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The Role of Microbes in Common Non-Infectious Diseases

The Role of Microbes in Common Non-Infectious Diseases

I.W. Fong

Springer-Verlag New York Inc.
2016
nidottu
This new volume in the series Emerging Infectious Diseases of the 21st Century is a novel book on the role of microbes in the pathogenesis of common and disabling non-infectious diseases. New insights have emerged over the past several years suggesting that our commensal microflora of the gut is extremely important in regulating physiological and immune functions of the body. Covered are the perturbations of the normal composition of our endogenous microbiota, influenced by diet and genetic predispositions, as well as the mechanisms to produce common disorders such as obesity, diabetes, irritable bowel syndrome, colon cancer and atherosclerotic vascular diseases. Also explored is the evidence suggesting that predisposition to increasingly common afflictions such as asthma and multiple sclerosis is influenced, in combination with our genetic composition, by early life exposure to environmental microbes and the time of onset of common viral infections. Chapters provide the most recent information on these disorders with regards to epidemiology, current concepts on pathogenesis and mechanisms of their biology, recent research and data on the role of microbes, analysis of their validity and conclusive remarks and areas for future research.The Role of Microbes in Common Non-Infectious Diseases is an excellent resource for both physicians and investigators from a broad range of disciplines that will help to stimulate new concepts of disease pathogenesis and lead to the unraveling of their mechanisms of diseases and to novel treatments.
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Children of the Shell

Children of the Shell

I W Hulke

Christian Faith Publishing, Inc.
2017
pokkari
In a distant future, a seventeen-year-old girl named Veena has lived out her entire life inside of a Dyson sphere, an enormous mega structure large enough to encapsulate an entire star. Everybody she's ever known and her entire civilization exist on the sphere's interior surface. Nobody enters the sphere and no one ever leaves.For twenty million years, trillions of people have inhabited the interior of the sphere with only rumor and legend explaining the shell's origins and the mysterious Sphere Builders themselves, but with a growing resistance to the sphere's designed origins spreading, those who believe in the universe beyond the shell and a Creator are only met with persecution.Some within the sphere say nothing exists outside of the shell, no space, no universe, and no Creator, but Veena and her father are among the few who possess an unwavering conviction that there is an Outside and more.But after Veena suffers an enormous emotional loss and a close personal betrayal, and with poverty, starvation, and illnesses all threatening to destroy her family, Veena is eventually forced to make a choice--either watch her family be destroyed, or do the unthinkable . . . Embrace both faith and forgiveness and embark upon the greatest adventure of mankind, first in hopes of saving her family from starvation and sickness, but later from a horrifying and unseen natural threat.
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Children of the Shell

Children of the Shell

I W Hulke

Christian Faith Publishing, Inc.
2017
sidottu
In a distant future, a seventeen-year-old girl named Veena has lived out her entire life inside of a Dyson sphere, an enormous mega structure large enough to encapsulate an entire star. Everybody she's ever known and her entire civilization exist on the sphere's interior surface. Nobody enters the sphere and no one ever leaves.For twenty million years, trillions of people have inhabited the interior of the sphere with only rumor and legend explaining the shell's origins and the mysterious Sphere Builders themselves, but with a growing resistance to the sphere's designed origins spreading, those who believe in the universe beyond the shell and a Creator are only met with persecution.Some within the sphere say nothing exists outside of the shell, no space, no universe, and no Creator, but Veena and her father are among the few who possess an unwavering conviction that there is an Outside and more.But after Veena suffers an enormous emotional loss and a close personal betrayal, and with poverty, starvation, and illnesses all threatening to destroy her family, Veena is eventually forced to make a choice--either watch her family be destroyed, or do the unthinkable . . . Embrace both faith and forgiveness and embark upon the greatest adventure of mankind, first in hopes of saving her family from starvation and sickness, but later from a horrifying and unseen natural threat.
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New Antimicrobials: For the Present and the Future

New Antimicrobials: For the Present and the Future

I.W. Fong

Springer International Publishing AG
2023
sidottu
This is a timely and essential companion to the recently published Antimicrobial Resistance in the 21st Century, Second Edition. Antimicrobial resistance is a major threat to global population health, with government reports projecting it could result in over 10 million deaths in the next 35 years. Development of new agents to combat this threat is one of the WHO's top priorities, but in 2017, it conceded that the current drug development pipeline was insufficient to mitigate the threat. This book discusses recent progress and bolster new agent discovery and development, by providing researchers and students who will soon enter the field with a thorough guide to the advancements made in the last decade. Coverage includes new systemic antimicrobials approved since 2010, with detailed analysis of antibiotics, antivirals, antifungals, and antiparasitics, as well as agents in development for future use. Discussion of each drug will include its chemical nature, pharmacology/pharmacokinetics, antimicrobial spectrum, dosage, adverse reactions, drug interactions, microbial resistance, indications, clinical efficacy compared to older agents, and lists of similar agents with cost comparison. This volume is designed for researchers and students of infectious disease and medical microbiology, as well as clinicians in need of a comprehensive guide to newly developed agents.
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Ergometrie

Ergometrie

I.-W. Franz

Springer-Verlag Berlin and Heidelberg GmbH Co. K
1984
nidottu
Ergometrische Untersuchungen haben sich zum Nachweis und zur Einschlitzung des Schweregrades der koronaren Herzkrank- heit in Klinik und Praxis weltweit durchgesetzt. Der Hauptgrund hierfiir diirfte sein, daB dieses Testverfahren bei richtiger Metho- dik reproduzierbare und vergleichbare Ergebnisse gewiihrleistet und den Untersucher schnell und ohne groBen apparativen Auf- wand objektiv informiert. 1m Vergleich zur koronaren Herzkrankheit wird eine ergometri- sche Untersuchung zur Einschiitzung der Hochdruckkrankheit noch wesentlich seltener durchgefUhrt. Bedenkt man jedoch, daB der Ruheblutdruck groBen Schwankungen unterliegt und beson- ders bei der milden Hypertonie mal erhOht aber auch grenzwertig bis normal ausfallen kann, so bietet sich die Ergometrie aufgrund der Reproduzierbarkeit der Ergebnisse auch besonders zur Dia- gnostik der grenzwertigen und labilen_Hypertonie an. Hinzu- kommt, daB es aufgrund tierexperimenteller Befunde, theoreti- scher Uberlegungen aber vor allen Dingen auch neuerer klini- scher Studien sehr wahrscheinlich ist, daB die akuten und chronischen Folgeerkrankungen nicht nur durch den Ruheblut- druck, sondem wesentlich auch durch die Blutdruckanstiege bei alltiiglichen physischen und psychischen Belastungen bestimmt werden. Da diese Blutdruckreaktionen durch eine ergometrische Untersuchung besser abgeschiitzt werden konnen, kommt der Er- gometrie auch eine prognostische Bedeutung zu. Ziel dieses Buches solI es sein, nicht nur auf die Bedeutung einer Ergometrie bei Hypertonie- und Koronarkranken hinzuweisen, sondem vor allen Dingen in kurzer iibersichtlicher Form eine praxisorientierte Durchfiihrung und richtige Bewertung zu er- leichtem. Grundvoraussetzung hierfiir ist die Kenntnis einer exakten ergo- metrischen Methodik fUr deren Standardisierung sich Prof. H.
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Ergometrie bei Hochdruckkranken

Ergometrie bei Hochdruckkranken

I.-W. Franz; P. Schölmerich

Springer-Verlag Berlin and Heidelberg GmbH Co. K
2014
nidottu
In den letzten beiden lahrzehnten sind der praktischen Medizin zu ihrer kurati- yen Funktion in gro13erem Umfang als friiher Aufgaben zugefallen, die unter dem Begriff "vorbeugende Gesundheitspflege" zusammengefa13t werden. Diese Entwicklung steht mit dem Wandel des Krankheitspanoramas in engem Zusam- menhang. In den okonomisch hoch entwickelten Uindern ist die durch Infekti- onskrankheiten bedingte Erkrankungsziffer stark zuriickgedrangt worden, auf der anderen Seite haben aber die verschiedenen Spielarten der Arteriosklerose, bestimmte Tumorerkrankungen und sogenannte funktionelle Syndrome den Charakter von Massenerscheinungen angenommen. Systematische epidemiologische Untersuchungen fUhrten zum Konzept der Ri- sikofaktoren, d. h. bestimmter exogener oder endogener Faktoren, deren Aus- schaltung im Idealfall die Manifestation einer Krankheit vermeiden oder aber sie im spateren Lebensablauf oder in milderer Form manifest werden la13t. Diese Gesichtspunkte haben gro13e soziookonomische und sozialmedizinische Bedeu- tung, wie sich aus allen Statistiken uber die Ursache von Arbeitsunfahigkeit und Friihberentung, sowie den Anteil verschiedener Erkrankungen an der Gesamt- sterblichkeit ergibt. Eine wirksame Vermeidung von Krankheiten durch primare Praevention (Aus- schaltung der Krankheitsursachen) oder eine Friiherfassung von Erkrankungs- symptomen (sekundare Praevention), die zur Friihbehandlung fUhrt, batten umso gro13ere Bedeutung als fUr einen Gro13teil der genannten Krankheitsfor- men nur symptomatische Behandlungsverfahren zur VerfUgung stehen, nicht aber kausal wirksame.
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New Antimicrobials: For the Present and the Future

New Antimicrobials: For the Present and the Future

I.W. Fong

Springer International Publishing AG
2024
nidottu
This is a timely and essential companion to the recently published Antimicrobial Resistance in the 21st Century, Second Edition. Antimicrobial resistance is a major threat to global population health, with government reports projecting it could result in over 10 million deaths in the next 35 years. Development of new agents to combat this threat is one of the WHO's top priorities, but in 2017, it conceded that the current drug development pipeline was insufficient to mitigate the threat. This book discusses recent progress and bolster new agent discovery and development, by providing researchers and students who will soon enter the field with a thorough guide to the advancements made in the last decade. Coverage includes new systemic antimicrobials approved since 2010, with detailed analysis of antibiotics, antivirals, antifungals, and antiparasitics, as well as agents in development for future use. Discussion of each drug will include its chemical nature, pharmacology/pharmacokinetics, antimicrobial spectrum, dosage, adverse reactions, drug interactions, microbial resistance, indications, clinical efficacy compared to older agents, and lists of similar agents with cost comparison. This volume is designed for researchers and students of infectious disease and medical microbiology, as well as clinicians in need of a comprehensive guide to newly developed agents.
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Fluid Flow in Discontinuous Rocks

Fluid Flow in Discontinuous Rocks

C.h. Lee; I.W. Farmer

Chapman and Hall
1993
sidottu
This is the first book to consider rock discontinuity systems and individual discontinuities as the controlling factors determining fluid flow through rocks. It develops simple usable fracture flow models based on an understanding of discontinuity structure and the mechanics of rock and discontinuity deformation.
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Principles of Engineering Geology

Principles of Engineering Geology

P.B. Attewell; I.W. Farmer

Springer
2011
nidottu
'Engineering geology' is one of those terms that invite definition. The American Geological Institute, for example, has expanded the term to mean 'the application of the geological sciences to engineering practice for the purpose of assuring that the geological factors affecting the location, design, construction, operation and mainten­ ance of engineering works are recognized and adequately provided for'. It has also been defined by W. R. Judd in the McGraw-Hill Encyclopaedia of Science and Technology as 'the application of education and experience in geology and other geosciences to solve geological problems posed by civil engineering structures'. Judd goes on to specify those branches of the geological or geo-sciences as surface (or surficial) geology, structural/fabric geology, geohydro­ logy, geophysics, soil and rock mechanics. Soil mechanics is firmly included as a geological science in spite of the perhaps rather unfortunate trends over the years (now happily being reversed) towards purely mechanistic analyses which may well provide acceptable solutions for only the simplest geology. Many subjects evolve through their subject areas from an interdisciplinary background and it is just such instances that pose the greatest difficulties of definition. Since the form of educational development experienced by the practitioners of the subject ulti­ mately bears quite strongly upon the corporate concept of the term 'engineering geology', it is useful briefly to consider that educational background.
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S.W.I.T.C.H:Chameleon Chaos

S.W.I.T.C.H:Chameleon Chaos

Ali Sparkes

Oxford University Press
2012
nidottu
Petty Potts' most recent reptoSWITCH spray doesn't seem to be working . . . not that Josh and Danny were all that excited about being chameleons anyway-alligators would be way better! Plus, they're distracted by the mystery of who is sending them clues to find marbles filled with scientific code. But at school the next day, time seems to be going too fast for the twins, and when one of Danny's eyeballs rolls right round in its socket, they know things are getting weird. While Danny is distracted by the leafy coolness of his teacher's pot plant, Josh is causing a stir in PE, escaping the class bullies by climbing right up to the top of the gym ropes! How long will it be before the boys are boys again? And will they be able to find the next marble (and get their own back on those bullies) in the meantime?
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W.I.T.C.H. Part 2, Vol. 2

W.I.T.C.H. Part 2, Vol. 2

Yen Press
2018
nidottu
Desperate to reclaim the power of Heart, Nerissa and her Knights of Vengeance deploy put their schemes into motion, and the W.I.T.C.H. girls and their friends won't escape unscathed... Could this be their first true failure as Guardians?
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