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183 tulosta hakusanalla Gomathi Swaminathan

Development and Assessment of an Emulgel with Melissa Officinalis Oil

Development and Assessment of an Emulgel with Melissa Officinalis Oil

Gomathi Swaminathan; S Manodhini Elakkiya; R Kalirajan

Lap Lambert Academic Publishing
2024
pokkari
Lemon balm (Melissa officinalis) is an aromatic herb from the mint family (Lamiaceae), known for its lemon-scented leaves. Essential oils derived from lemon balm contain plant compounds called terpenes, which contribute to the herb's relaxing and antimicrobial effects. Lemon balm also contains tannins, which may be responsible for many of its antimicrobial properties. Pre-formulation studies on lemon balm oil revealed that it is a pale-yellow volatile liquid with a lemon-like odor. Preliminary phytochemical screening has identified the presence of phenols, flavonoids, aldehydes, and volatile oils. An emulgel was prepared by incorporating an oil-in-water (O/W) emulsion into a gelling agent. The prepared emulgel was evaluated based on various parameters, including physical appearance, homogeneity, grittiness, and in-vitro antimicrobial activity. Based on the results, a Melissa officinalis oil emulgel was formulated. The prepared formulations exhibited prolonged release, which can reduce the frequency of administration. Additionally, the emulgel demonstrated antimicrobial activity.
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Biological Evaluation of Benzimidazole Derivatives

Biological Evaluation of Benzimidazole Derivatives

Gomathi Swaminathan; L Priyanka Dwarampudi; Shanmugam Ramaswamy

Lap Lambert Academic Publishing
2023
pokkari
Heterocycles are an important class of compounds, making up more than half of all known organic compounds. Benzimidazole is a dicyclic compound having imidazole ring (containing two nitrogen atoms at nonadjacent positions) fused to benzene. Benzimidazole and its derivatives are used in organic synthesis. The main aim of this proposed research work is to design and synthesize a novel class of (E)-2-(2-(5-nitro-1H-benzo d]imidazol-2-yl)vinyl)-4H-chromen-4-one derivatives and characterization by using IR, 1H NMR, 13C NMR, and mass spectroscopy, in vitro anticancer activity. Synthesized compound were evaluated for their in vitro anti cancer activity by SRB assay method against Human Cancer Cell line A-549. From the result the compound R1 and R6 allowed only 21.9 and 39.4 of % cell growth at the concentration of 80 g/mL. Whereas other compounds has showed 57-94% 0f %cell growth. From the results, it may conclude that the substitution on the Coumarin nucleus alter the biological activity. The un-substituted (R4) and Flouro (R6) and Chloro (R1) substituted Coumarin derivatives were found to be potent by producing biological activity.
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