Gurmeet Singh

Severe community acquired pneumonia (SCAP) remains a significant threat to global health, causing immense morbidity and mortality. This book explores recent advances in pathogens, host immunity, and antimicrobial resistance. Details on innovative diagnostic techniques, including novel imaging modalities and biomarkers for rapid and accurate diagnosis, provides up-to-date guidance on therapeutic strategies such as FAST HUGS BID, along with palliative care and rehabilitation, supported by case studies. This practical guide is a ready reckoner for internal medicine residents, pulmonologists, and critical care specialists.Key Features: Details on preventative measures, including vaccination strategies and public health interventions. Provides a comprehensive and up-to-date current resource companion for Internal Medicine Residency, Pulmonology and Critical Care Consultants. Offers a roadmap to navigate the ever-changing landscape of severe community-acquired pneumonia, including newer diagnostic methods, immunology, and up-to-date management.

Severe community acquired pneumonia (SCAP) remains a significant threat to global health, causing immense morbidity and mortality. This book explores recent advances in pathogens, host immunity, and antimicrobial resistance. Details on innovative diagnostic techniques, including novel imaging modalities and biomarkers for rapid and accurate diagnosis, provides up-to-date guidance on therapeutic strategies such as FAST HUGS BID, along with palliative care and rehabilitation, supported by case studies. This practical guide is a ready reckoner for internal medicine residents, pulmonologists, and critical care specialists.Key Features: Details on preventative measures, including vaccination strategies and public health interventions. Provides a comprehensive and up-to-date current resource companion for Internal Medicine Residency, Pulmonology and Critical Care Consultants. Offers a roadmap to navigate the ever-changing landscape of severe community-acquired pneumonia, including newer diagnostic methods, immunology, and up-to-date management.

The book covers a range of unique, challenging, and complicated respiratory and critical illness cases (pneumonia, cancer, asthma), and other internal medicine conditions. It provides an in-depth understanding of the underlying pathophysiology of diseases and applications of the latest interventional pulmonology techniques for diagnosing and treating patients. Additionally, it includes updates on current standard treatment options for critical illness conditions. Individual chapters provide a comprehensive and structured approach to each complex and distinct disease. It covers lung and airway diseases and conditions that affect other organs including, the pancreas, lymph nodes, and heart. Chapters are supplemented with original figures of patients’ radiology and/or biopsy results. It provides easy-to-follow explanations and key points in each chapter. It discusses cases treated by a multidisciplinary team; most early diagnosed and treated cases have a good prognosis. These cases help medical practitioners better understand and develop an early approach to similar cases in their daily clinical practice. The book also illustrates the benefits of early interventions, such as interventional pulmonology or surgical procedures. This book is useful for physicians, including intensivists, respirologists, internists and general practitioners, and medical students/trainees and students in the health field (nursing, public health, pharmacy).

Die Pharmakokinetik von Moxifloxacin @ 5mg.kg-1.K rpergewicht wurde bei gesunden und Bifenthrin-intoxizierten Ziegen (n=4) nach intraven ser Verabreichung untersucht. Die MHK von Moxifloxacin im Plasma wurde bei gesunden Ziegen bis zu 8 Stunden aufrechterhalten, w hrend sie bei Bifenthrin-intoxizierten Ziegen nur bis zu 6 Stunden aufrechterhalten wurde. Die AUC war bei Bifenthrin-intoxizierten Ziegen signifikant von 7,86 0,06g.ml-1h auf 6,90 0,076g.ml-1h verringert. Die Verteilungshalbwertszeit (t1/2) und das Verteilungsvolumen im Flie gleichgewicht (Vd(ss)) betrugen 0,08 0,0008 h bzw. 2,43 0,01L.kg-1 bei gesunden Ziegen und 0,081 0,0006h bzw. 2,32 0,03L.kg-1 bei bifenthrinintoxizierten Ziegen. Die Gesamtk rper-Clearance war von 636,06 4,68 ml.kg-1h-1 bei gesunden Ziegen auf 725,4 7,92 ml.kg-1h-1 bei vergifteten Ziegen erh ht. Allerdings wurde bei vergifteten Ziegen eine Verringerung der Eliminationshalbwertszeit (t1/2) von 2,81 0,04h auf 2,61 0,01h beobachtet. Das bei gesunden Tieren berechnete Dosierungsschema von Moxifloxacin betr gt 4,99 mg/kg-1, gefolgt von 4,73 mg/kg-1 in 12-st ndigen Abst nden, wirksam gegen bakterielle Isolate mit MHK

A farmacocin tica da moxifloxacina @ 5mg.kg-1.b.wt foi estudada em cabras saud veis e intoxicadas com bifentrina (n=4), ap s a sua administra o IV. A CIM da moxifloxacina no plasma foi mantida at 8h em cabras saud veis, enquanto que foi mantida apenas at 6h em cabras intoxicadas com bifentrina. A AUC diminuiu significativamente de 7,86 0,06g.ml-1h para 6,90 0,076g.ml-1h em cabras intoxicadas com bifentrina. A semi-vida de distribui o (t1/2) e o volume de distribui o no estado estacion rio Vd(ss) observados foram 0,08 0,0008 h e 2,43 0,01L.kg-1 respetivamente em cabras saud veis e 0,081 0,0006h e 2,32 0,03L.kg-1 em cabras intoxicadas com bifentrina. A depura o corporal total aumentou de 636,06 4,68 ml.kg-1h-1 em cabras saud veis para 725,4 7,92 ml.kg-1h-1 em cabras intoxicadas. No entanto, observou-se uma diminui o da semi-vida de elimina o (t1/2) de 2,81 0,04h para 2,61 0,01h em cabras intoxicadas. O regime de dosagem de moxifloxacina calculado em animais saud veis de 4,99 mg.kg-1 seguido de 4,73 mg.kg-1 com um intervalo de 12 horas, eficaz contra isolados bacterianos com CIM

La pharmacocin tique de la moxifloxacine @ 5mg.kg-1.b.wt a t tudi e chez des ch vres saines et intoxiqu es la bifenthrine (n=4), apr s son administration IV. La CMI de la moxifloxacine dans le plasma a t maintenue jusqu' 8 heures chez les ch vres saines alors qu'elle n'a t maintenue que jusqu' 6 heures chez les ch vres intoxiqu es par la bifenthrine. L'ASC a t significativement r duite de 7,86 0,06g.ml-1h 6,90 0,076g.ml-1h chez les ch vres intoxiqu es par la bifenthrine. La demi-vie de distribution (t1/2) et le volume de distribution l' tat d' quilibre Vd(ss) ¬observ s taient respectivement de 0,08 0,0008 h et 2,43 0,01L.kg-1 chez les ch vres saines et de 0,081 0,0006h et 2,32 0,03L.kg-1 chez les ch vres intoxiqu es la bifenthrine. La clairance corporelle totale est pass e de 636,06 4,68 ml.kg-1h-1 chez les ch vres saines 725,4 7,92 ml.kg-1h-1 chez les ch vres intoxiqu es. Cependant, une diminution de la demi-vie d' limination (t1/2) de 2,81 0,04h 2,61 0,01h a t observ e chez les ch vres intoxiqu es. Le sch ma posologique de la moxifloxacine calcul chez les animaux sains est de 4,99 mg.kg-1 suivi de 4,73 mg.kg-1 12h d'intervalle efficace contre les isolats bact riens avec une CMI

La farmacocinetica della moxifloxacina @ 5mg.kg-1.b.wt stata studiata in capre sane e intossicate da bifentrin (n=4), dopo la sua somministrazione endovenosa. La MIC della moxifloxacina nel plasma stata mantenuta fino a 8 ore nelle capre sane, mentre stata mantenuta solo fino a 6 ore nelle capre intossicate da bifentrin. L'AUC diminuita significativamente da 7,86 0,06g, ml-1h a 6,90 0,076g, ml-1h nelle capre intossicate da bifentrin. L'emivita di distribuzione (t1/2) e il volume di distribuzione allo stato stazionario Vd(ss) ¬osservati erano rispettivamente 0,08 0,0008 h e 2,43 0,01L.kg-1 nelle capre sane e 0,081 0,0006h e 2,32 0,03L.kg-1 nelle capre intossicate da bifentrin. La clearance corporea totale aumentata da 636,06 4,68 ml.kg-1h-1 nelle capre sane a 725,4 7,92 ml.kg-1h-1 nelle capre intossicate. Tuttavia, nelle capre intossicate stata osservata una diminuzione dell'emivita di eliminazione (t1/2) da 2,81 0,04h a 2,61 0,01h. Il regime di dosaggio della moxifloxacina calcolato negli animali sani di 4,99 mg.kg-1 seguiti da 4,73 mg.kg-1 a intervalli di 12 ore, efficace contro gli isolati batterici con MIC

Pharmacokinetics of moxifloxacin @ 5mg.kg-1.b.wt was studied in healthy and bifenthrin intoxicated goats (n=4), following its IV administration. The MIC of moxifloxacin in plasma was maintained up to 8h in healthy goats whereas it was maintained only up to 6h in bifenthrin-intoxicated goats. The AUC was significantly decreased from 7.86 0.06g.ml-1h to 6.90 0.076g.ml-1h in bifenthrin-intoxicated goats. The distribution half-life (t1/2) and volume of distribution at steady state Vd(ss) ¬observed were 0.08 0.0008 h and 2.43 0.01L.kg-1 respectively in healthy goats and 0.081 0.0006h and 2.32 0.03L.kg-1 in bifenthrin intoxicated goats. Total body clearance was increased from 636.06 4.68 ml.kg-1h-1 in healthy to 725.4 7.92 ml.kg-1h-1 in intoxicated goats. However, decrease in elimination half life (t1/2) from 2.81 0.04h to 2.61 0.01h was observed in intoxicated goats. The dosage regimen of moxifloxacin calculated in healthy animals is 4.99 mg.kg-1 followed by 4.73 mg.kg-1 at 12h interval effective against bacterial isolates with MIC

Dans la pr sente tude, on s'est efforc d'optimiser les param tres de fraisage CNC pour le mat riau D3 l'aide de la m thode des surfaces de r ponse (RSM) afin de maximiser le taux d'enl vement de mati re (MRR) et de minimiser la rugosit de la surface. La vitesse (tr/min), l'avance (mm/min) et la profondeur de coupe (mm) tant les principaux param tres de fraisage optimiser, les comp tences de l'op rateur, l'outil utilis , le mat riau de travail, les conditions d'usinage, le liquide de refroidissement utilis , etc. sont des facteurs de bruit. Les param tres optimiser dans la pr sente tude sont donc la vitesse, l'avance et la profondeur de coupe. La rugosit de surface (Ra) et le taux d'enl vement de mati re (Ra) sont les r ponses consid r es. L'usinage a t effectu sur une fraiseuse verticale CNC de la s rie 1992 de Kitumura avec un outil en carbure 4 goujures sur la matrice RSM des param tres d'entr e. Le taux d'enl vement de mati re (MRR) et la rugosit de surface (Ra) sont mesur s. Le travail d'analyse a ensuite t effectu l'aide d'un test de r gression. Apr s cela, nous avons obtenu des param tres optimis s pour le fraisage CNC afin d'obtenir un taux d'enl vement de mati re maximal et une rugosit de surface minimale.

Nel presente studio si cercato di ottimizzare i parametri di fresatura CNC per il materiale D3 utilizzando il metodo della superficie di risposta (RSM) per massimizzare il tasso di rimozione del materiale (MRR) e minimizzare la rugosit superficiale. Poich la velocit (rpm), l'avanzamento (mm/min) e la profondit di taglio (mm) sono i principali parametri di fresatura da ottimizzare, sono stati considerati come fattori di disturbo anche l'abilit dell'operatore, l'utensile utilizzato, il materiale di lavoro, le condizioni di lavorazione, il refrigerante utilizzato ecc. Pertanto, i parametri considerati da ottimizzare nel presente studio sono la velocit , l'avanzamento e la profondit di taglio. La rugosit superficiale (Ra) e il tasso di rimozione del materiale (Ra) sono le risposte considerate. La lavorazione stata eseguita su una fresatrice verticale a controllo numerico della serie Kitumura 1992 con un utensile in metallo duro a 4 taglienti, sulla base della matrice RSM dei parametri di input. Inoltre, sono stati misurati il tasso di rimozione del materiale (MRR) e la rugosit superficiale (Ra). Quindi stato effettuato un lavoro di analisi utilizzando il test di regressione. In seguito si sono ottenuti i parametri ottimizzati per la fresatura CNC per ottenere il massimo MRR e la minima Ra.

No presente estudo, foi feito um esfor o para otimizar os par metros de fresagem CNC para o material D3 utilizando o M todo da Superf cie de Resposta (RSM) para maximizar a taxa de remo o de material (MRR) e minimizar a rugosidade da superf cie. Como a Velocidade (rpm), o Avan o (mm/min) e a profundidade de corte (mm) s o os principais par metros de fresagem a otimizar, inclui a capacidade do operador, a Ferramenta utilizada, o material de trabalho, as condi es de maquina o, o l quido de refrigera o utilizado, etc. como factores de ru do. Por conseguinte, os par metros considerados para otimiza o no presente estudo s o a velocidade, o avan o e a profundidade de corte. A rugosidade da superf cie (Ra) e a taxa de remo o de material (Ra) s o as respostas consideradas. A maquinagem foi efectuada numa fresadora vertical CNC da s rie Kitumura 1992, modelo 1992, com uma ferramenta de carboneto de 4 canais, com base na matriz RSM dos par metros de entrada. Al m disso, s o medidas a taxa de remo o de material (MRR) e a rugosidade da superf cie (Ra). Em seguida, o trabalho de an lise foi efectuado utilizando o teste de regress o. Depois disso, obtivemos par metros optimizados para a fresagem CNC para obter a MRR m xima e a Ra m nima. Os valores ptimos dos par metros de maquina o - velocidade de corte, avan o e profundidade de corte foram determinados como 2210,07 rpm, 850 mm/min e 0,237430 mm, respetivamente.

In der vorliegenden Studie wurde versucht, die CNC-Fr sparameter f r das Material D3 mit Hilfe der Response Surface Method (RSM) zu optimieren, um die Materialabtragsrate (MRR) zu maximieren und die Oberfl chenrauheit zu minimieren. Da die Drehzahl (U/min), der Vorschub (mm/min) und die Schnitttiefe (mm) die wichtigsten zu optimierenden Fr sparameter sind, werden auch die F higkeiten des Bedieners, das verwendete Werkzeug, das Werkst ckmaterial, die Bearbeitungsbedingungen, das verwendete K hlmittel usw. als St rfaktoren ber cksichtigt. Die in der vorliegenden Studie zu optimierenden Parameter sind daher Drehzahl, Vorschub und Schnitttiefe. Oberfl chenrauhigkeit (Ra) und Materialabtragsrate (Ra) sind die betrachteten Antworten. Die Bearbeitung erfolgte auf einer CNC-Vertikalfr smaschine der Modellreihe Kitumura 1992 mit einem 4-Nuten-Hartmetallwerkzeug auf der RSM-Matrix der Eingangsparameter. Weiterhin wurden die Materialabtragsrate (MRR) und die Oberfl chenrauheit (Ra) gemessen. Dann wurde die Analyse mit Hilfe eines Regressionstests durchgef hrt. Danach haben wir optimierte Parameter f r das CNC-Fr sen erhalten, um maximale MRR und minimale Ra zu erhalten. Die optimalen Werte der Bearbeitungsparameter - Schnittgeschwindigkeit, Vorschub und Schnitttiefe - wurden mit 2210,07 U/min, 850 mm/min bzw. 0,237430 mm bestimmt.

Operations research (OR) is an analytical method of problem-solving and decision-making that is useful in the management of organizations. In operations research, problems are broken down into basic components and then solved in defined steps by mathematical analysis.The concept of operations research arose during World War II by military planners. After the war, the techniques used in their operations research were applied to addressing problems in business, the government and society.

The word “titanic” reminds one of the majestic ship Titanic and James Cameron’s epic romance movie Titanic—in many cases the film first and the ship next. The Titanic was the world’s largest passenger ship when it entered service, measuring 269 m (882 feet) in length, and the largest man-made moving object on earth. The colossal ship and the epic movie inspired the authors, Susai Rajendran (professor of chemistry) and Gurmeet Singh (a renowned academic administrator and an internationally reputed expert in the field of corrosion science and smart materials) to study why the Titanic collapsed. The main reason seems to be bimetallic corrosion, also known as galvanic corrosion. This book discusses various aspects of galvanic corrosion, namely causes, consequences, methods of control, and case studies. It also reports research on the causes of corrosion of the sunken ship, including microbiologically influenced corrosion (MIC) and metallurgical failure. The book is a great reference for research scholars in the field of corrosion, graduate- and postgraduate-level students, the general public, and marine engineers.

This book describes revelations about Jap Meditation as explained by Guru Nanak in Japji. Guru Nanak laid foundation of a revolutionary approach to Spirituality some 500 years back. The concepts in Japji elucidate the nature of "true reality" in Creation. The composition itself is a form of steps in the Jap meditation. It is a method that takes us deep within the mindscape where the inner voice of guidance is heard. With it we recognise our origin and the nature of consciousness. Our conscious awareness begins to have new vision. and ability. We can know the Sach, the Truth only when we go within. We can, with this method, reap the benefit of inner world in our worldly life. This is the way to be free of fear and anxiety. This is the method through which we can remove negative thoughts and inclinations from our personality. The move within to the Nirgun point is not only an awakening but an empowerment. At this point, we hear the Celestial Sound vibration of Creation. This shift to this Nirgun point is destined to shift humanity towards a life aligned with the truth of existence. This is an age in the history of mankind that despite the desire about spiritual awakening, there is so much misinformation. Japji tells us that Maya (the deceptive influence) is inbuilt in the world construct. It prevents an easy knowing of truth about the created world. The way out is to be guided by internal guidance. True understanding and guidance come by having an awareness of the Nirgun, the formless world within. Outside in the Physical world this "truth" is not perceptible as there our mind is involved in worldly affairs. We have a self-identity. There is purification and change of attitude. The mind then becomes aware of the presence of Truth. Humanity needs this to get to the next level.In this modern world there is an ongoing talk of consciousness revolution and "Fifth dimensional Living". The concepts for such a life were brought to this world by Guru Nanak with his advent in this world. He travelled more than 28,000 Kms in five major tours of the world during the period from 1500 to 1524 bringing the light of knowledge to the innumerable souls leaving behind his compositions. This book is an English translation of Japji and along with the comments reveals the indicated message. The composition not only reveals the "Truth" but also explains the realisation of it. Gurbani hymns are the words of the inner true Guru. Japji has at its beginning the main light in the form of the Mool Mantar.For awakening to the truth no rites, rituals or pilgrimages are needed. All we need is true guidance. Guru Nanak has brought this method for the humanity. This is the time it is explained with true meanings for humanity's transformation towards an awakened living.