Biswa Mohan Sahoo

Kinase inhibitors are the type of medications that target enzymes called kinases, which play a crucial role in signaling pathways involved in cell growth, proliferation, and survival. These inhibitors are used in the treatment of various cancers and other diseases. This book provides essential information in the design of new drug molecules for the development of kinase inhibitors. It includes the existing drugs and those under clinical trial that are involved in the development process. Key Features Highlights the synthesis, molecular mechanism, biochemical pathways, chemical and biological properties of kinase inhibitors. Focuses on recent advances in these drugs used in the field of cancer and other diseases. Researchers are provided with information on target identification, lead identification, and optimization during the drug development process.

This unique volume covers specific aspects of the biological chemistry of terpenoids. It provides extensive information related to classification, general methods of extraction and isolation of terpenoids, synthesis and pharmacological activities of monoterpenoids, synthesis and medicinal uses of diterpenoids, biogenesis of terpenoids, synthesis and medicinal uses of sesqui terpenoids and sesterpenoids. Some terpenes are also classified as diterpene alkaloids. Most of the terpenoids with diverse molecular structures are biologically active and are used for the treatment of various diseases such as cancer, malaria, inflammation, tuberculosis and infection, and this is discussed.Features:Activities and biological relationships of terpenes An accurate assessment of where and what terpenes can lead to Discusses how microbes, in particular the actinomycetales, have well over 400 different gene clusters that produce terpenes Arranged by biological activities and usage Provides information on eukaryotic enzymes that have been shown to be a source of “ethnobotanical” terpenes

Transportation typically entails crucial “life-death” choices, delegating crucial decisions to an AI algorithm without any explanation poses a serious threat. Hence, explainability and responsible AI is crucial in the context of intelligent transportation. In Intelligence Transportation System (ITS) implementations such as traffic management systems and autonomous driving applications, AI-based control mechanisms are gaining prominence.Explainable artificial intelligence for intelligent transportation system tackling certain challenges in the field of autonomous vehicle, traffic management system, data integration and analytics and monitor the surrounding environment.The book discusses and inform researchers on explainable Intelligent Transportation system. It also discusses prospective methods and techniques for enabling the interpretability of transportation systems. The book further focuses on ethical considerations apart from technical considerations.

This unique volume covers specific aspects of the biological chemistry of terpenoids. It provides extensive information related to classification, general methods of extraction and isolation of terpenoids, synthesis and pharmacological activities of monoterpenoids, synthesis and medicinal uses of diterpenoids, biogenesis of terpenoids, synthesis and medicinal uses of sesqui terpenoids and sesterpenoids. Some terpenes are also classified as diterpene alkaloids. Most of the terpenoids with diverse molecular structures are biologically active and are used for the treatment of various diseases such as cancer, malaria, inflammation, tuberculosis and infection, and this is discussed.Features:Activities and biological relationships of terpenes An accurate assessment of where and what terpenes can lead to Discusses how microbes, in particular the actinomycetales, have well over 400 different gene clusters that produce terpenes Arranged by biological activities and usage Provides information on eukaryotic enzymes that have been shown to be a source of “ethnobotanical” terpenes

Transportation typically entails crucial “life-death” choices, delegating crucial decisions to an AI algorithm without any explanation poses a serious threat. Hence, explainability and responsible AI is crucial in the context of intelligent transportation. In Intelligence Transportation System (ITS) implementations such as traffic management systems and autonomous driving applications, AI-based control mechanisms are gaining prominence.Explainable artificial intelligence for intelligent transportation system tackling certain challenges in the field of autonomous vehicle, traffic management system, data integration and analytics and monitor the surrounding environment.The book discusses and inform researchers on explainable Intelligent Transportation system. It also discusses prospective methods and techniques for enabling the interpretability of transportation systems. The book further focuses on ethical considerations apart from technical considerations.