Ajeet Kumar

L'Interferon Regulatory Factor-2 un fattore di trascrizione dei vertebrati di natura oncogena; antagonizza le funzioni dell'Interferon Regulatory Factor-1, un gene soppressore di tumori. Topi knockout per il gene IRF-2 mostrano un difetto nella linfopoiesi delle cellule B e muoiono in seguito a infezioni da LCMV (virus della coriomeningite linfocitica). IRF-2 funzionalmente l'opposto di IRF-1. interessante notare che, poich i topi IRF-1-/- (knock-out) mostrano una mancanza di cellule CD8+T e una bassa citotossicit delle cellule NK, la sovrapproduzione di IRF-2 nei topi potrebbe ripristinarla. Ma non cos , il motivo sconosciuto. Tuttavia, IRF-2 si lega alla sequenza dell'elemento di risposta stimolata dall'interferone nella cellula infettata dal virus. Questo libro tratta del clonaggio del cDNA del gene IRF-2 del topo e dell'espressione della proteina chimerica in E.coli. Questo studio servir come piattaforma per ulteriori analisi funzionali dell'IRF-2 chimerico, che un potente oncogene in condizioni aberranti.

1. UPSC CSAT Paper - 2 is a complete practice package 2. The book is contains 10 Practice sets under 4 Stages 3. It is loaded with good number Previous Years' Solved Papers and Practice Sets 4. Each Paper is provided with OMR SHEET and Subject wise performance Assessment Card Success doesn't happen by chance, it takes our precious time, hard work and focus. Presenting, the thoroughly revised and updated edition of "UPSC CSAT Paper - 2 Practice Sets" that is designed carefully and consciously on the Prescribed lines of UPSC Paper Pattern. The book has been divided into 4 stages for the complete practice. STAGE 1: KNOW THE EXAM TREND: this stage contains Previous Years' Solved Papers (2020-2015) to help aspirants know the latest trend of the examination. STAGE 2: PRACTICE WITH EXAM TREND: this stage provides 3 practice sets to practice according to the prescribed latest paper pattern, STAGE 3: CROSS THE CUT OFF: this stage has 4 Practice Sets that help students in crossing the cut-off of the exam. STAGE 4: BE READY FOR PRELIMS: Lastly, 3 practice sets given in this section make students to get ready for prelims. Each practice sets in this book contains OMR Sheet and Subject wise Performance Assessment Card to avoid errors and make them aware about weak linkages in their preparation. It is the perfect practice workbook to boost your preparation level for the upcoming Civil Services Aptitude Test. TABLE OF CONTENT STAGE 1: KNOW THE EXAM TREND: Previous Years' Solved Papers (2020-2015), STAGE 2: PRACTICE WITH EXAM TREND: Practice Sets (1-3), STAGE 3: CROSS THE CUT OFF: Practice Sets (4 -7), STAGE 4: BE READY FOR PRELIMS: Practice Sets (8-10).

Hormones are chemical messengers that are secreted directly into the blood, which transports them to organs and tissues of the body to exert their functions. There are several types of hormones that work on different aspects of body functions and processes. Estrogen, a steroid hormone, carries physiological messages to body organs and systems. These messages differ for each body organ and system. Estrogen sends messages to the uterus to grow and replace the lining that is shed during the previous menses. The three major naturally occurring estrogens in women are estrone (E1), estradiol (E2), and estriol (E3). Estradiol is the predominant estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity. The present book deals with some phytoestrogens most widely used.

Pharmaceutical Technology: A Practical Manual" discusses the techniques used in manufacturing and evaluation of different dosage forms in simple and easy to understand manner with the support of theory and experiments. Due to its organization, the manual can be used at different levels i.e., graduation and post graduation in Pharmaceutics as well as in Quality Assurance. Pharmaceutical Technology is one of the most important subject in pharmaceutical sciences and deals with preparation of various dosage forms by variety of techniques on laboratory scale as well as on large scale and their in-process and out process (final) evaluation.

Interferon Regulatory Factor-2 is a vertebrate transcription factor having oncogenic nature; it antagonises Interferon Regulatory Factor-1, a tumor suppressor gene, functions. Knockout mice for IRF-2 gene showed defect in B-cell lymphopoeisis, they died following LCMV (Lymphocytic Choriomeningitis Virus) infections. IRF-2 is functionally just opposite of IRF-1. Interestingly, one would have thought that as IRF-1-/- (knock-out) mice showed lack of CD8+T cells and low cytotoxicity of NK cells, the over production of IRF-2 in mice may restore it. But it does not happen so, the reason being unknown. However, IRF-2 binds at Interferon Stimulated Response Element sequence in viral infected cell. This book is about mouse IRF-2 gene cDNA cloning and expression of chimeric protein in E.coli. This study will serve as a platform for further functional analysis of chimeric IRF-2, which is potent oncogene in aberrant conditions.

The brief is the first to focus exclusively on environmentally friendly delivery of pesticides (controlled-release nanoparticulate formulation of pesticides using biodegradable polymers as carriers). The brief also introduces pesticides like Chlorpyrifos and biodegradable polymers like guar-gum. The brief will be extremely useful to the researchers in the field of agrochemicals and will be equally useful for advanced professionals in the field of biology, chemistry, environmental biology, entomology and horticulture.