M. Njeuma; Quinn Frederick

Macmillan Education
1989
nidottu
An explanation of the major events which, between 1809 and 1954 influenced small and scattered communities to unite into larger political entities. The studies touch on all aspects of the provinces of modern Cameroon at different periods in its varied history.
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Introduction to Computational Chemistry

Introduction to Computational Chemistry

John M. Galbraith; T. Daniel Crawford

Elsevier - Health Sciences Division
2026
nidottu
Introduction to Computational Chemistry provides a foundational, introductory overview of this critical and important field designed to give students a clear and supportive pathway. It is intended to be a non-mathematics heavy introduction to the methods used in computational chemistry, together with information about how HPC-style computers are set up and utilized for performing calculations. It also provides novel insight into the computational chemist mentality: sometimes, the way computational chemists operate can seem strange to someone not yet immersed in the field. The book starts with a basic discussion of computer functionality through operating systems, system administration, and programming followed by a look at the key computational methods for electronic structure methods and molecular mechanics, hybrid methods, and solid-state materials. For each subject, essential non-mathematical information is first provided so that the reader can immediately begin to effectively use computational chemistry software. This introductory material is followed by a section that provides more theoretical information and then references for the reader wishing to go much deeper. Often this type of book overloads the reader with too much information; this one is set up in such a way as to quickly present essential information regarding the fundamental approaches and applications of computational chemistry to beginners in a down to earth and uncluttered manner, while providing the means and resources for more advanced readers to explore further. Introduction to Computational Chemistry is written primarily for upper level undergraduate and entry level graduate students completely new to the field of computational chemistry, with little background knowledge; the book is well suited to entry level courses at this level.
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Patent Activity and Technical Change in US Industries

Patent Activity and Technical Change in US Industries

M. McAleer; Daniel Slottje; Pei Syn Wee

Elsevier Science Ltd
2005
sidottu
Description innovation is universally recognized as an important source of economic growth. Patents may be considered as a potential measure of innovation. As such, patents may alter isoquant maps, and measuring their elasticities is both intuitively and empirically appealing. This book investigates the impact of U.S.A. patent activity on technical change in 35 industries given in the KLEM (Jorgenson, 1996) data set for the period 1958-1996. Four patent variables, namely total patent applications, total patents granted, unsuccessful patent applications and foreign patents granted, are introduced as technology-changing parameters into the generalized Fechner-Thurstone (GFT) production function to determine the effect on the elasticity of the marginal rate of technical substitution (MRTS) between inputs of the GFT production function over time.It is found that all four patent variables have significant impacts on the marginal rates of technical substitution between various production inputs over time, with foreign patents granted being the most 'effective' parameter, and unsuccessful patent applications the least effective. In addition, the elasticity of the MRTS between materials and energy is found to be the most affected by patent activity, and that between materials and labor the least. The extent of technical change by patent activity varies across industries. Patent activity is found to be less effective as technology changes in some traditionally high patenting industries and more effective in others, which indicates that there are significant spillover effects of patents. Patent activity is found to have the greatest impact on technical change in the metal mining industry and the least impact in the chemicals industry.
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Tooth and Claw

Tooth and Claw

Robert M. Johnson; Sharon L. Gilman; Daniel Abel

PRINCETON UNIVERSITY PRESS
2023
sidottu
A marvelously illustrated look at the most deadly predators on the planetTooth and Claw presents the world’s top predators as you have never seen them before, from big cats and wild dogs to sharks, reptiles, and killer whales. Blending gorgeous photos and illustrations with spellbinding storytelling, this book is packed with the latest facts about these fearsome but often misunderstood animals. It covers apex and other top predators in each major vertebrate family, discussing where and how they live, how they are faring in the modern world, and why they matter. Along the way, the authors share informative and entertaining anecdotes from their decades in the field learning about predators and reveal hard truths about the role humans continue to play in their fate. Tooth and Claw also describes conservation successes and lays out some simple but crucial steps each of us can take to protect these magnificent beasts. Are humans top predators, too? Read this amazing book and find out.Offers an unparalleled look at a side of nature rarely witnessed up closeStunningly illustrated throughout and brimming with fun factsDescribes ultimate vertebrate predators ranging from sharks and reptiles to raptors, cats, dogs, bears, and marine mammalsProvides rare insights into the biology, ecology, and conservation of top predatorsDraws on the latest findings from habitats around the worldConveys the wonders of the natural world with engaging storytelling and lively personal anecdotes
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Distributed Situation Awareness

Distributed Situation Awareness

Paul M. Salmon; Neville A. Stanton; Daniel P. Jenkins

Ashgate Publishing Limited
2009
sidottu
Having an accurate understanding of what is going on is a key commodity for teams working within military systems. 'Situation awareness' (SA) is the term that is used within human factors circles to describe the level of awareness that operators have of the situation that they are engaged in; it focuses on how operators develop and maintain a sufficient understanding of 'what is going on' in order to achieve success in task performance. Over the past two decades, the construct has become a fundamental theme within the areas of system design and evaluation and has received considerable attention from the human factors research community. Despite this, there is still considerable debate over how SA operates in complex collaborative systems and how SA achievement and maintenance is best supported through system, procedure and interface design. This book focuses on the recently developed concept of distributed situation awareness, which takes a systems perspective on the concept and moves the focus on situation awareness out of the heads of individual operators and on to the overall joint cognitive system consisting of human and technological agents. Situation awareness is viewed as an emergent property of collaborative systems, something that resides in the interaction between elements of the system and not in the heads of individual operators working in that system. The first part of the book presents a comprehensive review and critique of existing SA theory and measurement approaches, following which a novel model for complex collaborative systems, the distributed SA model, and a new modelling procedure, the propositional network approach, are outlined and demonstrated. The next part focuses on real-world applications of the model and modelling procedure, and presents four case studies undertaken in the land warfare, multinational warfare and energy distribution domains. Each case study is described in terms of the domain in question, the methodology employed, and the findings derived in relation to situation awareness theory. The third and final part of the book then concentrates on theoretical development, and uses the academic literature and the findings from the case study applications to validate and extend the distributed SA model described at the beginning of the book. In closing, the utility of the distributed SA model and modeling procedure are outlined and a series of initial guidelines for supporting distributed SA through system design are articulated.
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Studying Children in Context

Studying Children in Context

M. Elizabeth Graue; Daniel J. Walsh

SAGE Publications Inc
1998
nidottu
What is the world like for todayÆs children? How do they construct meaning in it? Answering these key questions, Studying Children in Context explains the art and science of doing qualitative research involving children. Authors M. Elizabeth Graue and Daniel J. Walsh carefully discuss the research process, dealing succinctly with generic research issues yet emphasizing where work with children presents its own particular challenges. They look across the research enterprise in the first part of the book, conceptualizing it as a holistic activity. They next focus on fieldwork, and in the final section examine the interpreting and reporting aspects of qualitative research. In addition to presenting their own considerable experiences in fieldwork with children, Graue and Walsh also present the contributions of numerous researchers with their own insights on key issues. Studying Children in Context will be an invaluable addition to the libraries of teachers and researchers interested in qualitative research methods in general and in doing fieldwork with children in particular.
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