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Analiza profilu bialkowego szczepów Trypanosoma cruzi (ZIII)

Analiza profilu bialkowego szczepów Trypanosoma cruzi (ZIII)

Simone Akemi Kikuchi

Wydawnictwo Nasza Wiedza
2025
nidottu
Trypanosoma cruzi, czynnik etiologiczny choroby Chagasa, jest szeroko rozpowszechniony na kontynencie amerykańskim. Dzięki r żnym technikom biologii molekularnej zaobserwowano wyraźny dimorfizm między izolatami, co doprowadzilo do zgrupowania szczep w w dwie duże linie filogenetyczne: T.cruzi I (kt ra koreluje z ZI) i T.cruzi II (kt ra koreluje z ZII). Drzewo filogenetyczne oparte na niekt rych celach genomowych ujawnilo wyraźną dychotomię w ZIII, definiując dwie podgrupy (ZIII-A i ZIII-B). W ten spos b analiza proteomiczna szczep w należących do ZIII w por wnaniu z T. cruzi I i II może pom c w wyjaśnieniu tej kwestii. Gl wnym celem niniejszej pracy jest zdefiniowanie mapy bialek rozpuszczalnych szczep w należących do zimodemu III (3663 - ZIII-A i 4167 - ZIII-B), podkreślając r żnice między podgrupami ZIII-A i ZII-B. Wyniki określają mapę proteomową i klasyfikację niekt rych bialek izolat w ZIII, biorąc pod uwagę podgrupy genomowe występujące w naturze.
Analisi del profilo proteico dei ceppi di Trypanosoma cruzi (ZIII)
Il Trypanosoma cruzi, agente eziologico della malattia di Chagas, ampiamente diffuso nel continente americano. Attraverso diverse tecniche di biologia molecolare, stato osservato un chiaro dimorfismo tra gli isolati, che ha portato al raggruppamento dei ceppi in due grandi linee filogenetiche: T.cruzi I (correlato a ZI) e T.cruzi II (correlato a ZII). Un dendrogramma filogenetico basato su alcuni target genomici ha rivelato una chiara dicotomia in ZIII, definendo due sottogruppi (ZIII-A e ZIII-B). Pertanto, l'analisi proteomica dei ceppi appartenenti a ZIII rispetto a T. cruzi I e II pu contribuire a chiarire questa questione. Questo lavoro ha come obiettivo principale definire la mappa delle proteine solubili dei ceppi appartenenti al zimodema III (3663 - ZIII-A e 4167 - ZIII-B), sottolineando le differenze esistenti tra i sottogruppi ZIII-A e ZII-B. I risultati definiscono la mappa proteomica e la classificazione di alcune proteine degli isolati ZIII considerando i sottogruppi genomici circolanti in natura.
Analysis of the protein profile of Trypanosoma cruzi strains (ZIII)

Analysis of the protein profile of Trypanosoma cruzi strains (ZIII)

Simone Akemi Kikuchi

Our Knowledge Publishing
2025
pokkari
Trypanosoma cruzi, the etiological agent of Chagas disease, is widely distributed throughout the American continent. Using various molecular biology techniques, a clear dimorphism was observed between the isolates, leading to the grouping of strains into two major phylogenetic lineages: T. cruzi I (correlated with ZI) and T. cruzi II (correlated with ZII). A phylogenetic dendrogram based on some genomic targets revealed a clear dichotomy in ZIII, defining two subgroups (ZIII-A and ZIII-B). Thus, proteomic analysis of strains belonging to ZIII in comparison with T. cruzi I and II may contribute to elucidating this issue. The main objective of this study is to define the soluble protein map of strains belonging to zimodema III (3663 - ZIII-A and 4167 - ZIII-B), highlighting the differences between the ZIII-A and ZII-B subgroups. The results define the proteomic map and classification of some proteins from ZIII isolates considering the genomic subgroups circulating in nature.
Simone

Simone

Eduardo Lalo

University of Chicago Press
2015
nidottu
Eduardo Lalo is one of the most vital and unique voices of Latin American literature, but his work is relatively little known in the English-speaking world. That changes now: this masterful translation of his most celebrated novel, Simone—which won the 2013 Rómulo Gallegos International Novel Prize—will introduce an English-language audience to this extraordinary literary talent. A tale of alienation, love, suspense, imagination, and literature set on the streets of San Juan, Puerto Rico, Simone tells the story of a self-educated Chinese immigrant student courting (and stalking) a disillusioned, unnamed writer who is struggling to make a name for himself in a place that is not exactly a hotbed of literary fame. By turns solipsistic and political, romantic and dark, Simone begins with the writer’s frustrated, satiric observations on his native city and the banal life of the university where he teaches—forces utterly at odds with the sensuality of his writing. But, as mysterious messages and literary clues begin to appear—scrawled on sidewalks and walls, inside volumes set out in bookstores, left on his answering machine and under his windshield wiper—Simone progresses into a cat-and-mouse game between the writer and his mystery stalker. When the eponymous Simone’s identity is at last revealed, the writer finds in the life of this Chinese immigrant a plight not unlike his own. Traumatized and lonely, the pair moves towards bittersweet collaborations in passion, grief, and art.
Simone

Simone

D'Anna Duquesne

Lulu.com
2010
pokkari
Simone St. John, a contemporary feminist is not merely comfortable with her sexuality, she uses it to play men at their own game, wielding its power when its least expected. An Adept at sensual seduction, Simone meets her match in studio head Leland Bale, a man's-man, who to her disdain has both men and women catering to his every whim as if he's a god. In spite of the fact that both are in long-term marriages to other people, in this age old battle of genders, man versus woman, they engage in an evocative and sensual game of sex-play designed to establish superior one-upmanship. Their ratcheting sexual escapades build and intensify into deep emotions, ultimately, forcing them to alter their long-held stereotypes and generalized opinions of the opposite sex. The game is on! Book One - The Enlightened Erotica Series
Simone

Simone

Wicked Muse; Jamallah Bergman

Createspace Independent Publishing Platform
2016
nidottu
Simone BOOK TWORenzo, Gianni, Federico, Simone Cipriano Brothers who are well known in the town of Kellington.Each brother was thriving on their own working in what they were best in doing.But it's their mother's wish for her son's to find love and happiness like she had with their father, since they have not only been well known for their work ethics but also for their sexual conquest.Watch as the Cipriano brothers try and find love in probably some of the most unlikely of places. Along the way you'll meet some of the women who take their hearts as well as their minds on a whirlwind ride like no other.Simone never thought he would end up having these feelings again...Simone Cipriano is a successful lawyer, who is always there to get his client off or get the bad guy put into jail. And like most of the Cipriano men, he's handsome and could have any woman he wants. But the night he went to his mother's party, he saw the one woman that he had wanted for most of his life and realized what a mistake he made by letting her get away. Delia Whitney, co-owner of Timeless Treasures with her good friend Jaslyn is very well liked in the town of Kellington. Not only has business kept her busy but the love of her life, Rodger White has made every day a dream come true. But she feels that something is going on when she gets constant calls from Simone, who she has been friends with since childhood and who also was her first and only crush.Soon a series of events seem to plague Delia in which Simone must help out his best friend and one true love. Watch as Simone and Delia come to the conclusion that despite being apart that they had always been made for each other.
Simone

Simone

Viet Thanh Nguyen

Astra Publishing House
2024
sidottu
When Simone is awakened by her mom as a wildfire threatens their home, it is the beginning of a life-changing journey. On their way to take shelter in a high school gym, the family passes firefighters from a prison unit battling the fire. Simone’s mom tells her that when she was a girl in Viet Nam, she was forced to evacuate her home after a flood. Joined by other children sheltering in the gym, Simone, a budding artist, encourages everyone to draw as a way to process their situation. After a few days, Simone and her mom are able to return to their home, which is fortunately still standing and her outlook has changed. As Simone begins creating a piece of art with one of her new friends, she realises that even though they are young, they can dream and work together for a more sustainable future. With a poetic, haunting family story by esteemed author Viet Thanh Nguyen and gorgeous art from illustrator Minnie Phan, this powerful tale introduces an unforgettable young heroine who awakens to a new role fighting for her community and for the future of the planet.
Simone

Simone

Kamille Henry

Independently Published
2018
nidottu
Get into the mind of a woman who is out for revenge and will do anything to get it.Simone is the ultimate professional doing her civic duty to rid good wives of their cheating husbands. When she decides to take on a job from an anonymous woman, she soon finds herself wrapped in lives and situations that she wasn't prepared for, and trapped into doing business for a woman with a deadly vendetta.Enter this story of lies, scandal, and manipulation as Simone takes on the journey of her life.