Deepak Kaul

महाभारताच्या कथेला आधुनिक साज चढवत व्यावसायिक पार्श्वभूमीवर 'कॉर्पोक्षेत्र' ही कथा घडते. त्यामुळे जुन्या हस्तिनापूर साम्राज्याचे रूपांतर 'हस्तिनापूर एन्टरप्रायझेस'मध्ये होते. धृतराष्ट्र हा त्याचा अध्यक्ष बनतो. कृष्ण हा आधुनिक काळातला व्यवसाय सल्लागार म्हणून सामोरा येतो. वारणावत हे स्थळ 'फॅमिली हॉलिडे होम चे रूप घेते आणि हे सर्व नाट्य घडते ते व्यवसायातल्या भागभांडवलावर हक्क सांगण्यासाठी हस्तिनापूर एन्टरप्रायझेसभोवती फिरणारं हे नाट्य महाभारतातील व्यक्तिरेखांची स्वभाववैशिष्ट्यं कायम ठेवत घडतं. त्यामुळे महाभारतातील गुंतागुंत याही पुस्तकात प्रभावीपणे चित्रित झालेली दिसते.

In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians..