Computer Techniques in Preclinical and Clinical Drug Development

Kirjan Computer Techniques in Preclinical and Clinical Drug Development (2019) on kirjoittanut Robert C. Jackson. Kirjan kieli on englanti, ja sen on kustantanut CRC Press. Kirja on laajuudeltaan 256 sivua ja se on nidottu.

It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development? " Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.