Why, despite their similar goals, do the policy preferences of the European Union and United States diverge on so many multilateral issues? To answer that question, Allies at Odds? thoroughly examines recent international efforts in arms control, environmental protection, human rights, and military cooperation. Evidence from 20 separate cases supports the expectations of the realist approach to international politics, which focuses on the role of power above all. Neither cultural factors nor international institutions have as much influence as some expect. This finding was as true during the Clinton Presidency as during the Bush, indicating that focusing on personalities overlooks more substantial and longer-lasting differences between the Atlantic allies.
Why, despite their similar goals, do the policy preferences of the European Union and United States diverge on so many multilateral issues? To answer that question, Allies at Odds? thoroughly examines recent international efforts in arms control, environmental protection, human rights, and military cooperation. Evidence from 20 separate cases supports the expectations of the realist approach to international politics, which focuses on the role of power above all. Neither cultural factors nor international institutions have as much influence as some expect. This finding was as true during the Clinton Presidency as during the Bush, indicating that focusing on personalities overlooks more substantial and longer-lasting differences between the Atlantic allies.
This is the first book-length treatment of international politics in a unipolar world that adopts a structural realist perspective. It applies Waltz's microeconomic analogy to a market with a price leader. It concludes that unipolarity is sustainable as long as the unipole distributes rewards to other states.
This is the first book-length treatment of international politics in a unipolar world that adopts a structural realist perspective. It applies Waltz's microeconomic analogy to a market with a price leader. It concludes that unipolarity is sustainable as long as the unipole distributes rewards to other states.
This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated.Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated.Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.
Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.
Por el autor del best seller El arte de no amargarse la vida. La terapia que ha transformado a millones de personas. Una nueva mentalidad que har que te sientas cada d a m s contento, que no te enfades por peque eces y que goces de una gran autoestima. Este libro incluye cap tulos especiales para: - Combatir el sobrepeso con facilidad. - Conquistar el xito en lo que te propongas. - Resolver los conflictos de pareja. - Superar la muerte de un ser querido. Aprende a usar la mente a tu favor para conseguir alcanzar la felicidad plena. Rafael Santandreu vuelve a los fundamentos de la psicolog a cognitiva con un libro que es como una gran caja de herramientas: tengas el problema que tengas encontrar s claves y consejos para tratar el rea concreta que te preocupa. La psicolog a cognitiva te va a ayudar a: -Conseguir un objetivo personal como perder peso o alcanzar el xito profesional.-Mejorar tu relaci n con los dem s; trabajar mejor en equipo con xito o gestionar las relaciones de pareja.-Afrontar miedos y cuestionarse temas existenciales.-Ser m s positivo en tu vida y contigo mismo.-Saber gestionar el estr s de manera eficaz. ENGLISH DESCRIPTION By the bestselling author of The Art of Not Being Resentful. The therapy that has changed millions of people. A new mindset that will make you feel happier each day, not getting upset over the little things, and enjoying a great self-esteem. This book has special chapters to: Address overweight easily.Achieve success in everything you set your mind to.Solve relationship issues. Overcome the death of a loved one.
Dopuscheno Nauchno-metodicheskim sovetom po fizike Min-va obr. i nauki RF. Kurs prednaznachen dlja studentov tekhnicheskikh vuzov. Pervyj tom soderzhit kratkoe izlozhenie osnov mekhaniki v obeme, kotoryj neobkhodim dlja usvoenija posledujuschikh razdelov. Dalee sledujut molekuljarnaja fizika, osnovy termodinamiki, fizika realnykh gazov, zhidkostej i tverdykh tel. Poslednjaja chast pervogo toma posvjaschena ucheniju o kolebanijakh, volnakh i zvuke. Vtoroj tom soderzhit uchenie ob elektrichestve i magnetizme. Tretij tom posvjaschen voprosam optiki, fiziki atoma, atomnogo jadra i mikrochastits.
Por el autor del bestseller El arte de no amargarse la vida. La terapia que ha transformado a millones de personas. Una nueva mentalidad que har que te sientas cada d a m s contento, que no te enfades por peque eces y que goces de una gran autoestima. Este libro incluye cap tulos especiales para: - Combatir el sobrepeso con facilidad. - Conquistar el xito en lo que te propongas. - Resolver los conflictos de pareja. - Superar la muerte de un ser querido. «Un libro eficaz y profundo, basado en evidencia cient fica --Dr. LUIS MIGUEL MART N, psiquiatra, Hospital del Mar (Barcelona) «Si lo lees, quiz sientas que hay m s caminos que los que t cre as --MANOLO GARC A, m sico y excomponente de El ltimo de la Fila ENGLISH DESCRIPTION By the bestselling author of The Art of Not Being Resentful. The therapy that has changed millions of people. A new mindset that will make you feel happier each day, not getting upset over the little things, and enjoying a great self-esteem. This book has special chapters to: - Address and overcome weight issues easily - Achieve success in everything you set your mind to - Solve relationship problems - Overcome the death of a loved one Learn to use your mind to your advantage so you can reach complete happiness. Rafael Santandreu goes back to the fundamentals of cognitive psychology with a book that serves as a big toolbox: whatever problem you may have, you'll find tools and advice to address the specific area that is concerning you.
Dopuscheno Nauchno-metodicheskim sovetom po fizike Min-va obr. i nauki RF. Kurs prednaznachen dlja studentov tekhnicheskikh vuzov. Pervyj tom soderzhit kratkoe izlozhenie osnov mekhaniki v obeme, kotoryj neobkhodim dlja usvoenija posledujuschikh razdelov. Dalee sledujut molekuljarnaja fizika, osnovy termodinamiki, fizika realnykh gazov, zhidkostej i tverdykh tel. Poslednjaja chast pervogo toma posvjaschena ucheniju o kolebanijakh, volnakh i zvuke. Vtoroj tom soderzhit uchenie ob elektrichestve i magnetizme. Tretij tom posvjaschen voprosam optiki, fiziki atoma, atomnogo jadra i mikrochastits.
Recent scientific advances have revolutionized cancer research and practice, creating a body of molecular biology information that is important to research scientists and clinical oncologists alike. Cancer: Principles and Practice of Oncology: Primer of the Molecular Biology of Cancer, 3rd Edition, keeps you up to date with all that’s new in this rapidly changing field. Derived from DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology – widely regarded as the definitive clinical reference in oncology – the third edition of this popular Primer provides a single-volume, highly focused reference on every important frontier in the molecular biology of cancer. Compiles the knowledge and experience of leading scientists and clinicians in the field.Provides separate chapters on each of the 18 most common cancer types, with state-of-the-art information on how molecular biology advances are impacting clinical practice.Includes a thorough chapter on genetic counseling and genetic testing to help you navigate the challenges and ethical dilemmas of cancer genetics.Covers key topics such as Hallmarks of Cancer, Precision Medicine in Oncology, Cancer Immunotherapy, Pharmacogenomics, and many more. Enrich Your Ebook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone.Easily convert to audiobook, powering your content with natural language text-to-speech.
Genetics today is inexorably focused on DNA. The theme of Introduction to Genetics: A Molecular Approach is therefore the progression from molecules (DNA and genes) to processes (gene expression and DNA replication) to systems (cells, organisms and populations). This progression reflects both the basic logic of life and the way in which modern biological research is structured. The molecular approach is particularly suitable for the large number of students for whom genetics is a part of a broader program in biology, biochemistry, the biomedical sciences, and biotechnology. Introduction to Genetics presents the basic facts and concepts with enough depth of knowledge to stimulate students to move on to more advanced aspects of the subject. The book is divided into three parts. Part 1 examines the function of the gene as a unit of biological information. Part 2 studies the role of the gene as a unit of inheritance. And Part 3 explores some of the areas of research that are responsible for the high profile that genetics has in our modern world, from agriculture and industry to medicine and forensics, and the ethical challenges that genetic knowledge imparts. Introduction to Genetics is available for purchase as an e-book in its entirety or as individual chapters, and as a 1-year or 6-month rental.
