Frank C. Hoppensteadt

Beginning with realistic mathematical or verbal models of physical or biological phenomena, the author derives tractable mathematical models that are amenable to further mathematical analysis or to elucidating computer simulations. For the most part, derivations are based on perturbation methods. Because of this, the majority of the text is devoted to careful derivations of implicit function theorems, the method of averaging, and quasi-static state approximation methods. The duality between stability and perturbation is developed and used, relying heavily on the concept of stability under persistent disturbances. This explains why stability results developed for quite simple problems are often useful for more complicated, even chaotic, ones. Relevant topics about linear systems, nonlinear oscillations, and stability methods for difference, differential-delay, integro- differential and ordinary and partial differential equations are developed throughout the book. For the second edition, the author has restructured the chapters, placing special emphasis on introductory materials in Chapters 1 and 2 as distinct from presentation materials in Chapters 3 through 8. In addition, more material on bifurcations from the point of view of canonical models, sections on randomly perturbed systems, and several new computer simulations have been added.

This book is devoted to an analysis of general weakly connected neural networks (WCNNs) that can be written in the form (0.1) m Here, each Xi E IR is a vector that summarizes all physiological attributes of the ith neuron, n is the number of neurons, Ii describes the dynam­ ics of the ith neuron, and gi describes the interactions between neurons. The small parameter € indicates the strength of connections between the neurons. Weakly connected systems have attracted much attention since the sec­ ond half of seventeenth century, when Christian Huygens noticed that a pair of pendulum clocks synchronize when they are attached to a light­ weight beam instead of a wall. The pair of clocks is among the first weakly connected systems to have been studied. Systems of the form (0.1) arise in formal perturbation theories developed by Poincare, Liapunov and Malkin, and in averaging theories developed by Bogoliubov and Mitropolsky.

This book develops methods for describing random dynamical systems, and it illustrats how the methods can be used in a variety of applications. Appeals to researchers and graduate students who require tools to investigate stochastic systems.

Complex diseases involve most aspects of population biology, including genetics, demographics, epidemiology, and ecology. Mathematical methods, including differential, difference, and integral equations, numerical analysis, and random processes, have been used effectively in all of these areas. The aim of this book is to provide sufficient background in such mathematical and computational methods to enable the reader to better understand complex systems in biology, medicine, and the life sciences. It introduces concepts in mathematics to study population phenomena with the goal of describing complicated aspects of a disease, such as malaria, involving several species. The book is based on a graduate course in computational biology and applied mathematics taught at the Courant Institute of Mathematical Sciences in fall 2010. The mathematical level is kept to essentially advanced undergraduate mathematics, and the results in the book are intended to provide readers with tools for performing more in-depth analysis of population phenomena.

Mathematics in Medicine and the Life Sciences grew from lectures given by the authors at New York University, the University of Utah, and Michigan State University. The material is written for students who have had but one term of calculus, but it contains material that can be used in modeling courses in applied mathematics at all levels through early graduate courses. Numerous exercises are given as well, and solutions to selected exercises are included. Numerous illustrations depict physiological processes, population biology phenomena, models of them, and the results of computer simulations. Mathematical models and methods are becoming increasingly important in medicine and the life sciences. This book provides an introduction to a wide diversity of problems ranging from population phenomena to demographics, genetics, epidemics and dispersal; in physiological processes, including the circulation, gas exchange in the lungs, control of cell volume, the renal counter-current multiplier mechanism, and muscle mechanics; to mechanisms of neural control. Each chapter is graded in difficulty, so a reading of the first parts of each provides an elementary introduction to the processes and their models. Materials that deal with the same topics but in greater depth are included later. Finally, exercises and some solutions are given to test the reader on important parts of the material in the text, or to lead the reader to the discovery of interesting extensions of that material.

This book is based on a course on advanced topics in differential equations given in Spring 2010 at the Courant Institute of Mathematical Sciences. It describes aspects of mathematical modeling, analysis, computer simulation, and visualization in the mathematical sciences and engineering that involve singular perturbations. There is a large literature devoted to singular perturbation methods for ordinary and partial differential equations, but there are not many studies that deal with difference equations, Volterra integral equations, and purely nonlinear gradient systems where there is no dominant linear part. Designed for a one-semester course for students in applied mathematics, it is the purpose of this book to present sufficient rigorous methods and examples to position the reader to investigate singular perturbation problems in such equations. Titles in this series are co-published with the Courant Institute of Mathematical Sciences at New York University.|This book is based on a course on advanced topics in differential equations given in Spring 2010 at the Courant Institute of Mathematical Sciences. It describes aspects of mathematical modeling, analysis, computer simulation, and visualization in the mathematical sciences and engineering that involve singular perturbations. There is a large literature devoted to singular perturbation methods for ordinary and partial differential equations, but there are not many studies that deal with difference equations, Volterra integral equations, and purely nonlinear gradient systems where there is no dominant linear part. Designed for a one-semester course for students in applied mathematics, it is the purpose of this book to present sufficient rigorous methods and examples to position the reader to investigate singular perturbation problems in such equations. Titles in this series are co-published with the Courant Institute of Mathematical Sciences at New York University.

This book develops methods for describing random dynamical systems, and it illustrats how the methods can be used in a variety of applications. Appeals to researchers and graduate students who require tools to investigate stochastic systems.

This book is intended for second year undergraduate students majoring in science or engineering. It is directed at pre-medical students, life science majors, engineering students, and applied or computational mathematics majors.

Beginning with realistic mathematical or verbal models of physical or biological phenomena, the author derives tractable mathematical models that are amenable to further mathematical analysis or to elucidating computer simulations. For the most part, derivations are based on perturbation methods. Because of this, the majority of the text is devoted to careful derivations of implicit function theorems, the method of averaging, and quasi-static state approximation methods. The duality between stability and perturbation is developed and used, relying heavily on the concept of stability under persistent disturbances. This explains why stability results developed for quite simple problems are often useful for more complicated, even chaotic, ones. Relevant topics about linear systems, nonlinear oscillations, and stability methods for difference, differential-delay, integro- differential and ordinary and partial differential equations are developed throughout the book. For the second edition, the author has restructured the chapters, placing special emphasis on introductory materials in Chapters 1 and 2 as distinct from presentation materials in Chapters 3 through 8. In addition, more material on bifurcations from the point of view of canonical models, sections on randomly perturbed systems, and several new computer simulations have been added.

This book is devoted to an analysis of general weakly connected neural networks (WCNNs) that can be written in the form (0.1) m Here, each Xi E IR is a vector that summarizes all physiological attributes of the ith neuron, n is the number of neurons, Ii describes the dynam­ ics of the ith neuron, and gi describes the interactions between neurons. The small parameter € indicates the strength of connections between the neurons. Weakly connected systems have attracted much attention since the sec­ ond half of seventeenth century, when Christian Huygens noticed that a pair of pendulum clocks synchronize when they are attached to a light­ weight beam instead of a wall. The pair of clocks is among the first weakly connected systems to have been studied. Systems of the form (0.1) arise in formal perturbation theories developed by Poincare, Liapunov and Malkin, and in averaging theories developed by Bogoliubov and Mitropolsky.

This book describes the signal processing aspects of neural networks. It begins with a presentation of the necessary background material in electronic circuits, mathematical modeling and analysis, signal processing, and neurosciences, and then proceeds to applications. These applications include small networks of neurons, such as those used in control of warm-up and flight in moths and control of respiration during exercise in humans. Next, a theory of mnemonic surfaces is developed and studied and material on pattern formation and cellular automata is presented. Finally, large networks are studied, such as the thalamus-reticular complex circuit, believed to be involved in focusing attention, and the development of connections in the visual cortex. Additional material is also provided about nonlinear wave propagation in networks. This book will serve as an excellent text for advanced undergraduates and graduates in the physical sciences, mathematics, engineering, medicine and life sciences.

This book describes the signal processing aspects of neural networks. It begins with a presentation of the necessary background material in electronic circuits, mathematical modeling and analysis, signal processing, and neurosciences, and then proceeds to applications. These applications include small networks of neurons, such as those used in control of warm-up and flight in moths and control of respiration during exercise in humans. Next, a theory of mnemonic surfaces is developed and studied and material on pattern formation and cellular automata is presented. Finally, large networks are studied, such as the thalamus-reticular complex circuit, believed to be involved in focusing attention, and the development of connections in the visual cortex. Additional material is also provided about nonlinear wave propagation in networks. This book will serve as an excellent text for advanced undergraduates and graduates in the physical sciences, mathematics, engineering, medicine and life sciences.

This introduction to mathematical methods that are useful for studying population phenomena is intended for advanced undergraduate and graduate students, and will be accessible to scientists who do not have a strong mathematics background. The material is graded in mathematical difficulty. The earlier parts of the book involve elementary diference equations while later chapters present topics that require more mathematical preparation. Models of total population and population age structure are first derived and studied, and then models of random population events are presented in terms of Markov chains. The last two chapters deal with mathematical methods used to uncover qualitative behaviour of more complicated difference equations. Each chapter begins with a simple model, usually of some historical interest, that defines the primary goals of the chapter. Exercises, for which solutions are provided, illustrate material in the text and also deal with models more advanced than those derived and studied in the text.