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1000 tulosta hakusanalla Gene Gurney

Guardians of the Jesus Gene

Guardians of the Jesus Gene

Peter R. Hall

Thames River Press
2013
nidottu
As Nero’s Rome burns, Christ’s brother, Simon, and Pontius Pilate’s daughter, Clodia, are thrown together in the war between Rome and Jerusalem. Their son, Joshua, is the genetic link to Jesus, an inheritance that makes him a target of satanic forces. Can Simon and Clodia save the blood line of the House of David? A marvellously rich recreation of the world’s first Christians and Nero’s Rome.
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Chromatin and Gene Regulation

Chromatin and Gene Regulation

Bryan M. Turner

Blackwell Science Ltd
2001
nidottu
Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors, and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes in their environment and also to the maintenance of gene expression patterns from one cell generation to the next. This book will be an invaluable guide to undergraduate and postgraduate students in the biological sciences and all those with an interest in the medical implications of aberrant gene expression.
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Signaling and Gene Expression in the Immune System

Signaling and Gene Expression in the Immune System

Not Available (NA)

Cold Spring Harbor Laboratory Press,U.S.
2000
nidottu
For the past two decades, much effort has been made to understand the complex interactions between lymphocytes and antigen-presenting cells that result in immune responses. Immunologists have identified an extraordinary diversity of cytokines as players in these interactions, some the products of cellular activation which themselves activate surrounding cells. Meanwhile, another community of investigators, interested in how genes turn on, were using lymphocytes as easily cultivated cells with which to study transcriptional regulation from a molecular perspective. Connections between these areas of study, with their quite different technical vocabularies and experimental approaches, were limited. The 64th Annual Cold Spring Harbor Symposium was therefore a particularly imaginative meeting, intended to provoke a dialogue on the nature of the membrane signals and intracytoplasmic events that provoke the generation of immunity. It did. The debate ranged over biochemistry, physiology, and molecular genetics as well as classical cellular immunology, involving over 70 of the world's leading investigators in a discussion described by the summarizer as the best he had ever attended.The book prompted by the meeting contains personal summaries of the contributions these investigators have made to their fields over the years, with reference to their most recently reported data. This volume therefore contains a remarkably fresh and original perspective on an important aspect of immunology that is necessary to understand in order to undertake rational manipulation of immune responses. All laboratories committed to the future of immunology should have this book, as well as investigators in gene regulation seeking a wide-ranging survey of results achieved with lymphocytes.
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Inventing the Thrifty Gene

Inventing the Thrifty Gene

Travis Hay; Teri Redsky Fiddler

University of Manitoba Press
2021
nidottu
Though First Nations communities in Canada have historically lacked access to clean water, affordable food, and equitable healthcare, they have never lacked access to well-funded scientists seeking to study them. The Science of Settler Colonialism examines the relationship between science and settler colonialism through the lens of “Aboriginal diabetes” and the thrifty gene hypothesis, which posits that Indigenous peoples are genetically predisposed to type-II diabetes and obesity due to their alleged hunter-gatherer genes. Hay’s study begins with Charles Darwin’s travels and his observations on the Indigenous peoples he encountered to set the context for Canadian histories of medicine and colonialism, which are rooted in Victorian science and empire. It continues in the mid-twentieth century with a look at nutritional experimentation during the long career of Percy Moore, the medical director of Indian Affairs (1946–1965). Hay then turns to James Neel’s invention of the thrifty gene hypothesis in 1962 and Robert Hegele’s reinvention and application of the hypothesis to Sandy Lake First Nation in northern Ontario in the 1990s. Finally, Hay demonstrates the way in which settler colonial science was responded to and resisted by Indigenous leadership in Sandy Lake First Nation, who used monies from the thrifty gene study to fund wellness programs in their community. The Science of Settler Colonialism exposes the exploitative nature of settler science with Indigenous subjects, the flawed scientific theories stemming from faulty assumptions of Indigenous decline and disappearance, as well as the severe inequities in Canadian healthcare that persist even today.
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Inventing the Thrifty Gene

Inventing the Thrifty Gene

Travis Hay; Teri Redsky Fiddler

University of Manitoba Press
2021
sidottu
Though First Nations communities in Canada have historically lacked access to clean water, affordable food, and equitable healthcare, they have never lacked access to well-funded scientists seeking to study them. The Science of Settler Colonialism examines the relationship between science and settler colonialism through the lens of “Aboriginal diabetes” and the thrifty gene hypothesis, which posits that Indigenous peoples are genetically predisposed to type-II diabetes and obesity due to their alleged hunter-gatherer genes. Hay’s study begins with Charles Darwin’s travels and his observations on the Indigenous peoples he encountered to set the context for Canadian histories of medicine and colonialism, which are rooted in Victorian science and empire. It continues in the mid-twentieth century with a look at nutritional experimentation during the long career of Percy Moore, the medical director of Indian Affairs (1946–1965). Hay then turns to James Neel’s invention of the thrifty gene hypothesis in 1962 and Robert Hegele’s reinvention and application of the hypothesis to Sandy Lake First Nation in northern Ontario in the 1990s. Finally, Hay demonstrates the way in which settler colonial science was responded to and resisted by Indigenous leadership in Sandy Lake First Nation, who used monies from the thrifty gene study to fund wellness programs in their community. The Science of Settler Colonialism exposes the exploitative nature of settler science with Indigenous subjects, the flawed scientific theories stemming from faulty assumptions of Indigenous decline and disappearance, as well as the severe inequities in Canadian healthcare that persist even today.
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Regulation of Immune Gene Expression

Regulation of Immune Gene Expression

Marc Feldmann; Andrew McMichael

Humana Press Inc.
1986
sidottu
This book encompasses the proceedings of a conference held at Trinity College, Oxford on September 21-25, 1985 organized by a committee comprised of Drs. M. Crumpton, M. Feldmann, A. McMichael, and E. Simpson, and advised by many friends and colleagues. The immune response gene workshops that took place were based on the need to understand why certain experimental animal strains were high responders and others were low responders. It was assumed that identification of the immune response (Ir) genes and definition of their products would explain high and low responder status. Research in the ensuing years has identified the Ir gene products involved in antibody responses as the la antigens, or MHC Class II antigens. These proteins are now well defined as members of the immunoglobulin gene superfamily, and their domain structure is known. Epitopes have been defined by multiple mono­ clonal antibodies and regions of hypervariability identified. Their genes have been identified and cloned. The basic observation of high and low responsive­ ness to antigen is still not understood in mechanistic terms, however, at either the cellular or molecular level. This is because the rate of progress in immune regulation has been far slower than in the molecular biology of the MHC Class II antigens. This is not surprising, since immune regulation is a very complex field at the crossroads of many disciplines.
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Protocols for Gene Analysis

Protocols for Gene Analysis

Humana Press Inc.
1994
nidottu
It is now twenty years since Cohen and Boyer's first steps into DNA cloning. In the time since then, there has been an ever increasing acc- eration in the development and application of the cloning methodology. With the recent development of the polymerase chain reaction, a second generation of the technology has been born, enabling the isolation of DNA (and in particular, genes) with little more information than the p- tial knowledge of the sequence. In fact, DNA sequencing is now so advanced that it can almost be carried out on the industrial scale. As a consequence of these advances, it now appears feasible to sequence whole genomes, including one the size of the human. What are we going to do with this information? The future of basic molecular biology must lie in the ability to analyze DNA (and especially the genes within it) starting at the DNA level. It is for these problems that Protocols for Gene Analysis attempts to offer solutions. So you have a piece of DNA, possibly a gene--what do you do next? The first section of this book contains a number of "basic" te- niques that are required for further manipulation of the DNA. This s- tion is not intended to be a comprehensive collection of methods, but merely to serve as an up-to-date set of techniques. I refer you to other volumes in the Methods Molecular Biology series for further rec- binant DNA techniques.
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Nonviral Vectors for Gene Therapy

Nonviral Vectors for Gene Therapy

Humana Press Inc.
2001
sidottu
The purpose of this volume of Methods in Molecular Medicine is to set forth examples of the great variety of techniques and applications that are now emerging in the field of nonviral gene therapy. The book emphasizes not only specific approaches to gene delivery but, in particular, the best current me- ods to prepare, handle, and characterize gene delivery agents. These topics are of very broad importance since gene therapy evolves from its mostly ac- emy-based experimental and clinical research to the ever increasing number of industry-driven programs directed toward commercial development. S- cessful introduction of nonviral gene therapy agents into the clinic should be expected to require rigorous manufacturing and analytical methods that readily meet the regulatory guidelines under which new drug candidates are reviewed for marketing approval. Exactly what those guidelines will prove to be c- tainly depends on the established guidelines for review of both biological and chemical therapeutics. Additionally, many new techniques are being devised and applied to gene therapy research; these techniques will be instrumental in developing and characterizing successful gene delivery agents. Nonviral Vectors for Gene Therapy: Methods and Protocols has two main sections. To start with, there is a series of chapters on specific protocols for the synthesis, characterization, and application of gene delivery agents. S- eral chapters address the topic of materials to bind with DNA to form the compact condensed phases that facilitate cellular delivery.
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Cardiac Cell and Gene Transfer

Cardiac Cell and Gene Transfer

Humana Press Inc.
2002
sidottu
Heart disease is the leading cause of death in developed countries. Recent experimental advances featuring cellular, molecular, and genetic tools and technologies offer the potential for new therapeutic strategies directed toward remediation of inherited and acquired heart diseases. Whether these recent basic science advances will ultimately translate to clinical efficacy for patients with heart disease is unknown and is important to ascertain. Cardiac Cell and Gene Transfer: Principles, Protocols, and Applications is designed to provide the reader with up-to-date coverage of a myriad of specific methodo- gies and protocols for gene and cell transfer to the myocardium. Each chapter features a “Notes” section that provides useful “how to” problem-solving insights that are often left unstated in standard published protocols. Cardiac Cell and Gene Transfer: Principles, Protocols, and Appli- tions addresses principles and applications of cell and gene transfer to the heart, including protocols for vector production and purification. Detailed step-by-step methods and applications for first/second-generation adenoviral vectors, adeno-associated vectors, gutted adenoviral vectors, and lentiviral vectors are included. Additionally, detailed methods for cardiac cell grafting and transplantation are provided, and these chapters highlight the prospects of cell-based therapies for cardiac repair. The book also covers specific in vivo techniques for cardiac gene transfer, and specifies subsequent cellular and organ-level physiological assessment techniques and protocols. Accordingly, this book is designed for basic science and clinical researchers in the academic, pharmaceutical, and biotechnology sectors of the cardiovascular community.
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A Silent Gene Theory Of Evolution

A Silent Gene Theory Of Evolution

Warwick Collins

The University of Buckingham Press
2009
sidottu
Charles Darwin wrote in The Origin of Species that "... unless profitable variations do occur, natural selection can do nothing." As Darwin recognised, natural selection reduces variation in favour of an optimum type. So, what is the true source of variation in evolutionary systems? This is a question which has obsessed Warwick Collins, a novelist who had studied biology at University and for much of his adult life.In March 2000, Collins claimed that the required degree of variation could be achieved if large numbers of inert or silent genes existed within the genome. Such genes, because they do not code for physical characteristics, could freely mutate over time without deleteriously affecting the host organism. At a later stage they could be switched on, by largely random processes, and generate exotic new variants. Remarkably, his description of silent genes was found to correspond precisely with the so-called junk genes. Just as Collins predicted, the vast majority of significant mutation in the genomes of complex species arises from the silent genes. But Collins' powerful and ambitious theory moves well beyond the molecular realm. He argues that while natural selection is a major force in evolution, the great driver of complex evolution is the range of variation created by the silent genes. As Professor Donald Braben writes in his illuminating foreword, "Collins is proposing a general evolutionary theory which, if it continues to be supported by the data, may in due course come to rival Darwin's theory that evolution is driven by natural selection."
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The Alien Gene

The Alien Gene

Moira McGhee

Independent Network of UFO Researchers
2020
pokkari
The Alien Gene provides a comprehensive review of humanoid type visitors to Earth, and the genetic manipulation of particular families, from United States, Britain, Australia and other countries over the last century.
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The Quantum Love Gene: Evolve or perish Which will you choose?

The Quantum Love Gene: Evolve or perish Which will you choose?

Raymond J. Pilon

Anchor Counseling
2013
nidottu
The Quantum Love Gene by Raymond J. Pilon, is a spellbinding inspirational science fiction novel. The Quantum Love Gene is a book based on 41 consecutive dreams that the Author had; the premise being that we are all "Spirit Beings" and that we evolved from an ancient Alien civilization called the Pleiadians that actually traveled to earth and inhabited our planet some 26,000 years ago.
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The Angelic Gene

The Angelic Gene

Steve Goodwin

Software Development Pty, Limted
2013
nidottu
An orphan girl unsure of who she is or why a man wants her dead carries a secret. She will experience humanity. Are you ready? Join Sophia in a heart thumping adventure across England set in the 1870's, exploring faith, doubt, love and fear. A story, quoted by the editor as "really something special", you'll continue to contemplate long after the journey unfolds.
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