Kirjojen hintavertailu. Mukana 11 244 527 kirjaa ja 12 kauppaa.
Kirja.info

Kirjahaku

Etsi kirjoja tekijän nimen, kirjan nimen tai ISBN:n perusteella.

1000 tulosta hakusanalla Michael R. Lynch

Evolutionary Cell Biology

Evolutionary Cell Biology

Michael R. Lynch

Oxford University Press
2024
sidottu
The fields of molecular evolution, genome evolution, and evolutionary genetics are now well-established. Remarkably, however, although all evolutionary modifications begin at the cellular level, and despite the advances made in cell biology and microbiology over the past few decades, there is as yet no recognised discipline of evolutionary cell biology. The goal of this book is to help establish the foundations for this emerging field. Its principal aims are twofold: firstly, to promote an understanding among evolutionary biologists as to why the cellular details matter if we are to understand the mechanisms of evolution; secondly, to make clear to non-evolutionary biologists - cell biologists in particular - that evolution is not just a matter of natural selection and optimization, but a process whose reach depends on other population genetic features such as mutation, recombination, and random genetic drift. Although there are many excellent books on cell biology, microbiology, and biophysics, almost no attention is given to evolution. Likewise, although there are numerous evolutionary biology books on the market, none of them gives more than passing attention to details at the cellular level. Thus Evolutionary Cell Biology is genuinely novel, offering a broader understanding of evolutionary processes and an appreciation for the many interesting problems that remain to be solved at the cellular and subcellular levels. This advanced textbook is aimed at both cell biologists and evolutionary biologists. It will be accessible to upper-level undergraduates in biology, and certainly to graduate students in all areas of the life sciences. Professionals from a wide range of fields - cell biology, microbiology, evolution, biophysics, biochemistry, and mathematics - will be exposed to entirely new ideas not traditionally covered in their primary fields of expertise.
Vertaile hintoja
An Analysis of Michael R. Gottfredson and Travish Hirschi's A General Theory of Crime

An Analysis of Michael R. Gottfredson and Travish Hirschi's A General Theory of Crime

William Jenkins

Macat International Limited
2017
nidottu
Michael R. Gottfredson and Travish Hirschi’s 1990 A General Theory of Crime is a classic text that helped reshape the discipline of criminology. It is also a testament to the powers of clear reasoning and interpretation. In critical thinking terms, reasoning is all about presenting a solid and persuasive case – and as many people instinctively understand, the most persuasive reasoning is that which bases itself on a single, simple hook. In Gottfredson and Hirschi’s case, this hook was what has come to be known as the “self-control theory of crime” – the idea that the tendency to commit crime is directly related to an individual’s level of self-control. While the dominant schools of thought of the time tended to focus on crime as the product of complex environmental factors, with little attempt to unify different theories, Gottfredson and Hirschi sought to interpret things so as to provide a single overarching concept that explained why crimes of all sorts were committed. Moreover, while other theories of crime concentrated on understanding and explaining specific types of law-breaking, the self-control model could, in Gottfredson and Hirschi’s view, be seen as the basis for understanding the root cause for all crime in all contexts. While such simplicity inevitably attracted as much criticism as agreement, subsequent studies have provided real-world corroboration for the General Theory’s persuasive reasoning.
Vertaile hintoja
Summary: Think!: Review and Analysis of Michael R. LeGault's Book

Summary: Think!: Review and Analysis of Michael R. LeGault's Book

Businessnews Publishing

Political Book Summaries
2017
nidottu
The must-read summary of Michael R. LeGault in his book: "Think : Why Crucial Decisions Can't Be Made in the Blink of an Eye". This complete summary of "Think " by Michael R. LeGault, award-winning editor and writer, presents his argument that 'feel-good culture' and instantaneous results have contributed to a reduction in reasoning and critical thinking abilities, which might cause America to lose its competitiveness on the global landscape. Added-value of this summary: - Save time- Understand why reasoning and critical thinking remain important to modern society- Expand your knowledge of psychology and politicsTo learn more, read "Think " and discover why America needs to stay in touch with its intellectual traditions.
Vertaile hintoja
An Introduction to Bootstrap Methods with Applications to R

An Introduction to Bootstrap Methods with Applications to R

Michael R. Chernick; Robert A. LaBudde

John Wiley Sons Inc
2011
sidottu
A comprehensive introduction to bootstrap methods in the R programming environment Bootstrap methods provide a powerful approach to statistical data analysis, as they have more general applications than standard parametric methods. An Introduction to Bootstrap Methods with Applications to R explores the practicality of this approach and successfully utilizes R to illustrate applications for the bootstrap and other resampling methods. This book provides a modern introduction to bootstrap methods for readers who do not have an extensive background in advanced mathematics. Emphasis throughout is on the use of bootstrap methods as an exploratory tool, including its value in variable selection and other modeling environments. The authors begin with a description of bootstrap methods and its relationship to other resampling methods, along with an overview of the wide variety of applications of the approach. Subsequent chapters offer coverage of improved confidence set estimation, estimation of error rates in discriminant analysis, and applications to a wide variety of hypothesis testing and estimation problems, including pharmaceutical, genomics, and economics. To inform readers on the limitations of the method, the book also exhibits counterexamples to the consistency of bootstrap methods. An introduction to R programming provides the needed preparation to work with the numerous exercises and applications presented throughout the book. A related website houses the book's R subroutines, and an extensive listing of references provides resources for further study. Discussing the topic at a remarkably practical and accessible level, An Introduction to Bootstrap Methods with Applications to R is an excellent book for introductory courses on bootstrap and resampling methods at the upper-undergraduate and graduate levels. It also serves as an insightful reference for practitioners working with data in engineering, medicine, and the social sciences who would like to acquire a basic understanding of bootstrap methods.
Vertaile hintoja
Beyond Redemption

Beyond Redemption

Michael R Fletcher

Harper Voyager
2015
nidottu
A darkly imaginative writer in the tradition of Joe Abercrombie, Peter V. Brett, and Neil Gaiman conjures a gritty mind-bending fantasy, set in a world where delusion becomes reality ...and the fulfillment of humanity's desires may well prove to be its undoing. When belief defines reality, those with the strongest convictions-the crazy, the obsessive, the delusional-have the power to shape the world. And someone is just mad enough to believe he can create a god ...Violent and dark, the world is filled with the Geisteskranken-men and women whose delusions manifest. Sustained by their own belief-and the beliefs of those around them-they can manipulate their surroundings. For the High Priest Konig, that means creating order out of the chaos in his city-state, leading his believers to focus on one thing: helping a young man, Morgen, ascend to become a god. A god they can control. Trouble is, there are many who would see a god in their thrall, including the High Priest's own doppelgangers, a Slaver no one can resist, and three slaves led by possibly the only sane man left. As these forces converge on the boy, there's one more obstacle: time is running out. Because as the delusions become more powerful, the also become harder to control. The fate of the Geisteskranken is to inevitably find oneself in the Afterdeath. The question, then, is: Who will rule there?
Vertaile hintoja
Bursting Neurons and Fading Memories

Bursting Neurons and Fading Memories

Michael R. D'Andrea

Academic Press Inc
2014
nidottu
Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.
Vertaile hintoja
Intracellular Consequences of Amyloid in Alzheimer's Disease

Intracellular Consequences of Amyloid in Alzheimer's Disease

Michael R. D'Andrea

Academic Press Inc
2016
nidottu
Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.
Vertaile hintoja
The Truth About What Customers Want

The Truth About What Customers Want

Michael R. Solomon

Financial TImes Prentice Hall
2009
nidottu
Customers demystified! How you can move them to buy...buy more...and keep on buying! The truth about what customers really want, think, and feel The truth about keeping current customers happy-and loyal The truth about the newest trends and advances in consumer behaviorSimply the best thinkingTHE TRUTH AND NOTHING BUT THE TRUTHThis book reveals 50 bite-size, easy-to-use techniques for finding and keeping highly profitable customers"Michael Solomon's The Truth About What Customers Want contains great insights into consumer behavior and is a must-have tool for anyone working in a consumer-driven field. His 50 truths take the guesswork out of marketing intelligence and give insight into navigating today's technology-driven world."Tim Dunphy, Senior Marketing Manager, Consumer Insights, Black & Decker
Vertaile hintoja
Why Are There Differences in the Gospels?

Why Are There Differences in the Gospels?

Michael R. Licona; Craig A. Evans

Oxford University Press Inc
2017
sidottu
Anyone who reads the Gospels carefully will notice that there are differences in the manner in which they report the same events. These differences have led many conservative Christians to resort to harmonization efforts that are often quite strained, sometimes to the point of absurdity. Many people have concluded the Gospels are hopelessly contradictory and, therefore, historically unreliable accounts of Jesus. The majority of New Testament scholars now hold that most if not all of the Gospels belong to the genre of Greco-Roman biography and that this genre permitted some flexibility in the manner that historical events were narrated. However, few scholars provide a robust discussion on how this plays out in Gospel pericopes (self-contained passages). Why Are There Differences in the Gospels? provides a fresh approach to the matter by examining the works of Plutarch, a Greek essayist who lived in the first and second centuries CE. Michael R. Licona discovers three-dozen pericopes narrated two or more times in Plutarch's Lives, identifies differences between the accounts, and views these differences in light of compositional devices acknowledged by classical scholars to have been commonly employed by ancient authors. The book then uses the same approach with nineteen pericopes narrated in two or more Gospels to demonstrate that the major differences found in them likely result from the same compositional devices employed by Plutarch. By suggesting that both the strained harmonizations and the hasty dismissals of the Gospels as reliable accounts are misguided, Licona invites readers to view the Gospels in light of their biographical genre in order to gain a clearer understanding of why the differences are present.
Vertaile hintoja
The Long Tomorrow: How Advances in Evolutionary Biology Can Help Us Postpone Aging

The Long Tomorrow: How Advances in Evolutionary Biology Can Help Us Postpone Aging

Michael R. Rose

Oxford University Press
2005
sidottu
The conquest of aging is now within our grasp. It hasn't arrived yet, writes Michael R. Rose, but a scientific juggernaut has started rolling and is picking up speed. A long tomorrow is coming. In The Long Tomorrow, Rose offers us a delightfully written account of the modern science of aging, spiced with intriguing stories of his own career and leavened with the author's engaging sense of humor and rare ability to make contemporary research understandable to nonscientists. The book ranges from Rose's first experiments while a graduate student--counting a million fruit fly eggs, which took 3,000 hours over the course of a year--to some of his key scientific discoveries. We see how some of his earliest experiments helped demonstrate that "the force of natural selection" was key to understanding the aging process--a major breakthrough. Rose describes how he created the well-known Methuselah Flies, fruit flies that live far longer than average. Equally important, Rose surveys the entire field, offering colorful portraits of many leading scientists and shedding light on research findings from around the world. We learn that rodents given fifteen to forty percent fewer calories live about that much longer, and that volunteers in Biosphere II, who lived on reduced caloric intake for two years, all had improved vital signs. Perhaps most interesting, we discover that aging hits a plateau and stops. Popular accounts of Rose's work have appeared in The New Yorker, Time magazine, and Scientific American, but The Long Tomorrow is the first full account of this exciting new science written for the general reader. "Among his peers, Rose is considered a brilliantly innovative scientist, who has almost single-handedly brought the evolutionary theory of aging from an abstract notion to one of the most exciting topics in science."--Malcolm Gladwell, The New Yorker
Vertaile hintoja
The Dissenters: Volume I: From the Reformation to the French Revolution

The Dissenters: Volume I: From the Reformation to the French Revolution

Michael R. Watts

Clarendon Press
1985
nidottu
Religious dissent has been a persistent feature of English and Welsh history for over four hundred years, influencing the economic, cultural, and political history of the two nations as well as their religious life. The Dissenters is the first of a projected three-volume study on the subject, which promises to be the first comprehensive overview of the subject in more than sixty years.
Vertaile hintoja
The Dissenters: Volume II: The Expansion of Evangelical Nonconformity

The Dissenters: Volume II: The Expansion of Evangelical Nonconformity

Michael R. Watts

Clarendon Press
1995
sidottu
The expansion of Evangelical Nonconformity was one of the most important developments in English and Welsh history in the late eighteenth and early nineteenth centuries. In eighty years the number of Nonconformist chapels increased ten-fold, and by 1851, nearly one person in five worshipped in such chapels. For millions of people the gospel preached and the religion practised in these chapels determined their choice of marriage partners, conditioned the upbringing of their children, and moulded their family life. Religion pervaded education, shaped morals, controlled leisure, provided music and literature, motivated philanthropy and decided political loyalties. In this, the second of a projected three-volume history of Dissent, Michael Watts argues that while the Quakers constituted an increasingly wealthy but numerically declining community of businessmen, farmers, and retailers, and that in many towns the Unitarians formed a vibrant, progressive, intellectual élite, the appeal of Nonconformity was primarily to the poor, the ill-educated, and the unsophisticated. The working-class adherents of Evangelical Nonconformity vastly outnumbered those of political radicalism, trade unionism, or Chartism, and Dissent was a major factor in making a section of the working class respectable, thus contributing to the social harmony of the 1850s and 1860s. The history of late Georgian and Victorian England and Wales, argues Dr Watts, cannot be understood without a knowledge of Nonconformity.
Vertaile hintoja
The Dissenters

The Dissenters

Michael R. Watts

Oxford University Press
2015
sidottu
This third and final volume of Michael Watts's study of dissent examines the turbulent times of Victorian Nonconformity, a period of faith and of doubt. Watts assesses the impacts of the major Dissenting preachers and provides insights into the various movements, such as romanticism and the higher, often German, biblical criticism. He shows that the preaching of hell and eternal damnation was more effective in recruiting to the chapels than the gentler interpretations. A major feature of the volume is a thorough analysis of surviving records of attendance at Nonconformist services. He provides fascinating accounts of Spurgeon and the other key figures of Nonconformity, including of the Salvation Army. Dr Watts also provides a fresh discussion of the contribution which Nonconformity made to the politics of mid- to late-Victorian Britain. He examines such issues of reform as Forster's Education Act of 1871, temperance, and Balfour's Education Act of 1902, and considers Nonconformist interventions in such controversies as the Bulgarian Agitation, Home Rule for Ireland, the Armenian massacres of the mid 1890s, and the Boer War. The volume concludes with the Liberal landslide in the 1906 general election, which saw probably more Nonconformists elected than any time since the era of Oliver Cromwell.
Vertaile hintoja
From Modes to Keys in Early Modern Music Theory

From Modes to Keys in Early Modern Music Theory

Michael R. Dodds

OXFORD UNIVERSITY PRESS INC
2024
sidottu
From Modes to Keys in Early Modern Music Theory addresses one of the broadest and most elusive open topics in music history: the transition from the Renaissance modes to the major and minor keys of the high Baroque. The system Glarean proposed in his 1547 Dodecachordon comprised twelve modes at two transposition levels; the scheme J.S. Bach used to order The Well-Tempered Clavier in 1722 featured two modes at twelve transposition levels. What took place in between? Through deep engagement with the corpus of Western music theory, author Michael R. Dodds presents a model to clarify the factors of this complex shift. The essence of this model lies in the dynamic interplay of three historical-conceptual layers arising successively in the Middle Ages, Renaissance, and Baroque, each layer continuing once introduced. Medieval theorists conceptualized mode along a continuum between tune and scale. Renaissance theorists extended mode from plainchant to polyphony, applying modal theory to such features as cadential hierarchies and contrapuntal imitation. Early Baroque mapping of vocal modality onto the keyboard catalyzed a transformation from the diatonic gamut to the chromatic keyboard as background pitch system, with a corresponding change from ladder to circle as the dominant model for tonal space, culminating in the circle of fifths. Spanning two centuries of music and music theory, and incorporating dozens of diagrams from historical treatises, Dodds provides the first comprehensive study of the transition from the Renaissance modes to the major and minor keys.
Vertaile hintoja
123...50