David Wild

The current drug development paradigm---sometimes expressed as, ``One disease, one target, one drug''---is under question, as relatively few drugs have reached the market in the last two decades. Meanwhile, the research focus of drug discovery is being placed on the study of drug action on biological systems as a whole, rather than on individual components of such systems. The vast amount of biological information about genes and proteins and their modulation by small molecules is pushing drug discovery to its next critical steps, involving the integration of chemical knowledge with these biological databases. Systematic integration of these heterogeneous datasets and the provision of algorithms to mine the integrated datasets would enable investigation of the complex mechanisms of drug action; however, traditional approaches face challenges in the representation and integration of multi-scale datasets, and in the discovery of underlying knowledge in the integrated datasets. The Semantic Web, envisioned to enable machines to understand and respond to complex human requests and to retrieve relevant, yet distributed, data, has the potential to trigger system-level chemical-biological innovations. Chem2Bio2RDF is presented as an example of utilizing Semantic Web technologies to enable intelligent analyses for drug discovery.Table of Contents: Introduction / Data Representation and Integration Using RDF / Data Representation and Integration Using OWL / Finding Complex Biological Relationships in PubMed Articles using Bio-LDA / Integrated Semantic Approach for Systems Chemical Biology Knowledge Discovery / Semantic Link Association Prediction / Conclusions / References / Authors' Biographies

The Personal Digital Resilience Handbook is the essential guide to making your technology resilient - that is, reliable, robust, secure, private, and under your control. Technology is a vital foundation of our lives, and when it fails there can be devastating consequences like losing important files or having personal data stolen. If you feel like you are driving at 90mph on this technology freeway without a seatbelt and want to get some safety and control back, this book is for you. The first four chapters explain in easily-understandable detail how to make your computer and smartphone resilient, keep your files backed up, and use the Internet in a reliable, secure and private way. At the end of each chapter is a checklist you can use to measure your progress. Chapter five covers advanced topics for those who want to go a step further, including threat modeling, Linux and open-source software, an open-source smartphone, off-grid communications, Knowledge Reboot Kits and deleting your digital trail. Are you ready to be digitally resilient?

The book is the thoughts of an individual on life and death. There is no intention to upset or offend but subject matters may be upsetting.

The BBC's Jazz Book of the Year for 2008.Few jazz musicians have had the lasting influence or attracted as much scholarly study as John Coltrane. Yet, despite dozens of books, hundreds of articles, and his own recorded legacy, the "facts" about Coltrane's life and work have never been definitely established. Well-known Coltrane biographer and jazz educator Lewis Porter has assembled an international team of scholars to write The John Coltrane Reference, an indispensable guide to the life and music of John Coltrane.The John Coltrane Reference features a a day-by-day chronology, which extends from 1926-1967, detailing Coltrane's early years and every live performance given by Coltrane as either a sideman or leader, and a discography offering full session information from the first year of recordings, 1946, to the last, 1967. The appendices list every film and television appearance, as well as every recorded interview. Richly illustrated with over 250 album covers and photos from the collection of Yasuhiro Fujioka, The John Coltrane Reference will find a place in every major library supporting a jazz studies program, as well as John Coltrane enthusiasts.

Country music star Brad Paisley salutes others in the music world in this funny, personal, and fascinating portrait of what it's like to be country's leading guitar hero. The Story of a Life with Strings Attached Brad Paisley is one of country music's leading men--admired as a recording artist, a performer, a songwriter, and a guitar slinger. This was not always so. In Diary of a Player, Paisley for the first time fully retraces his entire musical and personal journey to date. And it all began with a loving grandfather who gave eight-year-old Brad Douglas Paisley a Sears Danelectro guitar--the Christmas gift that would alter Brad's life forever. In Brad's own words, we read his emotional tribute to his late great "Papaw," Warren Jarvis, who sparked his dream come true: When I was eight I got a gift from my grandpa. No coincidence that around that time I also got an identity. See, no matter how I have changed, learned, and evolved as a person, the guitar has been a major part of it, and really the only constant. A crutch, a shrink, a friend, love interest, parachute, flying machine, soapbox, canvas, liability, investment, jackpot, tease, a sage, a gateway, an addiction, a recovery, a temptress, a church, a voice, veil, armor, and lifeline. My grandpa knew it could be many of these things for me, but mostly he just wanted me to never be alone. He said if I learned to play, anything would be manageable, and life would be richer. You can get through some real tough moments with that guitar on your knee. When life gets intense, there are people who drink, who seek counseling, eat, or watch TV, pray, cry, sleep, and so on. I play.

The BBC's Jazz Book of the Year for 2008.Few jazz musicians have had the lasting influence or attracted as much scholarly study as John Coltrane. Yet, despite dozens of books, hundreds of articles, and his own recorded legacy, the "facts" about Coltrane's life and work have never been definitely established. Well-known Coltrane biographer and jazz educator Lewis Porter has assembled an international team of scholars to write The John Coltrane Reference, an indispensable guide to the life and music of John Coltrane.The John Coltrane Reference features a a day-by-day chronology, which extends from 1926-1967, detailing Coltrane's early years and every live performance given by Coltrane as either a sideman or leader, and a discography offering full session information from the first year of recordings, 1946, to the last, 1967. The appendices list every film and television appearance, as well as every recorded interview. Richly illustrated with over 250 album covers and photos from the collection of Yasuhiro Fujioka, The John Coltrane Reference will find a place in every major library supporting a jazz studies program, as well as John Coltrane enthusiasts.