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1000 tulosta hakusanalla Peter G Drake

RNA: Computational Methods for Structure, Kinetics, and Rational Design

RNA: Computational Methods for Structure, Kinetics, and Rational Design

Peter G. Clote

TAYLOR FRANCIS LTD
2026
nidottu
Comprising two volumes, RNA: Computational Methods for Structure, Kinetics, and Rational Design is a comprehensive treatment of computational methods concerning the secondary structure, folding kinetics and rational design of RNA. Volume 2 covers secondary structure folding kinetics, starting with an inquiry into whether the ensemble of RNA structures is small-world or scale-free, then proceeding to the identification of local energy minima that create a basin of attraction, leading to a coarse-grained kinetics model. The book describes Markov state models created from secondary structure folding trajectories generated by the kinetic Monte Carlo (Gillespie) algorithm, the first such application. Python code is available at the book’s website, allowing research teams to use the code and extend the approach. Current RNA research concerns the rational design of functional RNA molecules, which The book provides an overview and comparison of various inverse folding algorithms, combinatorial optimization, and the question of whether inverse folding is computationally hard (NP-complete). Another chapter focuses on various types of designed RNA including ribozymes, RNA thermometers, bistable switches, toehold switches, mRNA vaccines, and paper-based COVID-19 tests. The final chapter is a math appendix for the linear algebra and Markov chain results that are essential to folding kinetics. This book provides the nuts, bolts and tools for the next generation of computational work on RNA, especially for the rational design of functional molecules – a topic that not so long ago seemed more like science fiction. Exercises at the end of each chapter introduce new material or related concepts, and solutions are available at the book’s website. It is perfect for advanced undergraduate, graduate and post-graduate readers having analytical interests and skills from areas such as physical chemistry, physics, mathematics, computer science, and statistics.
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RNA: Computational Methods for Structure, Kinetics, and Rational Design

RNA: Computational Methods for Structure, Kinetics, and Rational Design

Peter G. Clote

TAYLOR FRANCIS LTD
2026
sidottu
Comprising two volumes, RNA: Computational Methods for Structure, Kinetics, and Rational Design is a comprehensive treatment of computational methods concerning the secondary structure, folding kinetics and rational design of RNA. Volume 2 covers secondary structure folding kinetics, starting with an inquiry into whether the ensemble of RNA structures is small-world or scale-free, then proceeding to the identification of local energy minima that create a basin of attraction, leading to a coarse-grained kinetics model. The book describes Markov state models created from secondary structure folding trajectories generated by the kinetic Monte Carlo (Gillespie) algorithm, the first such application. Python code is available at the book’s website, allowing research teams to use the code and extend the approach. Current RNA research concerns the rational design of functional RNA molecules, which The book provides an overview and comparison of various inverse folding algorithms, combinatorial optimization, and the question of whether inverse folding is computationally hard (NP-complete). Another chapter focuses on various types of designed RNA including ribozymes, RNA thermometers, bistable switches, toehold switches, mRNA vaccines, and paper-based COVID-19 tests. The final chapter is a math appendix for the linear algebra and Markov chain results that are essential to folding kinetics. This book provides the nuts, bolts and tools for the next generation of computational work on RNA, especially for the rational design of functional molecules – a topic that not so long ago seemed more like science fiction. Exercises at the end of each chapter introduce new material or related concepts, and solutions are available at the book’s website. It is perfect for advanced undergraduate, graduate and post-graduate readers having analytical interests and skills from areas such as physical chemistry, physics, mathematics, computer science, and statistics.
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Delegation in Local Government

Delegation in Local Government

Peter G. Richards

TAYLOR FRANCIS LTD
2024
sidottu
Originally published in 1956, this book outlines the history of delegation in local government since the establishment of county councils in 1888. It describes the use made of delegation over a wide range of council services. The technique of delegation has become more important in recent years and represents the compromise of the competing claims of county and district councils to control local government. This book is an important contribution both to the detailed study of local administration and to the debate on the future pattern of local government.
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Delegation in Local Government

Delegation in Local Government

Peter G. Richards

TAYLOR FRANCIS LTD
2026
nidottu
Originally published in 1956, this book outlines the history of delegation in local government since the establishment of county councils in 1888. It describes the use made of delegation over a wide range of council services. The technique of delegation has become more important in recent years and represents the compromise of the competing claims of county and district councils to control local government. This book is an important contribution both to the detailed study of local administration and to the debate on the future pattern of local government.
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The New Local Government System

The New Local Government System

Peter G. Richards

TAYLOR FRANCIS LTD
2024
sidottu
Originally published in 1956, this book outlines the history of delegation in local government since the establishment of county councils in 1888. It describes the use made of delegation over a wide range of council services. The technique of delegation has become more important in recent years and represents the compromise of the competing claims of county and district councils to control local government. This book is an important contribution both to the detailed study of local administration and to the debate on the future pattern of local government.
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The New Local Government System

The New Local Government System

Peter G. Richards

TAYLOR FRANCIS LTD
2026
nidottu
Originally published in 1956, this book outlines the history of delegation in local government since the establishment of county councils in 1888. It describes the use made of delegation over a wide range of council services. The technique of delegation has become more important in recent years and represents the compromise of the competing claims of county and district councils to control local government. This book is an important contribution both to the detailed study of local administration and to the debate on the future pattern of local government.
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Parliament and Conscience

Parliament and Conscience

Peter G. Richards

TAYLOR FRANCIS LTD
2024
sidottu
Originally published in 1970, this book has a dual purpose. Firstly, it is a study of how Parliament works when the party whips are withdrawn. The author shows how backbenchers can create legislation of great importance; he demonstrates the obstacles, political and procedural to social reform; he relates the votes of MPs to their personal characteristics e.g. age, religion and occupation, and he argues that Parliament achieves a fresh vigour and authority when MPs think and act independently of party policy. Secondly, Parliament and Conscience analyses 6 major controversies in British society in the late 20th Century: the death penalty, homosexuality, abortion, theatre censorship, divorce and Sunday entertainment.
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Parliament and Conscience

Parliament and Conscience

Peter G. Richards

TAYLOR FRANCIS LTD
2026
nidottu
Originally published in 1970, this book has a dual purpose. Firstly, it is a study of how Parliament works when the party whips are withdrawn. The author shows how backbenchers can create legislation of great importance; he demonstrates the obstacles, political and procedural to social reform; he relates the votes of MPs to their personal characteristics e.g. age, religion and occupation, and he argues that Parliament achieves a fresh vigour and authority when MPs think and act independently of party policy. Secondly, Parliament and Conscience analyses 6 major controversies in British society in the late 20th Century: the death penalty, homosexuality, abortion, theatre censorship, divorce and Sunday entertainment.
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The Reformed Local Government System

The Reformed Local Government System

Peter G. Richards

TAYLOR FRANCIS LTD
2024
sidottu
Originally published in 1973 and revised as a third edition in 1978, this book provides a concise introductory account of the system of local administration since the Local Government Act of 1972 produced the most-far-reaching change in England and Wales since 1888. The book shows why such a major shake-up was necessary, and how the policies evolved which produced the new pattern of local authorities. The book contains basic factual material about the constitution and powers of the new councils and discusses the major problems which confront them. It also considers the respective roles of councillors officials and the political circumstances within which local government has to work.
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The Reformed Local Government System

The Reformed Local Government System

Peter G. Richards

TAYLOR FRANCIS LTD
2026
nidottu
Originally published in 1973 and revised as a third edition in 1978, this book provides a concise introductory account of the system of local administration since the Local Government Act of 1972 produced the most-far-reaching change in England and Wales since 1888. The book shows why such a major shake-up was necessary, and how the policies evolved which produced the new pattern of local authorities. The book contains basic factual material about the constitution and powers of the new councils and discusses the major problems which confront them. It also considers the respective roles of councillors officials and the political circumstances within which local government has to work.
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Archaeology Versus Metal Detecting

Archaeology Versus Metal Detecting

Peter G. Spackman

PEN SWORD BOOKS LTD
2024
sidottu
This book offers a no-holds-barred insight into the often passionate, sometimes controversial, subject of tension and mistrust between the worlds of archaeology and metal detecting with the intent of shedding new light upon and bringing into the open some of the working practices, procedures and thoughts which have fuelled an ill-wind that flurries through levels of archaeological academia. Beginning in the mists of history, the author explores the birth of archaeological investigation from a Kings search, the grave robbers, through the antiquarian collectors, museum artefact collections through to a profession which appears these days to rely upon the construction industry and its commercialism for survival. Integrating various sources of information to highlight analytical information as well cultural, social, and economic intervention to form an unbiased argument. The later appearance of metal detecting as a hobby which fired discontent, distrust, and deliberate efforts to either govern or ban the hobby. This distrust is echoed by the author’s extensive research which uncovered a deep-set denial of the use, by archaeologists, of an innovative invention which has become an essential tool for artefact recovery, the metal detector. This hobby, also listed as a sport, boasts a practitioner membership of over thirty-five thousand in the UK alone, the history of which is covered in depth from the development of electro-magnetism, leading to an ever-increasing number of inventions, including machines for the detection of explosive devices which morphed into the metal detector as we know it today.
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Making the Enfield Pattern 1853 Rifle-Musket

Making the Enfield Pattern 1853 Rifle-Musket

Peter G. Smithurst

PEN SWORD BOOKS LTD
2025
sidottu
The Pattern 1853 Enfield Rifle Musket embodies a number of revolutionary milestones for Britain; it, and the carbines and short rifles derived from it, were the first rifled firearms to be issued universally to all troops; its design owed more to the French 1777 musket than to its English forbears; it was the first firearm to be produced en masse extensively by machinery; in 1857 it became the first firearm in Britain to be made fully interchangeable. The nature of this new rifle presented a number of challenges for the private contractors who traditionally had supplied military firearms and some unique contract documents specifying standards are shown. Their failure to meet contractual obligations led to the formation of the Select Committee on Small Arms in 1854 to examine its manufacture and procurement. However, its outcome was pre-empted - in that same year the Committee on the Machinery of the United States, was sent to America to examine the machinery used in gun manufacture and given authority to purchase appropriate machines for use at Enfield. Aspects of its manufacture at Enfield are covered in a small number of contemporary accounts. These vary in the detail provided and contain errors which have been noted and corrected. Access to a wealth of specimens, drawings and documents not previously studied or published, has allowed the manufacture of this iconic rifle using these new technologies to be presented in unprecedented detail.
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The Evolution of Gun Making

The Evolution of Gun Making

Peter G. Smithurst

PEN SWORD BOOKS LTD
2024
sidottu
A variety of factors surround military firearms – they needed to be produced in large numbers to a standardised pattern at an affordable price. This books examines the transition from traditional hand-craft methods to the beginnings of mechanised manufacture using as examples the French Model 1777 and the Russian Model 1808 infantry muskets. A number of factors led to this choice. The French Model 1777 musket, designed by Honoré Blanc working under General Gribeauval, contained many novel features which became blueprints for the arms of numerous countries and was copied in its entirety by Russia. Another factor is that they are the only firearms whose manufacture is covered in contemporary accounts. A third factor is that they provide contrasts in their methods of manufacture; the French 1777 musket was largely produced by hand-craft methods, whereas in Russia we see the beginnings of extensive mechanisation in the early 19th century. Another important aspect which appears is ‘interchangeability’ – the ability to exchange identical parts of identical mechanism without ‘special adjustment’. This is a vital factor at the foundation of modern manufacturing and first appears in early 18th century France, was pursued again by Blanc in 1777 and was picked up in Russia. For the first time, all these ‘technologies’ are examined, explained, compared and contrasted in extensive detail.
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The Evolution of Socket Bayonet Manufacture

The Evolution of Socket Bayonet Manufacture

Peter G. Smithurst

PEN SWORD BOOKS LTD
2025
sidottu
In the case of military muskets and rifles the bayonet was, and still is, an integral part of the ‘weapon system’. There are many excellent books covering the history of the bayonet in its myriad varieties adopted and used by the armed forces of the world. These books provide a wealth of detail on national variations and often include many rare, and in some instances, bizarre bayonets. They focus on the end of the bayonet’s story and do not cover its beginning – the conversion of more or less amorphous pieces of iron and steel into finished products. That is the focus of this publication. It might be asked why, out of all the bayonets of the world, these three have been selected since at first sight they appear very ordinary and mundane when compared with some of their more ‘exotic’ brethren. However, as with the arms they were fitted to and whose manufacture has been covered in two earlier companion volumes, they are the only bayonets whose manufacture is described in varying degrees of detail in contemporary publications. They also share another kinship since, like the weapons they fitted, the Russian M.1808 is a direct copy, and the Enfield Pattern 1853 bayonet a descendant of, the French M.1777. This bayonet was a major landmark in socket bayonet design. It may be distasteful and not something to be contemplated lightly, but the socket bayonet’s function at the end of a musket was to penetrate the body of an enemy in close combat. Earlier bayonets having a plain mortice or ‘zig-zag’ slot engaging with a stud on the barrel to hold them in place, might easily be removed from the musket by one or other of the adversaries twisting it in the wrong direction. Honoré Blanc’s design, with its medial locking ring, prevented such accidental removal and became the prototype for many, if not all, socket bayonets which followed through to the end of the 19th century.
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Leadership - International Student Edition

Leadership - International Student Edition

Peter G. Northouse

SAGE PUBLICATIONS INC
2021
muu
The market-leading Leadership: Theory and Practice by Peter G. Northouse presents an academically robust account of the major theories and models of leadership with a focus on how theory can inform practice. Case studies and questionnaires provide students with practical examples and opportunities to deepen their understanding of their own leadership style. The fully updated Ninth Edition features a new chapter on inclusive leadership, 17 new real-world cases that profile leaders from across the globe, a new discussion on leadership and morality, and examples of timely issues such as leadership during the COVID-19 pandemic. Key features include: A consistent chapter structure that outlines each approach and the major studies behind them, presents strengths and criticisms for each approach, and provides case studies and a self-assessment questionnaire at the end of each chapter, allowing students to easily compare and contrast the various theories.Three case studies in each chapter help students to apply leadership concepts in real-world scenarios.Self-assessments within each chapter provides self-assessment and reflection opportunities for each theory presented.
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Introduction to Leadership - International Student Edition

Introduction to Leadership - International Student Edition

Peter G. Northouse

SAGE PUBLICATIONS INC
2024
nidottu
Includes new chapter on Working with Groups! The Sixth Edition of Peter G. Northouse’s best-selling Introduction to Leadership: Concepts and Practice provides readers with a clear, concise overview of the complexities of practicing leadership and concrete strategies for becoming better leaders. The text is organized around key leader responsibilities such as creating a vision, engaging strengths, and managing conflict. Case studies, self-assessment questionnaires, observational exercises, and reflection and action worksheets engage readers to apply leadership concepts to their own lives. Grounded in leadership theory and the latest research, the fully updated, highly practical Sixth Edition includes a new chapter on working with groups, 2 new cases, and 6 new Leadership Snapshots.
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Leadership - International Student Edition

Leadership - International Student Edition

Peter G. Northouse

Sage Publications Inc Ebooks
2025
muu
Now with a new chapter on Social Identity Leadership! Adopted in thousands of courses in 89 countries and translated into 15 different languages, this market-leading text successfully combines an academically robust account of the major theories and models of leadership with an accessible style and focus on how leadership theory can inform leadership practice. Peter G. Northouse uses a consistent structure for each chapter, allowing readers to easily compare and contrast different theories. Case studies and questionnaires provide students with practical examples and opportunities to deepen their understanding of their own leadership style.
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Leadership Case Studies in Education

Leadership Case Studies in Education

Peter G. Northouse; Marie E. Lee

Sage Publications, Inc
2025
nidottu
Leadership Case Studies in Education 4th Edition by Peter G. Northouse and Marie Lee applies leadership theories in educational settings. Designed to be used alongside Leadership: Theory and Practice 10th Edition, this casebook provides relevant, substantive, and contemporary case studies on leadership issues in Higher Education and K-12 Education. Each of the 32 case studies include critical thinking questions that encourage students to apply leadership theory and concepts to real-life situations. Engaging, practical, and relevant, Leadership Case Studies in Education is the perfect companion for educational leadership courses. New cases explore social identity leadership and team leadership theories, with examples including the challenges of teaching virtually during the COVID-19 pandemic, the formation of a union of college adjunct professors, and a high school′s challenge in changing their offensive school mascot symbol.
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