Charles Fleming

In this heartfelt memoir from one of the youngest recipients of the transorbital lobotamy, Howard Dully shares the story of a painfully dysfunctional childhood, a misspent youth, his struggle to claim the life that was taken from him, and his redemption.At twelve, Howard Dully was guilty of the same crimes as other boys his age: he was moody and messy, rambunctious with his brothers, contrary just to prove a point, and perpetually at odds with his parents. Yet somehow, this normal boy became one of the youngest people on whom Dr. Walter Freeman performed his barbaric transorbital--or ice pick--lobotomy.Abandoned by his family within a year of the surgery, Howard spent his teen years in mental institutions, his twenties in jail, and his thirties in a bottle. It wasn't until he was in his forties that Howard began to pull his life together. But even as he began to live the "normal" life he had been denied, Howard struggled with one question: Why?There were only three people who would know the truth: Freeman, the man who performed the procedure; Lou, his cold and demanding stepmother who brought Howard to the doctor's attention; and his father, Rodney. Of the three, only Rodney, the man who hadn't intervened on his son's behalf, was still living. Time was running out. Stable and happy for the first time in decades, Howard began to search for answers.Through his research, Howard met other lobotomy patients and their families, talked with one of Freeman's sons about his father's controversial life's work, and confronted Rodney about his complicity. And, in the archive where the doctor's files are stored, he finally came face to face with the truth.Revealing what happened to a child no one--not his father, not the medical community, not the state--was willing to protect, My Lobotomy exposes a shameful chapter in the history of the treatment of mental illness. Yet, ultimately, this is a powerful and moving chronicle of the life of one man.

Howard Dully was 12 years old when he was given a lobotomy. Expelled from the mainstream medical community, his once-popular procedure now a grisly medical relic, Dr Walter Freeman was eager to turn this temperamental 12-year-old into a submissive boy - especially after hearing the terrible lies his stepmother told about him.

Reuma is een chronische ziekte die een grote impact heeft op het leven van miljoenen mensen wereldwijd. In de afgelopen decennia heeft medisch onderzoek echter aanzienlijke vooruitgang geboekt bij het verbeteren van de behandelmogelijkheden voor pati nten. Tegenwoordig beschikken we niet alleen over beproefde medicijnen, maar ook over volledig nieuwe therapeutische benaderingen die een revolutie teweegbrengen in de behandeling van reuma.De focus ligt niet alleen op de successen van de afgelopen decennia, maar vooral op de baanbrekende medicijnen die momenteel in klinisch onderzoek en ontwikkeling zijn. Van biologische geneesmiddelen en Janus kinase remmers tot gepersonaliseerde therapiebenaderingen: Het boek geeft inzicht in de verscheidenheid aan therapiemogelijkheden en legt uit welke rol nieuwe benaderingen spelen, zoals het blokkeren van cytokinen of het gebruik van gerichte kinaseremmers. Het laat zien hoe het gerichte gebruik van biomarkers het mogelijk maakt om therapie n steeds nauwkeuriger af te stemmen op individuele pati nten en schetst de veelbelovende ontwikkelingen die de komende jaren worden verwacht.Dit boek biedt een goed onderbouwde maar tegelijkertijd eenvoudig te begrijpen analyse van de huidige en toekomstige mogelijkheden in de reumatherapie. Het laat zien hoe moderne medicijnen kunnen helpen om de symptomen van reuma te verlichten, de kwaliteit van leven te verbeteren en de progressie van de ziekte op de lange termijn te vertragen. Voor zowel pati nten als specialisten is dit essenti le lectuur die niet alleen informatie verschaft, maar ook hoop geeft op een betere toekomst voor mensen met reuma.

El reumatismo es una enfermedad cr nica que afecta considerablemente a la vida de millones de personas en todo el mundo. Sin embargo, en las ltimas d cadas, la investigaci n m dica ha avanzado notablemente en la mejora de las opciones de tratamiento para los enfermos. Hoy no s lo disponemos de f rmacos de eficacia probada, sino tambi n de enfoques terap uticos completamente nuevos que est n revolucionando el tratamiento del reumatismo.La atenci n se centra no s lo en los xitos de las ltimas d cadas, sino sobre todo en los medicamentos pioneros que se encuentran actualmente en fase de investigaci n y desarrollo cl nico. Desde los biol gicos y los inhibidores de la quinasa Janus hasta los enfoques terap uticos personalizados: El libro ofrece una visi n de la variedad de opciones terap uticas y explica el papel que desempe an los nuevos enfoques, como el bloqueo de las citoquinas o el uso de inhibidores de la cinasa dirigidos. Muestra c mo el uso selectivo de biomarcadores permite adaptar las terapias de forma cada vez m s precisa a cada paciente y esboza los prometedores avances que se esperan en los pr ximos a os.Este libro ofrece un an lisis fundamentado, pero al mismo tiempo f cil de entender, de las posibilidades actuales y futuras en la terapia del reumatismo. Muestra c mo los medicamentos modernos pueden contribuir a aliviar los s ntomas del reumatismo, mejorar la calidad de vida y ralentizar la progresi n de la enfermedad a largo plazo. Tanto para los enfermos como para los especialistas, esta obra es una lectura esencial que no s lo proporciona informaci n, sino que tambi n da esperanzas de un futuro mejor para las personas con reumatismo.1a edici n 2024www.bremenuniversitypress.com

Rheumatism is a chronic disease that has a significant impact on the lives of millions of people worldwide. However, in recent decades, medical research has made significant progress in improving treatment options for sufferers. Today, we not only have proven drugs at our disposal, but also completely new therapeutic approaches that are revolutionizing the treatment of rheumatism.The focus is not only on the successes of the past decades, but above all on the pioneering drugs that are currently in clinical research and development. From biologics and Janus kinase inhibitors to personalized therapy approaches: The book provides insights into the variety of therapy options and explains the role played by new approaches such as the blockade of cytokines or the use of targeted kinase inhibitors. It shows how the targeted use of biomarkers allows therapies to be tailored ever more precisely to individual patients and outlines the promising developments that are expected in the coming years.This book offers a well-founded, yet easy-to-understand analysis of current and future possibilities in rheumatism therapy. It shows how modern drugs can help to alleviate the symptoms of rheumatism, improve quality of life and slow down the progression of the disease in the long term. For sufferers and specialists alike, this work is essential reading that not only provides information, but also gives hope for a better future for people with rheumatism.

Les rhumatismes sont une maladie chronique qui affecte de mani re significative la vie de millions de personnes dans le monde. Cependant, au cours des derni res d cennies, la recherche m dicale a r alis des progr s significatifs afin d'am liorer les possibilit s de traitement pour les personnes atteintes. Aujourd'hui, nous ne disposons pas seulement de m dicaments prouv s, mais aussi d'approches th rapeutiques enti rement nouvelles qui r volutionnent le traitement des rhumatismes.L'accent est mis non seulement sur les succ s des d cennies pass es, mais aussi et surtout sur les m dicaments d'avenir qui sont actuellement en phase de recherche et de d veloppement cliniques. Des produits biologiques aux inhibiteurs de Janus kinase en passant par les approches th rapeutiques personnalis es: Ce livre donne un aper u de la diversit des options th rapeutiques et explique le r le jou par les nouvelles approches telles que le blocage des cytokines ou l'utilisation d'inhibiteurs de kinases cibl s. Il montre comment l'utilisation cibl e de biomarqueurs permet d'adapter les th rapies de plus en plus pr cis ment aux patients individuels et esquisse les d veloppements prometteurs attendus dans les ann es venir.Ce livre offre une analyse la fois fond e et tr s compr hensible des possibilit s actuelles et futures dans le traitement des rhumatismes. Il montre comment les m dicaments modernes peuvent aider soulager les sympt mes des rhumatismes, am liorer la qualit de vie et, long terme, ralentir la progression de la maladie. Pour les personnes concern es comme pour les sp cialistes, cet ouvrage devient une lecture indispensable qui non seulement claire, mais donne aussi l'espoir d'un avenir meilleur pour les personnes atteintes de rhumatismes.

Rheuma ist eine chronische Erkrankung, die das Leben von Millionen Menschen weltweit ma geblich beeinflusst. Doch in den letzten Jahrzehnten hat die medizinische Forschung bedeutende Fortschritte erzielt, um die Behandlungsm glichkeiten f r Betroffene zu verbessern. Heute stehen uns nicht nur bew hrte Medikamente zur Verf gung, sondern auch v llig neue Therapieans tze, die die Rheumabehandlung revolutionieren. Im Mittelpunkt stehen nicht nur die Erfolge der vergangenen Dekaden, sondern vor allem die zukunftsweisenden Medikamente, die derzeit in der klinischen Forschung und Entwicklung sind. Von Biologika ber Januskinase-Inhibitoren bis hin zu personalisierten Therapieans tzen: Das Buch gibt Einblicke in die Vielfalt der Therapieoptionen und erkl rt, welche Rolle neue Ans tze wie die Blockade von Zytokinen oder der Einsatz zielgerichteter Kinasehemmer spielen. Es zeigt, wie durch den gezielten Einsatz von Biomarkern die Therapien immer genauer auf individuelle Patienten zugeschnitten werden k nnen, und skizziert die vielversprechenden Entwicklungen, die in den n chsten Jahren erwartet werden. Dieses Buch bietet eine fundierte, zugleich aber gut verst ndliche Analyse der aktuellen und zuk nftigen M glichkeiten in der Rheumatherapie. Es zeigt auf, wie moderne Medikamente helfen k nnen, die Symptome von Rheuma zu lindern, die Lebensqualit t zu verbessern und langfristig die Krankheitsprogression zu verlangsamen. F r Betroffene und Fachleute gleicherma en wird dieses Werk zu einer unverzichtbaren Lekt re, die nicht nur aufkl rt, sondern auch Hoffnung auf eine bessere Zukunft f r Menschen mit Rheuma macht.

Revised and Updated in September 2020!Secret Walks: A Walking Guide to the Hidden Trails of Los Angeles is a sequel to the popular Secret Stairs: A Walking Guide to the Historic Staircases of Los Angeles, and features another collection of exciting urban walks through parks, canyons, and neighborhoods unknown and unseen by most Angelinos. Each walk is rated for duration, distance, and difficulty, and is accompanied by a map.The walks, like those in Secret Stairs, are filled with fascinating factoids about historical landmarks?the original Bat Cave from Batman, the lake where Opie learned to fish on The Andy Griffith Show, or the storage barn for one of L.A.’s oldest wineries. The book also highlights the people who made the landmarks famous: the infamous water engineer William Mulholland; the convicted murderer and philanthropist Colonel Griffith J. Griffith; Charles Lummis, who walked from Cincinnati to Los Angeles to take a job on the L.A. Times; and tobacco millionaire Abbot Kinney, who dug canals to drain the marshes south of Santa Monica and create his American ?Venice.”Written in the entertainingly informed style that has made Secret Stairs a Los Angeles Times best-seller, Secret Walks is the perfect book for the walker eager to explore but tired of the crowds at Runyon Canyon or Temescal Park.

Revised and Updated in September 2020!The hills of the East Bay contain one of the finest and densest urban hiking environments in the state of California?more than 400 paved pathways and public staircases lattice up and down the slopes of Berkeley and Oakland alone. Rising high above the city centers, with towering views of the San Francisco Bay, the Bay Bridge, and San Francisco itself, these elegant civic walking trails?many of them shaded in oaks and redwoods, and many unknown even to local residents?present a unique landscape for both the casual walker and dedicated hiker.Charles Fleming, the Southern California author whose bestselling 2010 walking guide Secret Stairs turned the hidden public staircases of Los Angeles into popular hiking trails, now turns his eyes northward. For Secret Stairs: East Bay, Fleming has designed more than 30 individual hiking loops. Linking multiple staircases into one-to two-hour self-guided strolls, these urban treks will delight the tourist, newly arrived Berkeley undergraduate, and veteran Bay Area resident alike.The circular walks, each calibrated by length, difficulty, and duration?and each accompanied by a detailed, easy-to-follow map?are sprinkled with fascinating facts about the historic staircases, the historic homes around them, and the famous Bay Area characters who gave them their names. Walk the walks of Bret Harte, Mark Twain, and John Muir! Climb Berkeley’s massive Fred Herbert and Tamalpais Paths, hike Easter Way, and summit Sunset Trail! Mount Oakland’s Oakmore stairs, then tackle the hills of Upper Rockridge and Crocker Highlands via the public staircases. And do it all within easy walking distance from BART or bus stops, free parking, and excellent Bay Area cafés.

Revised and Updated in September 2020!Containing walks and detailed maps from throughout the city, Secret Stairs highlights the charms and quirks of a unique feature of the Los Angeles landscape, and chronicles the geographical, architectural, and historical aspects of the city’s staircases, as well as of the neighborhoods in which the steps are located.From strolling through the classic La Loma neighborhood in Pasadena to walking the Sunset Junction Loop in Silver Lake, to taking the Beachwood Canyon hike through ?Hollywoodland” to enjoying the magnificent ocean views from the Castellammare district in Pacific Palisades, Secret Stairs takes you on a tour of the staircases all across the City of Angels.The circular walks, rated for duration and difficulty, deliver tales of historic homes and their fascinating inhabitants, bits of unusual local trivia, and stories of the neighborhoods surrounding the stairs. That’s where William Faulkner was living when he wrote the screenplay for To Have and Have Not; that house was designed by Neutra; over there is a Schindler; that’s where Woody Guthrie lived, where Anais Nin died, and where Thelma Todd was murdered . . .Despite the fact that one of these staircases starred in an Oscar-winning short film?Laurel and Hardy’s The Music Box, from 1932?these civic treasures have been virtually unknown to most of the city’s residents and visitors. Now, Secret Stairs puts these hidden stairways back on the map, while introducing urban hikers to exciting new ?trails” all around the city of Los Angeles.

Using the life and career of Don Simpson as a point of departure, High Concept is an insight of Hollywood in the 1980's and 90's. For over two decades Simpson was Hollywood's reigning bad boy, yet at the same time with his partner Jerry Bruckheimer, they became the most successful independent producers.