David G. Nathan

Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski’s is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.

Hemoglobin is an iron-containing protein in red blood cells that transports oxygen to tissues throughout the body. The abundance, stability, and oxygen-carrying properties of hemoglobin can be altered by genetic mutations. More than 1000 hemoglobin disorders are known; hemoglobinopathies (e.g., sickle cell disease) and thalassemias are some of the most common human genetic diseases worldwide. Written and edited by experts in the field, this collection from Cold Srping Harbor Perspectives in Biology covers all aspects of hemoglobin and its diseases. Contributors examine the structure, expression, and evolution of the globin genes, the assembly of globin subunits into functional forms of hemoglobin, and the numerous variants that result from genetic alterations. The pathophysiological consequences of hemoglobin disorders (e.g., ineffective erythropoiesis and aberrant iron homeostasis), their clinical manifestations, and epidemiological trends are also described. This book includes discussions of management and treatment strategies for hemoglobin disorders, such as transfusions, iron- chelating agents, gene therapy, and stem cell transplantation. It is an indispensable reference for biochemists, geneticists, cell and developmental biologists, physiologists, and all who are interested in reducing the medical burden of these common genetic diseases.

Praise for The Cancer Treatment Revolution""A wonderful journey through modern medical science, told with warmth and insight, brought to life through the stories of people confronting cancer. This book will inspire and educate both laymen and caregivers.""--Jerome Groopman, M.D., author of The Measure of Our Days and The Anatomy of Hope and Recanati, Professor, Harvard Medical School""This is probably the best book on cancer that exists--beautifully written and unfailingly interesting, conveying a clear sense of hope for cancer patients and survivors. Cancer treatment has come a long way but not without intense struggles and passions, which David Nathan narrates from the inside as one of the leading players. He explains cancer more clearly than anyone else, and his portraits of great cancer doctors are sharp and unforgettable, a contribution to history.""--Richard Preston, author of The Hot Zone and The Demon in the Freezer""No one is better positioned to tell the tale of the cancer treatment revolution of the last half century than David Nathan. A brilliant physician-scientist, he has been present at the cusps of history in this life-and-death field. The story he tells here is fascinating, and his book is captivating.""--Atul Gawande, M.D., author of Complications: A Surgeon's Notes on an Imperfect Science and Better: A Surgeon's Notes on Performance and Assistant Professor of Surgery, Harvard Medical School""David Nathan is a true storyteller. In The Cancer Treatment Revolution, he tells stories that bridge cancer patients and cancer research as few others could. These gripping tales will be appreciated by those who live with cancer and those who strive to create new therapies.""--Thomas Cech, Ph.D., recipient of the 1989 Nobel Prize in Chemistry and President of the Howard Hughes Medical Institute""David Nathan, one of the nation's preeminent clinician-scientists, tells the stories of three cancer patients, revealing compelling human facets--the dedication of the remarkable teams that care for these patients and, even more, the bravery and fortitude of the patients and their families.""--Harold Varmus, M.D., recipient of the 1989 Nobel Prize in Medicine, President of the Memorial Sloan-Kettering Cancer Center, and former director of the National Institutes of Health""Engaged by the compelling triumphs and tragedies of patients whose normal lives are inevitably altered by a life-threatening cancer, the reader of The Cancer Treatment Revolution will easily appreciate the impact of the new cancer diagnostics and therapies compared to even relatively recent cancer treatments.""--Karen Antman, M.D., Dean, Boston University School of Medicine""This personal, highly readable account by one of the leaders of the cancer treatment revolution explains how the revolution has come about and how it will change the future.""--Sir Paul Nurse, Ph.D., President of Rockefeller University and recipient of the 2001 Nobel Prize in Medicine