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Human Dna Polymerases: Biology, Medicine And Biotechnology

Human Dna Polymerases: Biology, Medicine And Biotechnology

Giovanni Maga; Silvio Spadari; Giuseppe Villani; Ulrich Hubscher

World Scientific Publishing Co Pte Ltd
2018
sidottu
Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes.
Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions

Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions

Ulrich Hubscher; Giovanni Maga; Giuseppe Villani; Silvio Spadari

World Scientific Publishing Co Pte Ltd
2010
sidottu
Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.
Historias para dormir Dragones

Historias para dormir Dragones

Silvia Villanueva

Createspace Independent Publishing Platform
2016
nidottu
El porqu de los dragones. Hay hombres que comienzan a andar y llegan lejos. Se van buscando magia y son sorprendidos por toda clase de bufones. Son incautos e ingenuos y confunden a brujas con doncellas. Creen en la gente m s que en s mismos y evitan los problemas, siempre est n dispuestos a batirse en duelo si la causa amerita. Se vuelven caballeros que rescatan princesas y terminan casados con plebeyas...Y tambi n hay hombres que son magia en s mismos, sabenvolar porque son dragones o pegasos, deslumbran los ojos ysus palabras llegan hasta el alma. Es dif cil no rendirse ante su fuerza. Te fascina verlos alzarse y remontar. Su presencia se impone y te confunde y cuando sucumbes a su hechizo, te domina. Te enamoras de su libertad por imposible; les es inherente y se vuelve vital conforme crecen. Esos hombres escasos, casi extintos que comprenden que el mar y sus mareas dependen de la luna, igual que las mujeres.No lo s , pero a m me gustan esos hombres voladores, quecon sus pies tocan la tierra y con sus alas, el cosmos... Esos hombres que con una caricia pueden delimitar el infinito. Que no le tienen miedo a las palabras, aunque duelan, que asumen consecuencias de sus actos. Su presencia es intensa y su adi s, inminente. Y hoy, ahora, hacen que la hechicera quiera ser prisionera del drag n de los cuentos...
Santuarios y rituales en la Hispania Céltica

Santuarios y rituales en la Hispania Céltica

Silvia Alfayé Villa

BAR Publishing
2009
nidottu
This volume is a study of later Iberian prehistory and contributes to our understanding of the range of religious beliefs and practices present in the Celtic-speaking world. There is an overview of earlier perceptions of sacrificial stones and altars presented in the context of developing visions of Celts and Druids beginning in the seventeenth century. There follows an in-depth study of one of the most extensively excavated hill top settlements Numancia a site which presents a microcosm of the issues involved in attempting to use raw archaeological evidence to interpret human behaviour. In addition there is a detailed assessment of urban and domestic sanctuaries and votive deposits; a detailed consideration of cave sanctuaries; and studies of votive metalwork, of the enigmatic verracos, of epigraphy from sanctuaries and or ritual artefacts. Spanish text.
Die Villa der Signora

Die Villa der Signora

Silvia Gillardon

Books on Demand
2020
pokkari
Ein spannender Liebesroman f r Italienliebhaber, die fasziniert sind von der Sch nheit der Riviera und der charmanten, oft etwas chaotischen Italianit . Nach einem schweren Schicksalsschlag bekommt die sensible Journalistin Alessandra Janssen den Auftrag, an der ligurischen K ste eine Biografie ber den exaltierten Maler Enrico Spina zu verfassen. Dort freundet sie sich an mit der charismatischen Immobiliare Bianca Sposato und deren Familie. Bei einem gef hrlichen Langstrecken-Schwimmabenteuer kommt sie Biancas Bruder, dem faszinierenden Hotelier Flavio, n her als geplant. Verliebt beschliesst sie, an der Blumenriviera einen Neuanfang zu wagen und ihm bei der Suche nach einer romantischen Villa am Meer zu helfen. Doch dann bringt der schreckliche Fenstersturz des Kunstmalers alle Pl ne durcheinander. Und auch Flavio ist pl tzlich nicht mehr erreichbar.
From Villain to Hero

From Villain to Hero

Silvia Montiglio

The University of Michigan Press
2011
sidottu
Praise for Silvia Montiglio"[A] brilliant and important book. . . . " ---Journal of Religion, on Silence in the Land of Logos"[A]n invigorating reevaluation of both the ancient symbolic landscape and our preconceptions of it." ---American Journal of Philology, on Wandering in Ancient Greek Culture Best known for his adventures during his homeward journey as narrated in Homer's Odyssey, Odysseus remained a major figure and a source of inspiration in later literature, from Greek tragedy to Dante's Inferno to Joyce's Ulysses. Less commonly known, but equally interesting, are Odysseus' "wanderings" in ancient philosophy: Odysseus becomes a model of wisdom for Socrates and his followers, Cynics and Stoics, as well as for later Platonic thinkers. From Villain to Hero: Odysseus in Ancient Thought follows these wanderings in the world of ancient Greek and Roman philosophy, retracing the steps that led the cunning hero of Homeric epic and the villain of Attic tragedy to become a paradigm of the wise man. From Villain to Hero explores the reception of Odysseus in philosophy, a subject that so far has been treated only in tangential or limited ways. Diverging from previous studies, Montiglio outlines the philosophers' Odysseus across the spectrum, from the Socratics to the Middle Platonists. By the early centuries CE, Odysseus' credentials as a wise man are firmly established, and the start of Odysseus' rehabilitation by philosophers challenges current perceptions of him as a villain. More than merely a study in ancient philosophy, From Villain to Hero seeks to understand the articulations between philosophical readings of Odysseus and nonphilosophical ones, with an eye to the larger cultural contexts of both. While this book is the work of a classicist, it will also be of interest to students of philosophy, comparative literature, and reception studies.
La fauna del villaggio dell'età del Ferro di Bressanone-Stufles (Alto Adige, Italia)

La fauna del villaggio dell'età del Ferro di Bressanone-Stufles (Alto Adige, Italia)

Silvia Eccher

British Archaeological Reports (Oxford) Ltd
2024
pokkari
Il villaggio di Bressanone-Stufles (Alto Adige, Italia) stato oggetto di decennali indagini archeologiche che hanno confermato un'occupazione lungo tutta l'et del Ferro (VI-I sec. a.C.). L'ampio bacino di ossa animali analizzato, a cui sono stati aggiunti i dati editi di studi precedenti, ha permesso di formulare ipotesi sulla paleo-economia adottata dal villaggio e di stabilire un modello socio-economico dell'area retica.L'economia si basava primariamente sull'allevamento di bovini e ovicaprini al fine di sfruttarne i prodotti secondari (trazione, latte, riproduzione, lana). Integrando approcci diversi, archeologico e sociale, si tentato di stabilire le diverse destinazioni funzionali del villaggio e la presenza di gruppi sociali differenziati. L'analisi delle dimensioni degli animali si rivelata utile per valutarne i cambiamenti in senso cronologico e geografico con le regioni confinanti. Ci , assieme alla scoperta di un reperto riferibile ad un asino, ha aperto la strada ad ipotesi di legami con il mondo etrusco e mediterraneo.The village of Bressanone-Stufles (South Tyrol, Italy) has been the subject of archaeological investigations for decades; the excavations have confirmed a continuity of occupation throughout the Iron Age (6th-1st c. BC). The large animal bone assemblage analysed in this study, which includes published data from previous publication as well as unpublished materials, made it possible to formulate hypotheses on the palaeo-economy adopted by the human group inhabiting this village and to establish a socio-economic model for the Rhaetian area.The economy at the site was primarily based on the rearing of cattle and sheep/goats to exploit their secondary products (traction, milk, reproduction, wool). By adopting a social and archaeological approach a study of the possible functional uses of several areas of the village was carried out and an investigation of the presence of differentiated social groups was accomplished. A biometric comparison between the Bressanone-Stufles assemblage and assemblages from neighbouring regions was also conducted to understand whether livestock size differences through time could be identified. This analysis, together with the discovery of a bone find attributed to a donkey, points toward the likely existence of links with the Etruscan and Mediterranean worlds.
Ethnomathematics present in naval carpentry in the village of Itapuá-Vigia

Ethnomathematics present in naval carpentry in the village of Itapuá-Vigia

Dulcilene Freitas Palheta; Silvia Maria L Albuquerque

Our Knowledge Publishing
2023
pokkari
We live in a globalized society, traced by technological and industrial searches, where much is said about education and educational practices. However, some of these practices are still linked to traditionalism, where education is a means of trying to pass on to the student what he should learn, leaving aside his real needs, life perspectives, reflections and critical capacity, which affects the performance of his learning. In opposition to these facts, Ethnomathematics, a trend in Mathematics Education, comes to build an educational process based on the recognition of the mathematical knowledge developed in the daily practice of some coexisting cultures and to relate this knowledge to the teaching practice. The aim of this final work is to develop an anthropological research with an ethnomathematical approach found in the craft of the Naval Carpenters of the Vila do Itapu - Vigia/PA, using their informal mathematics as a mathematical model to teach Geometry by means of a pedagogical intervention.
Ethnomathématiques présentes dans la charpenterie navale du village d'Itapuá-Vigia

Ethnomathématiques présentes dans la charpenterie navale du village d'Itapuá-Vigia

Dulcilene Freitas Palheta; Silvia Maria L Albuquerque

Editions Notre Savoir
2023
pokkari
Nous vivons dans une soci t mondialis e, marqu e par les recherches technologiques et industrielles, o l'on parle beaucoup de l' ducation et des pratiques ducatives. Cependant, certaines de ces pratiques sont encore li es au traditionalisme, o l' ducation est un moyen d'essayer de transmettre l' tudiant ce qu'il doit apprendre, en laissant de c t ses besoins r els, ses perspectives de vie, ses r flexions et sa capacit critique, ce qui affecte la performance de son apprentissage. En opposition ces faits, l'ethnomath matique, un courant de l'enseignement des math matiques, vient construire un processus ducatif bas sur la reconnaissance des connaissances math matiques d velopp es dans la pratique quotidienne de certaines cultures coexistantes et de relier ces connaissances la pratique de l'enseignement. L'objectif de ce travail final est de d velopper une recherche anthropologique avec une approche ethnomath matique trouv e dans l'artisanat des charpentiers de marine de la Vila do Itapu - Vigia/PA, en utilisant leurs math matiques informelles comme mod le math matique pour enseigner la g om trie par le biais d'une intervention p dagogique.
Etnomatematica presente nella carpenteria navale del villaggio di Itapuá-Vigia

Etnomatematica presente nella carpenteria navale del villaggio di Itapuá-Vigia

Dulcilene Freitas Palheta; Silvia Maria L Albuquerque

Edizioni Sapienza
2023
pokkari
Viviamo in una societ globalizzata, tracciata dalla ricerca tecnologica e industriale, dove si parla molto di educazione e di pratiche educative. Tuttavia, alcune di queste pratiche sono ancora legate al tradizionalismo, dove l'educazione un mezzo per cercare di trasmettere allo studente ci che deve imparare, tralasciando i suoi reali bisogni, le sue prospettive di vita, le sue riflessioni e la sua capacit critica, che influisce sul rendimento del suo apprendimento. In opposizione a questi fatti, l'etnomatematica, una tendenza dell'educazione matematica, si propone di costruire un processo educativo basato sul riconoscimento delle conoscenze matematiche sviluppate nella pratica quotidiana di alcune culture coesistenti e di mettere in relazione queste conoscenze con la pratica didattica. L'obiettivo di questo lavoro finale quello di sviluppare una ricerca antropologica con un approccio etnomatematico trovato nell'artigianato dei carpentieri navali di Vila do Itapu - Vigia/PA, utilizzando la loro matematica informale come modello matematico per insegnare la geometria attraverso un intervento pedagogico. classe
La función pedagógica del médico docente

La función pedagógica del médico docente

Alejandro Villao Rodríguez; Silvia Lara Arriaga

Editorial Academica Espanola
2024
pokkari
Dentro del presente art culo, se realiz una exhaustiva exploraci n sobre la funci n pedag gica del m dico docente en la formaci n de estudiantes de medicina para la atenci n de emergencias obst tricas. La investigaci n, basada en entrevistas con m dicos docentes especializados en este campo, revel una tesis central que destaca la importancia crucial del m dico docente como gu a, l der y modelo tico en el proceso formativo. En respuesta a desaf os comunes, como la variabilidad en la experiencia cl nica y la gesti n del tiempo, se identificaron enfoques adaptativos y flexibles como estrategias efectivas. La adaptaci n emergi como un elemento fundamental para personalizar la ense anza, incorporando simulaciones realistas, aprendizaje basado en problemas y tecnolog as educativas. Mientras que la promoci n de la participaci n activa y el aprendizaje pr ctico, mediante escenarios interactivos y discusiones basadas en casos reales, se estableci como esencial en el proceso educativo. La inclusi n de la tica y la sensibilidad cultural en la ense anza fue reconocida como un factor clave para formar profesionales m dicos culturalmente competentes.